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Q68FD5

- CLH1_MOUSE

UniProt

Q68FD5 - CLH1_MOUSE

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Protein
Clathrin heavy chain 1
Gene
Cltc
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network By similarity.

GO - Molecular functioni

  1. double-stranded RNA binding Source: MGI
  2. structural molecule activity Source: InterPro

GO - Biological processi

  1. intracellular protein transport Source: InterPro
  2. negative regulation of hyaluronan biosynthetic process Source: UniProtKB
  3. receptor internalization Source: Ensembl
  4. spindle assembly involved in mitosis Source: MGI
  5. transferrin transport Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_196550. MHC class II antigen presentation.
REACT_222404. WNT5A-dependent internalization of FZD4.

Names & Taxonomyi

Protein namesi
Recommended name:
Clathrin heavy chain 1
Gene namesi
Name:Cltc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2388633. Cltc.

Subcellular locationi

Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Membranecoated pit; Peripheral membrane protein; Cytoplasmic side By similarity. Melanosome By similarity
Note: Cytoplasmic face of coated pits and vesicles By similarity.

GO - Cellular componenti

  1. Myb complex Source: MGI
  2. clathrin coat of coated pit Source: InterPro
  3. clathrin coat of trans-Golgi network vesicle Source: InterPro
  4. clathrin complex Source: Ensembl
  5. extracellular vesicular exosome Source: Ensembl
  6. melanosome Source: UniProtKB-SubCell
  7. membrane coat Source: MGI
  8. mitochondrion Source: MGI
  9. protein complex Source: MGI
  10. spindle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Coated pit, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 16751674Clathrin heavy chain 1
PRO_0000205779Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei184 – 1841Phosphotyrosine1 Publication
Modified residuei394 – 3941Phosphothreonine By similarity
Modified residuei634 – 6341Phosphotyrosine1 Publication
Modified residuei737 – 7371N6-succinyllysine1 Publication
Modified residuei856 – 8561N6-acetyllysine By similarity
Modified residuei899 – 8991Phosphotyrosine1 Publication
Modified residuei1206 – 12061Phosphotyrosine1 Publication
Modified residuei1441 – 14411N6-acetyllysine; alternate By similarity
Modified residuei1441 – 14411N6-succinyllysine; alternate1 Publication
Modified residuei1477 – 14771Phosphotyrosine1 Publication
Modified residuei1487 – 14871Phosphotyrosine1 Publication
Modified residuei1494 – 14941Phosphoserine By similarity
Modified residuei1501 – 15011N6-acetyllysine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ68FD5.
PaxDbiQ68FD5.
PRIDEiQ68FD5.

PTM databases

PhosphoSiteiQ68FD5.

Expressioni

Gene expression databases

ArrayExpressiQ68FD5.
BgeeiQ68FD5.
CleanExiMM_CLTC.
GenevestigatoriQ68FD5.

Interactioni

Subunit structurei

Clathrin triskelions, composed of 3 heavy chains and 3 light chains, are the basic subunits of the clathrin coat. In the presence of light chains, hub assembly is influenced by both the pH and the concentration of calcium. Interacts with HIP1 By similarity. Interacts with DENND1A, DENND1B and DENND1C. Interacts with ERBB2. Interacts with FKBP6 By similarity. Interacts with OCRL.1 Publication

Protein-protein interaction databases

BioGridi212086. 12 interactions.
DIPiDIP-31947N.
IntActiQ68FD5. 23 interactions.
MINTiMINT-4153227.

Structurei

3D structure databases

ProteinModelPortaliQ68FD5.
SMRiQ68FD5. Positions 1-493, 1077-1630.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati537 – 683147CHCR 1
Add
BLAST
Repeati686 – 828143CHCR 2
Add
BLAST
Repeati833 – 972140CHCR 3
Add
BLAST
Repeati979 – 1124146CHCR 4
Add
BLAST
Repeati1128 – 1269142CHCR 5
Add
BLAST
Repeati1274 – 1420147CHCR 6
Add
BLAST
Repeati1423 – 1566144CHCR 7
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 479478Globular terminal domain
Add
BLAST
Regioni24 – 6744WD40-like repeat 1
Add
BLAST
Regioni68 – 10740WD40-like repeat 2
Add
BLAST
Regioni108 – 14942WD40-like repeat 3
Add
BLAST
Regioni150 – 19546WD40-like repeat 4
Add
BLAST
Regioni196 – 25762WD40-like repeat 5
Add
BLAST
Regioni258 – 30144WD40-like repeat 6
Add
BLAST
Regioni302 – 33029WD40-like repeat 7
Add
BLAST
Regioni449 – 46517Binding site for the uncoating ATPase, involved in lattice disassembly Reviewed prediction
Add
BLAST
Regioni480 – 52344Flexible linker
Add
BLAST
Regioni524 – 16751152Heavy chain arm
Add
BLAST
Regioni524 – 634111Distal segment
Add
BLAST
Regioni639 – 16751037Proximal segment
Add
BLAST
Regioni1213 – 1522310Involved in binding clathrin light chain By similarity
Add
BLAST
Regioni1550 – 1675126Trimerization By similarity
Add
BLAST

Domaini

The N-terminal seven-bladed beta-propeller is formed by WD40-like repeats, and projects inward from the polyhedral outer clathrin coat. It consitutes a major protein-protein interaction node By similarity.

