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Protein

Ammonium transporter Rh type B

Gene

Rhbg

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a specific ammonium transporter.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ammonia transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-444411. Rhesus glycoproteins mediate ammonium transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Ammonium transporter Rh type B
Alternative name(s):
Rhesus blood group family type B glycoprotein
Short name:
Rh family type B glycoprotein
Short name:
Rh type B glycoprotein
Gene namesi
Name:Rhbg
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi727813. Rhbg.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 58ExtracellularSequence analysisAdd BLAST27
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Topological domaini80 – 83CytoplasmicSequence analysis4
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Topological domaini105 – 121ExtracellularSequence analysisAdd BLAST17
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Topological domaini143 – 148CytoplasmicSequence analysis6
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Topological domaini170 – 176ExtracellularSequence analysis7
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Topological domaini198 – 216CytoplasmicSequence analysisAdd BLAST19
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Topological domaini238 – 247ExtracellularSequence analysis10
Transmembranei248 – 270HelicalSequence analysisAdd BLAST23
Topological domaini271 – 274CytoplasmicSequence analysis4
Transmembranei275 – 295HelicalSequence analysisAdd BLAST21
Topological domaini296ExtracellularSequence analysis1
Transmembranei297 – 317HelicalSequence analysisAdd BLAST21
Topological domaini318 – 340CytoplasmicSequence analysisAdd BLAST23
Transmembranei341 – 361HelicalSequence analysisAdd BLAST21
Topological domaini362 – 390ExtracellularSequence analysisAdd BLAST29
Transmembranei391 – 411HelicalSequence analysisAdd BLAST21
Topological domaini412 – 455CytoplasmicSequence analysisAdd BLAST44

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002836051 – 455Ammonium transporter Rh type BAdd BLAST455

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi46N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ68FT6.
PRIDEiQ68FT6.

Expressioni

Tissue specificityi

Expressed in kidney by connecting segments and collecting tubules (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000019412.
ExpressionAtlasiQ68FT6. differential.

Interactioni

Subunit structurei

Interacts (via C-terminus) with ANK2 and ANK3; required for targeting to the basolateral membrane.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026396.

Structurei

3D structure databases

ProteinModelPortaliQ68FT6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni413 – 421Interaction with ANK3By similarity9

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3796. Eukaryota.
ENOG410XTF8. LUCA.
GeneTreeiENSGT00390000005787.
HOGENOMiHOG000007656.
HOVERGENiHBG004374.
InParanoidiQ68FT6.
KOiK06580.
OMAiFAIFVRY.
OrthoDBiEOG091G06KX.
PhylomeDBiQ68FT6.
TreeFamiTF314450.

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR001905. Ammonium_transpt.
IPR024041. NH4_transpt_AmtB-like_dom.
IPR002229. RhesusRHD.
[Graphical view]
PANTHERiPTHR11730. PTHR11730. 1 hit.
PfamiPF00909. Ammonium_transp. 1 hit.
[Graphical view]
PRINTSiPR00342. RHESUSRHD.
SUPFAMiSSF111352. SSF111352. 1 hit.

Sequencei

Sequence statusi: Complete.

Q68FT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARIPRHRRL VLPLLCLLFQ GATSLLFAIF VRYNHETDAA LWHWGNHSNV
60 70 80 90 100
DNEFYFRYPS FQDVHVMVFV GFGFLMVFLQ RYGFSSVGFT FLVATFTLQW
110 120 130 140 150
ATLLQGFLHS FHGGHIHIGV ESLINADFCA GAVLISFGAV LGKTGPAQLL
160 170 180 190 200
LMALLEAVLF SVNEFILLSL LGVRDAGGSM TIHTFGAYFG LFLSRVLYRS
210 220 230 240 250
QLEKSRHRQT SVYNSDLFAM IGTIFLWVFW PSFNSAPTAL GDGQHRTVVN
260 270 280 290 300
TYYSLTASTL STFALSALVS GDGRLDMVHI QNAALAGGVV VGTASEMMLT
310 320 330 340 350
PFGALAAGFL AGTVSTLGYK FFTPILESRF KLQDTCGVHN LHGMPGLLGA
360 370 380 390 400
ILGVLVAALA THEAYGDGLQ TVFPLIAKGQ RSATSQAMYQ LFGMFVTLVF
410 420 430 440 450
ASVGGSLGGL LLKLPFLDSP PDSQCFEDQV YWEVPGEQEA ETQRPLRTEE

PDTQA
Length:455
Mass (Da):49,731
Last modified:October 11, 2004 - v1
Checksum:i725815539CC2F19A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti347L → V in AAN07790 (PubMed:16227429).Curated1
Sequence conflicti355L → V in AAN07790 (PubMed:16227429).Curated1
Sequence conflicti413K → R in AAN07790 (PubMed:16227429).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY129072 mRNA. Translation: AAN07790.1.
BC079365 mRNA. Translation: AAH79365.1.
RefSeqiNP_898877.1. NM_183054.1.
UniGeneiRn.94552.

Genome annotation databases

EnsembliENSRNOT00000026396; ENSRNOP00000026396; ENSRNOG00000019412.
GeneIDi310625.
KEGGirno:310625.
UCSCiRGD:727813. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY129072 mRNA. Translation: AAN07790.1.
BC079365 mRNA. Translation: AAH79365.1.
RefSeqiNP_898877.1. NM_183054.1.
UniGeneiRn.94552.

3D structure databases

ProteinModelPortaliQ68FT6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026396.

Proteomic databases

PaxDbiQ68FT6.
PRIDEiQ68FT6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026396; ENSRNOP00000026396; ENSRNOG00000019412.
GeneIDi310625.
KEGGirno:310625.
UCSCiRGD:727813. rat.

Organism-specific databases

CTDi57127.
RGDi727813. Rhbg.

Phylogenomic databases

eggNOGiKOG3796. Eukaryota.
ENOG410XTF8. LUCA.
GeneTreeiENSGT00390000005787.
HOGENOMiHOG000007656.
HOVERGENiHBG004374.
InParanoidiQ68FT6.
KOiK06580.
OMAiFAIFVRY.
OrthoDBiEOG091G06KX.
PhylomeDBiQ68FT6.
TreeFamiTF314450.

Enzyme and pathway databases

ReactomeiR-RNO-444411. Rhesus glycoproteins mediate ammonium transport.

Miscellaneous databases

PROiQ68FT6.

Gene expression databases

BgeeiENSRNOG00000019412.
ExpressionAtlasiQ68FT6. differential.

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR001905. Ammonium_transpt.
IPR024041. NH4_transpt_AmtB-like_dom.
IPR002229. RhesusRHD.
[Graphical view]
PANTHERiPTHR11730. PTHR11730. 1 hit.
PfamiPF00909. Ammonium_transp. 1 hit.
[Graphical view]
PRINTSiPR00342. RHESUSRHD.
SUPFAMiSSF111352. SSF111352. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRHBG_RAT
AccessioniPrimary (citable) accession number: Q68FT6
Secondary accession number(s): Q7TNP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 11, 2004
Last modified: November 30, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.