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Q68FP3

- CCL6_RAT

UniProt

Q68FP3 - CCL6_RAT

Protein

C-C motif chemokine 6

Gene

Ccl6

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    GO - Molecular functioni

    1. chemokine activity Source: RGD

    GO - Biological processi

    1. apoptotic process Source: RGD
    2. cell chemotaxis Source: RGD
    3. immune response Source: InterPro

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 6
    Alternative name(s):
    Small-inducible cytokine A6
    Gene namesi
    Name:Ccl6
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 10

    Organism-specific databases

    RGDi1303200. Ccl6.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 11594C-C motif chemokine 6PRO_0000041846Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi49 ↔ 72By similarity
    Disulfide bondi50 ↔ 88By similarity
    Disulfide bondi59 ↔ 99By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ68FP3.

    Expressioni

    Gene expression databases

    GenevestigatoriQ68FP3.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000048296.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68FP3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG26004.
    GeneTreeiENSGT00730000110278.
    HOGENOMiHOG000036685.
    HOVERGENiHBG017871.
    InParanoidiQ68FP3.
    KOiK05510.
    OMAiSQSIPCS.
    OrthoDBiEOG79KPHQ.
    PhylomeDBiQ68FP3.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q68FP3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRHSKTAISF FILVAVLGSQ AGLIQDTVKE DRPFNPTIIH QGFQDSSDCC    50
    FSYASQIPCS RFIYYFPTSG GCTKPGIIFV TRKRKRVCAN PSDQRVQTCI 100
    STLKLGPRSG NSAIA 115
    Length:115
    Mass (Da):12,652
    Last modified:October 11, 2004 - v1
    Checksum:i6CCEB9AC300846FF
    GO

    Sequence cautioni

    The sequence AAT39514.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti16 – 161V → D in AAT39514. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY620903 mRNA. Translation: AAT39514.1. Different initiation.
    EF121992 mRNA. Translation: ABL63431.1.
    EF121993 mRNA. Translation: ABL63432.1.
    BC079460 mRNA. Translation: AAH79460.1.
    RefSeqiNP_001004202.1. NM_001004202.2.
    UniGeneiRn.7857.

    Genome annotation databases

    EnsembliENSRNOT00000045867; ENSRNOP00000048296; ENSRNOG00000030021.
    GeneIDi287910.
    KEGGirno:287910.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY620903 mRNA. Translation: AAT39514.1 . Different initiation.
    EF121992 mRNA. Translation: ABL63431.1 .
    EF121993 mRNA. Translation: ABL63432.1 .
    BC079460 mRNA. Translation: AAH79460.1 .
    RefSeqi NP_001004202.1. NM_001004202.2.
    UniGenei Rn.7857.

    3D structure databases

    ProteinModelPortali Q68FP3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000048296.

    Proteomic databases

    PRIDEi Q68FP3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000045867 ; ENSRNOP00000048296 ; ENSRNOG00000030021 .
    GeneIDi 287910.
    KEGGi rno:287910.

    Organism-specific databases

    CTDi 20305.
    RGDi 1303200. Ccl6.

    Phylogenomic databases

    eggNOGi NOG26004.
    GeneTreei ENSGT00730000110278.
    HOGENOMi HOG000036685.
    HOVERGENi HBG017871.
    InParanoidi Q68FP3.
    KOi K05510.
    OMAi SQSIPCS.
    OrthoDBi EOG79KPHQ.
    PhylomeDBi Q68FP3.
    TreeFami TF334888.

    Miscellaneous databases

    NextBioi 627197.
    PROi Q68FP3.

    Gene expression databases

    Genevestigatori Q68FP3.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of a rat chemokine-like cytokine."
      Guo B., Li W., Zhang S.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10."
      Saad Y., Garrett M.R., Manickavasagam E., Yerga-Woolwine S., Farms P., Radecki T., Joe B.
      Genomics 89:343-353(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Dahl salt-sensitive and Lewis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.

    Entry informationi

    Entry nameiCCL6_RAT
    AccessioniPrimary (citable) accession number: Q68FP3
    Secondary accession number(s): A1EC85, Q6IVB4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2005
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3