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Protein

F-box only protein 7

Gene

Fbxo7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PARK2 to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-RNO-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 7
Gene namesi
Name:Fbxo7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1305648. Fbxo7.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity
  • Mitochondrion By similarity
  • Cytoplasmcytosol By similarity

  • Note: Predominantly cytoplasmic. A minor proportion is detected in the nucleus. Relocates from the cytosol to depolarized mitochondria (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003077231 – 522F-box only protein 7Add BLAST522

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei431Omega-N-methylarginineBy similarity1
Modified residuei451Omega-N-methylarginineBy similarity1
Modified residuei518Asymmetric dimethylarginineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiQ68FS3.
PRIDEiQ68FS3.

PTM databases

iPTMnetiQ68FS3.
PhosphoSitePlusiQ68FS3.

Expressioni

Gene expression databases

BgeeiENSRNOG00000004637.
ExpressionAtlasiQ68FS3. baseline and differential.
GenevisibleiQ68FS3. RN.

Interactioni

Subunit structurei

Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO7) formed of CUL1, SKP1, RBX1 and FBXO7. Interacts via its C-terminal proline-rich region with DLGAP5. Interacts with BIRC2. Interacts with CDK6 and promotes its interaction with D-type cyclin. Interacts (via the N-terminal Ubl domain) with PARK2. Interacts (via N-terminal region) with PINK1. Interacts with PSMF1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006366.

Structurei

3D structure databases

ProteinModelPortaliQ68FS3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini329 – 375F-boxPROSITE-ProRule annotationAdd BLAST47

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 88Ubiquitin-likeBy similarityAdd BLAST88
Regioni92 – 129Important for interaction with PINK1By similarityAdd BLAST38
Regioni129 – 169Important for interaction with CDK6By similarityAdd BLAST41
Regioni180 – 324Important for dimerization and interaction with PSMF1By similarityAdd BLAST145
Regioni381 – 522Important for interaction with CDK6By similarityAdd BLAST142

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi481 – 484RFDP motif4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi416 – 509Pro-richAdd BLAST94

Domaini

The ubiquitin-like region mediates interaction with PARK2.By similarity
The proline-rich region is important for protein-protein interactions.By similarity

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IGV9. Eukaryota.
ENOG410XQUZ. LUCA.
GeneTreeiENSGT00390000006670.
HOGENOMiHOG000112551.
HOVERGENiHBG005648.
InParanoidiQ68FS3.
KOiK10293.
OMAiPMLCSES.
OrthoDBiEOG091G0FNN.
PhylomeDBiQ68FS3.
TreeFamiTF329830.

Family and domain databases

InterProiIPR001810. F-box_dom.
IPR021625. PI31_Prot_N.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF11566. PI31_Prot_N. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68FS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLRVRLQKR TQPLEVPESE PTLGQLRAHL IQDLLPTLGF SSDTRFAITL
60 70 80 90 100
NNKDALTGDE ETLASYGIVS GDLICLVLED EMPAPNLPSS TDSEHSSLQN
110 120 130 140 150
NDQPPLAATS SQANIPDEQG SDSSHGQVTQ YDAWTDDSME GPSHSAEAVS
160 170 180 190 200
IQDAMSVEEA SGFHPLEPML CSETEDGQVP HSLEALYQSA GCSTVSDALI
210 220 230 240 250
VLVHLLMLES GYIPQGTEAK AASMPEKWKS SGVYKLQYTH PLCEGGSAVL
260 270 280 290 300
TCVPLGKLIM INATIKVNGG IKNVKSVQLK PGAYVRRAEP GESAAKVYKD
310 320 330 340 350
LKKLSRLFKD QLVYPLLAFT RQVLNLPDVF GLVVLPLELK LRIFRLLDVH
360 370 380 390 400
SVLALSAVCH DLLIASNDPL LWRCLYLRDF RDSTIRGPDT DWKELYRKKH
410 420 430 440 450
IQRKEAQRMR HVMYLPSVHP IPFCPIPVYP RPYLPTTLLP PGIIGGEYDE
460 470 480 490 500
RPILPSVGDP VTSLIPRPGE PPSQFRPVRP RFDPVGPLPG SNSLLPGRAS
510 520
PNNRFPFRPG RGRSADNRLP YL
Length:522
Mass (Da):57,561
Last modified:October 11, 2004 - v1
Checksum:i1A1E5C131425CD7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079382 mRNA. Translation: AAH79382.1.
RefSeqiNP_001012222.1. NM_001012222.1.
UniGeneiRn.20218.

Genome annotation databases

EnsembliENSRNOT00000006366; ENSRNOP00000006366; ENSRNOG00000004637.
GeneIDi366854.
KEGGirno:366854.
UCSCiRGD:1305648. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079382 mRNA. Translation: AAH79382.1.
RefSeqiNP_001012222.1. NM_001012222.1.
UniGeneiRn.20218.

3D structure databases

ProteinModelPortaliQ68FS3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006366.

PTM databases

iPTMnetiQ68FS3.
PhosphoSitePlusiQ68FS3.

Proteomic databases

PaxDbiQ68FS3.
PRIDEiQ68FS3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006366; ENSRNOP00000006366; ENSRNOG00000004637.
GeneIDi366854.
KEGGirno:366854.
UCSCiRGD:1305648. rat.

Organism-specific databases

CTDi25793.
RGDi1305648. Fbxo7.

Phylogenomic databases

eggNOGiENOG410IGV9. Eukaryota.
ENOG410XQUZ. LUCA.
GeneTreeiENSGT00390000006670.
HOGENOMiHOG000112551.
HOVERGENiHBG005648.
InParanoidiQ68FS3.
KOiK10293.
OMAiPMLCSES.
OrthoDBiEOG091G0FNN.
PhylomeDBiQ68FS3.
TreeFamiTF329830.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-RNO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

PROiQ68FS3.

Gene expression databases

BgeeiENSRNOG00000004637.
ExpressionAtlasiQ68FS3. baseline and differential.
GenevisibleiQ68FS3. RN.

Family and domain databases

InterProiIPR001810. F-box_dom.
IPR021625. PI31_Prot_N.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF11566. PI31_Prot_N. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFBX7_RAT
AccessioniPrimary (citable) accession number: Q68FS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 11, 2004
Last modified: November 30, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.