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Protein

COP9 signalosome complex subunit 4

Gene

Cops4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-5696394. DNA Damage Recognition in GG-NER.
R-RNO-6781823. Formation of TC-NER Pre-Incision Complex.

Names & Taxonomyi

Protein namesi
Recommended name:
COP9 signalosome complex subunit 4
Short name:
SGN4
Short name:
Signalosome subunit 4
Alternative name(s):
JAB1-containing signalosome subunit 4
Gene namesi
Name:Cops4
Synonyms:Csn4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1302952. Cops4.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • COP9 signalosome Source: UniProtKB-KW
  • extracellular exosome Source: Ensembl
  • nucleoplasm Source: Ensembl
  • synaptic vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoplasmic vesicle, Nucleus, Signalosome, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 406405COP9 signalosome complex subunit 4PRO_0000120989Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei25 – 251N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ68FS2.
PRIDEiQ68FS2.

PTM databases

iPTMnetiQ68FS2.
PhosphoSiteiQ68FS2.

Expressioni

Gene expression databases

GenevisibleiQ68FS2. RN.

Interactioni

Subunit structurei

Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS2, COPS3, COPS5, COPS6, COPS7 (COPS7A or COPS7B) and COPS8. Interacts with TOR1A; the interaction is direct and associates TOR1A and SNAPIN with the CSN complex. Interacts with STON2; controls STON2 neddylation levels.1 Publication

Protein-protein interaction databases

IntActiQ68FS2. 4 interactions.
STRINGi10116.ENSRNOP00000003046.

Structurei

3D structure databases

ProteinModelPortaliQ68FS2.
SMRiQ68FS2. Positions 299-366.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini201 – 363163PCIAdd
BLAST

Sequence similaritiesi

Belongs to the CSN4 family.Curated
Contains 1 PCI domain.Curated

Phylogenomic databases

eggNOGiKOG1497. Eukaryota.
ENOG410XPDE. LUCA.
GeneTreeiENSGT00730000111161.
HOGENOMiHOG000158382.
HOVERGENiHBG051136.
InParanoidiQ68FS2.
KOiK12178.
OMAiKRFLDHM.
OrthoDBiEOG7P02HX.
PhylomeDBiQ68FS2.
TreeFamiTF101147.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000717. PCI_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01399. PCI. 1 hit.
[Graphical view]
SMARTiSM00088. PINT. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68FS2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAVRQDLA QLMNSSGSHK DLAGKYRQIL EKAIQLSGTE QLEALKAFVE
60 70 80 90 100
AMVNENVSLV ISRQLLTDFC THLPNLPDST AKEVYHFTLE KVQPRVISFE
110 120 130 140 150
EQVASIRQRL ASIYEKEEDW RNAAQVLVGI PLETGQKQYN VDYKLETYLK
160 170 180 190 200
IARLYLEDDD PVQAEAYINR ASLLQNESTN EQLQIHYKVC YARVLDYRRK
210 220 230 240 250
FIEAAQRYNE LSYKTIVHES ERLEALKHAL HCTILASAGQ QRSRMLATLF
260 270 280 290 300
KDERCQQLAA YGILEKMYLD RIIRGNQLQE FAAMLMPHQK ATTADGSSIL
310 320 330 340 350
DRAVIEHNLL SASKLYNNIT FEELGALLEI PAAKAEKIAS QMITEGRMNG
360 370 380 390 400
FIDQIDGIVH FETREALPTW DKQIQSLCFQ VNNLLEKISQ TAPEWTAQAM

EAQMAQ
Length:406
Mass (Da):46,290
Last modified:October 11, 2004 - v1
Checksum:iB0F34DFC48E8DDA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079384 mRNA. Translation: AAH79384.1.
RefSeqiNP_001004275.1. NM_001004275.1.
UniGeneiRn.7506.

Genome annotation databases

EnsembliENSRNOT00000003046; ENSRNOP00000003046; ENSRNOG00000023650.
GeneIDi360915.
KEGGirno:360915.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079384 mRNA. Translation: AAH79384.1.
RefSeqiNP_001004275.1. NM_001004275.1.
UniGeneiRn.7506.

3D structure databases

ProteinModelPortaliQ68FS2.
SMRiQ68FS2. Positions 299-366.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ68FS2. 4 interactions.
STRINGi10116.ENSRNOP00000003046.

PTM databases

iPTMnetiQ68FS2.
PhosphoSiteiQ68FS2.

Proteomic databases

PaxDbiQ68FS2.
PRIDEiQ68FS2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003046; ENSRNOP00000003046; ENSRNOG00000023650.
GeneIDi360915.
KEGGirno:360915.

Organism-specific databases

CTDi51138.
RGDi1302952. Cops4.

Phylogenomic databases

eggNOGiKOG1497. Eukaryota.
ENOG410XPDE. LUCA.
GeneTreeiENSGT00730000111161.
HOGENOMiHOG000158382.
HOVERGENiHBG051136.
InParanoidiQ68FS2.
KOiK12178.
OMAiKRFLDHM.
OrthoDBiEOG7P02HX.
PhylomeDBiQ68FS2.
TreeFamiTF101147.

Enzyme and pathway databases

ReactomeiR-RNO-5696394. DNA Damage Recognition in GG-NER.
R-RNO-6781823. Formation of TC-NER Pre-Incision Complex.

Miscellaneous databases

NextBioi674575.
PROiQ68FS2.

Gene expression databases

GenevisibleiQ68FS2. RN.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000717. PCI_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01399. PCI. 1 hit.
[Graphical view]
SMARTiSM00088. PINT. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process."
    Granata A., Koo S.J., Haucke V., Schiavo G., Warner T.T.
    EMBO J. 30:181-193(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH COPS4 AND STON2, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiCSN4_RAT
AccessioniPrimary (citable) accession number: Q68FS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 11, 2004
Last modified: May 11, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.