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Protein

Autophagy-related protein 9A

Gene

Atg9a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H (By similarity). Required for carbonyl cyanide m-chlorophenylhydrazone (CCCP)-induced ATG8 family proteins lipidation, a key autophagy step.By similarity1 Publication

GO - Biological processi

  • autophagosome assembly Source: MGI
  • autophagy Source: MGI
  • innate immune response Source: MGI
  • late nucleophagy Source: GO_Central
  • mitophagy Source: GO_Central
  • negative regulation of interferon-beta production Source: MGI
  • piecemeal microautophagy of nucleus Source: GO_Central
  • protein localization to Golgi apparatus Source: MGI
  • protein localization to pre-autophagosomal structure Source: GO_Central
  • protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Autophagy, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 9A
Alternative name(s):
APG9-like 1
Gene namesi
Name:Atg9a
Synonyms:Apg9l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2138446. Atg9a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei73 – 9321HelicalSequence analysisAdd
BLAST
Transmembranei132 – 15221HelicalSequence analysisAdd
BLAST
Transmembranei290 – 31021HelicalSequence analysisAdd
BLAST
Transmembranei372 – 39221HelicalSequence analysisAdd
BLAST
Transmembranei401 – 42121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 551550Autophagy-related protein 9APRO_0000119821Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei14 – 141PhosphoserineBy similarity
Modified residuei16 – 161PhosphoserineCombined sources
Modified residuei18 – 181PhosphoserineCombined sources
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence analysis
Modified residuei524 – 5241PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ68FE2.
PaxDbiQ68FE2.
PeptideAtlasiQ68FE2.
PRIDEiQ68FE2.

PTM databases

iPTMnetiQ68FE2.
PhosphoSiteiQ68FE2.

Expressioni

Gene expression databases

CleanExiMM_ATG9A.

Interactioni

Subunit structurei

Interacts with SUPT20H.By similarity

Protein-protein interaction databases

IntActiQ68FE2. 1 interaction.
STRINGi10090.ENSMUSP00000047449.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATG9 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2173. Eukaryota.
ENOG410XQBE. LUCA.
InParanoidiQ68FE2.
KOiK17907.

Family and domain databases

InterProiIPR007241. Autophagy-rel_prot_9.
[Graphical view]
PANTHERiPTHR13038. PTHR13038. 1 hit.
PfamiPF04109. APG9. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68FE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQFDTEYQR LEASYSDSPP GEEDLLVHVA EGSKSPWHHI ENLDLFFSRV
60 70 80 90 100
YNLHQKNGFT CMLIGEMFEL MQFLFVVAFT TFLVSCVDYD ILFANKMVNH
110 120 130 140 150
SLHPTEPVKV TLPDAFLPAQ VCSARIQENG SLITILVIAG VFWIHRLIKF
160 170 180 190 200
IYNICCYWEI HSFYLHALRI PMSALPYCTW QEVQARIVQT QKEHQICIHK
210 220 230 240 250
RELTELDIYH RILRFQNYMV ALVNKSLLPL RFRLPGLGEV VFFTRGLKYN
260 270 280 290 300
FELILFWGPG SLFLNEWSLK AEYKRGGQRL ELAQRLSNRI LWIGIANFLL
310 320 330 340 350
CPLILIWQIL YAFFSYAEVL KREPGALGAR CWSLYGRCYL RHFNELEHEL
360 370 380 390 400
QSRLNRGYKP ASKYMNCFLS PLLTLLAKNG AFFAGSILAV LIALTIYDED
410 420 430 440 450
VLAVEHVLTT VTLLGVTVTV CRSFIPDQHM VFCPEQLLRV ILAHIHYMPD
460 470 480 490 500
HWQGVHLGGV AESHRHTPHS HLLPPPSGPG DHRLLPQLYG RGRGCGRHLL
510 520 530 540 550
LCSDGRSPAW PSSVAVWRAD RGLSVPASRG REDRVVAHAL CHHQSRLAAP

S
Length:551
Mass (Da):63,138
Last modified:October 11, 2004 - v1
Checksum:iBDCDBA33E0D10C26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079884 mRNA. Translation: AAH79884.1.
RefSeqiNP_001003917.2. NM_001003917.4.
NP_001275541.1. NM_001288612.1.
UniGeneiMm.238266.
Mm.491221.

Genome annotation databases

GeneIDi245860.
KEGGimmu:245860.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079884 mRNA. Translation: AAH79884.1.
RefSeqiNP_001003917.2. NM_001003917.4.
NP_001275541.1. NM_001288612.1.
UniGeneiMm.238266.
Mm.491221.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ68FE2. 1 interaction.
STRINGi10090.ENSMUSP00000047449.

PTM databases

iPTMnetiQ68FE2.
PhosphoSiteiQ68FE2.

Proteomic databases

MaxQBiQ68FE2.
PaxDbiQ68FE2.
PeptideAtlasiQ68FE2.
PRIDEiQ68FE2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi245860.
KEGGimmu:245860.

Organism-specific databases

CTDi79065.
MGIiMGI:2138446. Atg9a.

Phylogenomic databases

eggNOGiKOG2173. Eukaryota.
ENOG410XQBE. LUCA.
InParanoidiQ68FE2.
KOiK17907.

Miscellaneous databases

ChiTaRSiAtg9a. mouse.
PROiQ68FE2.
SOURCEiSearch...

Gene expression databases

CleanExiMM_ATG9A.

Family and domain databases

InterProiIPR007241. Autophagy-rel_prot_9.
[Graphical view]
PANTHERiPTHR13038. PTHR13038. 1 hit.
PfamiPF04109. APG9. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATG9A_MOUSE
AccessioniPrimary (citable) accession number: Q68FE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: October 11, 2004
Last modified: September 7, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Isoform displayed in this entry matches to human isoform 3.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.