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Protein

Folliculin-interacting protein 1

Gene

Fnip1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular response to starvation Source: MGI
  • immature B cell differentiation Source: MGI
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  • negative regulation of TOR signaling Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • positive regulation of B cell apoptotic process Source: MGI
  • positive regulation of GTPase activity Source: MGI
  • positive regulation of peptidyl-serine phosphorylation Source: MGI
  • positive regulation of protein complex assembly Source: MGI
  • positive regulation of protein phosphorylation Source: UniProtKB
  • regulation of pro-B cell differentiation Source: MGI
  • regulation of protein phosphorylation Source: UniProtKB
  • TOR signaling Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Folliculin-interacting protein 1
Gene namesi
Name:Fnip1
Synonyms:Kiaa1961
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2444668. Fnip1.

Subcellular locationi

  • Cytoplasm By similarity

  • Note: Colocalizes with FLCN in the cytoplasm.By similarity

GO - Cellular componenti

  • cytoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11651165Folliculin-interacting protein 1PRO_0000308485Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei220 – 2201PhosphoserineBy similarity
Modified residuei593 – 5931PhosphoserineCombined sources
Modified residuei594 – 5941PhosphoserineCombined sources
Modified residuei760 – 7601PhosphoserineCombined sources
Modified residuei763 – 7631PhosphoserineCombined sources
Modified residuei907 – 9071PhosphoserineCombined sources
Modified residuei940 – 9401PhosphoserineCombined sources

Post-translational modificationi

Phosphorylated by AMPK.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ68FD7.
MaxQBiQ68FD7.
PaxDbiQ68FD7.
PRIDEiQ68FD7.

PTM databases

iPTMnetiQ68FD7.
PhosphoSiteiQ68FD7.

Expressioni

Gene expression databases

BgeeiQ68FD7.
CleanExiMM_FNIP1.
ExpressionAtlasiQ68FD7. baseline and differential.
GenevisibleiQ68FD7. MM.

Interactioni

Subunit structurei

Forms homomultimers and heteromultimers with FNIP2. Interacts with FLCN (via C-terminus), with HSPCA and with the PRKAA1, PRKAB1 and PRKAG1 subunits of 5'-AMP-activated protein kinase (AMPK). Phosphorylated FLCN and AMPK are preferentially bound (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
FlcnQ8QZS33EBI-6911068,EBI-6911093

Protein-protein interaction databases

IntActiQ68FD7. 1 interaction.
STRINGi10090.ENSMUSP00000049026.

Structurei

3D structure databases

ProteinModelPortaliQ68FD7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi96 – 994Poly-Ser

Sequence similaritiesi

Belongs to the FNIP family.Curated

Phylogenomic databases

eggNOGiKOG3693. Eukaryota.
ENOG410ZIEC. LUCA.
GeneTreeiENSGT00390000009391.
HOGENOMiHOG000112624.
HOVERGENiHBG059425.
InParanoidiQ68FD7.
OMAiRTPNCNC.
OrthoDBiEOG7JMGCQ.
PhylomeDBiQ68FD7.
TreeFamiTF324090.

Family and domain databases

InterProiIPR028086. FNIP_C_dom.
IPR026156. FNIP_fam.
IPR028085. FNIP_mid_dom.
IPR028084. FNIP_N_dom.
[Graphical view]
PANTHERiPTHR21634. PTHR21634. 1 hit.
PfamiPF14638. FNIP_C. 1 hit.
PF14637. FNIP_M. 1 hit.
PF14636. FNIP_N. 1 hit.
[Graphical view]
PRINTSiPR02073. FOLLICULNIP1.

Sequencei

Sequence statusi: Complete.