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG314149.
GeneTreeiENSGT00400000022107.
HOVERGENiHBG005344.
KOiK04646.
OrthoDBiEOG7Z0JVM.
TreeFamiTF300059.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
2.130.10.110. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000547. Clathrin_H-chain/VPS_repeat.
IPR016025. Clathrin_H-chain_link/propller.
IPR015348. Clathrin_H-chain_linker_core.
IPR001473. Clathrin_H-chain_propeller_N.
IPR022365. Clathrin_H-chain_propeller_rpt.
IPR016341. Clathrin_heavy_chain.
IPR011990. TPR-like_helical.
[Graphical view]
PfamiPF00637. Clathrin. 7 hits.
PF09268. Clathrin-link. 1 hit.
PF01394. Clathrin_propel. 3 hits.
[Graphical view]
PIRSFiPIRSF002290. Clathrin_H_chain. 1 hit.
SMARTiSM00299. CLH. 7 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 6 hits.
SSF50989. SSF50989. 1 hit.
PROSITEiPS50236. CHCR. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68FD5-1 [UniParc]FASTAAdd to Basket

« Hide

MAQILPIRFQ EHLQLQNLGI NPANIGFSTL TMESDKFICI REKVGEQAQV     50
VIIDMNDPSN PIRRPISADS AIMNPASKVI ALKAGKTLQI FNIEMKSKMK 100
AHTMTDDVTF WKWISLNTVA LVTDNAVYHW SMEGESQPVK MFDRHSSLAG 150
CQIINYRTDA KQKWLLLTGI SAQQNRVVGA MQLYSVDRKV SQPIEGHAAS 200
FAQFKMEGNA EESTLFCFAV RGQAGGKLHI IEVGTPPTGN QPFPKKAVDV 250
FFPPEAQNDF PVAMQISEKH DVVFLITKYG YIHLYDLETG TCIYMNRISG 300
ETIFVTAPHE ATAGIIGVNR KGQVLSVCVE EENIIPYITN VLQNPDLALR 350
MAVRNNLAGA EELFARKFNA LFAQGNYSEA AKVAANAPKG ILRTPDTIRR 400
FQSVPAQPGQ TSPLLQYFGI LLDQGQLNKY ESLELCRPVL QQGRKQLLEK 450
WLKEDKLECS EELGDLVKSV DPTLALSVYL RANVPNKVIQ CFAETGQVQK 500
IVLYAKKVGY TPDWIFLLRN VMRISPDQGQ QFAQMLVQDE EPLADITQIV 550
DVFMEYNLIQ QCTAFLLDAL KNNRPSEGPL QTRLLEMNLM HAPQVADAIL 600
GNQMFTHYDR AHIAQLCEKA GLLQRALEHF TDLYDIKRAV VHTHLLNPEW 650
LVNYFGSLSV EDSLECLRAM LSANIRQNLQ ICVQVASKYH EQLSTQSLIE 700
LFESFKSFEG LFYFLGSIVN FSQDPDVHFK YIQAACKTGQ IKEVERICRE 750
SNCYDPERVK NFLKEAKLTD QLPLIIVCDR FDFVHDLVLY LYRNNLQKYI 800
EIYVQKVNPS RLPVVIGGLL DVDCSEDVIK NLILVVRGQF STDELVAEVE 850
KRNRLKLLLP WLEARIHEGC EEPATHNALA KIYIDSNNNP ERFLRENPYY 900
DSRVVGKYCE KRDPHLACVA YERGQCDLEL INVCNENSLF KSLSRYLVRR 950
KDPELWGSVL LESNPYRRPL IDQVVQTALS ETQDPEEVSV TVKAFMTADL 1000
PNELIELLEK IVLDNSVFSE HRNLQNLLIL TAIKADRTRV MEYINRLDNY 1050
DAPDIANIAI SNELFEEAFA IFRKFDVNTS AVQVLIEHIG NLDRAYEFAE 1100
RCNEPAVWSQ LAKAQLQKGM VKEAIDSYIK ADDPSSYMEV VQAANASGNW 1150
EELVKYLQMA RKKARESYVE TELIFALAKT NRLAELEEFI NGPNNAHIQQ 1200
VGDRCYDEKM YDAAKLLYNN VSNFGRLAST LVHLGEYQAA VDGARKANST 1250
RTWKEVCFAC VDGKEFRLAQ MCGLHIVVHA DELEELINYY QDRGYFEELI 1300
TMLEAALGLE RAHMGMFTEL AILYSKFKPQ KMREHLELFW SRVNIPKVLR 1350
AAEQAHLWAE LVFLYDKYEE YDNAIITMMN HPTDAWKEGQ FKDIITKVAN 1400
VELYYKAIQF YLEFKPLLLN DLLMVLSPRL DHTRAVNYFS KVKQLPLVKP 1450
YLRSVQNHNN KSVNESLNNL FITEEDYQAL RTSIDAYDNF DNISLAQRLE 1500
KHELIEFRRI AAYLFKGNNR WKQSVELCKK DSLYKDAMQY ASESKDTELA 1550
EELLQWFLQE EKRECFGACL FTCYDLLRPD VVLETAWRHN IMDFAMPYFI 1600
QVMKEYLTKV DKLDASESLR KEEEQATETQ PIVYGQPQLM LTAGPSVAVP 1650
PQAPFGYGYT APPYGQPQPG FGYSM 1675
Length:1,675
Mass (Da):191,557
Last modified:January 23, 2007 - v3
Checksum:i6C41EBD89EB7D56B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL592222 Genomic DNA. Translation: CAI25362.1.
BC079897 mRNA. Translation: AAH79897.1.
CCDSiCCDS25204.1.
RefSeqiNP_001003908.1. NM_001003908.1.
UniGeneiMm.254588.

