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Protein

Elongation factor 1-gamma

Gene

Eef1g

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probably plays a role in anchoring the complex to other cellular components.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

ReactomeiR-RNO-156842. Eukaryotic Translation Elongation.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor 1-gamma
Short name:
EF-1-gamma
Alternative name(s):
eEF-1B gamma
Gene namesi
Name:Eef1g
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1302939. Eef1g.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 437436Elongation factor 1-gammaPRO_0000208817Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei147 – 1471N6-acetyllysineBy similarity
Modified residuei212 – 2121N6-acetyllysineBy similarity
Modified residuei401 – 4011N6-acetyllysineBy similarity
Modified residuei434 – 4341N6-acetyllysine; alternateBy similarity
Modified residuei434 – 4341N6-malonyllysine; alternateBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ68FR6.
PRIDEiQ68FR6.

2D gel databases

World-2DPAGE0004:Q68FR6.

PTM databases

iPTMnetiQ68FR6.
PhosphoSiteiQ68FR6.
SwissPalmiQ68FR6.

Expressioni

Gene expression databases

GenevisibleiQ68FR6. RN.

Interactioni

Subunit structurei

EF-1 is composed of four subunits: alpha, beta, delta, and gamma.

Protein-protein interaction databases

BioGridi254421. 2 interactions.
IntActiQ68FR6. 1 interaction.
STRINGi10116.ENSRNOP00000027305.

Structurei

3D structure databases

ProteinModelPortaliQ68FR6.
SMRiQ68FR6. Positions 276-437.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 8786GST N-terminalAdd
BLAST
Domaini88 – 216129GST C-terminalAdd
BLAST
Domaini276 – 437162EF-1-gamma C-terminalPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 EF-1-gamma C-terminal domain.PROSITE-ProRule annotation
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiKOG0867. Eukaryota.
KOG1627. Eukaryota.
COG0625. LUCA.
GeneTreeiENSGT00390000007552.
HOGENOMiHOG000201196.
HOVERGENiHBG051444.
InParanoidiQ68FR6.
KOiK03233.
OMAiDGWSLWF.
OrthoDBiEOG72G177.
PhylomeDBiQ68FR6.
TreeFamiTF314343.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.30.70.1010. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
IPR001662. Transl_elong_EF1_G_con.
[Graphical view]
PfamiPF00647. EF1G. 1 hit.
PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SMARTiSM01183. EF1G. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
SSF89942. SSF89942. 1 hit.
PROSITEiPS50040. EF1G_C. 1 hit.
PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68FR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGTLYTYP ENWRAFKALI AAQYSGAQIR VLSAPPHFHF GQTNRTPEFL
60 70 80 90 100
RKFPAGKVPA FEGDDGFCVF ESNAIAYYVS NEELRGSTPE AAAQVVQWVS
110 120 130 140 150
FADSDIVPPA STWVFPTLGI MHHNKQATEN AKEEVKRILG LLDTHLKTRT
160 170 180 190 200
FLVGERVTLA DITVVCTLLW LYKQVLEPSF RQAFPNTNRW FLTCINQPQF
210 220 230 240 250
RAILGEVKLC EKMAQFDAKK FAESQPKKDT PRKEKGSREE KQKPQTERKE
260 270 280 290 300
EKKAAAPAPE EEMDECEQAL AAEPKAKDPF AHLPKSTFVL DEFKRKYSNE
310 320 330 340 350
DTLSVALPYF WEHFDKDGWS LWYAEYRFPE ELTQTFMSCN LITGMFQRLD
360 370 380 390 400
KLRKNAFASV ILFGTNNSSS ISGVWVFRGQ DLAFPLSPDW QVDYESYTWR
410 420 430
KLDPGSEETQ TLVREYFSWE GAFQHVGKAV NQGKIFK
Length:437
Mass (Da):50,061
Last modified:January 23, 2007 - v3
Checksum:iD1AF3BE9FADB2F3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079398 mRNA. Translation: AAH79398.1.
BC098895 mRNA. Translation: AAH98895.1.
RefSeqiNP_001004223.1. NM_001004223.2.
UniGeneiRn.43300.

Genome annotation databases

EnsembliENSRNOT00000027305; ENSRNOP00000027305; ENSRNOG00000020075.
GeneIDi293725.
KEGGirno:293725.
UCSCiRGD:1302939. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079398 mRNA. Translation: AAH79398.1.
BC098895 mRNA. Translation: AAH98895.1.
RefSeqiNP_001004223.1. NM_001004223.2.
UniGeneiRn.43300.

3D structure databases

ProteinModelPortaliQ68FR6.
SMRiQ68FR6. Positions 276-437.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi254421. 2 interactions.
IntActiQ68FR6. 1 interaction.
STRINGi10116.ENSRNOP00000027305.

PTM databases

iPTMnetiQ68FR6.
PhosphoSiteiQ68FR6.
SwissPalmiQ68FR6.

2D gel databases

World-2DPAGE0004:Q68FR6.

Proteomic databases

PaxDbiQ68FR6.
PRIDEiQ68FR6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027305; ENSRNOP00000027305; ENSRNOG00000020075.
GeneIDi293725.
KEGGirno:293725.
UCSCiRGD:1302939. rat.

Organism-specific databases

CTDi1937.
RGDi1302939. Eef1g.

Phylogenomic databases

eggNOGiKOG0867. Eukaryota.
KOG1627. Eukaryota.
COG0625. LUCA.
GeneTreeiENSGT00390000007552.
HOGENOMiHOG000201196.
HOVERGENiHBG051444.
InParanoidiQ68FR6.
KOiK03233.
OMAiDGWSLWF.
OrthoDBiEOG72G177.
PhylomeDBiQ68FR6.
TreeFamiTF314343.

Enzyme and pathway databases

ReactomeiR-RNO-156842. Eukaryotic Translation Elongation.

Miscellaneous databases

NextBioi636856.
PROiQ68FR6.

Gene expression databases

GenevisibleiQ68FR6. RN.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.30.70.1010. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
IPR001662. Transl_elong_EF1_G_con.
[Graphical view]
PfamiPF00647. EF1G. 1 hit.
PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SMARTiSM01183. EF1G. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
SSF89942. SSF89942. 1 hit.
PROSITEiPS50040. EF1G_C. 1 hit.
PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen and Testis.

Entry informationi

Entry nameiEF1G_RAT
AccessioniPrimary (citable) accession number: Q68FR6
Secondary accession number(s): Q4FZZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: January 23, 2007
Last modified: May 11, 2016
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.