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Q68FU3

- ETFB_RAT

UniProt

Q68FU3 - ETFB_RAT

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Protein
Electron transfer flavoprotein subunit beta
Gene
Etfb
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) By similarity.

Cofactori

Binds 1 FAD per dimer By similarity.
Binds 1 AMP per subunit By similarity.

GO - Molecular functioni

  1. electron carrier activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. oxidation-reduction process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Electron transfer flavoprotein subunit beta
Short name:
Beta-ETF
Gene namesi
Name:Etfb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi1303312. Etfb.

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 255254Electron transfer flavoprotein subunit beta
PRO_0000231526Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei19 – 191N6-acetyllysine; alternate By similarity
Modified residuei19 – 191N6-succinyllysine; alternate By similarity
Modified residuei35 – 351N6-acetyllysine; alternate By similarity
Modified residuei35 – 351N6-succinyllysine; alternate By similarity
Modified residuei56 – 561N6-acetyllysine By similarity
Modified residuei59 – 591N6-acetyllysine; alternate By similarity
Modified residuei59 – 591N6-succinyllysine; alternate By similarity
Modified residuei110 – 1101N6-acetyllysine; alternate By similarity
Modified residuei110 – 1101N6-succinyllysine; alternate By similarity
Modified residuei114 – 1141N6-acetyllysine By similarity
Modified residuei116 – 1161N6-acetyllysine; alternate By similarity
Modified residuei116 – 1161N6-succinyllysine; alternate By similarity
Modified residuei200 – 2001N6-acetyllysine By similarity
Modified residuei210 – 2101N6-acetyllysine; alternate By similarity
Modified residuei210 – 2101N6-succinyllysine; alternate By similarity
Modified residuei238 – 2381N6-acetyllysine By similarity
Modified residuei248 – 2481N6-acetyllysine; alternate By similarity
Modified residuei248 – 2481N6-succinyllysine; alternate By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ68FU3.
PRIDEiQ68FU3.

PTM databases

PhosphoSiteiQ68FU3.

Expressioni

Gene expression databases

GenevestigatoriQ68FU3.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024083.

Structurei

3D structure databases

ProteinModelPortaliQ68FU3.
SMRiQ68FU3. Positions 4-255.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2086.
GeneTreeiENSGT00390000009936.
HOGENOMiHOG000247877.
HOVERGENiHBG005614.
InParanoidiQ68FU3.
KOiK03521.
OMAiPYDEVAV.
OrthoDBiEOG7X3QS5.
PhylomeDBiQ68FU3.
TreeFamiTF314039.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
InterProiIPR000049. ET-Flavoprotein_bsu_CS.
IPR014730. ETF_a/b_N.
IPR012255. ETF_b.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21294. PTHR21294. 1 hit.
PfamiPF01012. ETF. 1 hit.
[Graphical view]
PIRSFiPIRSF000090. Beta-ETF. 1 hit.
SMARTiSM00893. ETF. 1 hit.
[Graphical view]
PROSITEiPS01065. ETF_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68FU3-1 [UniParc]FASTAAdd to Basket

« Hide

MAELRALVAV KRVIDFAVKI RVKPDKSGVV TDGVKHSMNP FCEIAVEEAV    50
RLKEKKLVKE IIAVSCGPPQ CQETIRTALA MGADRGIHVE VPGAEAENLG 100
PLQVARVLAK LAEKEKVDLL FLGKQAIDDD CNQTGQMTAG LLDWPQGTFA 150
SQVTLEGDKV KVEREIDGGL ETIRLKLPAV VTADLRLNEP RYATLPNIMK 200
AKKKKIEVIK AGDLGVDLTS KVSVISVEEP PQRLAGVKVE TTEDLVAKLK 250
EVGRI 255
Length:255
Mass (Da):27,687
Last modified:January 23, 2007 - v3
Checksum:i3D916689B2CB6FAB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC079351 mRNA. Translation: AAH79351.1.
RefSeqiNP_001004220.1. NM_001004220.1.
UniGeneiRn.60152.

Genome annotation databases

EnsembliENSRNOT00000024083; ENSRNOP00000024083; ENSRNOG00000017851.
GeneIDi292845.
KEGGirno:292845.
UCSCiRGD:1303312. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC079351 mRNA. Translation: AAH79351.1 .
RefSeqi NP_001004220.1. NM_001004220.1.
UniGenei Rn.60152.

3D structure databases

ProteinModelPortali Q68FU3.
SMRi Q68FU3. Positions 4-255.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000024083.

PTM databases

PhosphoSitei Q68FU3.

Proteomic databases

PaxDbi Q68FU3.
PRIDEi Q68FU3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000024083 ; ENSRNOP00000024083 ; ENSRNOG00000017851 .
GeneIDi 292845.
KEGGi rno:292845.
UCSCi RGD:1303312. rat.

Organism-specific databases

CTDi 2109.
RGDi 1303312. Etfb.

Phylogenomic databases

eggNOGi COG2086.
GeneTreei ENSGT00390000009936.
HOGENOMi HOG000247877.
HOVERGENi HBG005614.
InParanoidi Q68FU3.
KOi K03521.
OMAi PYDEVAV.
OrthoDBi EOG7X3QS5.
PhylomeDBi Q68FU3.
TreeFami TF314039.

Miscellaneous databases

NextBioi 634891.
PROi Q68FU3.

Gene expression databases

Genevestigatori Q68FU3.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
InterProi IPR000049. ET-Flavoprotein_bsu_CS.
IPR014730. ETF_a/b_N.
IPR012255. ETF_b.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR21294. PTHR21294. 1 hit.
Pfami PF01012. ETF. 1 hit.
[Graphical view ]
PIRSFi PIRSF000090. Beta-ETF. 1 hit.
SMARTi SM00893. ETF. 1 hit.
[Graphical view ]
PROSITEi PS01065. ETF_BETA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiETFB_RAT
AccessioniPrimary (citable) accession number: Q68FU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 70 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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