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Q68FH0

- PKP4_MOUSE

UniProt

Q68FH0 - PKP4_MOUSE

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Protein
Plakophilin-4
Gene
Pkp4, Armrp
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques By similarity.

GO - Biological processi

  1. cell-cell junction assembly Source: UniProtKB
  2. positive regulation of Rho GTPase activity Source: UniProtKB
  3. positive regulation of cytokinesis Source: UniProtKB
  4. positive regulation of gene expression Source: UniProtKB
  5. single organismal cell-cell adhesion Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Plakophilin-4
Alternative name(s):
Armadillo-related protein
Gene namesi
Name:Pkp4
Synonyms:Armrp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:109281. Pkp4.

Subcellular locationi

Cell junctiondesmosome By similarity. Cytoplasmcytoskeletonspindle By similarity. Cytoplasmcytoskeletonspindle pole By similarity. Midbody By similarity. Cell membrane; Peripheral membrane protein By similarity
Note: Associated with the pericentrosomal region in interphase and with spindle poles during mitosis. In anaphase, during chromosome segregation, is recruited to the central microtubule bundle, focussed at the spindle midzone and ultimately localizes to the midbody at cytokinesis. Constituent of the midbody cytoskeletal matrix. Colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells By similarity.

GO - Cellular componenti

  1. cell-cell contact zone Source: Ensembl
  2. cell-cell junction Source: UniProtKB
  3. cytoplasm Source: UniProtKB
  4. cytoplasmic side of plasma membrane Source: UniProtKB
  5. cytoskeleton Source: UniProtKB
  6. desmosome Source: UniProtKB
  7. midbody Source: UniProtKB
  8. mitotic spindle Source: UniProtKB
  9. perinuclear region of cytoplasm Source: UniProtKB
  10. plasma membrane Source: UniProtKB
  11. spindle midzone Source: UniProtKB
  12. spindle pole Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11901190Plakophilin-4
PRO_0000064290Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei220 – 2201Phosphoserine By similarity
Modified residuei230 – 2301Phosphoserine By similarity
Modified residuei272 – 2721Phosphoserine By similarity
Modified residuei280 – 2801Phosphoserine By similarity
Modified residuei313 – 3131Phosphoserine1 Publication
Modified residuei326 – 3261Phosphoserine By similarity
Modified residuei371 – 3711Phosphotyrosine1 Publication
Modified residuei402 – 4021Phosphoserine By similarity
Modified residuei405 – 4051Phosphoserine1 Publication
Modified residuei414 – 4141Phosphotyrosine By similarity
Modified residuei477 – 4771Phosphotyrosine1 Publication
Cross-linki610 – 610Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
Modified residuei775 – 7751Phosphoserine By similarity
Modified residuei1133 – 11331Phosphoserine1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ68FH0.
PaxDbiQ68FH0.
PRIDEiQ68FH0.

PTM databases

PhosphoSiteiQ68FH0.

Expressioni

Gene expression databases

ArrayExpressiQ68FH0.
BgeeiQ68FH0.
CleanExiMM_PKP4.
GenevestigatoriQ68FH0.

Interactioni

Subunit structurei

Interacts (via the C-terminus) with FRMPD2 (via the PDZ 2 domain). Interacts with PDZD2. Interacts with RHOA; the interaction is detected at the midbody. Interacts with ECT2; the interaction is detected at the midbody By similarity.

Protein-protein interaction databases

BioGridi230696. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ68FH0.
SMRiQ68FH0. Positions 524-1010.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati517 – 55640ARM 1
Add
BLAST
Repeati559 – 59840ARM 2
Add
BLAST
Repeati603 – 64341ARM 3
Add
BLAST
Repeati861 – 90040ARM 4
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili36 – 6328 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi787 – 7937Poly-Lys

Sequence similaritiesi

Belongs to the beta-catenin family.
Contains 4 ARM repeats.

