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Q68FH0

- PKP4_MOUSE

UniProt

Q68FH0 - PKP4_MOUSE

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Protein

Plakophilin-4

Gene

Pkp4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques (By similarity).By similarity

GO - Biological processi

  1. cell-cell junction assembly Source: UniProtKB
  2. positive regulation of cytokinesis Source: UniProtKB
  3. positive regulation of gene expression Source: UniProtKB
  4. positive regulation of Rho GTPase activity Source: UniProtKB
  5. single organismal cell-cell adhesion Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Plakophilin-4
Alternative name(s):
Armadillo-related protein
Gene namesi
Name:Pkp4
Synonyms:Armrp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:109281. Pkp4.

Subcellular locationi

Cell junctiondesmosome By similarity. Cytoplasmcytoskeletonspindle By similarity. Cytoplasmcytoskeletonspindle pole By similarity. Midbody By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity
Note: Associated with the pericentrosomal region in interphase and with spindle poles during mitosis. In anaphase, during chromosome segregation, is recruited to the central microtubule bundle, focussed at the spindle midzone and ultimately localizes to the midbody at cytokinesis. Constituent of the midbody cytoskeletal matrix. Colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells (By similarity).By similarity

GO - Cellular componenti

  1. cell-cell contact zone Source: Ensembl
  2. cell-cell junction Source: UniProtKB
  3. cytoplasm Source: UniProtKB
  4. cytoplasmic side of plasma membrane Source: UniProtKB
  5. cytoskeleton Source: UniProtKB
  6. desmosome Source: UniProtKB
  7. midbody Source: UniProtKB
  8. mitotic spindle Source: UniProtKB
  9. perinuclear region of cytoplasm Source: UniProtKB
  10. plasma membrane Source: UniProtKB
  11. spindle midzone Source: UniProtKB
  12. spindle pole Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11901190Plakophilin-4PRO_0000064290Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei220 – 2201PhosphoserineBy similarity
Modified residuei230 – 2301PhosphoserineBy similarity
Modified residuei272 – 2721PhosphoserineBy similarity
Modified residuei280 – 2801PhosphoserineBy similarity
Modified residuei313 – 3131Phosphoserine1 Publication
Modified residuei326 – 3261PhosphoserineBy similarity
Modified residuei371 – 3711Phosphotyrosine1 Publication
Modified residuei402 – 4021PhosphoserineBy similarity
Modified residuei405 – 4051Phosphoserine1 Publication
Modified residuei414 – 4141PhosphotyrosineBy similarity
Modified residuei477 – 4771Phosphotyrosine1 Publication
Cross-linki610 – 610Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei775 – 7751PhosphoserineBy similarity
Modified residuei1133 – 11331Phosphoserine1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ68FH0.
PaxDbiQ68FH0.
PRIDEiQ68FH0.

PTM databases

PhosphoSiteiQ68FH0.

Expressioni

Gene expression databases

BgeeiQ68FH0.
CleanExiMM_PKP4.
ExpressionAtlasiQ68FH0. baseline and differential.
GenevestigatoriQ68FH0.

Interactioni

Subunit structurei

Interacts (via the C-terminus) with FRMPD2 (via the PDZ 2 domain). Interacts with PDZD2. Interacts with RHOA; the interaction is detected at the midbody. Interacts with ECT2; the interaction is detected at the midbody (By similarity).By similarity

Protein-protein interaction databases

BioGridi230696. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ68FH0.
SMRiQ68FH0. Positions 524-1010.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati517 – 55640ARM 1Add
BLAST
Repeati559 – 59840ARM 2Add
BLAST
Repeati603 – 64341ARM 3Add
BLAST
Repeati861 – 90040ARM 4Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili36 – 6328Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi787 – 7937Poly-Lys