Q68FD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPTLFQKLF SKRSGLGAPG RDARDPDCAF SWPLPEFDPS QIRLIVYQDC
60 70 80 90 100
ERRGRNVLFD SSVKRKNEDT SVSKLCNDAQ VKVFGKCCQL KPGGDSSSSL
110 120 130 140 150
DSSITLSSDG KDQCPKYQGS RCSSDANMLG EMMFGSVAMS YKGSTLKIHQ
160 170 180 190 200
IRSPPQLMLS KVFTARTGSS ICGSLNTLQD SLEFINQDSN TLKADSSTVS
210 220 230 240 250
NGLLGNIGLS QFCSPRRAFS EQGPLRLIRS ASFFAVHSNP MDMPGRELNE
260 270 280 290 300
DRDSGIARSA SLSSLFITPF PSPNSSLTRS CASSYQRRWR RSQTTSLENG
310 320 330 340 350
VFPRWSVEES FNLSDESCGP NPGIVRKKKI AIGVIFSLSK DEDENNKFNE
360 370 380 390 400
FFFSHFPLFE SHMNKLKSAI EQAMKMSRRS ADASQRSLAY NRILDALTEF
410 420 430 440 450
RTTICNLYTM PRIGEPVWLT MMSGTPEKNQ LCHRFMKEFT FLMENASKNQ
460 470 480 490 500
FLPALITAVL TNHLAWVPTV MPNGQPPIKI FLEKHSSQSV GMLAKTHPYN
510 520 530 540 550
PLWAQLGDLY GAIGSPVRLA RTVVVGKRQD LVQRLLYFLT YFIRCSELQE
560 570 580 590 600
THLLENGEDE AIVMPGTVIT TTLEKGEIEE SEYVLITMHR NKSSLLFKES
610 620 630 640 650
EETRTPNCNC KYCSHPVLGQ NTENVSQPER EDTQDNSKEL LGISDECQKI
660 670 680 690 700
SPPDCQEENA VDVQQYRDKL RTCLDTKLET VVCTGSAPAD KCVLSETCLE
710 720 730 740 750
PREESWQNKE LLDSDNHTGT AMRPTGIVVE KKPPDKNVPS AFSCEVTQTK
760 770 780 790 800
VTFLIGDSMS PDSDTELRSQ AVVDQINRHH SEPLKEDRGV ADKHQESKIT
810 820 830 840 850
KDQSEDSDTQ NIVSGESCEL PCWSHSDPES MSLFDEYFND DSIETRTIDD
860 870 880 890 900
VPVKTSTDSK EYCCMLEYPK RLYTKTNKQK SELCKCIETV HQDSCNACFP
910 920 930 940 950
QQDQRNSLSI LVPHGDKESS DKKNAVGTEW DIPRNESSDS ALGDSESEDT
960 970 980 990 1000
GPDIRRQAGG YCGGDQEDWT EEDEIPFPGS KLIEVSAVQP NIANFGRSLL
1010 1020 1030 1040 1050
GGYCSSYVPD FVLQGIGNDE RLRQCLVSDL SHAVQHPVLD EPIAEAVCII
1060 1070 1080 1090 1100
ADMDKWTVQV ASSQRRVTDN KLGKEVLVSS LVSNLLHSTL QLYKHNLSPN
1110 1120 1130 1140 1150
FCVMHLEDRL QELYFKSKML SEYLRGQMRV HVKELGVVLG IESSDLPLLA
1160
AVASTHSPYV AQILL
Length:1,165
Mass (Da):130,126
Last modified:October 11, 2004 - v1
Checksum:iA03A39AC2FB53D29
GO

Sequence cautioni

The sequence BAC33163.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC65856.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122574 mRNA. Translation: BAC65856.1. Different initiation.
AL596127 Genomic DNA. Translation: CAI51903.1.
BC079892 mRNA. Translation: AAH79892.1.
AK047814 mRNA. Translation: BAC33163.1. Different initiation.
CCDSiCCDS24698.1.
RefSeqiNP_776114.2. NM_173753.4.
UniGeneiMm.34087.

Genome annotation databases

EnsembliENSMUST00000046835; ENSMUSP00000049026; ENSMUSG00000035992.
GeneIDi216742.
KEGGimmu:216742.
UCSCiuc007ixx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122574 mRNA. Translation: BAC65856.1. Different initiation.
AL596127 Genomic DNA. Translation: CAI51903.1.
BC079892 mRNA. Translation: AAH79892.1.
AK047814 mRNA. Translation: BAC33163.1. Different initiation.
CCDSiCCDS24698.1.
RefSeqiNP_776114.2. NM_173753.4.
UniGeneiMm.34087.

3D structure databases

ProteinModelPortaliQ68FD7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ68FD7. 1 interaction.
STRINGi10090.ENSMUSP00000049026.

PTM databases

iPTMnetiQ68FD7.
PhosphoSiteiQ68FD7.

Proteomic databases

EPDiQ68FD7.
MaxQBiQ68FD7.
PaxDbiQ68FD7.
PRIDEiQ68FD7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046835; ENSMUSP00000049026; ENSMUSG00000035992.
GeneIDi216742.
KEGGimmu:216742.
UCSCiuc007ixx.2. mouse.

Organism-specific databases

CTDi96459.
MGIiMGI:2444668. Fnip1.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3693. Eukaryota.
ENOG410ZIEC. LUCA.
GeneTreeiENSGT00390000009391.
HOGENOMiHOG000112624.
HOVERGENiHBG059425.
InParanoidiQ68FD7.
OMAiRTPNCNC.
OrthoDBiEOG7JMGCQ.
PhylomeDBiQ68FD7.
TreeFamiTF324090.

Miscellaneous databases

ChiTaRSiFnip1. mouse.
PROiQ68FD7.
SOURCEiSearch...

Gene expression databases

BgeeiQ68FD7.
CleanExiMM_FNIP1.
ExpressionAtlasiQ68FD7. baseline and differential.
GenevisibleiQ68FD7. MM.

Family and domain databases

InterProiIPR028086. FNIP_C_dom.
IPR026156. FNIP_fam.
IPR028085. FNIP_mid_dom.
IPR028084. FNIP_N_dom.
[Graphical view]
PANTHERiPTHR21634. PTHR21634. 1 hit.
PfamiPF14638. FNIP_C. 1 hit.
PF14637. FNIP_M. 1 hit.
PF14636. FNIP_N. 1 hit.
[Graphical view]
PRINTSiPR02073. FOLLICULNIP1.
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Corpus striatum.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 882-1165.
    Strain: C57BL/6J.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  7. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-760; SER-763 AND SER-907, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-593; SER-594; SER-760; SER-763 AND SER-940, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Heart, Kidney, Spleen and Testis.

Entry informationi

Entry nameiFNIP1_MOUSE
AccessioniPrimary (citable) accession number: Q68FD7
Secondary accession number(s): Q80T72, Q8BQM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 11, 2004
Last modified: June 8, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.