Reviewed, UniProtKB/Swiss-Prot Q68FR6 (EF1G_RAT)

Names and origin

Protein names

Recommended name:
    Elongation factor 1-gamma
      Short name=EF-1-gamma
Alternative name(s):
    eEF-1B gamma

Gene names

Name:

Eef1g

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	437 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Probably plays a role in anchoring the complex to other cellular components.
Subunit structure	EF-1 is composed of four subunits: alpha, beta, delta, and gamma.
Sequence similarities	Contains 1 EF-1-gamma C-terminal domain. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Biological process	Protein biosynthesis
Molecular function	Elongation factor
PTM	Acetylation Phosphoprotein
Gene Ontology (GO)
Biological process	translational elongation Inferred from electronic annotation. Source: InterPro
Cellular component	eukaryotic translation elongation factor 1 complex Inferred from electronic annotation. Source: InterPro
Molecular function	translation elongation factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 437	436	Elongation factor 1-gamma		PRO_0000208817
Regions
	Domain	2 – 87	86	GST N-terminal
	Domain	88 – 216	129	GST C-terminal
	Domain	276 – 437	162	EF-1-gamma C-terminal
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
	Modified residue	43	1	Phosphothreonine By similarity
	Modified residue	46	1	Phosphothreonine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q68FR6-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: D1AF3BE9FADB2F3E	FASTA	437	50,061
	10 20 30 40 50 60 MAAGTLYTYP ENWRAFKALI AAQYSGAQIR VLSAPPHFHF GQTNRTPEFL RKFPAGKVPA 70 80 90 100 110 120 FEGDDGFCVF ESNAIAYYVS NEELRGSTPE AAAQVVQWVS FADSDIVPPA STWVFPTLGI 130 140 150 160 170 180 MHHNKQATEN AKEEVKRILG LLDTHLKTRT FLVGERVTLA DITVVCTLLW LYKQVLEPSF 190 200 210 220 230 240 RQAFPNTNRW FLTCINQPQF RAILGEVKLC EKMAQFDAKK FAESQPKKDT PRKEKGSREE 250 260 270 280 290 300 KQKPQTERKE EKKAAAPAPE EEMDECEQAL AAEPKAKDPF AHLPKSTFVL DEFKRKYSNE 310 320 330 340 350 360 DTLSVALPYF WEHFDKDGWS LWYAEYRFPE ELTQTFMSCN LITGMFQRLD KLRKNAFASV 370 380 390 400 410 420 ILFGTNNSSS ISGVWVFRGQ DLAFPLSPDW QVDYESYTWR KLDPGSEETQ TLVREYFSWE 430 GAFQHVGKAV NQGKIFK

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Spleen and Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC079398 mRNA. Translation: AAH79398.1. BC098895 mRNA. Translation: AAH98895.1.
IPI	IPI00470317.
RefSeq	NP_001004223.1.
UniGene	Rn.43300
3D structure databases
SMR	Q68FR6. Positions 275-436, 276-437.
ModBase	Search...
PTM databases
PhosphoSite	Q68FR6.
Proteomic databases
PRIDE	Q68FR6.
Genome annotation databases
Ensembl	ENSRNOG00000020075. Rattus norvegicus. [Contig view]
GeneID	293725.
KEGG	rno:293725.
NMPDR	fig|10116.3.peg.3666.
Organism-specific databases
RGD	1302939. Eef1g.
Phylogenomic databases
HOVERGEN	Q68FR6.
OMA	Q68FR6. KSIPYFW.
Gene expression databases
ArrayExpress	Q68FR6.
GermOnline	ENSRNOG00000020075. Rattus norvegicus.
Family and domain databases
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. IPR001662. Transl_elong_EF1_G_con. [Graphical view]
Gene3D	G3DSA:1.20.1050.10. GST_C_like. 1 hit. G3DSA:3.30.70.1010. Transl_elong_EF1_G_con. 1 hit.
Pfam	PF00647. EF1G. 1 hit. PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view]
ProDom	PD006217. EF1_G. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS50040. EF1G_C. 1 hit. PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	636856.

Entry information

Entry name

EF1G_RAT

Accession

Primary (citable) accession number: Q68FR6
Secondary accession number(s): Q4FZZ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 9, 2004
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 48 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)