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Q68FP3 (CCL6_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 6
Alternative name(s):
Small-inducible cytokine A6
Gene names
Name:Ccl6
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length115 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Sequence caution

The sequence AAT39514.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processChemotaxis
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Traceable author statement PubMed 12782599. Source: RGD

cell chemotaxis

Inferred from direct assay PubMed 16087246. Source: RGD

immune response

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionchemokine activity

Inferred from direct assay PubMed 16087246. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 11594C-C motif chemokine 6
PRO_0000041846

Amino acid modifications

Disulfide bond49 ↔ 72 By similarity
Disulfide bond50 ↔ 88 By similarity
Disulfide bond59 ↔ 99 By similarity

Experimental info

Sequence conflict161V → D in AAT39514. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q68FP3 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 6CCEB9AC300846FF

FASTA11512,652
        10         20         30         40         50         60 
MRHSKTAISF FILVAVLGSQ AGLIQDTVKE DRPFNPTIIH QGFQDSSDCC FSYASQIPCS 

        70         80         90        100        110 
RFIYYFPTSG GCTKPGIIFV TRKRKRVCAN PSDQRVQTCI STLKLGPRSG NSAIA 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of a rat chemokine-like cytokine."
Guo B., Li W., Zhang S.
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10."
Saad Y., Garrett M.R., Manickavasagam E., Yerga-Woolwine S., Farms P., Radecki T., Joe B.
Genomics 89:343-353(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Dahl salt-sensitive and Lewis.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY620903 mRNA. Translation: AAT39514.1. Different initiation.
EF121992 mRNA. Translation: ABL63431.1.
EF121993 mRNA. Translation: ABL63432.1.
BC079460 mRNA. Translation: AAH79460.1.
RefSeqNP_001004202.1. NM_001004202.2.
UniGeneRn.7857.

3D structure databases

ProteinModelPortalQ68FP3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000048296.

Proteomic databases

PRIDEQ68FP3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000045867; ENSRNOP00000048296; ENSRNOG00000030021.
GeneID287910.
KEGGrno:287910.

Organism-specific databases

CTD20305.
RGD1303200. Ccl6.

Phylogenomic databases

eggNOGNOG26004.
GeneTreeENSGT00730000110278.
HOGENOMHOG000036685.
HOVERGENHBG017871.
InParanoidQ68FP3.
KOK05510.
OMASQSIPCS.
OrthoDBEOG79KPHQ.
PhylomeDBQ68FP3.
TreeFamTF334888.

Gene expression databases

GenevestigatorQ68FP3.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio627197.
PROQ68FP3.

Entry information

Entry nameCCL6_RAT
AccessionPrimary (citable) accession number: Q68FP3
Secondary accession number(s): A1EC85, Q6IVB4
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: October 11, 2004
Last modified: April 16, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families