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Q68FF9 (S5A1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1

EC=1.3.1.22
Alternative name(s):
SR type 1
Steroid 5-alpha-reductase 1
Short name=S5AR 1
Gene names
Name:Srd5a1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length255 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology By similarity.

Catalytic activity

A 3-oxo-5-alpha-steroid + NADP+ = a 3-oxo-Delta(4)-steroid + NADPH.

Subcellular location

Microsome membrane; Multi-pass membrane protein By similarity. Endoplasmic reticulum membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the steroid 5-alpha reductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2552553-oxo-5-alpha-steroid 4-dehydrogenase 1
PRO_0000317711

Regions

Transmembrane6 – 2621Helical; Potential
Transmembrane82 – 10221Helical; Potential
Transmembrane107 – 12721Helical; Potential
Transmembrane142 – 16221Helical; Potential
Transmembrane205 – 22521Helical; Potential

Experimental info

Sequence conflict71C → R in AAH79863. Ref.1
Sequence conflict1421V → I in AAH94503. Ref.1
Sequence conflict1761E → D in AAH94503. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q68FF9 [UniParc].

Last modified February 5, 2008. Version 2.
Checksum: 80A5624B25D46D1A

FASTA25529,344
        10         20         30         40         50         60 
MELDELCLLD ALVYLEGFLA FVAFVGLQMV GSSYGRYSSQ WSGRRVPARP AWFLQELPSM 

        70         80         90        100        110        120 
AWPLYECIRP AAARLGNLPN RVLLAMFLIH YVQRTLVFPV LIRGGKPTLL FTFVLAFLFC 

       130        140        150        160        170        180 
TLNGYLQSRY LSQFAVYAED WVTHPCFLTG FALWLVGMVI NIHSDHILRN LRKPGETGYK 

       190        200        210        220        230        240 
IPRGGLFEYV SSANYFGELV EWCGFALASW SLQGVVFALF TLCALFTRAR QHHQWYLEKF 

       250 
EDYPKTRKIL IPFLL 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6 and FVB/N.
Tissue: Brain and Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC079863 mRNA. Translation: AAH79863.1.
BC094503 mRNA. Translation: AAH94503.1.
CCDSCCDS26624.1.
RefSeqNP_780492.2. NM_175283.3.
UniGeneMm.451912.
Mm.483181.

3D structure databases

ProteinModelPortalQ68FF9.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ68FF9.

Proteomic databases

PaxDbQ68FF9.
PRIDEQ68FF9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000091514; ENSMUSP00000089097; ENSMUSG00000021594.
GeneID78925.
KEGGmmu:78925.
UCSCuc007rck.1. mouse.

Organism-specific databases

CTD6715.
MGIMGI:98400. Srd5a1.

Phylogenomic databases

eggNOGNOG82739.
GeneTreeENSGT00510000046634.
HOGENOMHOG000050133.
HOVERGENHBG003402.
InParanoidQ68FF9.
KOK12343.
OrthoDBEOG75QR56.
PhylomeDBQ68FF9.
TreeFamTF314668.

Gene expression databases

BgeeQ68FF9.
CleanExMM_SRD5A1.
GenevestigatorQ68FF9.

Family and domain databases

InterProIPR016636. 3-oxo-5-alpha-steroid_4-DH.
IPR001104. 3-oxo-5_a-steroid_4-DH_C.
[Graphical view]
PfamPF02544. Steroid_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015596. 5_alpha-SR2. 1 hit.
PROSITEPS50244. S5A_REDUCTASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio349772.
PROQ68FF9.
SOURCESearch...

Entry information

Entry nameS5A1_MOUSE
AccessionPrimary (citable) accession number: Q68FF9
Secondary accession number(s): Q505K7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: July 9, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot