Q68FP8 (KAD8_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenylate kinase 8
EC=2.7.4.3

Gene names

Name:

Ak8

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	479 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Adenylate kinase. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP By similarity.
Catalytic activity	ATP + AMP = 2 ADP.
Subcellular location	Cytoplasm › cytosol By similarity.
Sequence similarities	Belongs to the adenylate kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Inferred from sequence or structural similarity. Source: UniProtKB cytidylate kinase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 479	479	Adenylate kinase 8		PRO_0000279386
Regions
	Nucleotide binding	275 – 282	8	ATP Potential
	Region	270 – 479	210	Adenylate kinase By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q68FP8 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: D2331D51EFC5A15A	FASTA	479	54,966
	10 20 30 40 50 60 MDATSAPHRI PPEMPQYGED YHIFEMMQSM LEQLLIHQPE DPISFMISHL RRNNDNVPRV 70 80 90 100 110 120 VILGPPASGK TTIAMWLCKH LNSNLITKEN LLEREFSLLS LEAKKHYQVY KRVPNSTLVS 130 140 150 160 170 180 LVQERLNEDD CLRRGWILDG IPERREQALM IQTLGLAPKH VIVLSAPDSV LIERNVGKRI 190 200 210 220 230 240 DPVTGEIYHT TFDWPPELEI QNRLIQPEGI SEIDTAKKLL EYHRHIIRIL PSYPKILKTI 250 260 270 280 290 300 SSDQPCVDVF YQALTYVQSG HRCNAPFTPK VLLCGPMGCG KKLQAALLSQ KYGLVNISCG 310 320 330 340 350 360 QLLKEAMAAE SSLGDLIEPF FEKRMTVPDS IITRVLTERL KQQDCIQKGW VLHGFPRDLD 370 380 390 400 410 420 QARLLNSMGY SPNRVFFLNV PLDSILERLT LRRTDPVTGE RFHLMYKPPP TIEVQARLLQ 430 440 450 460 470 NPKDSEEYIK LQTDLFYRNS GDLEQYYDRA IIVNGDQDPY TVFEYIESGI INPLPRKVT

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC079446 mRNA. Translation: AAH79446.1.
IPI	IPI00470327.
RefSeq	NP_001004266.1. NM_001004266.1.
UniGene	Rn.96599.
3D structure databases
HSSP	HSSP built from PDB template 1ZAK based on UniProtKB P43188.
ProteinModelPortal	Q68FP8.
ModBase	Search...
Proteomic databases
PRIDE	Q68FP8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000017029; ENSRNOP00000017029; ENSRNOG00000012761.
GeneID	311833.
KEGG	rno:311833.
NMPDR	fig|10116.3.peg.18311.
UCSC	NM_001004266. rat.
Organism-specific databases
CTD	158067.
RGD	1303144. Ak8.
Phylogenomic databases
eggNOG	roNOG06882.
GeneTree	ENSGT00600000084421.
HOVERGEN	HBG080569.
InParanoid	Q68FP8.
OMA	EYHRNIV.
OrthoDB	EOG49KFQW.
PhylomeDB	Q68FP8.
Gene expression databases
Genevestigator	Q68FP8.
Family and domain databases
InterPro	IPR000850. Adenylate_kin. IPR007862. Adenylate_kinase_lid-dom. [Graphical view]
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 2 hits. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
SUPFAM	SSF57774. Adenylate_kinase_Znf_lid. 1 hit.
PROSITE	PS00113. ADENYLATE_KINASE. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	664245.

Entry information

Entry name

KAD8_RAT

Accession

Primary (citable) accession number: Q68FP8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 6, 2007
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program