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Protein

C-C motif chemokine 6

Gene

Ccl6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. chemokine activity Source: RGD

GO - Biological processi

  1. apoptotic process Source: RGD
  2. cell chemotaxis Source: RGD
  3. immune response Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiREACT_233455. G alpha (i) signalling events.
REACT_263374. G alpha (q) signalling events.
REACT_263565. Formyl peptide receptors bind formyl peptides and many other ligands.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 6
Alternative name(s):
Small-inducible cytokine A6
Gene namesi
Name:Ccl6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi1303200. Ccl6.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 11594C-C motif chemokine 6PRO_0000041846Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 72By similarity
Disulfide bondi50 ↔ 88By similarity
Disulfide bondi59 ↔ 99By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ68FP3.

Expressioni

Gene expression databases

GenevestigatoriQ68FP3.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048296.

Structurei

3D structure databases

ProteinModelPortaliQ68FP3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG26004.
GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ68FP3.
KOiK05510.
OMAiSQSIPCS.
OrthoDBiEOG79KPHQ.
PhylomeDBiQ68FP3.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68FP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRHSKTAISF FILVAVLGSQ AGLIQDTVKE DRPFNPTIIH QGFQDSSDCC
60 70 80 90 100
FSYASQIPCS RFIYYFPTSG GCTKPGIIFV TRKRKRVCAN PSDQRVQTCI
110
STLKLGPRSG NSAIA
Length:115
Mass (Da):12,652
Last modified:October 11, 2004 - v1
Checksum:i6CCEB9AC300846FF
GO

Sequence cautioni

The sequence AAT39514.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161V → D in AAT39514 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY620903 mRNA. Translation: AAT39514.1. Different initiation.
EF121992 mRNA. Translation: ABL63431.1.
EF121993 mRNA. Translation: ABL63432.1.
BC079460 mRNA. Translation: AAH79460.1.
RefSeqiNP_001004202.1. NM_001004202.2.
UniGeneiRn.7857.

Genome annotation databases

EnsembliENSRNOT00000045867; ENSRNOP00000048296; ENSRNOG00000030021.
GeneIDi287910.
KEGGirno:287910.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY620903 mRNA. Translation: AAT39514.1. Different initiation.
EF121992 mRNA. Translation: ABL63431.1.
EF121993 mRNA. Translation: ABL63432.1.
BC079460 mRNA. Translation: AAH79460.1.
RefSeqiNP_001004202.1. NM_001004202.2.
UniGeneiRn.7857.

3D structure databases

ProteinModelPortaliQ68FP3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048296.

Proteomic databases

PRIDEiQ68FP3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000045867; ENSRNOP00000048296; ENSRNOG00000030021.
GeneIDi287910.
KEGGirno:287910.

Organism-specific databases

CTDi20305.
RGDi1303200. Ccl6.

Phylogenomic databases

eggNOGiNOG26004.
GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ68FP3.
KOiK05510.
OMAiSQSIPCS.
OrthoDBiEOG79KPHQ.
PhylomeDBiQ68FP3.
TreeFamiTF334888.

Enzyme and pathway databases

ReactomeiREACT_233455. G alpha (i) signalling events.
REACT_263374. G alpha (q) signalling events.
REACT_263565. Formyl peptide receptors bind formyl peptides and many other ligands.

Miscellaneous databases

NextBioi627197.
PROiQ68FP3.

Gene expression databases

GenevestigatoriQ68FP3.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a rat chemokine-like cytokine."
    Guo B., Li W., Zhang S.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10."
    Saad Y., Garrett M.R., Manickavasagam E., Yerga-Woolwine S., Farms P., Radecki T., Joe B.
    Genomics 89:343-353(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Dahl salt-sensitive and Lewis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiCCL6_RAT
AccessioniPrimary (citable) accession number: Q68FP3
Secondary accession number(s): A1EC85, Q6IVB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: October 11, 2004
Last modified: January 7, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.