Sequence similaritiesi

Belongs to the beta-catenin family.Curated
Contains 4 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG276924.
GeneTreeiENSGT00760000119167.
HOVERGENiHBG004284.
InParanoidiQ68FH0.
OMAiGIGNLQR.
OrthoDBiEOG7X6KZB.
PhylomeDBiQ68FH0.
TreeFamiTF321877.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028443. Plakophilin-4.
IPR028435. Plakophilin/d_Catenin.
[Graphical view]
PANTHERiPTHR10372. PTHR10372. 1 hit.
PTHR10372:SF8. PTHR10372:SF8. 1 hit.
PfamiPF00514. Arm. 3 hits.
[Graphical view]
SMARTiSM00185. ARM. 6 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q68FH0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPAPEQGSLV EEGQPQTHQE AVSTGPGMEP ETTATTILAS VKEQELQFQR
60 70 80 90 100
LTRELEVERQ IVASQLERCR LGAESPSIAS TSSTEKSFPW RSTDVPNPGV
110 120 130 140 150
SKPRVSDTIH PNNYLIRTEP EQGTLYSPEQ TSLHESEGSL GNSRSSTQMN
160 170 180 190 200
SYSDSGYQEA GSFHNSQTVN KADSRQHPFT GSTSNHVVRT SRAEGQTLVQ
210 220 230 240 250
PSVANRAMRR VSSVPSRAQS PSYVTSTGVS PSRGSLRTSL GSGFGSPSVT
260 270 280 290 300
DSRPLNPSAY SSSTLPAQRA ASPYSQRPAS PTAVRRVGSV TSRQTSNPNG
310 320 330 340 350
PVPQYQTTTR VGSPLTLTDA QTRVASPSQG QVGSSSPKRS GMTAVPQHLG
360 370 380 390 400
PSLQRTVHDM DQFGQQQYDI YERMVPPRPD SLTGLRSSYA SQHSQLGQEL
410 420 430 440 450
RSAVSPDLHI TPIYEGRTYY SPVYRSPNHG TVELQGSQTA LYRTGSVGIG
460 470 480 490 500
NLQRTSSQRS TLTYQRNNYA LNTAATYAEP YRPVQYRVQE CSYNRLQHTG
510 520 530 540 550
PADDGATRSP SIDSIQKDPR EFAWRDPELP EVIHMLQHQF PSVQANAAAY
560 570 580 590 600
LQHLCFGDNK VKMEVYRLGG IKHLVDLLDH RVLEVQKNAC GALRNLVFGK
610 620 630 640 650
STDENKIAMK NVGGIPALLR LLRKSIDAEV RELVTGVLWN LSSCDAVKMT
660 670 680 690 700
IIRDALSTLT NTVIVPHSGW NNSSFDDDHK IKFQTSLVLR NTTGCLRNLS
710 720 730 740 750
SAGEEARKQM RSCEGLVDSL LYVIHTCVNT SDYDSKTVEN CVCTLRNLSY
760 770 780 790 800
RLELEVPQAR LLGLNELDDL LGKESPSKDS EPSCWGKKKK KKKRTPQEDQ
810 820 830 840 850
WDGVGPIPGL SKSPKGVEML WHPSVVKPYL TLLAESSNPA TLEGSAGSLQ
860 870 880 890 900
NLSAGNWKFA AYIRAAVRKE KGLPILVELL RMDNDRVVSS VATALRNMAL
910 920 930 940 950
DVRNKELIGK YAMRDLVNRL PGGNGPSILS DETVAAICCA LHEVTSKNME
960 970 980 990 1000
NAKALADSGG IEKLVNITKG RGDRSSLKVV KAAAQVLNTL WQYRDLRSIY
1010 1020 1030 1040 1050
KKDGWNQNHF ITPVSTLERD RFKSHPSLST TNQQMSPIIQ SVGSTSSSPA
1060 1070 1080 1090 1100
LLGIREPRSE YDRTQPPMQY YNSQGDTTHK GLYPGSSKPS PIYISSYSSP
1110 1120 1130 1140 1150
AREQNRRLQH QQLYYQDDST RKTLDAYRLY LQSPRSYEDP YCDDRVHFPA
1160 1170 1180 1190
STDYSTQYGL KSTTNYVDFY STKRPSYRAE QYPGSPDSWV
Length:1,190
Mass (Da):131,551
Last modified:October 11, 2004 - v1
Checksum:iDB6548B5EBE72CFE
GO
Isoform 2 (identifier: Q68FH0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1042-1084: Missing.

Show »
Length:1,147
Mass (Da):126,783
Checksum:iDEC21F1C1F960B7A
GO
Isoform 3 (identifier: Q68FH0-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-341: Missing.
     637-637: V → G
     638-1190: Missing.

Show »
Length:296
Mass (Da):33,263
Checksum:iD0630AA63A0911E8
GO

Sequence cautioni

The sequence BAC37187.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti328 – 3281S → F in AAH78638. (PubMed:15489334)Curated
Sequence conflicti877 – 8771V → A in BAC36708. (PubMed:16141072)Curated
Sequence conflicti1118 – 11181D → G in BAC36708. (PubMed:16141072)Curated
Sequence conflicti1161 – 11611K → R in BAB32313. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 341341Missing in isoform 3. 1 PublicationVSP_012374Add
BLAST
Alternative sequencei637 – 6371V → G in isoform 3. 1 PublicationVSP_012375
Alternative sequencei638 – 1190553Missing in isoform 3. 1 PublicationVSP_012376Add
BLAST
Alternative sequencei1042 – 108443Missing in isoform 2. 1 PublicationVSP_012377Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL845536 Genomic DNA. Translation: CAM20481.1.
BC078638 mRNA. Translation: AAH78638.1.
BC079848 mRNA. Translation: AAH79848.1.
BC082578 mRNA. Translation: AAH82578.1.
AK021168 mRNA. Translation: BAB32313.1.
AK077250 mRNA. Translation: BAC36708.1.
AK078240 mRNA. Translation: BAC37187.1. Different initiation.
CCDSiCCDS16052.1. [Q68FH0-1]
CCDS50588.1. [Q68FH0-2]
RefSeqiNP_080637.1. NM_026361.2. [Q68FH0-1]
NP_780673.2. NM_175464.2. [Q68FH0-2]
XP_006499234.1. XM_006499171.1. [Q68FH0-1]
UniGeneiMm.260938.

