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Protein

Zinc finger C4H2 domain-containing protein

Gene

Zc4h2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in neuronal development and in neuromuscular junction formation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri189 – 206C4H2-typeAdd BLAST18

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger C4H2 domain-containing protein
Alternative name(s):
Hepatocellular carcinoma-associated antigen 127 homolog
Gene namesi
Name:Zc4h2
Synonyms:Hca127, Kiaa1166
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2679294. Zc4h2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Nucleus, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000839121 – 224Zinc finger C4H2 domain-containing proteinAdd BLAST224

Proteomic databases

PaxDbiQ68FG0.
PRIDEiQ68FG0.

PTM databases

PhosphoSitePlusiQ68FG0.

Expressioni

Tissue specificityi

Expressed in embryonic and adult brain and spinal cord.1 Publication

Developmental stagei

In all brain areas, expression levels are high during embryonic development and decrease postanatally.1 Publication

Gene expression databases

BgeeiENSMUSG00000035062.
ExpressionAtlasiQ68FG0. baseline and differential.
GenevisibleiQ68FG0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041236.

Structurei

3D structure databases

ProteinModelPortaliQ68FG0.
SMRiQ68FG0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili11 – 104Sequence analysisAdd BLAST94

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi125 – 128Poly-Glu4
Compositional biasi156 – 162Poly-Ala7

Sequence similaritiesi

Contains 1 C4H2-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri189 – 206C4H2-typeAdd BLAST18

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG4451. Eukaryota.
ENOG4111GRM. LUCA.
GeneTreeiENSGT00390000018389.
HOGENOMiHOG000008107.
HOVERGENiHBG051885.
InParanoidiQ68FG0.
OMAiNCRNKTL.
OrthoDBiEOG091G0RTI.
PhylomeDBiQ68FG0.
TreeFamiTF315275.

Family and domain databases

InterProiIPR018482. Znf-C4H2.
[Graphical view]
PfamiPF10146. zf-C4H2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q68FG0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADEQEIMCK LESIKEIRNK TLQMEKIKAR LKAEFEALES EERHLKEYKQ
60 70 80 90 100
EMDLLLQEKM AHVEELRLIH ADINVMENTI KQSENDLNKL LESTRRLHDE
110 120 130 140 150
YKPLKEHVDA LRMTLGLQRL PDLCEEEEKL SLDYFEKQKA EWQTEPQEPP
160 170 180 190 200
IPESLAAAAA AAQQLQVARK QDTRQTATFR QQPPPMKACL SCHQQIHRNA
210 220
PICPLCKAKS RSRNPKKPKR KQDE
Note: No experimental confirmation available.
Length:224
Mass (Da):26,244
Last modified:October 11, 2004 - v1
Checksum:iB8392407FB4A2012
GO
Isoform 2 (identifier: Q68FG0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-82: Missing.

Note: No experimental confirmation available.
Show »
Length:217
Mass (Da):25,399
Checksum:i7D4C545A0145FA59
GO

Sequence cautioni

The sequence BAC98112 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti50Q → R in AAH94942 (PubMed:15489334).Curated1
Sequence conflicti214N → Y in BAE33268 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01347076 – 82Missing in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129302 mRNA. Translation: BAC98112.1. Different initiation.
AK155445 mRNA. Translation: BAE33268.1.
AK162005 mRNA. Translation: BAE36676.1.
AL671982 Genomic DNA. Translation: CAM14599.1.
BC079862 mRNA. Translation: AAH79862.1.
BC094942 mRNA. Translation: AAH94942.1.
BC119285 mRNA. Translation: AAI19286.1.
BC119311 mRNA. Translation: AAI19312.1.
CCDSiCCDS30284.1. [Q68FG0-1]
CCDS81153.1. [Q68FG0-2]
RefSeqiNP_001003916.1. NM_001003916.2. [Q68FG0-1]
NP_001276625.1. NM_001289696.1.
NP_001276626.1. NM_001289697.1. [Q68FG0-2]
UniGeneiMm.336158.

Genome annotation databases

EnsembliENSMUST00000044382; ENSMUSP00000041236; ENSMUSG00000035062. [Q68FG0-1]
ENSMUST00000119640; ENSMUSP00000113689; ENSMUSG00000035062. [Q68FG0-2]
GeneIDi245522.
KEGGimmu:245522.
UCSCiuc009ttz.2. mouse. [Q68FG0-1]
uc012hmh.2. mouse. [Q68FG0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129302 mRNA. Translation: BAC98112.1. Different initiation.
AK155445 mRNA. Translation: BAE33268.1.
AK162005 mRNA. Translation: BAE36676.1.
AL671982 Genomic DNA. Translation: CAM14599.1.
BC079862 mRNA. Translation: AAH79862.1.
BC094942 mRNA. Translation: AAH94942.1.
BC119285 mRNA. Translation: AAI19286.1.
BC119311 mRNA. Translation: AAI19312.1.
CCDSiCCDS30284.1. [Q68FG0-1]
CCDS81153.1. [Q68FG0-2]
RefSeqiNP_001003916.1. NM_001003916.2. [Q68FG0-1]
NP_001276625.1. NM_001289696.1.
NP_001276626.1. NM_001289697.1. [Q68FG0-2]
UniGeneiMm.336158.

3D structure databases

ProteinModelPortaliQ68FG0.
SMRiQ68FG0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041236.

PTM databases

PhosphoSitePlusiQ68FG0.

Proteomic databases

PaxDbiQ68FG0.
PRIDEiQ68FG0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044382; ENSMUSP00000041236; ENSMUSG00000035062. [Q68FG0-1]
ENSMUST00000119640; ENSMUSP00000113689; ENSMUSG00000035062. [Q68FG0-2]
GeneIDi245522.
KEGGimmu:245522.
UCSCiuc009ttz.2. mouse. [Q68FG0-1]
uc012hmh.2. mouse. [Q68FG0-2]

Organism-specific databases

CTDi55906.
MGIiMGI:2679294. Zc4h2.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG4451. Eukaryota.
ENOG4111GRM. LUCA.
GeneTreeiENSGT00390000018389.
HOGENOMiHOG000008107.
HOVERGENiHBG051885.
InParanoidiQ68FG0.
OMAiNCRNKTL.
OrthoDBiEOG091G0RTI.
PhylomeDBiQ68FG0.
TreeFamiTF315275.

Miscellaneous databases

PROiQ68FG0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035062.
ExpressionAtlasiQ68FG0. baseline and differential.
GenevisibleiQ68FG0. MM.

Family and domain databases

InterProiIPR018482. Znf-C4H2.
[Graphical view]
PfamiPF10146. zf-C4H2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZC4H2_MOUSE
AccessioniPrimary (citable) accession number: Q68FG0
Secondary accession number(s): B1AUU6
, Q3TSJ9, Q3U274, Q504M3, Q6ZPW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.