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG276924.
GeneTreeiENSGT00690000101851.
HOVERGENiHBG004284.
InParanoidiA2AS46.
OMAiGIGNLQR.
OrthoDBiEOG7X6KZB.
PhylomeDBiQ68FH0.
TreeFamiTF321877.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028443. Plakophilin-4.
IPR028435. Plakophilin/d_Catenin.
[Graphical view]
PANTHERiPTHR10372. PTHR10372. 1 hit.
PTHR10372:SF8. PTHR10372:SF8. 1 hit.
PfamiPF00514. Arm. 3 hits.
[Graphical view]
SMARTiSM00185. ARM. 6 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q68FH0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPAPEQGSLV EEGQPQTHQE AVSTGPGMEP ETTATTILAS VKEQELQFQR     50
LTRELEVERQ IVASQLERCR LGAESPSIAS TSSTEKSFPW RSTDVPNPGV 100
SKPRVSDTIH PNNYLIRTEP EQGTLYSPEQ TSLHESEGSL GNSRSSTQMN 150
SYSDSGYQEA GSFHNSQTVN KADSRQHPFT GSTSNHVVRT SRAEGQTLVQ 200
PSVANRAMRR VSSVPSRAQS PSYVTSTGVS PSRGSLRTSL GSGFGSPSVT 250
DSRPLNPSAY SSSTLPAQRA ASPYSQRPAS PTAVRRVGSV TSRQTSNPNG 300
PVPQYQTTTR VGSPLTLTDA QTRVASPSQG QVGSSSPKRS GMTAVPQHLG 350
PSLQRTVHDM DQFGQQQYDI YERMVPPRPD SLTGLRSSYA SQHSQLGQEL 400
RSAVSPDLHI TPIYEGRTYY SPVYRSPNHG TVELQGSQTA LYRTGSVGIG 450
NLQRTSSQRS TLTYQRNNYA LNTAATYAEP YRPVQYRVQE CSYNRLQHTG 500
PADDGATRSP SIDSIQKDPR EFAWRDPELP EVIHMLQHQF PSVQANAAAY 550
LQHLCFGDNK VKMEVYRLGG IKHLVDLLDH RVLEVQKNAC GALRNLVFGK 600
STDENKIAMK NVGGIPALLR LLRKSIDAEV RELVTGVLWN LSSCDAVKMT 650
IIRDALSTLT NTVIVPHSGW NNSSFDDDHK IKFQTSLVLR NTTGCLRNLS 700
SAGEEARKQM RSCEGLVDSL LYVIHTCVNT SDYDSKTVEN CVCTLRNLSY 750
RLELEVPQAR LLGLNELDDL LGKESPSKDS EPSCWGKKKK KKKRTPQEDQ 800
WDGVGPIPGL SKSPKGVEML WHPSVVKPYL TLLAESSNPA TLEGSAGSLQ 850
NLSAGNWKFA AYIRAAVRKE KGLPILVELL RMDNDRVVSS VATALRNMAL 900
DVRNKELIGK YAMRDLVNRL PGGNGPSILS DETVAAICCA LHEVTSKNME 950
NAKALADSGG IEKLVNITKG RGDRSSLKVV KAAAQVLNTL WQYRDLRSIY 1000
KKDGWNQNHF ITPVSTLERD RFKSHPSLST TNQQMSPIIQ SVGSTSSSPA 1050
LLGIREPRSE YDRTQPPMQY YNSQGDTTHK GLYPGSSKPS PIYISSYSSP 1100
AREQNRRLQH QQLYYQDDST RKTLDAYRLY LQSPRSYEDP YCDDRVHFPA 1150
STDYSTQYGL KSTTNYVDFY STKRPSYRAE QYPGSPDSWV 1190
Length:1,190
Mass (Da):131,551
Last modified:October 11, 2004 - v1
Checksum:iDB6548B5EBE72CFE
GO
Isoform 2 (identifier: Q68FH0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1042-1084: Missing.

Show »
Length:1,147
Mass (Da):126,783
Checksum:iDEC21F1C1F960B7A
GO
Isoform 3 (identifier: Q68FH0-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-341: Missing.
     637-637: V → G
     638-1190: Missing.

Show »
Length:296
Mass (Da):33,263
Checksum:iD0630AA63A0911E8
GO

Sequence cautioni

The sequence BAC37187.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 341341Missing in isoform 3.
VSP_012374Add
BLAST
Alternative sequencei637 – 6371V → G in isoform 3.
VSP_012375
Alternative sequencei638 – 1190553Missing in isoform 3.
VSP_012376Add
BLAST
Alternative sequencei1042 – 108443Missing in isoform 2.
VSP_012377Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti328 – 3281S → F in AAH78638. 1 Publication
Sequence conflicti877 – 8771V → A in BAC36708. 1 Publication
Sequence conflicti1118 – 11181D → G in BAC36708. 1 Publication
Sequence conflicti1161 – 11611K → R in BAB32313. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL845536 Genomic DNA. Translation: CAM20481.1.
BC078638 mRNA. Translation: AAH78638.1.
BC079848 mRNA. Translation: AAH79848.1.
BC082578 mRNA. Translation: AAH82578.1.
AK021168 mRNA. Translation: BAB32313.1.
AK077250 mRNA. Translation: BAC36708.1.
AK078240 mRNA. Translation: BAC37187.1. Different initiation.
CCDSiCCDS16052.1. [Q68FH0-1]
CCDS50588.1. [Q68FH0-2]
RefSeqiNP_080637.1. NM_026361.2. [Q68FH0-1]
NP_780673.2. NM_175464.2. [Q68FH0-2]
XP_006499234.1. XM_006499171.1. [Q68FH0-1]
UniGeneiMm.260938.

