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Protein

Snurportin-1

Gene

Snupn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.By similarity

GO - Molecular functioni

  • protein transporter activity Source: InterPro
  • RNA cap binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-RNO-191859. snRNP Assembly.

Names & Taxonomyi

Protein namesi
Recommended name:
Snurportin-1
Alternative name(s):
RNA U transporter 1
Gene namesi
Name:Snupn
Synonyms:Rnut1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1303191. Snupn.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

  • Note: Nucleoplasmic shuttling protein. Its nuclear import involves the nucleocytoplasmic transport receptor importin beta. It is re-exported to the cytoplasm by the XPO1-dependent nuclear export receptor pathway.By similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • extracellular exosome Source: Ensembl
  • nuclear cap binding complex Source: RGD
  • nuclear pore Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910731 – 358Snurportin-1Add BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei75PhosphoserineBy similarity1
Modified residuei351PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ68FP5.
PRIDEiQ68FP5.

PTM databases

iPTMnetiQ68FP5.
PhosphoSitePlusiQ68FP5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000005426.
GenevisibleiQ68FP5. RN.

Interactioni

Subunit structurei

Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. Component of a nuclear export receptor complex composed of KPNB1, Ran, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, Ran and XPO1. Interacts (via IBB domain) with KPNB1; the interaction is direct. Interacts with DDX20, IPO7, SMN1, SNRPB and XPO1. Interacts directly with XPO1. Its interaction with XPO1 and binding to m3G-cap U snRNPs appears to be mutually exclusive.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei106Interaction with m3G-cap structureBy similarity1
Sitei145Interaction with m3G-cap structureBy similarity1
Sitei278Interaction with m3G-cap structureBy similarity1

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007261.

Structurei

3D structure databases

ProteinModelPortaliQ68FP5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 73IBBPROSITE-ProRule annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 160Necessary for interaction with XPO1By similarityAdd BLAST160
Regioni1 – 65Necessary for interaction with KPNB1 and m3G-cap U1 and U5 snRNP import receptor activityBy similarityAdd BLAST65
Regioni128 – 130Interaction with m3G-cap structureBy similarity3
Regioni210 – 329Necessary for binding to the m3G-cap structureBy similarityAdd BLAST120

Sequence similaritiesi

Belongs to the snurportin family.Curated
Contains 1 IBB domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3132. Eukaryota.
ENOG410XQNJ. LUCA.
GeneTreeiENSGT00510000047494.
HOGENOMiHOG000012990.
HOVERGENiHBG053257.
InParanoidiQ68FP5.
KOiK13151.
OMAiYHRQTHY.
OrthoDBiEOG091G0PL0.
PhylomeDBiQ68FP5.
TreeFamiTF313108.

Family and domain databases

InterProiIPR002652. Importin-a_IBB.
IPR017336. Snurportin-1.
IPR024721. Snurportin-1_N.
[Graphical view]
PfamiPF11538. Snurportin1. 1 hit.
[Graphical view]
PIRSFiPIRSF037955. Snurportin-1. 1 hit.
PROSITEiPS51214. IBB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68FP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEELSQALAS SFSVSQELNS TAAPHPRLSQ YKSKYSSLEQ SERRRQLLEL
60 70 80 90 100
QKSKRLDYVN HARRLAEDDW TGMESGEEEK KKDEEEMDLD PVKKLPKRYA
110 120 130 140 150
NQLMLSEWLI DVPSDLGQEW IVVVCPVGKR ALIVASRGST SAYTKSGYCV
160 170 180 190 200
NRFSSLLPGG NRRNSTTAKD YTILDCIYSE VNQTYYVLDV MCWRGHPFYD
210 220 230 240 250
CQTDFRFYWM NSKLPEEEGL GEKTKINPFK FVGLKNFPCT PESLCKVLSM
260 270 280 290 300
DFPFEVDGLL FYHKQTHYSP GSTPLVGWLR PYMVSDILGV AVPAGPLTTK
310 320 330 340 350
PEYAGHQLQQ IIEHKRSQED TKEKLTHKAS ENGHYELEHL STPKLRSPPH

SSESLMDS
Length:358
Mass (Da):40,964
Last modified:October 11, 2004 - v1
Checksum:iDFF1B7B274A8ED2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079451 mRNA. Translation: AAH79451.1.
RefSeqiNP_001004270.1. NM_001004270.1.
XP_006243187.1. XM_006243125.1.
XP_006243188.1. XM_006243126.1.
XP_006243189.1. XM_006243127.3.
UniGeneiRn.46302.

Genome annotation databases

EnsembliENSRNOT00000007261; ENSRNOP00000007261; ENSRNOG00000005426.
GeneIDi316108.
KEGGirno:316108.
UCSCiRGD:1303191. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079451 mRNA. Translation: AAH79451.1.
RefSeqiNP_001004270.1. NM_001004270.1.
XP_006243187.1. XM_006243125.1.
XP_006243188.1. XM_006243126.1.
XP_006243189.1. XM_006243127.3.
UniGeneiRn.46302.

3D structure databases

ProteinModelPortaliQ68FP5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007261.

PTM databases

iPTMnetiQ68FP5.
PhosphoSitePlusiQ68FP5.

Proteomic databases

PaxDbiQ68FP5.
PRIDEiQ68FP5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000007261; ENSRNOP00000007261; ENSRNOG00000005426.
GeneIDi316108.
KEGGirno:316108.
UCSCiRGD:1303191. rat.

Organism-specific databases

CTDi10073.
RGDi1303191. Snupn.

Phylogenomic databases

eggNOGiKOG3132. Eukaryota.
ENOG410XQNJ. LUCA.
GeneTreeiENSGT00510000047494.
HOGENOMiHOG000012990.
HOVERGENiHBG053257.
InParanoidiQ68FP5.
KOiK13151.
OMAiYHRQTHY.
OrthoDBiEOG091G0PL0.
PhylomeDBiQ68FP5.
TreeFamiTF313108.

Enzyme and pathway databases

ReactomeiR-RNO-191859. snRNP Assembly.

Miscellaneous databases

PROiQ68FP5.

Gene expression databases

BgeeiENSRNOG00000005426.
GenevisibleiQ68FP5. RN.

Family and domain databases

InterProiIPR002652. Importin-a_IBB.
IPR017336. Snurportin-1.
IPR024721. Snurportin-1_N.
[Graphical view]
PfamiPF11538. Snurportin1. 1 hit.
[Graphical view]
PIRSFiPIRSF037955. Snurportin-1. 1 hit.
PROSITEiPS51214. IBB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPN1_RAT
AccessioniPrimary (citable) accession number: Q68FP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.