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Protein

Snurportin-1

Gene

Snupn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.By similarity

GO - Molecular functioni

  • nuclear import signal receptor activity Source: InterPro
  • RNA cap binding Source: RGD

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processTransport

Enzyme and pathway databases

ReactomeiR-RNO-191859 snRNP Assembly

Names & Taxonomyi

Protein namesi
Recommended name:
Snurportin-1
Alternative name(s):
RNA U transporter 1
Gene namesi
Name:Snupn
Synonyms:Rnut1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1303191 Snupn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910731 – 358Snurportin-1Add BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei75PhosphoserineBy similarity1
Modified residuei351PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ68FP5
PRIDEiQ68FP5

PTM databases

iPTMnetiQ68FP5
PhosphoSitePlusiQ68FP5

Expressioni

Gene expression databases

BgeeiENSRNOG00000005426
GenevisibleiQ68FP5 RN

Interactioni

Subunit structurei

Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. Component of a nuclear export receptor complex composed of KPNB1, Ran, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, Ran and XPO1. Interacts (via IBB domain) with KPNB1; the interaction is direct. Interacts with DDX20, IPO7, SMN1, SNRPB and XPO1. Interacts directly with XPO1. Its interaction with XPO1 and binding to m3G-cap U snRNPs appears to be mutually exclusive.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei106Interaction with m3G-cap structureBy similarity1
Sitei145Interaction with m3G-cap structureBy similarity1
Sitei278Interaction with m3G-cap structureBy similarity1

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007261

Structurei

3D structure databases

ProteinModelPortaliQ68FP5
SMRiQ68FP5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 73IBBPROSITE-ProRule annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 160Necessary for interaction with XPO1By similarityAdd BLAST160
Regioni1 – 65Necessary for interaction with KPNB1 and m3G-cap U1 and U5 snRNP import receptor activityBy similarityAdd BLAST65
Regioni128 – 130Interaction with m3G-cap structureBy similarity3
Regioni210 – 329Necessary for binding to the m3G-cap structureBy similarityAdd BLAST120

Sequence similaritiesi

Belongs to the snurportin family.Curated

Phylogenomic databases

eggNOGiKOG3132 Eukaryota
ENOG410XQNJ LUCA
GeneTreeiENSGT00510000047494
HOGENOMiHOG000012990
HOVERGENiHBG053257
InParanoidiQ68FP5
KOiK13151
OMAiYHRQTHY
OrthoDBiEOG091G0PL0
PhylomeDBiQ68FP5
TreeFamiTF313108

Family and domain databases

InterProiView protein in InterPro
IPR002652 Importin-a_IBB
IPR017336 Snurportin-1
IPR024721 Snurportin-1_N
PfamiView protein in Pfam
PF11538 Snurportin1, 1 hit
PIRSFiPIRSF037955 Snurportin-1, 1 hit
PROSITEiView protein in PROSITE
PS51214 IBB, 1 hit

Sequencei

Sequence statusi: Complete.

Q68FP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEELSQALAS SFSVSQELNS TAAPHPRLSQ YKSKYSSLEQ SERRRQLLEL
60 70 80 90 100
QKSKRLDYVN HARRLAEDDW TGMESGEEEK KKDEEEMDLD PVKKLPKRYA
110 120 130 140 150
NQLMLSEWLI DVPSDLGQEW IVVVCPVGKR ALIVASRGST SAYTKSGYCV
160 170 180 190 200
NRFSSLLPGG NRRNSTTAKD YTILDCIYSE VNQTYYVLDV MCWRGHPFYD
210 220 230 240 250
CQTDFRFYWM NSKLPEEEGL GEKTKINPFK FVGLKNFPCT PESLCKVLSM
260 270 280 290 300
DFPFEVDGLL FYHKQTHYSP GSTPLVGWLR PYMVSDILGV AVPAGPLTTK
310 320 330 340 350
PEYAGHQLQQ IIEHKRSQED TKEKLTHKAS ENGHYELEHL STPKLRSPPH

SSESLMDS
Length:358
Mass (Da):40,964
Last modified:October 11, 2004 - v1
Checksum:iDFF1B7B274A8ED2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079451 mRNA Translation: AAH79451.1
RefSeqiNP_001004270.1, NM_001004270.1
XP_006243187.1, XM_006243125.1
XP_006243188.1, XM_006243126.1
XP_006243189.1, XM_006243127.3
UniGeneiRn.46302

Genome annotation databases

EnsembliENSRNOT00000007261; ENSRNOP00000007261; ENSRNOG00000005426
GeneIDi316108
KEGGirno:316108
UCSCiRGD:1303191 rat

Similar proteinsi

Entry informationi

Entry nameiSPN1_RAT
AccessioniPrimary (citable) accession number: Q68FP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 11, 2004
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health