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Protein

Trimeric intracellular cation channel type B

Gene

Tmem38b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Trimeric intracellular cation channel type B
Short name:
TRIC-B
Short name:
TRICB
Alternative name(s):
Transmembrane protein 38B
Gene namesi
Name:Tmem38b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1305703. Tmem38b.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 49LumenalSequence analysisAdd BLAST49
Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Topological domaini71 – 75CytoplasmicSequence analysis5
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Topological domaini97 – 139CytoplasmicSequence analysisAdd BLAST43
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Topological domaini161 – 205LumenalSequence analysisAdd BLAST45
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Topological domaini227 – 291CytoplasmicSequence analysisAdd BLAST65

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002915261 – 291Trimeric intracellular cation channel type BAdd BLAST291

Proteomic databases

PaxDbiQ68FV1.
PRIDEiQ68FV1.

Expressioni

Gene expression databases

BgeeiENSRNOG00000028063.
GenevisibleiQ68FV1. RN.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033050.

Family & Domainsi

Domaini

The second transmembrane domain has been proposed to cross only half of the lipid bilayer and to loop back into the cytosol, so that the domains on each side of this domain are both found on the cytosolic face of the membrane. The cytosolic loop may form an ion-conducting pore (By similarity).By similarity

Sequence similaritiesi

Belongs to the TMEM38 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3944. Eukaryota.
ENOG410XQ0P. LUCA.
GeneTreeiENSGT00390000018845.
HOGENOMiHOG000037929.
HOVERGENiHBG059853.
InParanoidiQ68FV1.
OMAiKMSYPSK.
OrthoDBiEOG091G0GQP.
PhylomeDBiQ68FV1.
TreeFamiTF313483.

Family and domain databases

InterProiIPR007866. TRIC_channel.
[Graphical view]
PANTHERiPTHR12454. PTHR12454. 1 hit.
PfamiPF05197. TRIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68FV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYPWDDLTL AFSRTSMFPF FDIAHYLVSV MALKQRPGAV AAAWSNPLSS
60 70 80 90 100
WLSAMLHCFG GGILSCILLA EPPLKFLTNH TNILLASSIW YIVFFCPRDL
110 120 130 140 150
VSQGYSYQPI QLLAAGMKEV TRTWKIVGGV AHANGYYRNG WIVMIAVGWA
160 170 180 190 200
RGAGGAIITA CEQLLKGDWK PEGDEWLKMS FPCKVTLLGS IMFTFQHTRH
210 220 230 240 250
LAISKHDLMF LYTIFLVTIK VTMMMTKDAA VTLTPFEDTL TRMLFGRQQQ
260 270 280 290
QFSLSEKKAE VKPSSNGSAS SASKRGTEPP SSAKRHAKKE D
Length:291
Mass (Da):32,445
Last modified:October 11, 2004 - v1
Checksum:iA2A821E0058EEE96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079336 mRNA. Translation: AAH79336.1.
RefSeqiNP_001014213.1. NM_001014191.1.
UniGeneiRn.22285.

Genome annotation databases

EnsembliENSRNOT00000034570; ENSRNOP00000033050; ENSRNOG00000028063.
GeneIDi362521.
KEGGirno:362521.
UCSCiRGD:1305703. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079336 mRNA. Translation: AAH79336.1.
RefSeqiNP_001014213.1. NM_001014191.1.
UniGeneiRn.22285.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033050.

Proteomic databases

PaxDbiQ68FV1.
PRIDEiQ68FV1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000034570; ENSRNOP00000033050; ENSRNOG00000028063.
GeneIDi362521.
KEGGirno:362521.
UCSCiRGD:1305703. rat.

Organism-specific databases

CTDi55151.
RGDi1305703. Tmem38b.

Phylogenomic databases

eggNOGiKOG3944. Eukaryota.
ENOG410XQ0P. LUCA.
GeneTreeiENSGT00390000018845.
HOGENOMiHOG000037929.
HOVERGENiHBG059853.
InParanoidiQ68FV1.
OMAiKMSYPSK.
OrthoDBiEOG091G0GQP.
PhylomeDBiQ68FV1.
TreeFamiTF313483.

Miscellaneous databases

PROiQ68FV1.

Gene expression databases

BgeeiENSRNOG00000028063.
GenevisibleiQ68FV1. RN.

Family and domain databases

InterProiIPR007866. TRIC_channel.
[Graphical view]
PANTHERiPTHR12454. PTHR12454. 1 hit.
PfamiPF05197. TRIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM38B_RAT
AccessioniPrimary (citable) accession number: Q68FV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.