Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

RNA polymerase II-associated protein 3

Gene

Rpap3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II-associated protein 3
Gene namesi
Name:Rpap3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1303036 Rpap3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003027962 – 659RNA polymerase II-associated protein 3Add BLAST658

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineBy similarity1
Modified residuei87PhosphoserineBy similarity1
Modified residuei116PhosphoserineBy similarity1
Modified residuei119PhosphoserineBy similarity1
Modified residuei121PhosphoserineCombined sources1
Modified residuei474PhosphoserineBy similarity1
Cross-linki491Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PRIDEiQ68FQ7

PTM databases

iPTMnetiQ68FQ7
PhosphoSitePlusiQ68FQ7

Expressioni

Gene expression databases

BgeeiENSRNOG00000053405
GenevisibleiQ68FQ7 RN

Interactioni

Subunit structurei

Tightly associated with the RNA polymerase II complex. Component of the R2TP complex composed at least of PIHD1, RUVBL1, RUVBL2 and RPAP3. Interacts with PIH1D1.By similarity

Protein-protein interaction databases

IntActiQ68FQ7, 1 interactor
MINTiQ68FQ7

Structurei

3D structure databases

ProteinModelPortaliQ68FQ7
SMRiQ68FQ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati8 – 41TPR 1Add BLAST34
Repeati133 – 166TPR 2Add BLAST34
Repeati168 – 200TPR 3Add BLAST33
Repeati201 – 234TPR 4Add BLAST34
Repeati282 – 315TPR 5Add BLAST34
Repeati317 – 349TPR 6Add BLAST33
Repeati350 – 383TPR 7Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi63 – 70Poly-Lys8

Sequence similaritiesi

Belongs to the RPAP3 family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

GeneTreeiENSGT00730000110724
HOGENOMiHOG000154181
HOVERGENiHBG059892
InParanoidiQ68FQ7
OMAiSYSKAFA
OrthoDBiEOG091G0IS5

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR025986 RPAP3-like_C
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR001440 TPR_1
IPR013105 TPR_2
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF13877 RPAP3_C, 1 hit
PF00515 TPR_1, 1 hit
PF07719 TPR_2, 1 hit
PF13176 TPR_7, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 6 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 5 hits
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68FQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSTSKAVEL QLQVKHNAEE LQDFMRDLEH WEKTMRQKDL ELRRQSGVPE
60 70 80 90 100
ENLPPIRNGS FRKKKKRKTK DSSKKTKEEN TKNRIKSFDY DAWAKLDVDS
110 120 130 140 150
ILDELDKEDS THDSVSQESE SDEDGVRVDS QKALVLKEKG NKYFKQGKYD
160 170 180 190 200
EAIECYTKGM DADPYNPVLP TNRASAYFRL KKFAVAESDC NLAIALSRSY
210 220 230 240 250
TKAYARRGAA RFALQKLEDA RKDYVKVLEL EPDNFEATNE LRKIDQALTS
260 270 280 290 300
KENSHPKDIA AVIKPAEGER KANEDQRGRQ KAIAEKDLGN GFFKEGKYEQ
310 320 330 340 350
AIECYTRGIA ADSTNALLPA NRAMAYLKVQ KYEEAERDCT QAILLDGSYS
360 370 380 390 400
KAFARRGTAR TFLGKINEAK QDFETVLLLE PGNKQAVTEL SRIKKELIEK
410 420 430 440 450
GRWDDVFLDS TQRHNVVKPV DSPHRGSPKA LKKVFIEETG NLIESVDAPE
460 470 480 490 500
SSATVPESDR AAVAVDTGRK KDFSQGDSVS SGETPRAKVL KIEAVGDSSA
510 520 530 540 550
PQAQVDVKQG VRQSVSEKTS VRVAQTPGQL AAVVLPPVPA NSFQLESDFR
560 570 580 590 600
QLRSSPEMLY QYVKKIEPSL YPKLFQKNLD PDVFNQIIKI LHDFYVEREK
610 620 630 640 650
PALIFEVLER LSQLRRFDMA VMFMSGTERE LTKVLFNHLE KSELKEDSVE

ELKKRYGGG
Length:659
Mass (Da):74,645
Last modified:October 11, 2004 - v1
Checksum:i519D6C55825593B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079414 mRNA Translation: AAH79414.1
RefSeqiNP_001004243.1, NM_001004243.1
XP_008763912.1, XM_008765690.2
XP_017450273.1, XM_017594784.1
XP_017450274.1, XM_017594785.1
UniGeneiRn.49051

Genome annotation databases

EnsembliENSRNOT00000083926; ENSRNOP00000074251; ENSRNOG00000053405
GeneIDi300189
KEGGirno:300189
UCSCiRGD:1303036 rat

Similar proteinsi

Entry informationi

Entry nameiRPAP3_RAT
AccessioniPrimary (citable) accession number: Q68FQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 11, 2004
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health