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Protein

C-C motif chemokine 6

Gene

Ccl6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis

Enzyme and pathway databases

ReactomeiR-RNO-416476 G alpha (q) signalling events
R-RNO-418594 G alpha (i) signalling events
R-RNO-444473 Formyl peptide receptors bind formyl peptides and many other ligands

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 6
Alternative name(s):
Small-inducible cytokine A6
Gene namesi
Name:Ccl6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1303200 Ccl6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000004184622 – 115C-C motif chemokine 6Add BLAST94

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 72By similarity
Disulfide bondi50 ↔ 88By similarity
Disulfide bondi59 ↔ 99By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ68FP3
PRIDEiQ68FP3

Expressioni

Gene expression databases

BgeeiENSRNOG00000030021
GenevisibleiQ68FP3 RN

Interactioni

GO - Molecular functioni

  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048296

Structurei

3D structure databases

ProteinModelPortaliQ68FP3
SMRiQ68FP3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4DG Eukaryota
ENOG4111C2C LUCA
GeneTreeiENSGT00910000144306
HOGENOMiHOG000036685
HOVERGENiHBG017871
InParanoidiQ68FP3
KOiK05510
OMAiSDCCFSY
OrthoDBiEOG091G14Y2
PhylomeDBiQ68FP3
TreeFamiTF334888

Family and domain databases

InterProiView protein in InterPro
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68FP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRHSKTAISF FILVAVLGSQ AGLIQDTVKE DRPFNPTIIH QGFQDSSDCC
60 70 80 90 100
FSYASQIPCS RFIYYFPTSG GCTKPGIIFV TRKRKRVCAN PSDQRVQTCI
110
STLKLGPRSG NSAIA
Length:115
Mass (Da):12,652
Last modified:October 11, 2004 - v1
Checksum:i6CCEB9AC300846FF
GO

Sequence cautioni

The sequence AAT39514 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16V → D in AAT39514 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY620903 mRNA Translation: AAT39514.1 Different initiation.
EF121992 mRNA Translation: ABL63431.1
EF121993 mRNA Translation: ABL63432.1
BC079460 mRNA Translation: AAH79460.1
RefSeqiNP_001004202.1, NM_001004202.2
UniGeneiRn.7857

Genome annotation databases

EnsembliENSRNOT00000045867; ENSRNOP00000048296; ENSRNOG00000030021
GeneIDi287910
KEGGirno:287910

Similar proteinsi

Entry informationi

Entry nameiCCL6_RAT
AccessioniPrimary (citable) accession number: Q68FP3
Secondary accession number(s): A1EC85, Q6IVB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: October 11, 2004
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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