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Protein

Selenocysteine lyase

Gene

Scly

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium.By similarity

Catalytic activityi

L-selenocysteine + reduced acceptor = selenide + L-alanine + acceptor.

Cofactori

pyridoxal 5'-phosphate1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei375S-selanylcysteine intermediate1 Publication1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Lyase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BRENDAi4.4.1.16. 5301.
ReactomeiR-RNO-2408508. Metabolism of ingested SeMet, Sec, MeSec into H2Se.

Names & Taxonomyi

Protein namesi
Recommended name:
Selenocysteine lyase (EC:4.4.1.16)
Gene namesi
Name:Scly
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi1359514. Scly.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003170141 – 432Selenocysteine lyaseAdd BLAST432

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei117PhosphoserineBy similarity1
Modified residuei247N6-(pyridoxal phosphate)lysine1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ68FT9.
PRIDEiQ68FT9.

Expressioni

Gene expression databases

BgeeiENSRNOG00000020083.
GenevisibleiQ68FT9. RN.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027220.

Structurei

Secondary structure

1432
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni24 – 26Combined sources3
Helixi32 – 44Combined sources13
Helixi54 – 74Combined sources21
Helixi78 – 80Combined sources3
Beta strandi81 – 85Combined sources5
Helixi87 – 108Combined sources22
Beta strandi125 – 129Combined sources5
Helixi134 – 145Combined sources12
Beta strandi150 – 154Combined sources5
Turni158 – 160Combined sources3
Helixi165 – 170Combined sources6
Beta strandi176 – 180Combined sources5
Turni186 – 188Combined sources3
Helixi194 – 211Combined sources18
Beta strandi217 – 221Combined sources5
Turni223 – 228Combined sources6
Helixi233 – 236Combined sources4
Beta strandi239 – 244Combined sources6
Helixi245 – 247Combined sources3
Beta strandi254 – 258Combined sources5
Turni259 – 263Combined sources5
Helixi276 – 279Combined sources4
Helixi287 – 326Combined sources40
Helixi327 – 329Combined sources3
Beta strandi330 – 334Combined sources5
Beta strandi345 – 350Combined sources6
Helixi357 – 363Combined sources7
Beta strandi365 – 368Combined sources4
Beta strandi370 – 372Combined sources3
Helixi374 – 379Combined sources6
Helixi385 – 389Combined sources5
Helixi394 – 397Combined sources4
Beta strandi400 – 404Combined sources5
Helixi411 – 429Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3A9XX-ray2.00A/B1-432[»]
3A9YX-ray1.85A/B1-432[»]
3A9ZX-ray1.55A/B1-432[»]
DisProtiDP00620.
ProteinModelPortaliQ68FT9.
SMRiQ68FT9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ68FT9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1549. Eukaryota.
COG1104. LUCA.
GeneTreeiENSGT00530000063513.
HOGENOMiHOG000017510.
HOVERGENiHBG003708.
InParanoidiQ68FT9.
KOiK01763.
OMAiVRPNTCL.
OrthoDBiEOG091G0CBR.
PhylomeDBiQ68FT9.
TreeFamiTF313550.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR000192. Aminotrans_V_dom.
IPR016454. Cysteine_dSase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF005572. NifS. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q68FT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVARNGARG SVESPPNRKV YMDYNATTPL EPEVIQAVTE AMKEAWGNPS
60 70 80 90 100
SSYVAGRKAK DIINTARASL AKMIGGKPQD IIFTSGGTES NNLVIHSTVR
110 120 130 140 150
CFHEQQTLQG RTVDQISPEE GTRPHFITCT VEHDSIRLPL EHLVEDQVAE
160 170 180 190 200
VTFVPVSKVN GQVEVEDILA AVRPTTCLVT IMLANNETGV IMPISEISRR
210 220 230 240 250
IKALNQIRAA SGLPRVLVHT DAAQALGKRR VDVEDLGVDF LTIVGHKFYG
260 270 280 290 300
PRIGALYVRG VGKLTPLYPM LFGGGQERNF RPGTENTPMI AGLGKAADLV
310 320 330 340 350
SENCETYEAH MRDIRDYLEE RLEAEFGKRI HLNSRFPGVE RLPNTCNFSI
360 370 380 390 400
QGSQLRGYMV LAQCQTLLAS VGASCHSDHE DRPSPVLLSC GIPVDVARNA
410 420 430
VRLSVGRSTT RAEVDLIVQD LKQAVNQLEG PV
Length:432
Mass (Da):47,256
Last modified:October 11, 2004 - v1
Checksum:iFA5BB9DD941516A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079358 mRNA. Translation: AAH79358.1.
RefSeqiNP_001007756.1. NM_001007755.1.
UniGeneiRn.23954.

Genome annotation databases

EnsembliENSRNOT00000027220; ENSRNOP00000027220; ENSRNOG00000020083.
GeneIDi363285.
KEGGirno:363285.
UCSCiRGD:1359514. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079358 mRNA. Translation: AAH79358.1.
RefSeqiNP_001007756.1. NM_001007755.1.
UniGeneiRn.23954.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3A9XX-ray2.00A/B1-432[»]
3A9YX-ray1.85A/B1-432[»]
3A9ZX-ray1.55A/B1-432[»]
DisProtiDP00620.
ProteinModelPortaliQ68FT9.
SMRiQ68FT9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027220.

Proteomic databases

PaxDbiQ68FT9.
PRIDEiQ68FT9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027220; ENSRNOP00000027220; ENSRNOG00000020083.
GeneIDi363285.
KEGGirno:363285.
UCSCiRGD:1359514. rat.

Organism-specific databases

CTDi51540.
RGDi1359514. Scly.

Phylogenomic databases

eggNOGiKOG1549. Eukaryota.
COG1104. LUCA.
GeneTreeiENSGT00530000063513.
HOGENOMiHOG000017510.
HOVERGENiHBG003708.
InParanoidiQ68FT9.
KOiK01763.
OMAiVRPNTCL.
OrthoDBiEOG091G0CBR.
PhylomeDBiQ68FT9.
TreeFamiTF313550.

Enzyme and pathway databases

BRENDAi4.4.1.16. 5301.
ReactomeiR-RNO-2408508. Metabolism of ingested SeMet, Sec, MeSec into H2Se.

Miscellaneous databases

EvolutionaryTraceiQ68FT9.
PROiQ68FT9.

Gene expression databases

BgeeiENSRNOG00000020083.
GenevisibleiQ68FT9. RN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR000192. Aminotrans_V_dom.
IPR016454. Cysteine_dSase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF005572. NifS. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSCLY_RAT
AccessioniPrimary (citable) accession number: Q68FT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.