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Q68FF9

- S5A1_MOUSE

UniProt

Q68FF9 - S5A1_MOUSE

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Protein

3-oxo-5-alpha-steroid 4-dehydrogenase 1

Gene

Srd5a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology (By similarity).By similarity

Catalytic activityi

A 3-oxo-5-alpha-steroid + NADP+ = a 3-oxo-Delta(4)-steroid + NADPH.

GO - Molecular functioni

  1. 3-oxo-5-alpha-steroid 4-dehydrogenase activity Source: UniProtKB
  2. cholestenone 5-alpha-reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. androgen biosynthetic process Source: MGI
  2. cell differentiation Source: UniProtKB-KW
  3. sex differentiation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Differentiation, Sexual differentiation

Keywords - Ligandi

NADP

Enzyme and pathway databases

ReactomeiREACT_220332. Androgen biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (EC:1.3.1.22)
Alternative name(s):
SR type 1
Steroid 5-alpha-reductase 1
Short name:
S5AR 1
Gene namesi
Name:Srd5a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:98400. Srd5a1.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2552553-oxo-5-alpha-steroid 4-dehydrogenase 1PRO_0000317711Add
BLAST

Proteomic databases

PaxDbiQ68FF9.
PRIDEiQ68FF9.

PTM databases

PhosphoSiteiQ68FF9.

Expressioni

Gene expression databases

BgeeiQ68FF9.
CleanExiMM_SRD5A1.
GenevestigatoriQ68FF9.

Structurei

3D structure databases

ProteinModelPortaliQ68FF9.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621HelicalSequence AnalysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence AnalysisAdd
BLAST
Transmembranei107 – 12721HelicalSequence AnalysisAdd
BLAST
Transmembranei142 – 16221HelicalSequence AnalysisAdd
BLAST
Transmembranei205 – 22521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the steroid 5-alpha reductase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG82739.
GeneTreeiENSGT00510000046634.
HOGENOMiHOG000050133.
HOVERGENiHBG003402.
InParanoidiQ68FF9.
KOiK12343.
OrthoDBiEOG75QR56.
PhylomeDBiQ68FF9.
TreeFamiTF314668.

Family and domain databases

InterProiIPR016636. 3-oxo-5-alpha-steroid_4-DH.
IPR001104. 3-oxo-5_a-steroid_4-DH_C.
[Graphical view]
PfamiPF02544. Steroid_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015596. 5_alpha-SR2. 1 hit.
PROSITEiPS50244. S5A_REDUCTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68FF9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELDELCLLD ALVYLEGFLA FVAFVGLQMV GSSYGRYSSQ WSGRRVPARP
60 70 80 90 100
AWFLQELPSM AWPLYECIRP AAARLGNLPN RVLLAMFLIH YVQRTLVFPV
110 120 130 140 150
LIRGGKPTLL FTFVLAFLFC TLNGYLQSRY LSQFAVYAED WVTHPCFLTG
160 170 180 190 200
FALWLVGMVI NIHSDHILRN LRKPGETGYK IPRGGLFEYV SSANYFGELV
210 220 230 240 250
EWCGFALASW SLQGVVFALF TLCALFTRAR QHHQWYLEKF EDYPKTRKIL

IPFLL
Length:255
Mass (Da):29,344
Last modified:February 5, 2008 - v2
Checksum:i80A5624B25D46D1A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71C → R in AAH79863. (PubMed:15489334)Curated
Sequence conflicti142 – 1421V → I in AAH94503. (PubMed:15489334)Curated
Sequence conflicti176 – 1761E → D in AAH94503. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC079863 mRNA. Translation: AAH79863.1.
BC094503 mRNA. Translation: AAH94503.1.
CCDSiCCDS26624.1.
RefSeqiNP_780492.2. NM_175283.3.
UniGeneiMm.451912.
Mm.483181.

Genome annotation databases

EnsembliENSMUST00000091514; ENSMUSP00000089097; ENSMUSG00000021594.
GeneIDi78925.
KEGGimmu:78925.
UCSCiuc007rck.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC079863 mRNA. Translation: AAH79863.1 .
BC094503 mRNA. Translation: AAH94503.1 .
CCDSi CCDS26624.1.
RefSeqi NP_780492.2. NM_175283.3.
UniGenei Mm.451912.
Mm.483181.

3D structure databases

ProteinModelPortali Q68FF9.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q68FF9.

Proteomic databases

PaxDbi Q68FF9.
PRIDEi Q68FF9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000091514 ; ENSMUSP00000089097 ; ENSMUSG00000021594 .
GeneIDi 78925.
KEGGi mmu:78925.
UCSCi uc007rck.1. mouse.

Organism-specific databases

CTDi 6715.
MGIi MGI:98400. Srd5a1.

Phylogenomic databases

eggNOGi NOG82739.
GeneTreei ENSGT00510000046634.
HOGENOMi HOG000050133.
HOVERGENi HBG003402.
InParanoidi Q68FF9.
KOi K12343.
OrthoDBi EOG75QR56.
PhylomeDBi Q68FF9.
TreeFami TF314668.

Enzyme and pathway databases

Reactomei REACT_220332. Androgen biosynthesis.

Miscellaneous databases

NextBioi 349772.
PROi Q68FF9.
SOURCEi Search...

Gene expression databases

Bgeei Q68FF9.
CleanExi MM_SRD5A1.
Genevestigatori Q68FF9.

Family and domain databases

InterProi IPR016636. 3-oxo-5-alpha-steroid_4-DH.
IPR001104. 3-oxo-5_a-steroid_4-DH_C.
[Graphical view ]
Pfami PF02544. Steroid_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015596. 5_alpha-SR2. 1 hit.
PROSITEi PS50244. S5A_REDUCTASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6 and FVB/N.
    Tissue: Brain and Liver.

Entry informationi

Entry nameiS5A1_MOUSE
AccessioniPrimary (citable) accession number: Q68FF9
Secondary accession number(s): Q505K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: October 29, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3