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Protein

Junctional adhesion molecule C

Gene

Jam3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May participate in cell-cell adhesion distinct from tight junctions.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-RNO-202733 Cell surface interactions at the vascular wall
R-RNO-216083 Integrin cell surface interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Junctional adhesion molecule C
Short name:
JAM-C
Alternative name(s):
Junctional adhesion molecule 3
Short name:
JAM-3
Gene namesi
Name:Jam3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1303248 Jam3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 241ExtracellularSequence analysisAdd BLAST210
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Topological domaini263 – 310CytoplasmicSequence analysisAdd BLAST48

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000001507332 – 310Junctional adhesion molecule CAdd BLAST279

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 115PROSITE-ProRule annotation
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi160 ↔ 219PROSITE-ProRule annotation
Glycosylationi192N-linked (GlcNAc...) asparagine; alternateSequence analysis1
Glycosylationi192N-linked (HexNAc...) asparagine; alternateCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ68FQ2
PRIDEiQ68FQ2

PTM databases

SwissPalmiQ68FQ2
UniCarbKBiQ68FQ2

Expressioni

Gene expression databases

BgeeiENSRNOG00000009149
GenevisibleiQ68FQ2 RN

Interactioni

Subunit structurei

Interacts with JAM2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi261047, 1 interactor
DIPiDIP-46159N
IntActiQ68FQ2, 1 interactor
STRINGi10116.ENSRNOP00000012247

Structurei

3D structure databases

ProteinModelPortaliQ68FQ2
SMRiQ68FQ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 127Ig-like V-typeAdd BLAST93
Domaini139 – 236Ig-like C2-typeAdd BLAST98

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGQI Eukaryota
ENOG41100KX LUCA
GeneTreeiENSGT00730000110678
HOGENOMiHOG000247041
HOVERGENiHBG000518
InParanoidiQ68FQ2
KOiK06785
OMAiGICCAYR
OrthoDBiEOG091G0DWZ
PhylomeDBiQ68FQ2
TreeFamiTF331459

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SM00406 IGv, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68FQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSRRLRLR LCARLPDFFL LLLFRGCVIE AVNLKSSNRN PVVHEFESVE
60 70 80 90 100
LSCIITDSQT NDPRIEWKKI QDGQTTYVYF DNKIQGDLAG RTDVFGKTSL
110 120 130 140 150
RIWNVTRSDS AIYRCEVVAL NDRKEVDELT IELIVQVKPV APVCRVPKAV
160 170 180 190 200
PVGKAATLQC QESEGYPRPY YSWYRNDVPL PTDSRANPRF QNSSFHVNSE
210 220 230 240 250
TGTLVFSAVH KEDSGQYYCI ASNDAGAARC EGQDMEVYDL NIAGIIGGVL
260 270 280 290 300
VVLIVLAVIT MGICCAYRRG CFISSKQDGE SYKSPGKHEG VNYIRTSEEG
310
DFRHKSSFVI
Length:310
Mass (Da):34,783
Last modified:October 11, 2004 - v1
Checksum:iBB0CAD5EE41D383B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079429 mRNA Translation: AAH79429.1
RefSeqiNP_001004269.1, NM_001004269.1
UniGeneiRn.104684

Genome annotation databases

EnsembliENSRNOT00000012247; ENSRNOP00000012247; ENSRNOG00000009149
GeneIDi315509
KEGGirno:315509
UCSCiRGD:1303248 rat

Similar proteinsi

Entry informationi

Entry nameiJAM3_RAT
AccessioniPrimary (citable) accession number: Q68FQ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: October 11, 2004
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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