Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ubiquinone biosynthesis protein COQ9, mitochondrial

Gene

Coq9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Binds a phospholipid of at least 10 carbons in each acyl group. May be required to present its bound-lipid to COQ7.By similarity

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.By similarity
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubiquinone biosynthesis

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquinone biosynthesis protein COQ9, mitochondrial
Gene namesi
Name:Coq9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1586040. Coq9.

Subcellular locationi

  • Mitochondrion By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4545MitochondrionSequence analysisAdd
BLAST
Chaini46 – 312267Ubiquinone biosynthesis protein COQ9, mitochondrialPRO_0000228639Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei80 – 801PhosphoserineCombined sources
Modified residuei169 – 1691N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ68FT1.
PRIDEiQ68FT1.

PTM databases

iPTMnetiQ68FT1.
PhosphoSiteiQ68FT1.

Expressioni

Gene expression databases

GenevisibleiQ68FT1. RN.

Interactioni

Subunit structurei

Homodimer. Interacts with COQ7.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021716.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni235 – 2384Lipid bindingBy similarity

Domaini

Structurally similar to the bacterial FadR protein (fatty acid metabolism regulator protein).By similarity

Sequence similaritiesi

Belongs to the COQ9 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2969. Eukaryota.
COG5590. LUCA.
GeneTreeiENSGT00390000009328.
HOGENOMiHOG000231991.
HOVERGENiHBG079760.
InParanoidiQ68FT1.
KOiK18587.
OMAiMFGKDGS.
OrthoDBiEOG75B85W.
PhylomeDBiQ68FT1.
TreeFamiTF324653.

Family and domain databases

InterProiIPR013718. COQ9.
IPR012762. Ubiq_biosynth_COQ9.
[Graphical view]
PfamiPF08511. COQ9. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02396. diverge_rpsU. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68FT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATAAVSGV LRRLGWRLLQ LRCLPVARCQ SPLMPRAFHT AVGFRSSEEQ
60 70 80 90 100
RQQPPHSSQQ HSETQGPEFS RPPPRYTDQS GEEEEDYESE EQIQHRILTA
110 120 130 140 150
ALEFVPDHGW TAEAIAEGAQ SLGLSSAAAS MFGSDGSELI LHFVTQCNAR
160 170 180 190 200
LNHVLEEEQK LVQLGQAEKR KTDQFLRDAV ETRLRMLIPY IEHWPRALSI
210 220 230 240 250
LLLPQNIPPS LSLLTSMVDD MWHYAGDQST DFNWYTRRAV LAGIYNTTEL
260 270 280 290 300
VMMQDSSPDF EDTWRFLDNR INDAMNMGHT AKQVKSTGEA LVQGLMGAAV
310
TLKNLTGLNQ RR
Length:312
Mass (Da):35,146
Last modified:March 21, 2006 - v2
Checksum:i7A52D53775DDE649
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03113798 Genomic DNA. No translation available.
AABR03113818 Genomic DNA. No translation available.
BC079370 mRNA. Translation: AAH79370.1.
BC104702 mRNA. Translation: AAI04703.1.
BC127449 mRNA. Translation: AAI27450.1.
RefSeqiNP_001030334.1. NM_001035257.1.
UniGeneiRn.22044.

Genome annotation databases

EnsembliENSRNOT00000021716; ENSRNOP00000021716; ENSRNOG00000016190.
GeneIDi498909.
KEGGirno:498909.
UCSCiRGD:1586040. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03113798 Genomic DNA. No translation available.
AABR03113818 Genomic DNA. No translation available.
BC079370 mRNA. Translation: AAH79370.1.
BC104702 mRNA. Translation: AAI04703.1.
BC127449 mRNA. Translation: AAI27450.1.
RefSeqiNP_001030334.1. NM_001035257.1.
UniGeneiRn.22044.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021716.

PTM databases

iPTMnetiQ68FT1.
PhosphoSiteiQ68FT1.

Proteomic databases

PaxDbiQ68FT1.
PRIDEiQ68FT1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021716; ENSRNOP00000021716; ENSRNOG00000016190.
GeneIDi498909.
KEGGirno:498909.
UCSCiRGD:1586040. rat.

Organism-specific databases

CTDi57017.
RGDi1586040. Coq9.

Phylogenomic databases

eggNOGiKOG2969. Eukaryota.
COG5590. LUCA.
GeneTreeiENSGT00390000009328.
HOGENOMiHOG000231991.
HOVERGENiHBG079760.
InParanoidiQ68FT1.
KOiK18587.
OMAiMFGKDGS.
OrthoDBiEOG75B85W.
PhylomeDBiQ68FT1.
TreeFamiTF324653.

Enzyme and pathway databases

UniPathwayiUPA00232.

Miscellaneous databases

NextBioi701229.
PROiQ68FT1.

Gene expression databases

GenevisibleiQ68FT1. RN.

Family and domain databases

InterProiIPR013718. COQ9.
IPR012762. Ubiq_biosynth_COQ9.
[Graphical view]
PfamiPF08511. COQ9. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02396. diverge_rpsU. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Kidney.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCOQ9_RAT
AccessioniPrimary (citable) accession number: Q68FT1
Secondary accession number(s): A1L109
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: May 11, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.