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Q68FU3 (ETFB_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Electron transfer flavoprotein subunit beta

Short name=Beta-ETF
Gene names
Name:Etfb
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length255 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) By similarity.

Cofactor

Binds 1 FAD per dimer By similarity.

Binds 1 AMP per subunit By similarity.

Subunit structure

Heterodimer of an alpha and a beta subunit By similarity.

Subcellular location

Mitochondrion matrix By similarity.

Sequence similarities

Belongs to the ETF beta-subunit/FixA family.

Ontologies

Keywords
   Biological processElectron transport
Transport
   Cellular componentMitochondrion
   LigandFAD
Flavoprotein
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processoxidation-reduction process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentmitochondrial matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionelectron carrier activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 255254Electron transfer flavoprotein subunit beta
PRO_0000231526

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue191N6-acetyllysine; alternate By similarity
Modified residue191N6-succinyllysine; alternate By similarity
Modified residue351N6-acetyllysine; alternate By similarity
Modified residue351N6-succinyllysine; alternate By similarity
Modified residue561N6-acetyllysine By similarity
Modified residue591N6-acetyllysine; alternate By similarity
Modified residue591N6-succinyllysine; alternate By similarity
Modified residue1101N6-acetyllysine; alternate By similarity
Modified residue1101N6-succinyllysine; alternate By similarity
Modified residue1141N6-acetyllysine By similarity
Modified residue1161N6-acetyllysine; alternate By similarity
Modified residue1161N6-succinyllysine; alternate By similarity
Modified residue2001N6-acetyllysine By similarity
Modified residue2101N6-acetyllysine; alternate By similarity
Modified residue2101N6-succinyllysine; alternate By similarity
Modified residue2381N6-acetyllysine By similarity
Modified residue2481N6-acetyllysine; alternate By similarity
Modified residue2481N6-succinyllysine; alternate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q68FU3 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 3D916689B2CB6FAB

FASTA25527,687
        10         20         30         40         50         60 
MAELRALVAV KRVIDFAVKI RVKPDKSGVV TDGVKHSMNP FCEIAVEEAV RLKEKKLVKE 

        70         80         90        100        110        120 
IIAVSCGPPQ CQETIRTALA MGADRGIHVE VPGAEAENLG PLQVARVLAK LAEKEKVDLL 

       130        140        150        160        170        180 
FLGKQAIDDD CNQTGQMTAG LLDWPQGTFA SQVTLEGDKV KVEREIDGGL ETIRLKLPAV 

       190        200        210        220        230        240 
VTADLRLNEP RYATLPNIMK AKKKKIEVIK AGDLGVDLTS KVSVISVEEP PQRLAGVKVE 

       250 
TTEDLVAKLK EVGRI 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC079351 mRNA. Translation: AAH79351.1.
RefSeqNP_001004220.1. NM_001004220.1.
UniGeneRn.60152.

3D structure databases

ProteinModelPortalQ68FU3.
SMRQ68FU3. Positions 4-255.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000024083.

PTM databases

PhosphoSiteQ68FU3.

Proteomic databases

PaxDbQ68FU3.
PRIDEQ68FU3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000024083; ENSRNOP00000024083; ENSRNOG00000017851.
GeneID292845.
KEGGrno:292845.
UCSCRGD:1303312. rat.

Organism-specific databases

CTD2109.
RGD1303312. Etfb.

Phylogenomic databases

eggNOGCOG2086.
GeneTreeENSGT00390000009936.
HOGENOMHOG000247877.
HOVERGENHBG005614.
InParanoidQ68FU3.
KOK03521.
OMAEDPPVRQ.
OrthoDBEOG7X3QS5.
PhylomeDBQ68FU3.
TreeFamTF314039.

Gene expression databases

GenevestigatorQ68FU3.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
InterProIPR000049. ET-Flavoprotein_bsu_CS.
IPR014730. ETF_a/b_N.
IPR012255. ETF_b.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERPTHR21294. PTHR21294. 1 hit.
PfamPF01012. ETF. 1 hit.
[Graphical view]
PIRSFPIRSF000090. Beta-ETF. 1 hit.
SMARTSM00893. ETF. 1 hit.
[Graphical view]
PROSITEPS01065. ETF_BETA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio634891.
PROQ68FU3.

Entry information

Entry nameETFB_RAT
AccessionPrimary (citable) accession number: Q68FU3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 69 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families