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Protein

Junctional adhesion molecule C

Gene

Jam3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May participate in cell-cell adhesion distinct from tight junctions.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiR-RNO-202733. Cell surface interactions at the vascular wall.
R-RNO-216083. Integrin cell surface interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Junctional adhesion molecule C
Short name:
JAM-C
Alternative name(s):
Junctional adhesion molecule 3
Short name:
JAM-3
Gene namesi
Name:Jam3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1303248. Jam3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 241ExtracellularSequence analysisAdd BLAST210
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Topological domaini263 – 310CytoplasmicSequence analysisAdd BLAST48

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000001507332 – 310Junctional adhesion molecule CAdd BLAST279

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 115PROSITE-ProRule annotation
Glycosylationi104N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi160 ↔ 219PROSITE-ProRule annotation
Glycosylationi192N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ68FQ2.
PRIDEiQ68FQ2.

PTM databases

SwissPalmiQ68FQ2.
UniCarbKBiQ68FQ2.

Expressioni

Gene expression databases

BgeeiENSRNOG00000009149.
GenevisibleiQ68FQ2. RN.

Interactioni

Subunit structurei

Interacts with JAM2.By similarity

Protein-protein interaction databases

BioGridi261047. 1 interactor.
DIPiDIP-46159N.
STRINGi10116.ENSRNOP00000012247.

Structurei

3D structure databases

ProteinModelPortaliQ68FQ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 127Ig-like V-typeAdd BLAST93
Domaini139 – 236Ig-like C2-typeAdd BLAST98

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGQI. Eukaryota.
ENOG41100KX. LUCA.
GeneTreeiENSGT00730000110678.
HOGENOMiHOG000247041.
HOVERGENiHBG000518.
InParanoidiQ68FQ2.
KOiK06785.
OMAiSYKNPGK.
OrthoDBiEOG091G0DWZ.
PhylomeDBiQ68FQ2.
TreeFamiTF331459.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SM00406. IGv. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68FQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSRRLRLR LCARLPDFFL LLLFRGCVIE AVNLKSSNRN PVVHEFESVE
60 70 80 90 100
LSCIITDSQT NDPRIEWKKI QDGQTTYVYF DNKIQGDLAG RTDVFGKTSL
110 120 130 140 150
RIWNVTRSDS AIYRCEVVAL NDRKEVDELT IELIVQVKPV APVCRVPKAV
160 170 180 190 200
PVGKAATLQC QESEGYPRPY YSWYRNDVPL PTDSRANPRF QNSSFHVNSE
210 220 230 240 250
TGTLVFSAVH KEDSGQYYCI ASNDAGAARC EGQDMEVYDL NIAGIIGGVL
260 270 280 290 300
VVLIVLAVIT MGICCAYRRG CFISSKQDGE SYKSPGKHEG VNYIRTSEEG
310
DFRHKSSFVI
Length:310
Mass (Da):34,783
Last modified:October 11, 2004 - v1
Checksum:iBB0CAD5EE41D383B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079429 mRNA. Translation: AAH79429.1.
RefSeqiNP_001004269.1. NM_001004269.1.
UniGeneiRn.104684.

Genome annotation databases

EnsembliENSRNOT00000012247; ENSRNOP00000012247; ENSRNOG00000009149.
GeneIDi315509.
KEGGirno:315509.
UCSCiRGD:1303248. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079429 mRNA. Translation: AAH79429.1.
RefSeqiNP_001004269.1. NM_001004269.1.
UniGeneiRn.104684.

3D structure databases

ProteinModelPortaliQ68FQ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi261047. 1 interactor.
DIPiDIP-46159N.
STRINGi10116.ENSRNOP00000012247.

PTM databases

SwissPalmiQ68FQ2.
UniCarbKBiQ68FQ2.

Proteomic databases

PaxDbiQ68FQ2.
PRIDEiQ68FQ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012247; ENSRNOP00000012247; ENSRNOG00000009149.
GeneIDi315509.
KEGGirno:315509.
UCSCiRGD:1303248. rat.

Organism-specific databases

CTDi83700.
RGDi1303248. Jam3.

Phylogenomic databases

eggNOGiENOG410IGQI. Eukaryota.
ENOG41100KX. LUCA.
GeneTreeiENSGT00730000110678.
HOGENOMiHOG000247041.
HOVERGENiHBG000518.
InParanoidiQ68FQ2.
KOiK06785.
OMAiSYKNPGK.
OrthoDBiEOG091G0DWZ.
PhylomeDBiQ68FQ2.
TreeFamiTF331459.

Enzyme and pathway databases

ReactomeiR-RNO-202733. Cell surface interactions at the vascular wall.
R-RNO-216083. Integrin cell surface interactions.

Miscellaneous databases

PROiQ68FQ2.

Gene expression databases

BgeeiENSRNOG00000009149.
GenevisibleiQ68FQ2. RN.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SM00406. IGv. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiJAM3_RAT
AccessioniPrimary (citable) accession number: Q68FQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: October 11, 2004
Last modified: September 7, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.