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Protein

Electron transfer flavoprotein subunit beta

Gene

Etfb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:7334008). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase. Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei9AMP; via carbonyl oxygenBy similarity1
Binding sitei66AMP; via amide nitrogen and carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi39 – 42AMPBy similarity4
Nucleotide bindingi123 – 134AMPBy similarityAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport
LigandNucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-611105 Respiratory electron transport
R-RNO-8876725 Protein methylation

Names & Taxonomyi

Protein namesi
Recommended name:
Electron transfer flavoprotein subunit betaCurated
Short name:
Beta-ETFBy similarity
Gene namesi
Name:EtfbImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1303312 Etfb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002315262 – 255Electron transfer flavoprotein subunit betaAdd BLAST254

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei200N6,N6,N6-trimethyllysine; by ETFBKMT; alternateBy similarity1
Modified residuei200N6-acetyllysine; alternateBy similarity1
Modified residuei200N6-methyllysine; alternateBy similarity1
Modified residuei203N6,N6,N6-trimethyllysine; by ETFBKMTBy similarity1
Modified residuei210N6-acetyllysine; alternateBy similarity1
Modified residuei210N6-succinyllysine; alternateBy similarity1
Modified residuei223PhosphoserineBy similarity1
Modified residuei226PhosphoserineBy similarity1
Modified residuei238N6-acetyllysineBy similarity1
Modified residuei248N6-acetyllysine; alternateBy similarity1
Modified residuei248N6-succinyllysine; alternateBy similarity1

Post-translational modificationi

Methylated. Trimethylation at Lys-200 and Lys-203 may negatively regulate the activity in electron transfer from acyl-CoA dehydrogenases.By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ68FU3
PRIDEiQ68FU3

PTM databases

iPTMnetiQ68FU3
PhosphoSitePlusiQ68FU3

Expressioni

Gene expression databases

BgeeiENSRNOG00000017851
GenevisibleiQ68FU3 RN

Interactioni

Subunit structurei

Heterodimer composed of ETFA and ETFB (PubMed:7334008). Identified in a complex that contains ETFA, ETFB and ETFRF1. Interacts with ACADM (By similarity).By similarity1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024083

Structurei

3D structure databases

ProteinModelPortaliQ68FU3
SMRiQ68FU3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni183 – 205Recognition loopBy similarityAdd BLAST23

Domaini

The recognition loop recognizes a hydrophobic patch at the surface of interacting dehydrogenases and acts as a static anchor at the interface.By similarity

Sequence similaritiesi

Belongs to the ETF beta-subunit/FixA family.Curated

Phylogenomic databases

eggNOGiKOG3180 Eukaryota
COG2086 LUCA
GeneTreeiENSGT00390000009936
HOGENOMiHOG000247877
HOVERGENiHBG005614
InParanoidiQ68FU3
KOiK03521
OMAiRIPNMRG
OrthoDBiEOG091G0KHH
PhylomeDBiQ68FU3
TreeFamiTF314039

Family and domain databases

CDDicd01714 ETF_beta, 1 hit
Gene3Di3.40.50.620, 1 hit
InterProiView protein in InterPro
IPR000049 ET-Flavoprotein_bsu_CS
IPR014730 ETF_a/b_N
IPR012255 ETF_b
IPR033948 ETF_beta_N
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR21294 PTHR21294, 1 hit
PfamiView protein in Pfam
PF01012 ETF, 1 hit
PIRSFiPIRSF000090 Beta-ETF, 1 hit
SMARTiView protein in SMART
SM00893 ETF, 1 hit
PROSITEiView protein in PROSITE
PS01065 ETF_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68FU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELRALVAV KRVIDFAVKI RVKPDKSGVV TDGVKHSMNP FCEIAVEEAV
60 70 80 90 100
RLKEKKLVKE IIAVSCGPPQ CQETIRTALA MGADRGIHVE VPGAEAENLG
110 120 130 140 150
PLQVARVLAK LAEKEKVDLL FLGKQAIDDD CNQTGQMTAG LLDWPQGTFA
160 170 180 190 200
SQVTLEGDKV KVEREIDGGL ETIRLKLPAV VTADLRLNEP RYATLPNIMK
210 220 230 240 250
AKKKKIEVIK AGDLGVDLTS KVSVISVEEP PQRLAGVKVE TTEDLVAKLK

EVGRI
Length:255
Mass (Da):27,687
Last modified:January 23, 2007 - v3
Checksum:i3D916689B2CB6FAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079351 mRNA Translation: AAH79351.1
RefSeqiNP_001004220.1, NM_001004220.1
UniGeneiRn.60152

Genome annotation databases

EnsembliENSRNOT00000024083; ENSRNOP00000024083; ENSRNOG00000017851
GeneIDi292845
KEGGirno:292845
UCSCiRGD:1303312 rat

Similar proteinsi

Entry informationi

Entry nameiETFB_RAT
AccessioniPrimary (citable) accession number: Q68FU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 99 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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