Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q68FD7 (FNIP1_MOUSE)

UniProt

Q68FD7 - FNIP1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Folliculin-interacting protein 1

Gene

Fnip1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular response to starvation Source: MGI
  • immature B cell differentiation Source: MGI
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  • negative regulation of TOR signaling Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • positive regulation of B cell apoptotic process Source: MGI
  • positive regulation of peptidyl-serine phosphorylation Source: MGI
  • positive regulation of protein complex assembly Source: MGI
  • positive regulation of protein phosphorylation Source: UniProtKB
  • regulation of pro-B cell differentiation Source: MGI
  • regulation of protein phosphorylation Source: UniProtKB
  • TOR signaling Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Folliculin-interacting protein 1
Gene namesi
Name:Fnip1
Synonyms:Kiaa1961
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2444668. Fnip1.

Subcellular locationi

  • Cytoplasm By similarity

    • Note: Colocalizes with FLCN in the cytoplasm.By similarity

GO - Cellular componenti

  • cytoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11651165Folliculin-interacting protein 1PRO_0000308485Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei220 – 2201PhosphoserineBy similarity
Modified residuei294 – 2941PhosphothreonineBy similarity
Modified residuei296 – 2961PhosphoserineBy similarity
Modified residuei593 – 5931PhosphoserineCombined sources
Modified residuei594 – 5941PhosphoserineCombined sources
Modified residuei760 – 7601PhosphoserineCombined sources
Modified residuei763 – 7631PhosphoserineCombined sources
Modified residuei907 – 9071PhosphoserineCombined sources
Modified residuei940 – 9401PhosphoserineCombined sources

Post-translational modificationi

Phosphorylated by AMPK.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ68FD7.
PaxDbiQ68FD7.
PeptideAtlasiQ68FD7.
PRIDEiQ68FD7.

PTM databases

iPTMnetiQ68FD7.
PhosphoSiteiQ68FD7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000035992.
CleanExiMM_FNIP1.
ExpressionAtlasiQ68FD7. baseline and differential.
GenevisibleiQ68FD7. MM.

Interactioni

Subunit structurei

Forms homomultimers and heteromultimers with FNIP2. Interacts with FLCN (via C-terminus), with HSPCA and with the PRKAA1, PRKAB1 and PRKAG1 subunits of 5'-AMP-activated protein kinase (AMPK). Phosphorylated FLCN and AMPK are preferentially bound (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
FlcnQ8QZS33EBI-6911068,EBI-6911093

Protein-protein interaction databases

IntActiQ68FD7. 1 interaction.
STRINGi10090.ENSMUSP00000049026.

Structurei

3D structure databases

ProteinModelPortaliQ68FD7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi96 – 994Poly-Ser

Sequence similaritiesi

Belongs to the FNIP family.Curated

Phylogenomic databases

eggNOGiKOG3693. Eukaryota.
ENOG410ZIEC. LUCA.
GeneTreeiENSGT00390000009391.
HOGENOMiHOG000112624.
HOVERGENiHBG059425.
InParanoidiQ68FD7.
OMAiPNCNCKY.
OrthoDBiEOG091G016D.
PhylomeDBiQ68FD7.
TreeFamiTF324090.

Family and domain databases

InterProiIPR028086. FNIP_C_dom.
IPR026156. FNIP_fam.
IPR028085. FNIP_mid_dom.
IPR028084. FNIP_N_dom.
[Graphical view]
PANTHERiPTHR21634. PTHR21634. 1 hit.
PfamiPF14638. FNIP_C. 1 hit.
PF14637. FNIP_M. 1 hit.
PF14636. FNIP_N. 1 hit.
[Graphical view]
PRINTSiPR02073. FOLLICULNIP1.

Sequencei

Sequence statusi: Complete.

