Reviewed, UniProtKB/Swiss-Prot Q68FF0 (K1841_MOUSE)

Names and origin

Protein names

Recommended name:
    Uncharacterized protein KIAA1841

Gene names

Name:

Kiaa1841

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	718 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities	Belongs to the KIAA1841 family.
Sequence caution	The sequence AAH72622.1 differs from that shown. Reason: Frameshift at position 594. The sequence CAM16941.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAM16943.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAM16946.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q68FF0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q68FF0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-146: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 718	718	Uncharacterized protein KIAA1841		PRO_0000324599
Natural variations
	Alternative sequence	1 – 146	146	Missing in isoform 2.		VSP_032303
Experimental info
	Sequence conflict	149	1	I → V in BAC35550. Ref.4
	Sequence conflict	483	1	I → L in AAH79876. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 18, 2008. Version 2. Checksum: F8730D777D57C272	FASTA	718	81,996
	10 20 30 40 50 60 MSRGYPENNN FLNNNNQMVL DMILYPLIGI PQTINWETVA RLVPGLTPKE CVKRFDELKS 70 80 90 100 110 120 CGSSPVDNQY NPLMATGEGP VETLATYIKS SLLDTQGDFQ ETPVDQDTVS KAGRHSIATT 130 140 150 160 170 180 RNCSSESENC TARNAGEETG ESEGPNMVIH VCDEAKSLKE DFICPRDLLI SEMKYFAEYL 190 200 210 220 230 240 SMDAQRWEEV DISVHCDVHI FNWLIKYVKR NTKESKDCEI PALEPGNVIS ILISSEFLKM 250 260 270 280 290 300 DSLVEQCIQY CHKNMNAIVA APCNMNCINA NLLTRIADLF THNEIDDLKD KKDKFRSKLF 310 320 330 340 350 360 CKKIERLFDP EYSNPDSRNN AATLYRCCLC KKLLTRETER RIPCIPGKIN VDRHGNIIYI 370 380 390 400 410 420 HIRDKTWDVH EYLNSLFEEL KSWRDVYWRL WGTVNWLTCS RCYQAFLCIE FSHCQYHSEV 430 440 450 460 470 480 VVYSSTVNSL NTVGTGIYPC CNQKVLRFDP TQLTKGCKVR DHMVVLHDQG ENDDSPSCPP 490 500 510 520 530 540 AKILDDLHKH KDVIAVPFLK DAVSDPGVGS CDEKGLEYEI LLEPNTPWGS KTGELNAFLS 550 560 570 580 590 600 LKNWTLQLKQ QSLFSEEEEY TTGSEVTEDE VGDEEEIAKK QRKKEKPKKF TKPPKKQLSS 610 620 630 640 650 660 PCSQKKEKTL EKSTSRDVSP FVVSMQKNKW DASRSLRFNQ DAQREDDQRR MSEITGHLIK 670 680 690 700 710 MRLGDLDRVK AKESKEFAGG IYSRLEAQVR ASVPVTARQN SSDKNQRSKS RFGQGRPA
	Isoform 2. Checksum: 2210E9D1D5FC0D4B	FASTA	572	66,040
	10 20 30 40 50 60 MVIHVCDEAK SLKEDFICPR DLLISEMKYF AEYLSMDAQR WEEVDISVHC DVHIFNWLIK 70 80 90 100 110 120 YVKRNTKESK DCEIPALEPG NVISILISSE FLKMDSLVEQ CIQYCHKNMN AIVAAPCNMN 130 140 150 160 170 180 CINANLLTRI ADLFTHNEID DLKDKKDKFR SKLFCKKIER LFDPEYSNPD SRNNAATLYR 190 200 210 220 230 240 CCLCKKLLTR ETERRIPCIP GKINVDRHGN IIYIHIRDKT WDVHEYLNSL FEELKSWRDV 250 260 270 280 290 300 YWRLWGTVNW LTCSRCYQAF LCIEFSHCQY HSEVVVYSST VNSLNTVGTG IYPCCNQKVL 310 320 330 340 350 360 RFDPTQLTKG CKVRDHMVVL HDQGENDDSP SCPPAKILDD LHKHKDVIAV PFLKDAVSDP 370 380 390 400 410 420 GVGSCDEKGL EYEILLEPNT PWGSKTGELN AFLSLKNWTL QLKQQSLFSE EEEYTTGSEV 430 440 450 460 470 480 TEDEVGDEEE IAKKQRKKEK PKKFTKPPKK QLSSPCSQKK EKTLEKSTSR DVSPFVVSMQ 490 500 510 520 530 540 KNKWDASRSL RFNQDAQRED DQRRMSEITG HLIKMRLGDL DRVKAKESKE FAGGIYSRLE 550 560 570 AQVRASVPVT ARQNSSDKNQ RSKSRFGQGR PA

References

[1]	"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H. DNA Res. 10:167-180(2003) [PubMed: 14621295] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: C57BL/6. Tissue: Brain.
[4]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-335 AND 536-718 (ISOFORM 2). Strain: C57BL/6J. Tissue: Eye, Heart and Kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK129454 mRNA. Translation: BAC98264.1. Different initiation. AL672049 Genomic DNA. Translation: CAM16941.1. Sequence problems. AL672049 Genomic DNA. Translation: CAM16942.1. AL672049 Genomic DNA. Translation: CAM16943.1. Sequence problems. AL672049 Genomic DNA. Translation: CAM16945.1. AL672049 Genomic DNA. Translation: CAM16946.1. Sequence problems. BC072622 mRNA. Translation: AAH72622.1. Frameshift. BC079876 mRNA. Translation: AAH79876.1. AK002465 mRNA. Translation: BAB22119.1. AK053838 mRNA. Translation: BAC35550.1. AK142320 mRNA. Translation: BAE25029.1.
IPI	IPI00420513. IPI00648258.
RefSeq	NP_082136.2.
UniGene	Mm.48031
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q68FF0.
Genome annotation databases
Ensembl	ENSMUST00000043356; ENSMUSP00000044265; ENSMUSG00000042208; Mus musculus. [Genome view]
GeneID	71675.
KEGG	mmu:71675.
Organism-specific databases
MGI	MGI:1918925. 0610010F05Rik.
Rouge	Search...
Phylogenomic databases
HOVERGEN	Q68FF0.
OMA	HCDVHIF
OrthoDB	EOG9K9DXD
Gene expression databases
ArrayExpress	Q68FF0.
Bgee	Q68FF0.
CleanEx	MM_0610010F05RIK.
Genevestigator	Q68FF0.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	334201.
SOURCE	Search...

Entry information

Entry name

K1841_MOUSE

Accession

Primary (citable) accession number: Q68FF0
Secondary accession number(s): A2AF87 , A2AF88, A2AF89, A2AF91, A2AF92, Q3UQL0, Q6GQU5, Q6ZPH2, Q8BPK6, Q9CWA7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	March 18, 2008
Last modified:	November 24, 2009
This is version 46 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)