UniProtKB - Q68FD7 (FNIP1_MOUSE)
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Protein
Folliculin-interacting protein 1
Gene
Fnip1
Organism
Mus musculus (Mouse)
Status
Functioni
Acts as a co-chaperone of HSP90AA1. Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. Facilitates the binding of client protein FLCN to HSP90AA1. Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1.By similarity
GO - Molecular functioni
- ATPase inhibitor activity Source: UniProtKB
- chaperone binding Source: UniProtKB
- guanyl-nucleotide exchange factor activity Source: UniProtKB
GO - Biological processi
- cellular response to starvation Source: MGI
- immature B cell differentiation Source: MGI
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
- negative regulation of TOR signaling Source: MGI
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of B cell apoptotic process Source: MGI
- positive regulation of peptidyl-serine phosphorylation Source: MGI
- positive regulation of protein complex assembly Source: MGI
- positive regulation of protein phosphorylation Source: UniProtKB
- regulation of pro-B cell differentiation Source: MGI
- regulation of protein phosphorylation Source: UniProtKB
- TOR signaling Source: UniProtKB
Names & Taxonomyi
Protein namesi | Recommended name: Folliculin-interacting protein 1 |
Gene namesi | Name:Fnip1 Synonyms:Kiaa1961 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2444668. Fnip1. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000308485 | 1 – 1165 | Folliculin-interacting protein 1Add BLAST | 1165 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 220 | PhosphoserineBy similarity | 1 | |
Modified residuei | 294 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 296 | PhosphoserineBy similarity | 1 | |
Modified residuei | 593 | PhosphoserineCombined sources | 1 | |
Modified residuei | 594 | PhosphoserineCombined sources | 1 | |
Modified residuei | 760 | PhosphoserineCombined sources | 1 | |
Modified residuei | 763 | PhosphoserineCombined sources | 1 | |
Modified residuei | 907 | PhosphoserineCombined sources | 1 | |
Modified residuei | 940 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylated by AMPK.By similarity
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | Q68FD7. |
PaxDbi | Q68FD7. |
PeptideAtlasi | Q68FD7. |
PRIDEi | Q68FD7. |
PTM databases
iPTMneti | Q68FD7. |
PhosphoSitePlusi | Q68FD7. |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000035992. |
CleanExi | MM_FNIP1. |
ExpressionAtlasi | Q68FD7. baseline and differential. |
Genevisiblei | Q68FD7. MM. |
Interactioni
Subunit structurei
Homodimer and homomultimer. Heterodimer and heteromultimer with FNIP2. Interacts with FLCN (via C-terminus). Interacts with HSPCA and with the PRKAA1, PRKAB1 and PRKAG1 subunits of 5'-AMP-activated protein kinase (AMPK). Phosphorylated FLCN and AMPK are preferentially bound. Interacts with HSP70, STIP1, PTGES3, CDC37, BRAF, GCR and CDK4. Interacts with HSP90AA1; the interaction inhibits HSP90AA1 ATPase activity.By similarity
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
Flcn | Q8QZS3 | 3 | EBI-6911068,EBI-6911093 |
GO - Molecular functioni
- chaperone binding Source: UniProtKB
- guanyl-nucleotide exchange factor activity Source: UniProtKB
Protein-protein interaction databases
IntActi | Q68FD7. 1 interactor. |
STRINGi | 10090.ENSMUSP00000049026. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 37 – 478 | uDENN FNIP1/2-typePROSITE-ProRule annotationAdd BLAST | 442 | |
Domaini | 486 – 1091 | cDENN FNIP1/2-typePROSITE-ProRule annotationAdd BLAST | 606 | |
Domaini | 1101 – 1156 | dDENN FNIP1/2-typePROSITE-ProRule annotationAdd BLAST | 56 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 928 – 1165 | Interaction with HSP90AA1By similarityAdd BLAST | 238 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 96 – 99 | Poly-Ser | 4 |
