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Protein

Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

Gene

Coq6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Ubiquinone biosynthesis

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrialUniRule annotation (EC:1.14.13.-UniRule annotation)
Alternative name(s):
Coenzyme Q10 monooxygenase 6UniRule annotation
Gene namesi
Name:Coq6UniRule annotation
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1311149. Coq6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Golgi apparatus, Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4242MitochondrionSequence analysisAdd
BLAST
Chaini43 – 476434Ubiquinone biosynthesis monooxygenase COQ6, mitochondrialPRO_0000418621Add
BLAST

Proteomic databases

PaxDbiQ68FU7.
PRIDEiQ68FU7.

PTM databases

PhosphoSiteiQ68FU7.

Expressioni

Tissue specificityi

In the kidney, expressed almost exclusively in glomerular podocytes. In the inner ear, expressed in the spiral ganglion, as well as in stria vascularis and spiral ligament cells.1 Publication

Gene expression databases

BgeeiENSRNOG00000011164.
GenevisibleiQ68FU7. RN.

Interactioni

Subunit structurei

Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ7.UniRule annotation

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014914.

Structurei

3D structure databases

ProteinModelPortaliQ68FU7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UbiH/COQ6 family.UniRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3855. Eukaryota.
COG0654. LUCA.
GeneTreeiENSGT00390000015152.
HOGENOMiHOG000255772.
HOVERGENiHBG029533.
InParanoidiQ68FU7.
KOiK06126.
OMAiSCRRWSG.
OrthoDBiEOG091G0NNO.
PhylomeDBiQ68FU7.
TreeFamiTF105772.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
HAMAPiMF_03193. COQ6_monooxygenase. 1 hit.
InterProiIPR002938. FAD-bd.
IPR023753. FAD/NAD-binding_dom.
IPR018168. Ubi_Hdrlase_CS.
IPR010971. UbiH/COQ6.
IPR000689. UbQ_mOase_COQ6.
[Graphical view]
PfamiPF01494. FAD_binding_3. 2 hits.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
TIGRFAMsiTIGR01989. COQ6. 1 hit.
TIGR01988. Ubi-OHases. 1 hit.
PROSITEiPS01304. UBIH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68FU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARIGPMAG LLCVRWWSTA QLAARGGPLV ACRRWTSSST DSVYDVVVSG
60 70 80 90 100
GGMVGSAMAC ALGHDIHFHD KKILLLEAGP KKTLEKLSET YSNRVSSISL
110 120 130 140 150
GSTTLLSSFG AWDHICNMRC KAFRRMQVWD SCSEALIMFD KDNLDDMGYI
160 170 180 190 200
VENDVIMHAI TKQLEAVADR VKVLYESKAV GYAWPGPFSL ADSSPWVHIT
210 220 230 240 250
LGDGSTLQTK LLIGADGHNS GVRQAAGIQN VGWNYDQSAV VATLHLSEAT
260 270 280 290 300
ENNVAWQRFL PSGPIALLPL SDTLSSLVWS TSHAHAAELV SMHEEEFVDA
310 320 330 340 350
INSAFWSDVH HTDFVDSASA MVHHAVALLK PTKVSARQLP PSVAKVDAKS
360 370 380 390 400
RALFPLGLGH AAEYVRPRVA LIGDAAHRVH PLAGQGVNMG FGDISSLIHY
410 420 430 440 450
LSTAAFNGKD LGSMSHLTGY ETDRQRHNTA LLAATDLLKR LYSTSTTPLV
460 470
LLRTWGLQAT NAVSPLKEQI MAFASR
Length:476
Mass (Da):51,496
Last modified:October 11, 2004 - v1
Checksum:iCD4D2BC7D7C03880
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473982 Genomic DNA. Translation: EDL81500.1.
BC079342 mRNA. Translation: AAH79342.1.
RefSeqiNP_001011983.1. NM_001011983.1.
UniGeneiRn.9283.

Genome annotation databases

EnsembliENSRNOT00000014913; ENSRNOP00000014914; ENSRNOG00000011164.
GeneIDi299195.
KEGGirno:299195.
UCSCiRGD:1311149. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473982 Genomic DNA. Translation: EDL81500.1.
BC079342 mRNA. Translation: AAH79342.1.
RefSeqiNP_001011983.1. NM_001011983.1.
UniGeneiRn.9283.

3D structure databases

ProteinModelPortaliQ68FU7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014914.

PTM databases

PhosphoSiteiQ68FU7.

Proteomic databases

PaxDbiQ68FU7.
PRIDEiQ68FU7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000014913; ENSRNOP00000014914; ENSRNOG00000011164.
GeneIDi299195.
KEGGirno:299195.
UCSCiRGD:1311149. rat.

Organism-specific databases

CTDi51004.
RGDi1311149. Coq6.

Phylogenomic databases

eggNOGiKOG3855. Eukaryota.
COG0654. LUCA.
GeneTreeiENSGT00390000015152.
HOGENOMiHOG000255772.
HOVERGENiHBG029533.
InParanoidiQ68FU7.
KOiK06126.
OMAiSCRRWSG.
OrthoDBiEOG091G0NNO.
PhylomeDBiQ68FU7.
TreeFamiTF105772.

Enzyme and pathway databases

UniPathwayiUPA00232.

Miscellaneous databases

PROiQ68FU7.

Gene expression databases

BgeeiENSRNOG00000011164.
GenevisibleiQ68FU7. RN.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
HAMAPiMF_03193. COQ6_monooxygenase. 1 hit.
InterProiIPR002938. FAD-bd.
IPR023753. FAD/NAD-binding_dom.
IPR018168. Ubi_Hdrlase_CS.
IPR010971. UbiH/COQ6.
IPR000689. UbQ_mOase_COQ6.
[Graphical view]
PfamiPF01494. FAD_binding_3. 2 hits.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
TIGRFAMsiTIGR01989. COQ6. 1 hit.
TIGR01988. Ubi-OHases. 1 hit.
PROSITEiPS01304. UBIH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOQ6_RAT
AccessioniPrimary (citable) accession number: Q68FU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2012
Last sequence update: October 11, 2004
Last modified: September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.