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Protein

3-oxo-5-alpha-steroid 4-dehydrogenase 1

Gene

Srd5a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology (By similarity).By similarity

Catalytic activityi

A 3-oxo-5-alpha-steroid + NADP+ = a 3-oxo-Delta(4)-steroid + NADPH.

GO - Molecular functioni

GO - Biological processi

  • androgen biosynthetic process Source: MGI
  • cell differentiation Source: UniProtKB-KW
  • sex differentiation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Differentiation, Sexual differentiation

Keywords - Ligandi

NADP

Enzyme and pathway databases

ReactomeiREACT_305222. Androgen biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (EC:1.3.1.22)
Alternative name(s):
SR type 1
Steroid 5-alpha-reductase 1
Short name:
S5AR 1
Gene namesi
Name:Srd5a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:98400. Srd5a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621HelicalSequence AnalysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence AnalysisAdd
BLAST
Transmembranei107 – 12721HelicalSequence AnalysisAdd
BLAST
Transmembranei142 – 16221HelicalSequence AnalysisAdd
BLAST
Transmembranei205 – 22521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2552553-oxo-5-alpha-steroid 4-dehydrogenase 1PRO_0000317711Add
BLAST

Proteomic databases

PaxDbiQ68FF9.
PRIDEiQ68FF9.

PTM databases

PhosphoSiteiQ68FF9.

Expressioni

Gene expression databases

BgeeiQ68FF9.
CleanExiMM_SRD5A1.
GenevestigatoriQ68FF9.

Structurei

3D structure databases

ProteinModelPortaliQ68FF9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the steroid 5-alpha reductase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG82739.
HOGENOMiHOG000050133.
HOVERGENiHBG003402.
InParanoidiQ68FF9.
KOiK12343.
OrthoDBiEOG75QR56.
PhylomeDBiQ68FF9.
TreeFamiTF314668.

Family and domain databases

InterProiIPR016636. 3-oxo-5-alpha-steroid_4-DH.
IPR001104. 3-oxo-5_a-steroid_4-DH_C.
[Graphical view]
PfamiPF02544. Steroid_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015596. 5_alpha-SR2. 1 hit.
PROSITEiPS50244. S5A_REDUCTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68FF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELDELCLLD ALVYLEGFLA FVAFVGLQMV GSSYGRYSSQ WSGRRVPARP
60 70 80 90 100
AWFLQELPSM AWPLYECIRP AAARLGNLPN RVLLAMFLIH YVQRTLVFPV
110 120 130 140 150
LIRGGKPTLL FTFVLAFLFC TLNGYLQSRY LSQFAVYAED WVTHPCFLTG
160 170 180 190 200
FALWLVGMVI NIHSDHILRN LRKPGETGYK IPRGGLFEYV SSANYFGELV
210 220 230 240 250
EWCGFALASW SLQGVVFALF TLCALFTRAR QHHQWYLEKF EDYPKTRKIL

IPFLL
Length:255
Mass (Da):29,344
Last modified:February 5, 2008 - v2
Checksum:i80A5624B25D46D1A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71C → R in AAH79863 (PubMed:15489334).Curated
Sequence conflicti142 – 1421V → I in AAH94503 (PubMed:15489334).Curated
Sequence conflicti176 – 1761E → D in AAH94503 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079863 mRNA. Translation: AAH79863.1.
BC094503 mRNA. Translation: AAH94503.1.
CCDSiCCDS26624.1.
RefSeqiNP_780492.2. NM_175283.3.
UniGeneiMm.451912.
Mm.483181.

Genome annotation databases

GeneIDi78925.
KEGGimmu:78925.
UCSCiuc007rck.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079863 mRNA. Translation: AAH79863.1.
BC094503 mRNA. Translation: AAH94503.1.
CCDSiCCDS26624.1.
RefSeqiNP_780492.2. NM_175283.3.
UniGeneiMm.451912.
Mm.483181.

3D structure databases

ProteinModelPortaliQ68FF9.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ68FF9.

Proteomic databases

PaxDbiQ68FF9.
PRIDEiQ68FF9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi78925.
KEGGimmu:78925.
UCSCiuc007rck.1. mouse.

Organism-specific databases

CTDi6715.
MGIiMGI:98400. Srd5a1.

Phylogenomic databases

eggNOGiNOG82739.
HOGENOMiHOG000050133.
HOVERGENiHBG003402.
InParanoidiQ68FF9.
KOiK12343.
OrthoDBiEOG75QR56.
PhylomeDBiQ68FF9.
TreeFamiTF314668.

Enzyme and pathway databases

ReactomeiREACT_305222. Androgen biosynthesis.

Miscellaneous databases

ChiTaRSiSrd5a1. mouse.
NextBioi349772.
PROiQ68FF9.
SOURCEiSearch...

Gene expression databases

BgeeiQ68FF9.
CleanExiMM_SRD5A1.
GenevestigatoriQ68FF9.

Family and domain databases

InterProiIPR016636. 3-oxo-5-alpha-steroid_4-DH.
IPR001104. 3-oxo-5_a-steroid_4-DH_C.
[Graphical view]
PfamiPF02544. Steroid_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015596. 5_alpha-SR2. 1 hit.
PROSITEiPS50244. S5A_REDUCTASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6 and FVB/N.
    Tissue: Brain and Liver.

Entry informationi

Entry nameiS5A1_MOUSE
AccessioniPrimary (citable) accession number: Q68FF9
Secondary accession number(s): Q505K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: May 27, 2015
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.