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Protein

Integrator complex subunit 4

Gene

ints4

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Integrator complex subunit 4
Short name:
Int4
Gene namesi
Name:ints4
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5841134 ints4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002595401 – 969Integrator complex subunit 4Add BLAST969

Proteomic databases

MaxQBiQ68F70

Interactioni

Subunit structurei

Belongs to the multiprotein complex Integrator.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ68F70
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati68 – 107HEAT 1Add BLAST40
Repeati147 – 185HEAT 2Add BLAST39
Repeati192 – 230HEAT 3Add BLAST39
Repeati231 – 265HEAT 4Add BLAST35
Repeati279 – 315HEAT 5Add BLAST37
Repeati371 – 407HEAT 6Add BLAST37
Repeati408 – 446HEAT 7Add BLAST39
Repeati448 – 486HEAT 8Add BLAST39

Sequence similaritiesi

Belongs to the Integrator subunit 4 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG081801
KOiK13141

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
SUPFAMiSSF48371 SSF48371, 3 hits

Sequencei

Sequence statusi: Complete.

Q68F70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAHLKKRVY EEFTRVVQQQ PLEEPSAKKL RLTKPSKSAA LHIDLCKATS
60 70 80 90 100
PADALQYLLQ FARKPVEAES VEGVVRILLE HYYKENDTSV RLKIASLLGL
110 120 130 140 150
LSKTAGFCPD SIVDDVINTL QNEKSHQVLA QLLDTLLEIG LKLLDIVSHR
160 170 180 190 200
MRLVDVACKH LSDTSHGVRN KCLQLLGCLG SVEASPAKEV ENAVAKDVQK
210 220 230 240 250
IIGDYFIDQD PRVRTAAIKA MLQLHERGLK LQQAMYNQAC KLLTDDYEQV
260 270 280 290 300
RSAAVELSWV LSQLYSESIV PIPSSNEEIR LVDDAFGKVC HMVSDGSWVV
310 320 330 340 350
RVQACKLLGS MLQVSPHFLE QTLDKKLMSD LRRKRTAHER AKELYSSGEF
360 370 380 390 400
SSGRKWGDDA PKEELDTGAV NLIDSGACGA FVHGLEDEMY EVRIAAVESL
410 420 430 440 450
CLLARSSAPF AEKCLDFLVD MFNDEIEEVR LQSIHTMRKI SDNITLREDQ
460 470 480 490 500
LDTVLAVLED KSRDIREALH ELLCCTNVST KECIQLALVE LLKNLSKYPT
510 520 530 540 550
DRESIWKCLK FLGSRHPTLV LSLVPELLST HPFFDTPEPD MDDPAYIAVL
560 570 580 590 600
VLIFNAAKCC PTMPALFSDH TFRHYTYLRD SLSHLVPALN LPSVRWSWIP
610 620 630 640 650
DVITEAPPED PSQQFLQLSL ERVHNLQHLG SQGTQELLEF TIRDLQRIGE
660 670 680 690 700
LQSDLAGMAD FSATYLRCHL LLTKALNEKL WNLAAPLFLK NSLTTNAVKQ
710 720 730 740 750
ILEETYKMEF MYSGLETRQV AIIHHMRLQA KALQLLVTAR TTKGAEPLFG
760 770 780 790 800
MCEEFLQEVD FFQRCFISEL PHMQDSFVDK LLDLVPRLVN SKPLEMVKIL
810 820 830 840 850
QTTLRQCTFL RLTLPEQIHR ASSHIIEPAE ESDNPIRFTS GLVVALDVDA
860 870 880 890 900
TLEHVQEPQS TVKVQVVYPD GQVQIIHPKP ADFRNPGPGR HRLITQVYLS
910 920 930 940 950
HTAWTEPCQI EVRLLLAYSS SRSKVMSRAS NSTWGESTET VPSTESSTEG
960
TIPFSKPVKV FLMPKPARR
Length:969
Mass (Da):109,256
Last modified:October 11, 2004 - v1
Checksum:i3F27196C3CE4C54A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079973 mRNA Translation: AAH79973.1
RefSeqiNP_001087469.1, NM_001094000.1
UniGeneiXl.29729

Genome annotation databases

GeneIDi447293
KEGGixla:447293

Similar proteinsi

Entry informationi

Entry nameiINT4_XENLA
AccessioniPrimary (citable) accession number: Q68F70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 11, 2004
Last modified: August 30, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

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