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Protein

Ammonium transporter Rh type B

Gene

Rhbg

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a specific ammonium transporter.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ammonia transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-444411. Rhesus glycoproteins mediate ammonium transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Ammonium transporter Rh type B
Alternative name(s):
Rhesus blood group family type B glycoprotein
Short name:
Rh family type B glycoprotein
Short name:
Rh type B glycoprotein
Gene namesi
Name:Rhbg
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi727813. Rhbg.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicSequence analysis
Transmembranei11 – 3121HelicalSequence analysisAdd
BLAST
Topological domaini32 – 5827ExtracellularSequence analysisAdd
BLAST
Transmembranei59 – 7921HelicalSequence analysisAdd
BLAST
Topological domaini80 – 834CytoplasmicSequence analysis
Transmembranei84 – 10421HelicalSequence analysisAdd
BLAST
Topological domaini105 – 12117ExtracellularSequence analysisAdd
BLAST
Transmembranei122 – 14221HelicalSequence analysisAdd
BLAST
Topological domaini143 – 1486CytoplasmicSequence analysis
Transmembranei149 – 16921HelicalSequence analysisAdd
BLAST
Topological domaini170 – 1767ExtracellularSequence analysis
Transmembranei177 – 19721HelicalSequence analysisAdd
BLAST
Topological domaini198 – 21619CytoplasmicSequence analysisAdd
BLAST
Transmembranei217 – 23721HelicalSequence analysisAdd
BLAST
Topological domaini238 – 24710ExtracellularSequence analysis
Transmembranei248 – 27023HelicalSequence analysisAdd
BLAST
Topological domaini271 – 2744CytoplasmicSequence analysis
Transmembranei275 – 29521HelicalSequence analysisAdd
BLAST
Topological domaini296 – 2961ExtracellularSequence analysis
Transmembranei297 – 31721HelicalSequence analysisAdd
BLAST
Topological domaini318 – 34023CytoplasmicSequence analysisAdd
BLAST
Transmembranei341 – 36121HelicalSequence analysisAdd
BLAST
Topological domaini362 – 39029ExtracellularSequence analysisAdd
BLAST
Transmembranei391 – 41121HelicalSequence analysisAdd
BLAST
Topological domaini412 – 45544CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 455455Ammonium transporter Rh type BPRO_0000283605Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi46 – 461N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ68FT6.
PRIDEiQ68FT6.

Expressioni

Tissue specificityi

Expressed in kidney by connecting segments and collecting tubules (at protein level).1 Publication

Gene expression databases

ExpressionAtlasiQ68FT6. baseline.

Interactioni

Subunit structurei

Interacts (via C-terminus) with ANK2 and ANK3; required for targeting to the basolateral membrane.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026396.

Structurei

3D structure databases

ProteinModelPortaliQ68FT6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni413 – 4219Interaction with ANK3By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3796. Eukaryota.
ENOG410XTF8. LUCA.
GeneTreeiENSGT00390000005787.
HOGENOMiHOG000007656.
HOVERGENiHBG004374.
InParanoidiQ68FT6.
KOiK06580.
OMAiFAIFVRY.
OrthoDBiEOG73NG3C.
PhylomeDBiQ68FT6.
TreeFamiTF314450.

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR001905. Ammonium_transpt.
IPR024041. NH4_transpt_AmtB-like_dom.
IPR002229. RhesusRHD.
[Graphical view]
PANTHERiPTHR11730. PTHR11730. 1 hit.
PfamiPF00909. Ammonium_transp. 1 hit.
[Graphical view]
PRINTSiPR00342. RHESUSRHD.
SUPFAMiSSF111352. SSF111352. 1 hit.

Sequencei

Sequence statusi: Complete.

Q68FT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARIPRHRRL VLPLLCLLFQ GATSLLFAIF VRYNHETDAA LWHWGNHSNV
60 70 80 90 100
DNEFYFRYPS FQDVHVMVFV GFGFLMVFLQ RYGFSSVGFT FLVATFTLQW
110 120 130 140 150
ATLLQGFLHS FHGGHIHIGV ESLINADFCA GAVLISFGAV LGKTGPAQLL
160 170 180 190 200
LMALLEAVLF SVNEFILLSL LGVRDAGGSM TIHTFGAYFG LFLSRVLYRS
210 220 230 240 250
QLEKSRHRQT SVYNSDLFAM IGTIFLWVFW PSFNSAPTAL GDGQHRTVVN
260 270 280 290 300
TYYSLTASTL STFALSALVS GDGRLDMVHI QNAALAGGVV VGTASEMMLT
310 320 330 340 350
PFGALAAGFL AGTVSTLGYK FFTPILESRF KLQDTCGVHN LHGMPGLLGA
360 370 380 390 400
ILGVLVAALA THEAYGDGLQ TVFPLIAKGQ RSATSQAMYQ LFGMFVTLVF
410 420 430 440 450
ASVGGSLGGL LLKLPFLDSP PDSQCFEDQV YWEVPGEQEA ETQRPLRTEE

PDTQA
Length:455
Mass (Da):49,731
Last modified:October 11, 2004 - v1
Checksum:i725815539CC2F19A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti347 – 3471L → V in AAN07790 (PubMed:16227429).Curated
Sequence conflicti355 – 3551L → V in AAN07790 (PubMed:16227429).Curated
Sequence conflicti413 – 4131K → R in AAN07790 (PubMed:16227429).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY129072 mRNA. Translation: AAN07790.1.
BC079365 mRNA. Translation: AAH79365.1.
RefSeqiNP_898877.1. NM_183054.1.
UniGeneiRn.94552.

Genome annotation databases

EnsembliENSRNOT00000026396; ENSRNOP00000026396; ENSRNOG00000019412.
GeneIDi310625.
KEGGirno:310625.
UCSCiRGD:727813. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY129072 mRNA. Translation: AAN07790.1.
BC079365 mRNA. Translation: AAH79365.1.
RefSeqiNP_898877.1. NM_183054.1.
UniGeneiRn.94552.

3D structure databases

ProteinModelPortaliQ68FT6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026396.

Proteomic databases

PaxDbiQ68FT6.
PRIDEiQ68FT6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026396; ENSRNOP00000026396; ENSRNOG00000019412.
GeneIDi310625.
KEGGirno:310625.
UCSCiRGD:727813. rat.

Organism-specific databases

CTDi57127.
RGDi727813. Rhbg.

Phylogenomic databases

eggNOGiKOG3796. Eukaryota.
ENOG410XTF8. LUCA.
GeneTreeiENSGT00390000005787.
HOGENOMiHOG000007656.
HOVERGENiHBG004374.
InParanoidiQ68FT6.
KOiK06580.
OMAiFAIFVRY.
OrthoDBiEOG73NG3C.
PhylomeDBiQ68FT6.
TreeFamiTF314450.

Enzyme and pathway databases

ReactomeiR-RNO-444411. Rhesus glycoproteins mediate ammonium transport.

Miscellaneous databases

NextBioi662243.
PROiQ68FT6.

Gene expression databases

ExpressionAtlasiQ68FT6. baseline.

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR001905. Ammonium_transpt.
IPR024041. NH4_transpt_AmtB-like_dom.
IPR002229. RhesusRHD.
[Graphical view]
PANTHERiPTHR11730. PTHR11730. 1 hit.
PfamiPF00909. Ammonium_transp. 1 hit.
[Graphical view]
PRINTSiPR00342. RHESUSRHD.
SUPFAMiSSF111352. SSF111352. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Evolutionary conservation and diversification of Rh family genes and proteins."
    Huang C.-H., Peng J.
    Proc. Natl. Acad. Sci. U.S.A. 102:15512-15517(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  3. "RhBG and RhCG, the putative ammonia transporters, are expressed in the same cells in the distal nephron."
    Quentin F., Eladari D., Cheval L., Lopez C., Goossens D., Colin Y., Cartron J.-P., Paillard M., Chambrey R.
    J. Am. Soc. Nephrol. 14:545-554(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, GLYCOSYLATION, TISSUE SPECIFICITY.
  4. "The ammonium transporter RhBG: requirement of a tyrosine-based signal and ankyrin-G for basolateral targeting and membrane anchorage in polarized kidney epithelial cells."
    Lopez C., Metral S., Eladari D., Drevensek S., Gane P., Chambrey R., Bennett V., Cartron J.-P., Le Van Kim C., Colin Y.
    J. Biol. Chem. 280:8221-8228(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiRHBG_RAT
AccessioniPrimary (citable) accession number: Q68FT6
Secondary accession number(s): Q7TNP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 11, 2004
Last modified: May 11, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.