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Protein

Teashirt homolog 2

Gene

Tshz2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential).Curated

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri216 – 24025C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri276 – 30025C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri381 – 40525C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
BLAST
DNA bindingi837 – 90771HomeoboxAdd
BLAST
Zinc fingeri922 – 94423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri990 – 101324C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Teashirt homolog 2
Alternative name(s):
SDCCAG33-like protein
Zinc finger protein 218
Gene namesi
Name:Tshz2
Synonyms:Kiaa4248, Sdccag33l, Tsh2, Zfp218, Znf218
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2153084. Tshz2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10301030Teashirt homolog 2PRO_0000047065Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki480 – 480Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei976 – 9761PhosphoserineCombined sources

Post-translational modificationi

Sumoylated.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ68FE9.
PaxDbiQ68FE9.
PRIDEiQ68FE9.

PTM databases

iPTMnetiQ68FE9.
PhosphoSiteiQ68FE9.

Expressioni

Developmental stagei

Expressed in mesenchymal cells in proximal ureters at 14 dpc, preceding the smooth muscle precursor cells differentiation and the expression of contractile proteins from 15 dpc.1 Publication

Gene expression databases

BgeeiQ68FE9.
CleanExiMM_TSHZ2.
ExpressionAtlasiQ68FE9. baseline and differential.
GenevisibleiQ68FE9. MM.

Interactioni

Subunit structurei

Interacts (via homeobox domain) with APBB1 (via PID domain 1).1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104785.

Structurei

3D structure databases

ProteinModelPortaliQ68FE9.
SMRiQ68FE9. Positions 202-304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili11 – 4232Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 homeobox DNA-binding domain.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri216 – 24025C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri276 – 30025C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri381 – 40525C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri922 – 94423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri990 – 101324C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Homeobox, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IJ7P. Eukaryota.
ENOG4110HP7. LUCA.
GeneTreeiENSGT00390000014977.
HOGENOMiHOG000231480.
HOVERGENiHBG079626.
InParanoidiQ68FE9.
KOiK09236.
OMAiLFQTSEG.
OrthoDBiEOG7NPFSF.
PhylomeDBiQ68FE9.
TreeFamiTF328447.

Family and domain databases

InterProiIPR001356. Homeobox_dom.
IPR027008. Teashirt_fam.
IPR027010. Tshz2.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PANTHERiPTHR12487. PTHR12487. 1 hit.
PTHR12487:SF3. PTHR12487:SF3. 1 hit.
SMARTiSM00389. HOX. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68FE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRRKQQAPK RAAGYAQEEV LKEEEEIKEE EEEEEDSGSV AQHQSSNDTG
60 70 80 90 100
TDEELETGPE QKGYFSCQNS PGSHLSNQDA ENESLLSDAS DQVSDVKSVC
110 120 130 140 150
GRDVSDKKAN THPKLPSEPH NCMDKMTAVY ANILSDSYWS GLGLGFKLSN
160 170 180 190 200
SERRNCDTRN SSGKNDFDWH QDALSKSLQQ NLPSRSVSKP SLFSSVQLYR
210 220 230 240 250
QSSKLCGSVF TGASRFRCRQ CSAAYDTLVE LTVHMNETGH YQDDNRKKDK
260 270 280 290 300
LRPTSYSKPR KRAFQDMDKE DAQKVLKCMF CGDSFDSLQD LSVHMIKTKH
310 320 330 340 350
YQKVPLKEPV PTISSKMVTP AKKRVFDVNR PCSPDSTTGS LADSFSSQKS
360 370 380 390 400
ANLQLPSNSR YGYQNGASYT WQFEACKSQI LKCMECGSSH DTLQQLTTHM
410 420 430 440 450
MVTGHFLKVT SSASKKGKQL VLDPLAVEKM QSLSETPNSE SLAPKPSSNS
460 470 480 490 500
PSECTASTTE LKKESKKEKG EGIEDEQGVK SEDYEDSLQK PLDPTIKYQY
510 520 530 540 550
LREEDLEDGS KGGGDILKSL ENTVTTAINK AQNGAPSWSA YPSIHAAYQL
560 570 580 590 600
SEGTKPPMAM GSQILQIRPN LANKLRPIAP KWKGMPLGPV PTSLALYTQV
610 620 630 640 650
KKETEDKDEV VKQCGKESPH EEATSFSQPE GESFSKIEPP SESRKAEPCP
660 670 680 690 700
LKEEEKPQKE KPEPLEPVSS LTNGCAPANH TPALPSINPL SALQSVLNNH
710 720 730 740 750
LGKATEPLRS PSCSSPNSST SPVFHKSSLH VVDKPVISPT STRPAASVAR
760 770 780 790 800
HYLFENTDQP IDLTKSKSKR AESSQAQSCT SPPQKHALCD IADMVKVLPK
810 820 830 840 850
ATTPKPAASS RVPPMKLEID VRRFEDVSSE VSTLHKRKGR QSNWNPQHLL
860 870 880 890 900
ILQAQFASSL FQTSEGKYLL SDLGPQERMQ ISKFTGLSMT TISHWLANVK
910 920 930 940 950
YQLRKTGGTK FLKNMDKGHP IFYCSDCASQ FRTPSTYISH LESHLGFQMK
960 970 980 990 1000
DMTRMAADQQ SKVEQEISRV SSAQRSPETI AGEEDTDSKF KCKLCRRTFV
1010 1020 1030
SKHAVKLHLS KTHSKSPEHH SQFVADVDEE
Length:1,030
Mass (Da):114,223
Last modified:October 11, 2004 - v1
Checksum:i1F8075095AE4D60E
GO