Genome annotation databases

EnsembliENSMUST00000102754; ENSMUSP00000099815; ENSMUSG00000026991. [Q68FH0-1]
ENSMUST00000168631; ENSMUSP00000129836; ENSMUSG00000026991. [Q68FH0-2]
GeneIDi227937.
KEGGimmu:227937.
UCSCiuc008jtb.1. mouse. [Q68FH0-1]
uc008jtd.1. mouse. [Q68FH0-2]
uc008jtg.1. mouse. [Q68FH0-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL845536 Genomic DNA. Translation: CAM20481.1 .
BC078638 mRNA. Translation: AAH78638.1 .
BC079848 mRNA. Translation: AAH79848.1 .
BC082578 mRNA. Translation: AAH82578.1 .
AK021168 mRNA. Translation: BAB32313.1 .
AK077250 mRNA. Translation: BAC36708.1 .
AK078240 mRNA. Translation: BAC37187.1 . Different initiation.
CCDSi CCDS16052.1. [Q68FH0-1 ]
CCDS50588.1. [Q68FH0-2 ]
RefSeqi NP_080637.1. NM_026361.2. [Q68FH0-1 ]
NP_780673.2. NM_175464.2. [Q68FH0-2 ]
XP_006499234.1. XM_006499171.1. [Q68FH0-1 ]
UniGenei Mm.260938.

3D structure databases

ProteinModelPortali Q68FH0.
SMRi Q68FH0. Positions 524-1010.
ModBasei Search...

Protein-protein interaction databases

BioGridi 230696. 3 interactions.

PTM databases

PhosphoSitei Q68FH0.

Proteomic databases

MaxQBi Q68FH0.
PaxDbi Q68FH0.
PRIDEi Q68FH0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000102754 ; ENSMUSP00000099815 ; ENSMUSG00000026991 . [Q68FH0-1 ]
ENSMUST00000168631 ; ENSMUSP00000129836 ; ENSMUSG00000026991 . [Q68FH0-2 ]
GeneIDi 227937.
KEGGi mmu:227937.
UCSCi uc008jtb.1. mouse. [Q68FH0-1 ]
uc008jtd.1. mouse. [Q68FH0-2 ]
uc008jtg.1. mouse. [Q68FH0-3 ]

Organism-specific databases

CTDi 8502.
MGIi MGI:109281. Pkp4.

Phylogenomic databases

eggNOGi NOG276924.
GeneTreei ENSGT00690000101851.
HOVERGENi HBG004284.
InParanoidi A2AS46.
OMAi GIGNLQR.
OrthoDBi EOG7X6KZB.
PhylomeDBi Q68FH0.
TreeFami TF321877.

Miscellaneous databases

ChiTaRSi PKP4. mouse.
NextBioi 378870.
PROi Q68FH0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q68FH0.
Bgeei Q68FH0.
CleanExi MM_PKP4.
Genevestigatori Q68FH0.

Family and domain databases

Gene3Di 1.25.10.10. 2 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028443. Plakophilin-4.
IPR028435. Plakophilin/d_Catenin.
[Graphical view ]
PANTHERi PTHR10372. PTHR10372. 1 hit.
PTHR10372:SF8. PTHR10372:SF8. 1 hit.
Pfami PF00514. Arm. 3 hits.
[Graphical view ]
SMARTi SM00185. ARM. 6 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
PROSITEi PS50176. ARM_REPEAT. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6 and Czech II.
    Tissue: Brain, Eye and Mammary cancer.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 747-1190 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Olfactory bulb, Ovary and Uterus.
  4. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-313; SER-405 AND SER-1133, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  5. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.
  6. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-371 AND TYR-477, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiPKP4_MOUSE
AccessioniPrimary (citable) accession number: Q68FH0
Secondary accession number(s): A2AS46
, Q640N0, Q68G56, Q8BK47, Q8BVH1, Q9CRE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 11, 2004
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi