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Q68F50

- TWF1_XENLA

UniProt

Q68F50 - TWF1_XENLA

Protein

Twinfilin-1

Gene

twf1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin By similarity.By similarity

    GO - Biological processi

    1. negative regulation of actin filament polymerization Source: InterPro

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Twinfilin-1
    Gene namesi
    Name:twf1
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-865829. twf1.

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. cytoskeleton Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 350350Twinfilin-1PRO_0000232407Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with G-actin; ADP-actin form.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ68F50.
    SMRiQ68F50. Positions 7-138, 161-313.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 139136ADF-H 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini177 – 313137ADF-H 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 ADF-H domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    HOVERGENiHBG000848.
    KOiK08870.

    Family and domain databases

    Gene3Di3.40.20.10. 2 hits.
    InterProiIPR002108. ADF-H.
    IPR029006. ADF-H/Gelsolin-like_dom.
    IPR028458. Twinfilin.
    [Graphical view]
    PANTHERiPTHR13759. PTHR13759. 1 hit.
    PfamiPF00241. Cofilin_ADF. 2 hits.
    [Graphical view]
    SMARTiSM00102. ADF. 2 hits.
    [Graphical view]
    PROSITEiPS51263. ADF_H. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q68F50-1 [UniParc]FASTAAdd to Basket

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    MSHQTGIQAS EDVLEMFARA RNGKYRLLKL DIEDEQLTVS ACEKPTRSWE    50
    QEYDNFILPL LEDKQPCYIL YRLDSQNAQG FEWIFIAWSP DYSHVRQKML 100
    YAATRATVKK EFGGGHIKEE IFGTVKDDIS LKGYYKYLAC QSAPAPLTTA 150
    EEELRQIKIK ETPTDIAVDT KHQTLQGIAF PIEKAAFQAL EQLREKRLNY 200
    VQLKIDIKNE IIILADTTNT EVRDLPKRIP KDAARYHFFL YKHSHEGDYL 250
    DSFVFIYSMP GYTCSIRERM LYSSCKNPLL DAIENRLLME IARKIEIDNG 300
    DELTPDFLYE EVHPKQHAHK QNFAKPKGPA GKRGIRRLIR GPAEAETAND 350
    Length:350
    Mass (Da):40,454
    Last modified:October 11, 2004 - v1
    Checksum:i75654B74886ABA04
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC079994 mRNA. Translation: AAH79994.1.
    RefSeqiNP_001087483.1. NM_001094014.1.
    UniGeneiXl.15194.

    Genome annotation databases

    GeneIDi447307.
    KEGGixla:447307.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Molecular embrace - Issue 73 of August 2006

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC079994 mRNA. Translation: AAH79994.1 .
    RefSeqi NP_001087483.1. NM_001094014.1.
    UniGenei Xl.15194.

    3D structure databases

    ProteinModelPortali Q68F50.
    SMRi Q68F50. Positions 7-138, 161-313.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 447307.
    KEGGi xla:447307.

    Organism-specific databases

    CTDi 5756.
    Xenbasei XB-GENE-865829. twf1.

    Phylogenomic databases

    HOVERGENi HBG000848.
    KOi K08870.

    Family and domain databases

    Gene3Di 3.40.20.10. 2 hits.
    InterProi IPR002108. ADF-H.
    IPR029006. ADF-H/Gelsolin-like_dom.
    IPR028458. Twinfilin.
    [Graphical view ]
    PANTHERi PTHR13759. PTHR13759. 1 hit.
    Pfami PF00241. Cofilin_ADF. 2 hits.
    [Graphical view ]
    SMARTi SM00102. ADF. 2 hits.
    [Graphical view ]
    PROSITEi PS51263. ADF_H. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiTWF1_XENLA
    AccessioniPrimary (citable) accession number: Q68F50
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3