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Protein
Submitted name:

Rho guanine nucleotide exchange factor (GEF) 11

Gene

Arhgef11

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-193648. NRAGE signals death through JNK.
R-MMU-194840. Rho GTPase cycle.
R-MMU-416482. G alpha (12/13) signalling events.
R-MMU-416572. Sema4D induced cell migration and growth-cone collapse.

Names & Taxonomyi

Protein namesi
Submitted name:
Rho guanine nucleotide exchange factor (GEF) 11Imported
Gene namesi
Name:Arhgef11Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2441869. Arhgef11.

Subcellular locationi

Expressioni

Gene expression databases

BgeeiENSMUSG00000041977.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ68FM7. 5 interactors.
STRINGi10090.ENSMUSP00000039900.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 111PDZInterPro annotationAdd BLAST65
Domaini353 – 443RGSInterPro annotationAdd BLAST91
Domaini764 – 953DHInterPro annotationAdd BLAST190
Domaini995 – 1109PHInterPro annotationAdd BLAST115

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili205 – 225Sequence analysisAdd BLAST21
Coiled coili442 – 462Sequence analysisAdd BLAST21
Coiled coili487 – 507Sequence analysisAdd BLAST21
Coiled coili940 – 960Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG3520. Eukaryota.
COG5422. LUCA.
GeneTreeiENSGT00760000119193.
HOGENOMiHOG000034045.
HOVERGENiHBG101340.
KOiK12331.
OMAiTGNCFYV.
OrthoDBiEOG091G0CZH.
TreeFamiTF106495.

Family and domain databases

CDDicd13391. PH_PRG. 1 hit.
cd08753. RGS_PDZRhoGEF. 1 hit.
cd00160. RhoGEF. 1 hit.
Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiView protein in InterPro
IPR035899. DBL_dom_sf.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR001478. PDZ.
IPR032919. PDZ-RhoGEF.
IPR036034. PDZ_sf.
IPR037889. PDZRhoGEF_RGS.
IPR011993. PH-like_dom_sf.
IPR001849. PH_domain.
IPR037803. PRG_PH.
IPR016137. RGS.
IPR015212. RGS-like_dom.
IPR036305. RGS_sf.
PANTHERiPTHR12673:SF111. PTHR12673:SF111. 1 hit.
PfamiView protein in Pfam
PF00595. PDZ. 1 hit.
PF09128. RGS-like. 1 hit.
PF00621. RhoGEF. 1 hit.
SMARTiView protein in SMART
SM00228. PDZ. 1 hit.
SM00233. PH. 1 hit.
SM00315. RGS. 1 hit.
SM00325. RhoGEF. 1 hit.
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF48097. SSF48097. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiView protein in PROSITE
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50132. RGS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q68FM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIRLPHSID RLSSLSSLGD STPERTSPSH HRQPSDTSET TGLVQRCVII
60 70 80 90 100
QKDQHGFGFT VSGDRIVLVQ SVRPGGAAMR AGVKEGDRII KVNGTMVTNS
110 120 130 140 150
SHLEVVKLIK SGAYVALTLL GSSPSSIGVS GLQQNPSLSG GPRVNPMIPP
160 170 180 190 200
PPPPPPLPPP QHITGPKPLQ DPEVQKHATQ ILRNMLRQEE KELQRICEVY
210 220 230 240 250
SRNPASLLEE QIEGARRRVT QLQLKIQQET GGLVDVLPLC GETSQRTCEG
260 270 280 290 300
RLSVDSQEAD SGLDSGTERF PSISESLVNR NSVLSDPGLD SPQTSPVILA
310 320 330 340 350
RVGQHHRRQG SDAAVHPLNH QGIDQSPKPL IIGPEEDYDP GYFNNESDII
360 370 380 390 400
FQDLEKLKSH PAYLVVFLRY IFSQADPGPL LFYLCSEVYQ QTNPKDSRNL
410 420 430 440 450
GKDIWNIFLE KNAPLRVKIP EMLQAEIDLR LRNSEDPRSA LYEAQEAVMP
460 470 480 490 500
EIQEQINDYR SKRTLGLGSL YGENDLLDLD GDPLRERQMA EKQLAALGDI
510 520 530 540 550
LSKYEEDRSA PMDFAVNTYM SHTGIRLRES RPSSTAEKTQ SAPDKDKWLP
560 570 580 590 600
FFPKTKKSSN SKKEKDALED KKRNPILRYI GKPKSSSQSI KPGNVRNIIQ
610 620 630 640 650
HFENSHQYDV PEPGTQRLST GSFPEDLLES DSSRSEIRLG RSESLKGREE
660 670 680 690 700
MKRSRKAENV PRSRSDVDMD AAAEATRLHQ SASSSASSLS TRSLENPTPP
710 720 730 740 750
FTPKMGRRSI ESPNLGFCTD VILPHLLEDD LGQLSDLEPE PEVQNWQHTV
760 770 780 790 800
GKDVVANLTQ REIDRQEVIN ELFVTEASHL RTLRVLDLIF YQRMKKENLM
810 820 830 840 850
PREELSRLFP NLPELIEIHN SWCEAMKKLR EEGPIIRDIS DLMLARFDGP
860 870 880 890 900
AREELQQVAA QFCSYQSVAL ELIRTKQRKE SRFQLFMQEA ESHPQCRRLQ
910 920 930 940 950
LRDLIISEMQ RLTKYPLLLE NIIKHTAGGT SEYEKLCRAR DQCREILKFV
960 970 980 990 1000
NEAVKQTENR HRLEGYQKRL DATALERASN PLAAEFKSLD LTTRKMIHEG
1010 1020 1030 1040 1050
PLTWRISKDK TLDLQVLLLE DLVVLLQRQE EKLLLKCHSK TAVGSSDSKQ
1060 1070 1080 1090 1100
TFSPVLKLNA VLIRSVATDK RAFFIICTSE LGPPQIYELV ALTSSDKNIW
1110 1120 1130 1140 1150
MELLEEAVQN ATKHPGDAPV LNHPSPPGSQ EPAYQGSTSS RVEVNDSEVY
1160 1170 1180 1190 1200
PTEREPKKPS EGPGPEQRGQ DKQLLAQEGP EQEEDAEELR ALPCPPPSLD
1210 1220 1230 1240 1250
GENRGIRTRD PVLLALTGPL LMEGLADAAL EDVENLRHLI LWSLLPGHTV
1260 1270 1280 1290 1300
KTQAAGEPED DLTPTPSVVS ITSHPWDPGS PGQAPAISDN TQFPRPEGSQ
1310 1320 1330 1340 1350
PEGEDVALCS LAHLPPRTRN SGIWDSPELD RNPAEEASSS EPAGSYKVVR
1360 1370 1380 1390 1400
KVSLLPGGGV GAAKVAGSNV TPALPESGQS ESELSEVEGG AQATGNCFYV
1410 1420 1430 1440 1450
SMPAEPLDSS TEPPGTPPSL SQCHSLPAWP TEPPQHRGVT GGQRSSLVLR
1460 1470 1480 1490 1500
DMGVIFHTIE QLTVKLHRLK DMELAHRELL NSLGGESSGG TTPVGSFHTE
1510 1520 1530 1540 1550
AARWTDYSLS PPAKEALTSD PQNNQEQGSY PEEGSDTPLE DSATDTASSP

GP
Length:1,552
Mass (Da):171,803
Last modified:October 11, 2004 - v1
Checksum:i8FF6AFC41AD63258
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC139241 Genomic DNA. No translation available.
AC161454 Genomic DNA. No translation available.
BC079565 mRNA. Translation: AAH79565.1.
RefSeqiNP_001003912.1. NM_001003912.1.
UniGeneiMm.287267.

Genome annotation databases

EnsembliENSMUST00000039476; ENSMUSP00000039900; ENSMUSG00000041977.
GeneIDi213498.
KEGGimmu:213498.
UCSCiuc008psm.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiQ68FM7_MOUSE
AccessioniPrimary (citable) accession number: Q68FM7
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2004
Last sequence update: October 11, 2004
Last modified: March 28, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported