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Protein

Selenocysteine lyase

Gene

Scly

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium.By similarity

Catalytic activityi

L-selenocysteine + reduced acceptor = selenide + L-alanine + acceptor.

Cofactori

pyridoxal 5'-phosphate1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei375S-selanylcysteine intermediate1 Publication1

GO - Molecular functioni

  • amino acid binding Source: CAFA
  • protein homodimerization activity Source: CAFA
  • selenocysteine lyase activity Source: CAFA
  • transferase activity Source: UniProtKB-KW
  • vitamin B6 binding Source: CAFA

GO - Biological processi

Keywordsi

Molecular functionLyase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

BRENDAi4.4.1.16 5301
ReactomeiR-RNO-2408508 Metabolism of ingested SeMet, Sec, MeSec into H2Se

Names & Taxonomyi

Protein namesi
Recommended name:
Selenocysteine lyase (EC:4.4.1.16)
Gene namesi
Name:Scly
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi1359514 Scly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003170141 – 432Selenocysteine lyaseAdd BLAST432

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei117PhosphoserineBy similarity1
Modified residuei247N6-(pyridoxal phosphate)lysine1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ68FT9
PRIDEiQ68FT9

Expressioni

Gene expression databases

BgeeiENSRNOG00000020083
GenevisibleiQ68FT9 RN

Interactioni

Subunit structurei

Homodimer.1 Publication

GO - Molecular functioni

  • protein homodimerization activity Source: CAFA

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027220

Structurei

Secondary structure

1432
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni24 – 26Combined sources3
Helixi32 – 44Combined sources13
Helixi54 – 74Combined sources21
Helixi78 – 80Combined sources3
Beta strandi81 – 85Combined sources5
Helixi87 – 108Combined sources22
Beta strandi125 – 129Combined sources5
Helixi134 – 145Combined sources12
Beta strandi150 – 154Combined sources5
Turni158 – 160Combined sources3
Helixi165 – 170Combined sources6
Beta strandi176 – 180Combined sources5
Turni186 – 188Combined sources3
Helixi194 – 211Combined sources18
Beta strandi217 – 221Combined sources5
Turni223 – 228Combined sources6
Helixi233 – 236Combined sources4
Beta strandi239 – 244Combined sources6
Helixi245 – 247Combined sources3
Beta strandi254 – 258Combined sources5
Turni259 – 263Combined sources5
Helixi276 – 279Combined sources4
Helixi287 – 326Combined sources40
Helixi327 – 329Combined sources3
Beta strandi330 – 334Combined sources5
Beta strandi345 – 350Combined sources6
Helixi357 – 363Combined sources7
Beta strandi365 – 368Combined sources4
Beta strandi370 – 372Combined sources3
Helixi374 – 379Combined sources6
Helixi385 – 389Combined sources5
Helixi394 – 397Combined sources4
Beta strandi400 – 404Combined sources5
Helixi411 – 429Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3A9XX-ray2.00A/B1-432[»]
3A9YX-ray1.85A/B1-432[»]
3A9ZX-ray1.55A/B1-432[»]
DisProtiDP00620
ProteinModelPortaliQ68FT9
SMRiQ68FT9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ68FT9

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1549 Eukaryota
COG1104 LUCA
GeneTreeiENSGT00530000063513
HOGENOMiHOG000017510
HOVERGENiHBG003708
InParanoidiQ68FT9
KOiK01763
OMAiVIYGQSE
OrthoDBiEOG091G0CBR
PhylomeDBiQ68FT9
TreeFamiTF313550

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR000192 Aminotrans_V_dom
IPR016454 Cysteine_dSase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00266 Aminotran_5, 1 hit
PIRSFiPIRSF005572 NifS, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q68FT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVARNGARG SVESPPNRKV YMDYNATTPL EPEVIQAVTE AMKEAWGNPS
60 70 80 90 100
SSYVAGRKAK DIINTARASL AKMIGGKPQD IIFTSGGTES NNLVIHSTVR
110 120 130 140 150
CFHEQQTLQG RTVDQISPEE GTRPHFITCT VEHDSIRLPL EHLVEDQVAE
160 170 180 190 200
VTFVPVSKVN GQVEVEDILA AVRPTTCLVT IMLANNETGV IMPISEISRR
210 220 230 240 250
IKALNQIRAA SGLPRVLVHT DAAQALGKRR VDVEDLGVDF LTIVGHKFYG
260 270 280 290 300
PRIGALYVRG VGKLTPLYPM LFGGGQERNF RPGTENTPMI AGLGKAADLV
310 320 330 340 350
SENCETYEAH MRDIRDYLEE RLEAEFGKRI HLNSRFPGVE RLPNTCNFSI
360 370 380 390 400
QGSQLRGYMV LAQCQTLLAS VGASCHSDHE DRPSPVLLSC GIPVDVARNA
410 420 430
VRLSVGRSTT RAEVDLIVQD LKQAVNQLEG PV
Length:432
Mass (Da):47,256
Last modified:October 11, 2004 - v1
Checksum:iFA5BB9DD941516A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079358 mRNA Translation: AAH79358.1
RefSeqiNP_001007756.1, NM_001007755.1
UniGeneiRn.23954

Genome annotation databases

EnsembliENSRNOT00000027220; ENSRNOP00000027220; ENSRNOG00000020083
GeneIDi363285
KEGGirno:363285
UCSCiRGD:1359514 rat

Similar proteinsi

Entry informationi

Entry nameiSCLY_RAT
AccessioniPrimary (citable) accession number: Q68FT9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 11, 2004
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health