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Protein

Serum paraoxonase/lactonase 3

Gene

Pon3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents (By similarity).By similarity

Catalytic activityi

A phenyl acetate + H2O = a phenol + acetate.
An aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol.
An N-acyl-L-homoserine lactone + H2O = an N-acyl-L-homoserine.

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi53Calcium 1; catalyticBy similarity1
Metal bindingi54Calcium 2By similarity1
Active sitei114Proton acceptorBy similarity1
Metal bindingi116Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi167Calcium 1; catalyticBy similarity1
Metal bindingi168Calcium 2By similarity1
Metal bindingi223Calcium 1; catalyticBy similarity1
Metal bindingi268Calcium 1; catalyticBy similarity1
Metal bindingi269Calcium 1; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

  • coumarin catabolic process Source: RGD
  • negative regulation of superoxide anion generation Source: Ensembl
  • phenylacetate catabolic process Source: RGD
  • response to toxic substance Source: GO_Central

Keywordsi

Molecular functionHydrolase
LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.1.2. 5301.
3.1.1.25. 5301.
3.1.8.1. 5301.
ReactomeiR-RNO-2142688. Synthesis of 5-eicosatetraenoic acids.

Names & Taxonomyi

Protein namesi
Recommended name:
Serum paraoxonase/lactonase 3 (EC:3.1.1.2, EC:3.1.1.81, EC:3.1.8.1)
Gene namesi
Name:Pon3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1302965. Pon3.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: Ensembl
  • extracellular space Source: RGD
  • intracellular membrane-bounded organelle Source: RGD

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002232921 – 354Serum paraoxonase/lactonase 3Add BLAST354
Signal peptidei1 – ?Not cleavedSequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi42 ↔ 352By similarity
Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei165PhosphoserineBy similarity1
Glycosylationi269N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi323N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated.By similarity
The signal sequence is not cleaved.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ68FP2.
PRIDEiQ68FP2.

Expressioni

Gene expression databases

BgeeiENSRNOG00000009096.
GenevisibleiQ68FP2. RN.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

MINTiMINT-4655760.
STRINGi10116.ENSRNOP00000012050.

Structurei

3D structure databases

ProteinModelPortaliQ68FP2.
SMRiQ68FP2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the paraoxonase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHDV. Eukaryota.
ENOG4111QK7. LUCA.
GeneTreeiENSGT00390000008932.
HOGENOMiHOG000252960.
HOVERGENiHBG003604.
InParanoidiQ68FP2.
KOiK01045.
OMAiYATRDHY.
OrthoDBiEOG091G0AV9.
PhylomeDBiQ68FP2.
TreeFamiTF322436.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiView protein in InterPro
IPR011042. 6-blade_b-propeller_TolB-like.
IPR002640. Arylesterase.
IPR008364. Paraoxonase2.
PfamiView protein in Pfam
PF01731. Arylesterase. 1 hit.
PRINTSiPR01785. PARAOXONASE.
PR01787. PARAOXONASE2.

Sequencei

Sequence statusi: Complete.

Q68FP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKLVALTVL GASLALLGER LLNFRERVST SREIKPTEPQ NCHLIEGLEN
60 70 80 90 100
GSEDIDILPS GLAFISTGLK YPGMPSFAPD KPGRIFLMDL NEPYPKAQAL
110 120 130 140 150
EISDGFDQDS LNPHGISTFI DKDNTVYLYA VNHPHMDSTV EIFKFEEQPR
160 170 180 190 200
SLVHLKTIKH ELFESVNDIV VLGPEQFYAT RDHYFTSHFL VLLEMILDPH
210 220 230 240 250
WTSVLFYSPK EVKVVAQGFS SANGITVSLD QKYVYVADVT AKNIHIMKKH
260 270 280 290 300
NNWDLTPVKV IQLGTLVDNL TVDPATGDIL AGCHPNPMKL LIYNPEDPPG
310 320 330 340 350
SEVLRIQDPL SDNPRVSTLY SNNGSVLQGS TVASVYHKKM LIGTIFHKAL

YCEL
Length:354
Mass (Da):39,458
Last modified:October 11, 2004 - v1
Checksum:i913C28243E4B0D7F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079466 mRNA. Translation: AAH79466.1.
RefSeqiNP_001004086.1. NM_001004086.1.
UniGeneiRn.16469.

Genome annotation databases

EnsembliENSRNOT00000012050; ENSRNOP00000012050; ENSRNOG00000009096.
GeneIDi312086.
KEGGirno:312086.
UCSCiRGD:1302965. rat.

Similar proteinsi

Entry informationi

Entry nameiPON3_RAT
AccessioniPrimary (citable) accession number: Q68FP2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 11, 2004
Last modified: August 30, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families