Sequence similaritiesi
Belongs to the FNIP family.Curated
Phylogenomic databases
eggNOGi | KOG3693. Eukaryota. ENOG410ZIEC. LUCA. |
GeneTreei | ENSGT00390000009391. |
HOGENOMi | HOG000112624. |
HOVERGENi | HBG059425. |
InParanoidi | Q68FD7. |
KOi | K20400. |
OMAi | PNCNCKY. |
OrthoDBi | EOG091G016D. |
PhylomeDBi | Q68FD7. |
TreeFami | TF324090. |
Family and domain databases
InterProi | View protein in InterPro IPR037545. DENN_FNIP1/2. IPR028086. FNIP_C_dom. IPR026156. FNIP_fam. IPR028085. FNIP_mid_dom. IPR028084. FNIP_N_dom. |
PANTHERi | PTHR21634. PTHR21634. 1 hit. |
Pfami | View protein in Pfam PF14638. FNIP_C. 1 hit. PF14637. FNIP_M. 1 hit. PF14636. FNIP_N. 1 hit. |
PRINTSi | PR02073. FOLLICULNIP1. |
PROSITEi | View protein in PROSITE PS51836. DENN_FNIP12. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q68FD7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPTLFQKLF SKRSGLGAPG RDARDPDCAF SWPLPEFDPS QIRLIVYQDC
60 70 80 90 100
ERRGRNVLFD SSVKRKNEDT SVSKLCNDAQ VKVFGKCCQL KPGGDSSSSL
110 120 130 140 150
DSSITLSSDG KDQCPKYQGS RCSSDANMLG EMMFGSVAMS YKGSTLKIHQ
160 170 180 190 200
IRSPPQLMLS KVFTARTGSS ICGSLNTLQD SLEFINQDSN TLKADSSTVS
210 220 230 240 250
NGLLGNIGLS QFCSPRRAFS EQGPLRLIRS ASFFAVHSNP MDMPGRELNE
260 270 280 290 300
DRDSGIARSA SLSSLFITPF PSPNSSLTRS CASSYQRRWR RSQTTSLENG
310 320 330 340 350
VFPRWSVEES FNLSDESCGP NPGIVRKKKI AIGVIFSLSK DEDENNKFNE
360 370 380 390 400
FFFSHFPLFE SHMNKLKSAI EQAMKMSRRS ADASQRSLAY NRILDALTEF
410 420 430 440 450
RTTICNLYTM PRIGEPVWLT MMSGTPEKNQ LCHRFMKEFT FLMENASKNQ
460 470 480 490 500
FLPALITAVL TNHLAWVPTV MPNGQPPIKI FLEKHSSQSV GMLAKTHPYN
510 520 530 540 550
PLWAQLGDLY GAIGSPVRLA RTVVVGKRQD LVQRLLYFLT YFIRCSELQE
560 570 580 590 600
THLLENGEDE AIVMPGTVIT TTLEKGEIEE SEYVLITMHR NKSSLLFKES
610 620 630 640 650
EETRTPNCNC KYCSHPVLGQ NTENVSQPER EDTQDNSKEL LGISDECQKI
660 670 680 690 700
SPPDCQEENA VDVQQYRDKL RTCLDTKLET VVCTGSAPAD KCVLSETCLE
710 720 730 740 750
PREESWQNKE LLDSDNHTGT AMRPTGIVVE KKPPDKNVPS AFSCEVTQTK
760 770 780 790 800
VTFLIGDSMS PDSDTELRSQ AVVDQINRHH SEPLKEDRGV ADKHQESKIT
810 820 830 840 850
KDQSEDSDTQ NIVSGESCEL PCWSHSDPES MSLFDEYFND DSIETRTIDD
860 870 880 890 900
VPVKTSTDSK EYCCMLEYPK RLYTKTNKQK SELCKCIETV HQDSCNACFP
910 920 930 940 950
QQDQRNSLSI LVPHGDKESS DKKNAVGTEW DIPRNESSDS ALGDSESEDT
960 970 980 990 1000
GPDIRRQAGG YCGGDQEDWT EEDEIPFPGS KLIEVSAVQP NIANFGRSLL
1010 1020 1030 1040 1050
GGYCSSYVPD FVLQGIGNDE RLRQCLVSDL SHAVQHPVLD EPIAEAVCII
1060 1070 1080 1090 1100
ADMDKWTVQV ASSQRRVTDN KLGKEVLVSS LVSNLLHSTL QLYKHNLSPN
1110 1120 1130 1140 1150
FCVMHLEDRL QELYFKSKML SEYLRGQMRV HVKELGVVLG IESSDLPLLA
1160
AVASTHSPYV AQILL
Sequence cautioni
The sequence BAC33163 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC65856 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK122574 mRNA. Translation: BAC65856.1. Different initiation. AL596127 Genomic DNA. No translation available. BC079892 mRNA. Translation: AAH79892.1. AK047814 mRNA. Translation: BAC33163.1. Different initiation. |
CCDSi | CCDS24698.1. |
RefSeqi | NP_776114.2. NM_173753.4. |
UniGenei | Mm.34087. |
Genome annotation databases
Ensembli | ENSMUST00000046835; ENSMUSP00000049026; ENSMUSG00000035992. |
GeneIDi | 216742. |
KEGGi | mmu:216742. |
UCSCi | uc007ixx.2. mouse. |
Similar proteinsi
Entry informationi
Entry namei | FNIP1_MOUSE | |
Accessioni | Q68FD7Primary (citable) accession number: Q68FD7 Secondary accession number(s): Q80T72, Q8BQM0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 23, 2007 |
Last sequence update: | October 11, 2004 | |
Last modified: | March 28, 2018 | |
This is version 98 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |