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Protein

Ubiquinone biosynthesis protein COQ9, mitochondrial

Gene

Coq9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Binds a phospholipid of at least 10 carbons in each acyl group. May be required to present its bound-lipid to COQ7.By similarity

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.By similarity
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbiquinone biosynthesis
LigandLipid-binding

Enzyme and pathway databases

UniPathwayiUPA00232

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquinone biosynthesis protein COQ9, mitochondrial
Gene namesi
Name:Coq9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1586040 Coq9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 45MitochondrionSequence analysisAdd BLAST45
ChainiPRO_000022863946 – 312Ubiquinone biosynthesis protein COQ9, mitochondrialAdd BLAST267

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei80PhosphoserineCombined sources1
Modified residuei169N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ68FT1
PRIDEiQ68FT1

PTM databases

iPTMnetiQ68FT1
PhosphoSitePlusiQ68FT1

Expressioni

Gene expression databases

BgeeiENSRNOG00000016190
GenevisibleiQ68FT1 RN

Interactioni

Subunit structurei

Homodimer. Interacts with COQ7.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021716

Structurei

3D structure databases

SMRiQ68FT1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni235 – 238Lipid bindingBy similarity4

Domaini

Structurally similar to the bacterial FadR protein (fatty acid metabolism regulator protein).By similarity

Sequence similaritiesi

Belongs to the COQ9 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2969 Eukaryota
COG5590 LUCA
GeneTreeiENSGT00390000009328
HOGENOMiHOG000231991
HOVERGENiHBG079760
InParanoidiQ68FT1
KOiK18587
OMAiDEIWHAV
OrthoDBiEOG091G0M72
PhylomeDBiQ68FT1
TreeFamiTF324653

Family and domain databases

InterProiView protein in InterPro
IPR013718 COQ9
IPR012762 Ubiq_biosynth_COQ9
PANTHERiPTHR21427 PTHR21427, 1 hit
PfamiView protein in Pfam
PF08511 COQ9, 1 hit
TIGRFAMsiTIGR02396 diverge_rpsU, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68FT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATAAVSGV LRRLGWRLLQ LRCLPVARCQ SPLMPRAFHT AVGFRSSEEQ
60 70 80 90 100
RQQPPHSSQQ HSETQGPEFS RPPPRYTDQS GEEEEDYESE EQIQHRILTA
110 120 130 140 150
ALEFVPDHGW TAEAIAEGAQ SLGLSSAAAS MFGSDGSELI LHFVTQCNAR
160 170 180 190 200
LNHVLEEEQK LVQLGQAEKR KTDQFLRDAV ETRLRMLIPY IEHWPRALSI
210 220 230 240 250
LLLPQNIPPS LSLLTSMVDD MWHYAGDQST DFNWYTRRAV LAGIYNTTEL
260 270 280 290 300
VMMQDSSPDF EDTWRFLDNR INDAMNMGHT AKQVKSTGEA LVQGLMGAAV
310
TLKNLTGLNQ RR
Length:312
Mass (Da):35,146
Last modified:March 21, 2006 - v2
Checksum:i7A52D53775DDE649
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03113798 Genomic DNA No translation available.
AABR03113818 Genomic DNA No translation available.
BC079370 mRNA Translation: AAH79370.1
BC104702 mRNA Translation: AAI04703.1
BC127449 mRNA Translation: AAI27450.1
RefSeqiNP_001030334.1, NM_001035257.1
UniGeneiRn.22044

Genome annotation databases

EnsembliENSRNOT00000021716; ENSRNOP00000021716; ENSRNOG00000016190
GeneIDi498909
KEGGirno:498909
UCSCiRGD:1586040 rat

Similar proteinsi

Entry informationi

Entry nameiCOQ9_RAT
AccessioniPrimary (citable) accession number: Q68FT1
Secondary accession number(s): A1L109
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: May 23, 2018
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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