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Protein

Adenylate kinase 8

Gene

Ak8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity.By similarity

Catalytic activityi

ATP + AMP = 2 ADP.By similarity
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei147AMP 1By similarity1
Binding sitei203AMP 1By similarity1
Binding sitei361AMP 2By similarity1
Binding sitei392ATP 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi67 – 72ATP 1By similarity6
Nucleotide bindingi140 – 143AMP 1By similarity4
Nucleotide bindingi278 – 283ATP 2By similarity6
Nucleotide bindingi325 – 327AMP 2By similarity3
Nucleotide bindingi354 – 357AMP 2By similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-499943. Synthesis and interconversion of nucleotide di- and triphosphates.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate kinase 8 (EC:2.7.4.3, EC:2.7.4.6)
Short name:
AK 8
Alternative name(s):
ATP-AMP transphosphorylase 8
Gene namesi
Name:Ak8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1303144. Ak8.

Subcellular locationi

  • Cytoplasmcytosol By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002793861 – 479Adenylate kinase 8Add BLAST479

Proteomic databases

PaxDbiQ68FP8.
PRIDEiQ68FP8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000012761.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017029.

Structurei

3D structure databases

ProteinModelPortaliQ68FP8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni58 – 258Adenylate kinase 1By similarityAdd BLAST201
Regioni87 – 113NMPbind 1By similarityAdd BLAST27
Regioni177 – 206LID 1By similarityAdd BLAST30
Regioni269 – 471Adenylate kinase 2By similarityAdd BLAST203
Regioni298 – 327NMPbind 2By similarityAdd BLAST30
Regioni391 – 424LID 2By similarityAdd BLAST34

Sequence similaritiesi

Belongs to the adenylate kinase family.Curated

Phylogenomic databases

eggNOGiKOG3078. Eukaryota.
COG0563. LUCA.
GeneTreeiENSGT00830000128340.
HOVERGENiHBG080569.
InParanoidiQ68FP8.
KOiK00939.
OMAiMQNMLEQ.
OrthoDBiEOG091G06BH.
PhylomeDBiQ68FP8.
TreeFamiTF328560.

Family and domain databases

CDDicd01428. ADK. 2 hits.
Gene3Di3.40.50.300. 3 hits.
HAMAPiMF_00235. Adenylate_kinase_Adk. 1 hit.
InterProiIPR000850. Adenylat/UMP-CMP_kin.
IPR007862. Adenylate_kinase_lid-dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR23359. PTHR23359. 1 hit.
PRINTSiPR00094. ADENYLTKNASE.
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF57774. SSF57774. 2 hits.

Sequencei

Sequence statusi: Complete.

Q68FP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDATSAPHRI PPEMPQYGED YHIFEMMQSM LEQLLIHQPE DPISFMISHL
60 70 80 90 100
RRNNDNVPRV VILGPPASGK TTIAMWLCKH LNSNLITKEN LLEREFSLLS
110 120 130 140 150
LEAKKHYQVY KRVPNSTLVS LVQERLNEDD CLRRGWILDG IPERREQALM
160 170 180 190 200
IQTLGLAPKH VIVLSAPDSV LIERNVGKRI DPVTGEIYHT TFDWPPELEI
210 220 230 240 250
QNRLIQPEGI SEIDTAKKLL EYHRHIIRIL PSYPKILKTI SSDQPCVDVF
260 270 280 290 300
YQALTYVQSG HRCNAPFTPK VLLCGPMGCG KKLQAALLSQ KYGLVNISCG
310 320 330 340 350
QLLKEAMAAE SSLGDLIEPF FEKRMTVPDS IITRVLTERL KQQDCIQKGW
360 370 380 390 400
VLHGFPRDLD QARLLNSMGY SPNRVFFLNV PLDSILERLT LRRTDPVTGE
410 420 430 440 450
RFHLMYKPPP TIEVQARLLQ NPKDSEEYIK LQTDLFYRNS GDLEQYYDRA
460 470
IIVNGDQDPY TVFEYIESGI INPLPRKVT
Length:479
Mass (Da):54,966
Last modified:October 11, 2004 - v1
Checksum:iD2331D51EFC5A15A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079446 mRNA. Translation: AAH79446.1.
RefSeqiNP_001004266.1. NM_001004266.1.
UniGeneiRn.96599.

Genome annotation databases

EnsembliENSRNOT00000017029; ENSRNOP00000017029; ENSRNOG00000012761.
GeneIDi311833.
KEGGirno:311833.
UCSCiRGD:1303144. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079446 mRNA. Translation: AAH79446.1.
RefSeqiNP_001004266.1. NM_001004266.1.
UniGeneiRn.96599.

3D structure databases

ProteinModelPortaliQ68FP8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017029.

Proteomic databases

PaxDbiQ68FP8.
PRIDEiQ68FP8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000017029; ENSRNOP00000017029; ENSRNOG00000012761.
GeneIDi311833.
KEGGirno:311833.
UCSCiRGD:1303144. rat.

Organism-specific databases

CTDi158067.
RGDi1303144. Ak8.

Phylogenomic databases

eggNOGiKOG3078. Eukaryota.
COG0563. LUCA.
GeneTreeiENSGT00830000128340.
HOVERGENiHBG080569.
InParanoidiQ68FP8.
KOiK00939.
OMAiMQNMLEQ.
OrthoDBiEOG091G06BH.
PhylomeDBiQ68FP8.
TreeFamiTF328560.

Enzyme and pathway databases

ReactomeiR-RNO-499943. Synthesis and interconversion of nucleotide di- and triphosphates.

Miscellaneous databases

PROiQ68FP8.

Gene expression databases

BgeeiENSRNOG00000012761.

Family and domain databases

CDDicd01428. ADK. 2 hits.
Gene3Di3.40.50.300. 3 hits.
HAMAPiMF_00235. Adenylate_kinase_Adk. 1 hit.
InterProiIPR000850. Adenylat/UMP-CMP_kin.
IPR007862. Adenylate_kinase_lid-dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR23359. PTHR23359. 1 hit.
PRINTSiPR00094. ADENYLTKNASE.
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF57774. SSF57774. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiKAD8_RAT
AccessioniPrimary (citable) accession number: Q68FP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.