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Protein

C-C motif chemokine 6

Gene

Ccl6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. chemokine activity Source: RGD

GO - Biological processi

  1. apoptotic process Source: RGD
  2. cell chemotaxis Source: RGD
  3. immune response Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 6
Alternative name(s):
Small-inducible cytokine A6
Gene namesi
Name:Ccl6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1303200. Ccl6.

Subcellular locationi

  1. Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 11594C-C motif chemokine 6PRO_0000041846Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 72By similarity
Disulfide bondi50 ↔ 88By similarity
Disulfide bondi59 ↔ 99By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ68FP3.

Expressioni

Gene expression databases

GenevestigatoriQ68FP3.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048296.

Structurei

3D structure databases

ProteinModelPortaliQ68FP3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG26004.
GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ68FP3.
KOiK05510.
OMAiSQSIPCS.
OrthoDBiEOG79KPHQ.
PhylomeDBiQ68FP3.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68FP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRHSKTAISF FILVAVLGSQ AGLIQDTVKE DRPFNPTIIH QGFQDSSDCC
60 70 80 90 100
FSYASQIPCS RFIYYFPTSG GCTKPGIIFV TRKRKRVCAN PSDQRVQTCI
110
STLKLGPRSG NSAIA
Length:115
Mass (Da):12,652
Last modified:October 11, 2004 - v1
Checksum:i6CCEB9AC300846FF
GO

Sequence cautioni

The sequence AAT39514.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161V → D in AAT39514 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY620903 mRNA. Translation: AAT39514.1. Different initiation.
EF121992 mRNA. Translation: ABL63431.1.
EF121993 mRNA. Translation: ABL63432.1.
BC079460 mRNA. Translation: AAH79460.1.
RefSeqiNP_001004202.1. NM_001004202.2.
UniGeneiRn.7857.

Genome annotation databases

EnsembliENSRNOT00000045867; ENSRNOP00000048296; ENSRNOG00000030021.
GeneIDi287910.
KEGGirno:287910.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY620903 mRNA. Translation: AAT39514.1. Different initiation.
EF121992 mRNA. Translation: ABL63431.1.
EF121993 mRNA. Translation: ABL63432.1.
BC079460 mRNA. Translation: AAH79460.1.
RefSeqiNP_001004202.1. NM_001004202.2.
UniGeneiRn.7857.

3D structure databases

ProteinModelPortaliQ68FP3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048296.

Proteomic databases

PRIDEiQ68FP3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000045867; ENSRNOP00000048296; ENSRNOG00000030021.
GeneIDi287910.
KEGGirno:287910.

Organism-specific databases

CTDi20305.
RGDi1303200. Ccl6.

Phylogenomic databases

eggNOGiNOG26004.
GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ68FP3.
KOiK05510.
OMAiSQSIPCS.
OrthoDBiEOG79KPHQ.
PhylomeDBiQ68FP3.
TreeFamiTF334888.

Miscellaneous databases

NextBioi627197.
PROiQ68FP3.

Gene expression databases

GenevestigatoriQ68FP3.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a rat chemokine-like cytokine."
    Guo B., Li W., Zhang S.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10."
    Saad Y., Garrett M.R., Manickavasagam E., Yerga-Woolwine S., Farms P., Radecki T., Joe B.
    Genomics 89:343-353(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Dahl salt-sensitive and Lewis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiCCL6_RAT
AccessioniPrimary (citable) accession number: Q68FP3
Secondary accession number(s): A1EC85, Q6IVB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: October 11, 2004
Last modified: April 1, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.