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Q68FP3

- CCL6_RAT

UniProt

Q68FP3 - CCL6_RAT

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Protein
C-C motif chemokine 6
Gene
Ccl6
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. chemokine activity Source: RGD

GO - Biological processi

  1. apoptotic process Source: RGD
  2. cell chemotaxis Source: RGD
  3. immune response Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 6
Alternative name(s):
Small-inducible cytokine A6
Gene namesi
Name:Ccl6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi1303200. Ccl6.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 11594C-C motif chemokine 6
PRO_0000041846Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 72 By similarity
Disulfide bondi50 ↔ 88 By similarity
Disulfide bondi59 ↔ 99 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ68FP3.

Expressioni

Gene expression databases

GenevestigatoriQ68FP3.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048296.

Structurei

3D structure databases

ProteinModelPortaliQ68FP3.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG26004.
GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ68FP3.
KOiK05510.
OMAiSQSIPCS.
OrthoDBiEOG79KPHQ.
PhylomeDBiQ68FP3.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68FP3-1 [UniParc]FASTAAdd to Basket

« Hide

MRHSKTAISF FILVAVLGSQ AGLIQDTVKE DRPFNPTIIH QGFQDSSDCC    50
FSYASQIPCS RFIYYFPTSG GCTKPGIIFV TRKRKRVCAN PSDQRVQTCI 100
STLKLGPRSG NSAIA 115
Length:115
Mass (Da):12,652
Last modified:October 11, 2004 - v1
Checksum:i6CCEB9AC300846FF
GO

Sequence cautioni

The sequence AAT39514.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161V → D in AAT39514. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY620903 mRNA. Translation: AAT39514.1. Different initiation.
EF121992 mRNA. Translation: ABL63431.1.
EF121993 mRNA. Translation: ABL63432.1.
BC079460 mRNA. Translation: AAH79460.1.
RefSeqiNP_001004202.1. NM_001004202.2.
UniGeneiRn.7857.

Genome annotation databases

EnsembliENSRNOT00000045867; ENSRNOP00000048296; ENSRNOG00000030021.
GeneIDi287910.
KEGGirno:287910.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY620903 mRNA. Translation: AAT39514.1 . Different initiation.
EF121992 mRNA. Translation: ABL63431.1 .
EF121993 mRNA. Translation: ABL63432.1 .
BC079460 mRNA. Translation: AAH79460.1 .
RefSeqi NP_001004202.1. NM_001004202.2.
UniGenei Rn.7857.

3D structure databases

ProteinModelPortali Q68FP3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000048296.

Proteomic databases

PRIDEi Q68FP3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000045867 ; ENSRNOP00000048296 ; ENSRNOG00000030021 .
GeneIDi 287910.
KEGGi rno:287910.

Organism-specific databases

CTDi 20305.
RGDi 1303200. Ccl6.

Phylogenomic databases

eggNOGi NOG26004.
GeneTreei ENSGT00730000110278.
HOGENOMi HOG000036685.
HOVERGENi HBG017871.
InParanoidi Q68FP3.
KOi K05510.
OMAi SQSIPCS.
OrthoDBi EOG79KPHQ.
PhylomeDBi Q68FP3.
TreeFami TF334888.

Miscellaneous databases

NextBioi 627197.
PROi Q68FP3.

Gene expression databases

Genevestigatori Q68FP3.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a rat chemokine-like cytokine."
    Guo B., Li W., Zhang S.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10."
    Saad Y., Garrett M.R., Manickavasagam E., Yerga-Woolwine S., Farms P., Radecki T., Joe B.
    Genomics 89:343-353(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Dahl salt-sensitive and Lewis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiCCL6_RAT
AccessioniPrimary (citable) accession number: Q68FP3
Secondary accession number(s): A1EC85, Q6IVB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: October 11, 2004
Last modified: April 16, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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