Genome annotation databases

EnsembliENSMUST00000103186; ENSMUSP00000099475; ENSMUSG00000047126.
GeneIDi67300.
KEGGimmu:67300.
UCSCiuc007kta.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL592222 Genomic DNA. Translation: CAI25362.1 .
BC079897 mRNA. Translation: AAH79897.1 .
CCDSi CCDS25204.1.
RefSeqi NP_001003908.1. NM_001003908.1.
UniGenei Mm.254588.

3D structure databases

ProteinModelPortali Q68FD5.
SMRi Q68FD5. Positions 1-493, 1077-1630.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 212086. 12 interactions.
DIPi DIP-31947N.
IntActi Q68FD5. 23 interactions.
MINTi MINT-4153227.

PTM databases

PhosphoSitei Q68FD5.

Proteomic databases

MaxQBi Q68FD5.
PaxDbi Q68FD5.
PRIDEi Q68FD5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000103186 ; ENSMUSP00000099475 ; ENSMUSG00000047126 .
GeneIDi 67300.
KEGGi mmu:67300.
UCSCi uc007kta.1. mouse.

Organism-specific databases

CTDi 1213.
MGIi MGI:2388633. Cltc.

Phylogenomic databases

eggNOGi NOG314149.
GeneTreei ENSGT00400000022107.
HOVERGENi HBG005344.
KOi K04646.
OrthoDBi EOG7Z0JVM.
TreeFami TF300059.

Enzyme and pathway databases

Reactomei REACT_196550. MHC class II antigen presentation.
REACT_222404. WNT5A-dependent internalization of FZD4.

Miscellaneous databases

ChiTaRSi CLTC. mouse.
NextBioi 324168.
PROi Q68FD5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q68FD5.
Bgeei Q68FD5.
CleanExi MM_CLTC.
Genevestigatori Q68FD5.

Family and domain databases

Gene3Di 1.25.40.10. 4 hits.
2.130.10.110. 1 hit.
InterProi IPR016024. ARM-type_fold.
IPR000547. Clathrin_H-chain/VPS_repeat.
IPR016025. Clathrin_H-chain_link/propller.
IPR015348. Clathrin_H-chain_linker_core.
IPR001473. Clathrin_H-chain_propeller_N.
IPR022365. Clathrin_H-chain_propeller_rpt.
IPR016341. Clathrin_heavy_chain.
IPR011990. TPR-like_helical.
[Graphical view ]
Pfami PF00637. Clathrin. 7 hits.
PF09268. Clathrin-link. 1 hit.
PF01394. Clathrin_propel. 3 hits.
[Graphical view ]
PIRSFi PIRSF002290. Clathrin_H_chain. 1 hit.
SMARTi SM00299. CLH. 7 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 6 hits.
SSF50989. SSF50989. 1 hit.
PROSITEi PS50236. CHCR. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-184; TYR-634; TYR-899; TYR-1206; TYR-1477 AND TYR-1487, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  5. "Two closely related endocytic proteins that share a common OCRL-binding motif with APPL1."
    Swan L.E., Tomasini L., Pirruccello M., Lunardi J., De Camilli P.
    Proc. Natl. Acad. Sci. U.S.A. 107:3511-3516(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH OCRL.
  6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-737 AND LYS-1441, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiCLH1_MOUSE
AccessioniPrimary (citable) accession number: Q68FD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 89 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi