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Q68FF9

- S5A1_MOUSE

UniProt

Q68FF9 - S5A1_MOUSE

Protein

3-oxo-5-alpha-steroid 4-dehydrogenase 1

Gene

Srd5a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 2 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology By similarity.By similarity

    Catalytic activityi

    A 3-oxo-5-alpha-steroid + NADP+ = a 3-oxo-Delta(4)-steroid + NADPH.

    GO - Molecular functioni

    1. 3-oxo-5-alpha-steroid 4-dehydrogenase activity Source: UniProtKB
    2. cholestenone 5-alpha-reductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. androgen biosynthetic process Source: MGI
    2. cell differentiation Source: UniProtKB-KW
    3. sex differentiation Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Differentiation, Sexual differentiation

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    ReactomeiREACT_220332. Androgen biosynthesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-oxo-5-alpha-steroid 4-dehydrogenase 1 (EC:1.3.1.22)
    Alternative name(s):
    SR type 1
    Steroid 5-alpha-reductase 1
    Short name:
    S5AR 1
    Gene namesi
    Name:Srd5a1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:98400. Srd5a1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2552553-oxo-5-alpha-steroid 4-dehydrogenase 1PRO_0000317711Add
    BLAST

    Proteomic databases

    PaxDbiQ68FF9.
    PRIDEiQ68FF9.

    PTM databases

    PhosphoSiteiQ68FF9.

    Expressioni

    Gene expression databases

    BgeeiQ68FF9.
    CleanExiMM_SRD5A1.
    GenevestigatoriQ68FF9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68FF9.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei6 – 2621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei82 – 10221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei107 – 12721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei142 – 16221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei205 – 22521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the steroid 5-alpha reductase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG82739.
    GeneTreeiENSGT00510000046634.
    HOGENOMiHOG000050133.
    HOVERGENiHBG003402.
    InParanoidiQ68FF9.
    KOiK12343.
    OrthoDBiEOG75QR56.
    PhylomeDBiQ68FF9.
    TreeFamiTF314668.

    Family and domain databases

    InterProiIPR016636. 3-oxo-5-alpha-steroid_4-DH.
    IPR001104. 3-oxo-5_a-steroid_4-DH_C.
    [Graphical view]
    PfamiPF02544. Steroid_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015596. 5_alpha-SR2. 1 hit.
    PROSITEiPS50244. S5A_REDUCTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q68FF9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELDELCLLD ALVYLEGFLA FVAFVGLQMV GSSYGRYSSQ WSGRRVPARP    50
    AWFLQELPSM AWPLYECIRP AAARLGNLPN RVLLAMFLIH YVQRTLVFPV 100
    LIRGGKPTLL FTFVLAFLFC TLNGYLQSRY LSQFAVYAED WVTHPCFLTG 150
    FALWLVGMVI NIHSDHILRN LRKPGETGYK IPRGGLFEYV SSANYFGELV 200
    EWCGFALASW SLQGVVFALF TLCALFTRAR QHHQWYLEKF EDYPKTRKIL 250
    IPFLL 255
    Length:255
    Mass (Da):29,344
    Last modified:February 5, 2008 - v2
    Checksum:i80A5624B25D46D1A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti7 – 71C → R in AAH79863. (PubMed:15489334)Curated
    Sequence conflicti142 – 1421V → I in AAH94503. (PubMed:15489334)Curated
    Sequence conflicti176 – 1761E → D in AAH94503. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC079863 mRNA. Translation: AAH79863.1.
    BC094503 mRNA. Translation: AAH94503.1.
    CCDSiCCDS26624.1.
    RefSeqiNP_780492.2. NM_175283.3.
    UniGeneiMm.451912.
    Mm.483181.

    Genome annotation databases

    EnsembliENSMUST00000091514; ENSMUSP00000089097; ENSMUSG00000021594.
    GeneIDi78925.
    KEGGimmu:78925.
    UCSCiuc007rck.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC079863 mRNA. Translation: AAH79863.1 .
    BC094503 mRNA. Translation: AAH94503.1 .
    CCDSi CCDS26624.1.
    RefSeqi NP_780492.2. NM_175283.3.
    UniGenei Mm.451912.
    Mm.483181.

    3D structure databases

    ProteinModelPortali Q68FF9.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q68FF9.

    Proteomic databases

    PaxDbi Q68FF9.
    PRIDEi Q68FF9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000091514 ; ENSMUSP00000089097 ; ENSMUSG00000021594 .
    GeneIDi 78925.
    KEGGi mmu:78925.
    UCSCi uc007rck.1. mouse.

    Organism-specific databases

    CTDi 6715.
    MGIi MGI:98400. Srd5a1.

    Phylogenomic databases

    eggNOGi NOG82739.
    GeneTreei ENSGT00510000046634.
    HOGENOMi HOG000050133.
    HOVERGENi HBG003402.
    InParanoidi Q68FF9.
    KOi K12343.
    OrthoDBi EOG75QR56.
    PhylomeDBi Q68FF9.
    TreeFami TF314668.

    Enzyme and pathway databases

    Reactomei REACT_220332. Androgen biosynthesis.

    Miscellaneous databases

    NextBioi 349772.
    PROi Q68FF9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q68FF9.
    CleanExi MM_SRD5A1.
    Genevestigatori Q68FF9.

    Family and domain databases

    InterProi IPR016636. 3-oxo-5-alpha-steroid_4-DH.
    IPR001104. 3-oxo-5_a-steroid_4-DH_C.
    [Graphical view ]
    Pfami PF02544. Steroid_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015596. 5_alpha-SR2. 1 hit.
    PROSITEi PS50244. S5A_REDUCTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6 and FVB/N.
      Tissue: Brain and Liver.

    Entry informationi

    Entry nameiS5A1_MOUSE
    AccessioniPrimary (citable) accession number: Q68FF9
    Secondary accession number(s): Q505K7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 76 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3