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Q68FU3

- ETFB_RAT

UniProt

Q68FU3 - ETFB_RAT

Protein

Electron transfer flavoprotein subunit beta

Gene

Etfb

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) By similarity.By similarity

    Cofactori

    Binds 1 FAD per dimer.By similarity
    Binds 1 AMP per subunit.By similarity

    GO - Molecular functioni

    1. electron carrier activity Source: InterPro

    GO - Biological processi

    1. oxidation-reduction process Source: UniProtKB-KW

    Keywords - Biological processi

    Electron transport, Transport

    Keywords - Ligandi

    FAD, Flavoprotein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Electron transfer flavoprotein subunit beta
    Short name:
    Beta-ETF
    Gene namesi
    Name:Etfb
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi1303312. Etfb.

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 255254Electron transfer flavoprotein subunit betaPRO_0000231526Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei19 – 191N6-acetyllysine; alternateBy similarity
    Modified residuei19 – 191N6-succinyllysine; alternateBy similarity
    Modified residuei35 – 351N6-acetyllysine; alternateBy similarity
    Modified residuei35 – 351N6-succinyllysine; alternateBy similarity
    Modified residuei56 – 561N6-acetyllysineBy similarity
    Modified residuei59 – 591N6-acetyllysine; alternateBy similarity
    Modified residuei59 – 591N6-succinyllysine; alternateBy similarity
    Modified residuei110 – 1101N6-acetyllysine; alternateBy similarity
    Modified residuei110 – 1101N6-succinyllysine; alternateBy similarity
    Modified residuei114 – 1141N6-acetyllysineBy similarity
    Modified residuei116 – 1161N6-acetyllysine; alternateBy similarity
    Modified residuei116 – 1161N6-succinyllysine; alternateBy similarity
    Modified residuei200 – 2001N6-acetyllysineBy similarity
    Modified residuei210 – 2101N6-acetyllysine; alternateBy similarity
    Modified residuei210 – 2101N6-succinyllysine; alternateBy similarity
    Modified residuei238 – 2381N6-acetyllysineBy similarity
    Modified residuei248 – 2481N6-acetyllysine; alternateBy similarity
    Modified residuei248 – 2481N6-succinyllysine; alternateBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ68FU3.
    PRIDEiQ68FU3.

    PTM databases

    PhosphoSiteiQ68FU3.

    Expressioni

    Gene expression databases

    GenevestigatoriQ68FU3.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta subunit.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000024083.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68FU3.
    SMRiQ68FU3. Positions 4-255.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ETF beta-subunit/FixA family.Curated

    Phylogenomic databases

    eggNOGiCOG2086.
    GeneTreeiENSGT00390000009936.
    HOGENOMiHOG000247877.
    HOVERGENiHBG005614.
    InParanoidiQ68FU3.
    KOiK03521.
    OMAiPYDEVAV.
    OrthoDBiEOG7X3QS5.
    PhylomeDBiQ68FU3.
    TreeFamiTF314039.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    InterProiIPR000049. ET-Flavoprotein_bsu_CS.
    IPR014730. ETF_a/b_N.
    IPR012255. ETF_b.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR21294. PTHR21294. 1 hit.
    PfamiPF01012. ETF. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000090. Beta-ETF. 1 hit.
    SMARTiSM00893. ETF. 1 hit.
    [Graphical view]
    PROSITEiPS01065. ETF_BETA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q68FU3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAELRALVAV KRVIDFAVKI RVKPDKSGVV TDGVKHSMNP FCEIAVEEAV    50
    RLKEKKLVKE IIAVSCGPPQ CQETIRTALA MGADRGIHVE VPGAEAENLG 100
    PLQVARVLAK LAEKEKVDLL FLGKQAIDDD CNQTGQMTAG LLDWPQGTFA 150
    SQVTLEGDKV KVEREIDGGL ETIRLKLPAV VTADLRLNEP RYATLPNIMK 200
    AKKKKIEVIK AGDLGVDLTS KVSVISVEEP PQRLAGVKVE TTEDLVAKLK 250
    EVGRI 255
    Length:255
    Mass (Da):27,687
    Last modified:January 23, 2007 - v3
    Checksum:i3D916689B2CB6FAB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC079351 mRNA. Translation: AAH79351.1.
    RefSeqiNP_001004220.1. NM_001004220.1.
    UniGeneiRn.60152.

    Genome annotation databases

    EnsembliENSRNOT00000024083; ENSRNOP00000024083; ENSRNOG00000017851.
    GeneIDi292845.
    KEGGirno:292845.
    UCSCiRGD:1303312. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC079351 mRNA. Translation: AAH79351.1 .
    RefSeqi NP_001004220.1. NM_001004220.1.
    UniGenei Rn.60152.

    3D structure databases

    ProteinModelPortali Q68FU3.
    SMRi Q68FU3. Positions 4-255.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000024083.

    PTM databases

    PhosphoSitei Q68FU3.

    Proteomic databases

    PaxDbi Q68FU3.
    PRIDEi Q68FU3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000024083 ; ENSRNOP00000024083 ; ENSRNOG00000017851 .
    GeneIDi 292845.
    KEGGi rno:292845.
    UCSCi RGD:1303312. rat.

    Organism-specific databases

    CTDi 2109.
    RGDi 1303312. Etfb.

    Phylogenomic databases

    eggNOGi COG2086.
    GeneTreei ENSGT00390000009936.
    HOGENOMi HOG000247877.
    HOVERGENi HBG005614.
    InParanoidi Q68FU3.
    KOi K03521.
    OMAi PYDEVAV.
    OrthoDBi EOG7X3QS5.
    PhylomeDBi Q68FU3.
    TreeFami TF314039.

    Miscellaneous databases

    NextBioi 634891.
    PROi Q68FU3.

    Gene expression databases

    Genevestigatori Q68FU3.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    InterProi IPR000049. ET-Flavoprotein_bsu_CS.
    IPR014730. ETF_a/b_N.
    IPR012255. ETF_b.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR21294. PTHR21294. 1 hit.
    Pfami PF01012. ETF. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000090. Beta-ETF. 1 hit.
    SMARTi SM00893. ETF. 1 hit.
    [Graphical view ]
    PROSITEi PS01065. ETF_BETA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiETFB_RAT
    AccessioniPrimary (citable) accession number: Q68FU3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 71 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3