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Protein

Zinc finger C4H2 domain-containing protein

Gene

Zc4h2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in interneurons differentiation. Involved in neuronal development and in neuromuscular junction formation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri189 – 206C4H2-typeAdd BLAST18

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger C4H2 domain-containing protein
Alternative name(s):
Hepatocellular carcinoma-associated antigen 127 homolog
Gene namesi
Name:Zc4h2
Synonyms:Hca127, Kiaa1166
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2679294 Zc4h2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Nucleus, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000839121 – 224Zinc finger C4H2 domain-containing proteinAdd BLAST224

Proteomic databases

PaxDbiQ68FG0
PRIDEiQ68FG0

PTM databases

PhosphoSitePlusiQ68FG0

Expressioni

Tissue specificityi

Expressed in embryonic and adult brain and spinal cord.1 Publication

Developmental stagei

In all brain areas, expression levels are high during embryonic development and decrease postanatally.1 Publication

Gene expression databases

BgeeiENSMUSG00000035062
ExpressionAtlasiQ68FG0 baseline and differential
GenevisibleiQ68FG0 MM

Interactioni

Protein-protein interaction databases

BioGridi232785, 1 interactor
IntActiQ68FG0, 1 interactor
STRINGi10090.ENSMUSP00000041236

Structurei

3D structure databases

ProteinModelPortaliQ68FG0
SMRiQ68FG0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili11 – 104Sequence analysisAdd BLAST94

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi125 – 128Poly-Glu4
Compositional biasi156 – 162Poly-Ala7

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri189 – 206C4H2-typeAdd BLAST18

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG4451 Eukaryota
ENOG4111GRM LUCA
GeneTreeiENSGT00390000018389
HOGENOMiHOG000008107
HOVERGENiHBG051885
InParanoidiQ68FG0
OMAiQKAEWRV
OrthoDBiEOG091G0RTI
PhylomeDBiQ68FG0
TreeFamiTF315275

Family and domain databases

InterProiView protein in InterPro
IPR018482 Znf-C4H2
PANTHERiPTHR31058 PTHR31058, 1 hit
PfamiView protein in Pfam
PF10146 zf-C4H2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q68FG0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADEQEIMCK LESIKEIRNK TLQMEKIKAR LKAEFEALES EERHLKEYKQ
60 70 80 90 100
EMDLLLQEKM AHVEELRLIH ADINVMENTI KQSENDLNKL LESTRRLHDE
110 120 130 140 150
YKPLKEHVDA LRMTLGLQRL PDLCEEEEKL SLDYFEKQKA EWQTEPQEPP
160 170 180 190 200
IPESLAAAAA AAQQLQVARK QDTRQTATFR QQPPPMKACL SCHQQIHRNA
210 220
PICPLCKAKS RSRNPKKPKR KQDE
Note: No experimental confirmation available.
Length:224
Mass (Da):26,244
Last modified:October 11, 2004 - v1
Checksum:iB8392407FB4A2012
GO
Isoform 2 (identifier: Q68FG0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-82: Missing.

Note: No experimental confirmation available.
Show »
Length:217
Mass (Da):25,399
Checksum:i7D4C545A0145FA59
GO

Sequence cautioni

The sequence BAC98112 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti50Q → R in AAH94942 (PubMed:15489334).Curated1
Sequence conflicti214N → Y in BAE33268 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01347076 – 82Missing in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129302 mRNA Translation: BAC98112.1 Different initiation.
AK155445 mRNA Translation: BAE33268.1
AK162005 mRNA Translation: BAE36676.1
AL671982 Genomic DNA No translation available.
BC079862 mRNA Translation: AAH79862.1
BC094942 mRNA Translation: AAH94942.1
BC119285 mRNA Translation: AAI19286.1
BC119311 mRNA Translation: AAI19312.1
CCDSiCCDS30284.1 [Q68FG0-1]
CCDS81153.1 [Q68FG0-2]
RefSeqiNP_001003916.1, NM_001003916.2 [Q68FG0-1]
NP_001276625.1, NM_001289696.1
NP_001276626.1, NM_001289697.1 [Q68FG0-2]
UniGeneiMm.336158

Genome annotation databases

EnsembliENSMUST00000044382; ENSMUSP00000041236; ENSMUSG00000035062 [Q68FG0-1]
ENSMUST00000119640; ENSMUSP00000113689; ENSMUSG00000035062 [Q68FG0-2]
GeneIDi245522
KEGGimmu:245522
UCSCiuc009ttz.2 mouse [Q68FG0-1]
uc012hmh.2 mouse [Q68FG0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZC4H2_MOUSE
AccessioniPrimary (citable) accession number: Q68FG0
Secondary accession number(s): B1AUU6
, Q3TSJ9, Q3U274, Q504M3, Q6ZPW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 11, 2004
Last modified: April 25, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health