Genome annotation databases

EnsembliENSMUST00000102754; ENSMUSP00000099815; ENSMUSG00000026991. [Q68FH0-1]
ENSMUST00000168631; ENSMUSP00000129836; ENSMUSG00000026991. [Q68FH0-2]
GeneIDi227937.
KEGGimmu:227937.
UCSCiuc008jtb.1. mouse. [Q68FH0-1]
uc008jtd.1. mouse. [Q68FH0-2]
uc008jtg.1. mouse. [Q68FH0-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL845536 Genomic DNA. Translation: CAM20481.1 .
BC078638 mRNA. Translation: AAH78638.1 .
BC079848 mRNA. Translation: AAH79848.1 .
BC082578 mRNA. Translation: AAH82578.1 .
AK021168 mRNA. Translation: BAB32313.1 .
AK077250 mRNA. Translation: BAC36708.1 .
AK078240 mRNA. Translation: BAC37187.1 . Different initiation.
CCDSi CCDS16052.1. [Q68FH0-1 ]
CCDS50588.1. [Q68FH0-2 ]
RefSeqi NP_080637.1. NM_026361.2. [Q68FH0-1 ]
NP_780673.2. NM_175464.2. [Q68FH0-2 ]
XP_006499234.1. XM_006499171.1. [Q68FH0-1 ]
UniGenei Mm.260938.

3D structure databases

ProteinModelPortali Q68FH0.
SMRi Q68FH0. Positions 524-1010.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 230696. 3 interactions.

PTM databases

PhosphoSitei Q68FH0.

Proteomic databases

MaxQBi Q68FH0.
PaxDbi Q68FH0.
PRIDEi Q68FH0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000102754 ; ENSMUSP00000099815 ; ENSMUSG00000026991 . [Q68FH0-1 ]
ENSMUST00000168631 ; ENSMUSP00000129836 ; ENSMUSG00000026991 . [Q68FH0-2 ]
GeneIDi 227937.
KEGGi mmu:227937.
UCSCi uc008jtb.1. mouse. [Q68FH0-1 ]
uc008jtd.1. mouse. [Q68FH0-2 ]
uc008jtg.1. mouse. [Q68FH0-3 ]

Organism-specific databases

CTDi 8502.
MGIi MGI:109281. Pkp4.

Phylogenomic databases

eggNOGi NOG276924.
GeneTreei ENSGT00760000119167.
HOVERGENi HBG004284.
InParanoidi Q68FH0.
OMAi GIGNLQR.
OrthoDBi EOG7X6KZB.
PhylomeDBi Q68FH0.
TreeFami TF321877.

Miscellaneous databases

ChiTaRSi Pkp4. mouse.
NextBioi 378870.
PROi Q68FH0.
SOURCEi Search...

Gene expression databases

Bgeei Q68FH0.
CleanExi MM_PKP4.
ExpressionAtlasi Q68FH0. baseline and differential.
Genevestigatori Q68FH0.

Family and domain databases

Gene3Di 1.25.10.10. 2 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028443. Plakophilin-4.
IPR028435. Plakophilin/d_Catenin.
[Graphical view ]
PANTHERi PTHR10372. PTHR10372. 1 hit.
PTHR10372:SF8. PTHR10372:SF8. 1 hit.
Pfami PF00514. Arm. 3 hits.
[Graphical view ]
SMARTi SM00185. ARM. 6 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
PROSITEi PS50176. ARM_REPEAT. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6 and Czech II.
    Tissue: Brain, Eye and Mammary cancer.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 747-1190 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Olfactory bulb, Ovary and Uterus.
  4. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-313; SER-405 AND SER-1133, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  5. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.
  6. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-371 AND TYR-477, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiPKP4_MOUSE
AccessioniPrimary (citable) accession number: Q68FH0
Secondary accession number(s): A2AS46
, Q640N0, Q68G56, Q8BK47, Q8BVH1, Q9CRE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 11, 2004
Last modified: November 26, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3