Sequence cautioni

The sequence AAF64095.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAD90333.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti159 – 22769Missing in AAH79550 (PubMed:15489334).CuratedAdd
BLAST
Sequence conflicti607 – 6071K → R in AAF64095 (PubMed:10704881).Curated
Sequence conflicti1012 – 10121T → A in AAF64095 (PubMed:10704881).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079877 mRNA. Translation: AAH79877.1.
BC079550 mRNA. Translation: AAH79550.1.
AK220569 mRNA. Translation: BAD90333.1. Different initiation.
AF207880 Genomic DNA. Translation: AAF64095.1. Different initiation.
CCDSiCCDS50805.1.
RefSeqiNP_536703.2. NM_080455.2.
XP_011237817.1. XM_011239515.1.
UniGeneiMm.315789.
Mm.468546.
Mm.482636.

Genome annotation databases

EnsembliENSMUST00000109157; ENSMUSP00000104785; ENSMUSG00000047907.
ENSMUST00000109159; ENSMUSP00000104787; ENSMUSG00000047907.
GeneIDi228911.
KEGGimmu:228911.
UCSCiuc008obo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079877 mRNA. Translation: AAH79877.1.
BC079550 mRNA. Translation: AAH79550.1.
AK220569 mRNA. Translation: BAD90333.1. Different initiation.
AF207880 Genomic DNA. Translation: AAF64095.1. Different initiation.
CCDSiCCDS50805.1.
RefSeqiNP_536703.2. NM_080455.2.
XP_011237817.1. XM_011239515.1.
UniGeneiMm.315789.
Mm.468546.
Mm.482636.

3D structure databases

ProteinModelPortaliQ68FE9.
SMRiQ68FE9. Positions 202-304.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104785.

PTM databases

iPTMnetiQ68FE9.
PhosphoSiteiQ68FE9.

Proteomic databases

MaxQBiQ68FE9.
PaxDbiQ68FE9.
PRIDEiQ68FE9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109157; ENSMUSP00000104785; ENSMUSG00000047907.
ENSMUST00000109159; ENSMUSP00000104787; ENSMUSG00000047907.
GeneIDi228911.
KEGGimmu:228911.
UCSCiuc008obo.2. mouse.

Organism-specific databases

CTDi128553.
MGIiMGI:2153084. Tshz2.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IJ7P. Eukaryota.
ENOG4110HP7. LUCA.
GeneTreeiENSGT00390000014977.
HOGENOMiHOG000231480.
HOVERGENiHBG079626.
InParanoidiQ68FE9.
KOiK09236.
OMAiLFQTSEG.
OrthoDBiEOG7NPFSF.
PhylomeDBiQ68FE9.
TreeFamiTF328447.

Miscellaneous databases

ChiTaRSiTshz2. mouse.
PROiQ68FE9.
SOURCEiSearch...

Gene expression databases

BgeeiQ68FE9.
CleanExiMM_TSHZ2.
ExpressionAtlasiQ68FE9. baseline and differential.
GenevisibleiQ68FE9. MM.

Family and domain databases

InterProiIPR001356. Homeobox_dom.
IPR027008. Teashirt_fam.
IPR027010. Tshz2.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PANTHERiPTHR12487. PTHR12487. 1 hit.
PTHR12487:SF3. PTHR12487:SF3. 1 hit.
SMARTiSM00389. HOX. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal brain.
  3. "Vertebrate orthologues of the Drosophila region-specific patterning gene teashirt."
    Caubit X., Core N., Boned A., Kerridge S., Djabali M., Fasano L.
    Mech. Dev. 91:445-448(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 13-1030, FUNCTION.
  4. "Three putative murine Teashirt orthologues specify trunk structures in Drosophila in the same way as the Drosophila teashirt gene."
    Manfroid I., Caubit X., Kerridge S., Fasano L.
    Development 131:1065-1073(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE FUNCTION.
  5. Cited for: INTERACTION WITH APBB1.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-976, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney and Spleen.
  7. "Analysis of TSHZ2 and TSHZ3 genes in congenital pelvi-ureteric junction obstruction."
    Jenkins D., Caubit X., Dimovski A., Matevska N., Lye C.M., Cabuk F., Gucev Z., Tasic V., Fasano L., Woolf A.S.
    Nephrol. Dial. Transplant. 25:54-60(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiTSH2_MOUSE
AccessioniPrimary (citable) accession number: Q68FE9
Secondary accession number(s): Q5DTF1, Q6AXH5, Q9JL71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 11, 2004
Last modified: June 8, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.