Q68FD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPTLFQKLF SKRSGLGAPG RDARDPDCAF SWPLPEFDPS QIRLIVYQDC 
        60         70         80         90        100
ERRGRNVLFD SSVKRKNEDT SVSKLCNDAQ VKVFGKCCQL KPGGDSSSSL 
       110        120        130        140        150
DSSITLSSDG KDQCPKYQGS RCSSDANMLG EMMFGSVAMS YKGSTLKIHQ 
       160        170        180        190        200
IRSPPQLMLS KVFTARTGSS ICGSLNTLQD SLEFINQDSN TLKADSSTVS 
       210        220        230        240        250
NGLLGNIGLS QFCSPRRAFS EQGPLRLIRS ASFFAVHSNP MDMPGRELNE 
       260        270        280        290        300
DRDSGIARSA SLSSLFITPF PSPNSSLTRS CASSYQRRWR RSQTTSLENG 
       310        320        330        340        350
VFPRWSVEES FNLSDESCGP NPGIVRKKKI AIGVIFSLSK DEDENNKFNE 
       360        370        380        390        400
FFFSHFPLFE SHMNKLKSAI EQAMKMSRRS ADASQRSLAY NRILDALTEF 
       410        420        430        440        450
RTTICNLYTM PRIGEPVWLT MMSGTPEKNQ LCHRFMKEFT FLMENASKNQ 
       460        470        480        490        500
FLPALITAVL TNHLAWVPTV MPNGQPPIKI FLEKHSSQSV GMLAKTHPYN 
       510        520        530        540        550
PLWAQLGDLY GAIGSPVRLA RTVVVGKRQD LVQRLLYFLT YFIRCSELQE 
       560        570        580        590        600
THLLENGEDE AIVMPGTVIT TTLEKGEIEE SEYVLITMHR NKSSLLFKES 
       610        620        630        640        650
EETRTPNCNC KYCSHPVLGQ NTENVSQPER EDTQDNSKEL LGISDECQKI 
       660        670        680        690        700
SPPDCQEENA VDVQQYRDKL RTCLDTKLET VVCTGSAPAD KCVLSETCLE 
       710        720        730        740        750
PREESWQNKE LLDSDNHTGT AMRPTGIVVE KKPPDKNVPS AFSCEVTQTK 
       760        770        780        790        800
VTFLIGDSMS PDSDTELRSQ AVVDQINRHH SEPLKEDRGV ADKHQESKIT 
       810        820        830        840        850
KDQSEDSDTQ NIVSGESCEL PCWSHSDPES MSLFDEYFND DSIETRTIDD 
       860        870        880        890        900
VPVKTSTDSK EYCCMLEYPK RLYTKTNKQK SELCKCIETV HQDSCNACFP 
       910        920        930        940        950
QQDQRNSLSI LVPHGDKESS DKKNAVGTEW DIPRNESSDS ALGDSESEDT 
       960        970        980        990       1000
GPDIRRQAGG YCGGDQEDWT EEDEIPFPGS KLIEVSAVQP NIANFGRSLL 
      1010       1020       1030       1040       1050
GGYCSSYVPD FVLQGIGNDE RLRQCLVSDL SHAVQHPVLD EPIAEAVCII 
      1060       1070       1080       1090       1100
ADMDKWTVQV ASSQRRVTDN KLGKEVLVSS LVSNLLHSTL QLYKHNLSPN 
      1110       1120       1130       1140       1150
FCVMHLEDRL QELYFKSKML SEYLRGQMRV HVKELGVVLG IESSDLPLLA 
      1160 
AVASTHSPYV AQILL
Length:1,165
Mass (Da):130,126
Last modified:October 11, 2004 - v1
Checksum:iA03A39AC2FB53D29
GO

Sequence cautioni

The sequence BAC33163 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC65856 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122574 mRNA. Translation: BAC65856.1. Different initiation.
AL596127 Genomic DNA. Translation: CAI51903.1.
BC079892 mRNA. Translation: AAH79892.1.
AK047814 mRNA. Translation: BAC33163.1. Different initiation.
CCDSiCCDS24698.1.
RefSeqiNP_776114.2. NM_173753.4.
UniGeneiMm.34087.

Genome annotation databases

EnsembliENSMUST00000046835; ENSMUSP00000049026; ENSMUSG00000035992.
GeneIDi216742.
KEGGimmu:216742.
UCSCiuc007ixx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122574 mRNA. Translation: BAC65856.1. Different initiation.
AL596127 Genomic DNA. Translation: CAI51903.1.
BC079892 mRNA. Translation: AAH79892.1.
AK047814 mRNA. Translation: BAC33163.1. Different initiation.
CCDSiCCDS24698.1.
RefSeqiNP_776114.2. NM_173753.4.
UniGeneiMm.34087.

3D structure databases

ProteinModelPortaliQ68FD7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ68FD7. 1 interaction.
STRINGi10090.ENSMUSP00000049026.

PTM databases

iPTMnetiQ68FD7.
PhosphoSiteiQ68FD7.

Proteomic databases

MaxQBiQ68FD7.
PaxDbiQ68FD7.
PeptideAtlasiQ68FD7.
PRIDEiQ68FD7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046835; ENSMUSP00000049026; ENSMUSG00000035992.
GeneIDi216742.
KEGGimmu:216742.
UCSCiuc007ixx.2. mouse.

Organism-specific databases

CTDi96459.
MGIiMGI:2444668. Fnip1.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3693. Eukaryota.
ENOG410ZIEC. LUCA.
GeneTreeiENSGT00390000009391.
HOGENOMiHOG000112624.
HOVERGENiHBG059425.
InParanoidiQ68FD7.
OMAiPNCNCKY.
OrthoDBiEOG091G016D.
PhylomeDBiQ68FD7.
TreeFamiTF324090.

Miscellaneous databases

ChiTaRSiFnip1. mouse.
PROiQ68FD7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035992.
CleanExiMM_FNIP1.
ExpressionAtlasiQ68FD7. baseline and differential.
GenevisibleiQ68FD7. MM.

Family and domain databases

InterProiIPR028086. FNIP_C_dom.
IPR026156. FNIP_fam.
IPR028085. FNIP_mid_dom.
IPR028084. FNIP_N_dom.
[Graphical view]
PANTHERiPTHR21634. PTHR21634. 1 hit.
PfamiPF14638. FNIP_C. 1 hit.
PF14637. FNIP_M. 1 hit.
PF14636. FNIP_N. 1 hit.
[Graphical view]
PRINTSiPR02073. FOLLICULNIP1.
ProtoNetiSearch...

Entry informationi

Entry nameiFNIP1_MOUSE
AccessioniPrimary (citable) accession number: Q68FD7
Secondary accession number(s): Q80T72, Q8BQM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 11, 2004
Last modified: September 7, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.