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Protein

Twinfilin-1

Gene

twf1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin (By similarity).By similarity

GO - Biological processi

  1. negative regulation of actin filament polymerization Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Twinfilin-1
Gene namesi
Name:twf1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-865829. twf1.

Subcellular locationi

  1. Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350Twinfilin-1PRO_0000232407Add
BLAST

Interactioni

Subunit structurei

Interacts with G-actin; ADP-actin form.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ68F50.
SMRiQ68F50. Positions 7-138, 161-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 139136ADF-H 1PROSITE-ProRule annotationAdd
BLAST
Domaini177 – 313137ADF-H 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ADF-H domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG000848.
KOiK08870.

Family and domain databases

Gene3Di3.40.20.10. 2 hits.
InterProiIPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR028458. Twinfilin.
[Graphical view]
PANTHERiPTHR13759. PTHR13759. 1 hit.
PfamiPF00241. Cofilin_ADF. 2 hits.
[Graphical view]
SMARTiSM00102. ADF. 2 hits.
[Graphical view]
PROSITEiPS51263. ADF_H. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68F50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHQTGIQAS EDVLEMFARA RNGKYRLLKL DIEDEQLTVS ACEKPTRSWE
60 70 80 90 100
QEYDNFILPL LEDKQPCYIL YRLDSQNAQG FEWIFIAWSP DYSHVRQKML
110 120 130 140 150
YAATRATVKK EFGGGHIKEE IFGTVKDDIS LKGYYKYLAC QSAPAPLTTA
160 170 180 190 200
EEELRQIKIK ETPTDIAVDT KHQTLQGIAF PIEKAAFQAL EQLREKRLNY
210 220 230 240 250
VQLKIDIKNE IIILADTTNT EVRDLPKRIP KDAARYHFFL YKHSHEGDYL
260 270 280 290 300
DSFVFIYSMP GYTCSIRERM LYSSCKNPLL DAIENRLLME IARKIEIDNG
310 320 330 340 350
DELTPDFLYE EVHPKQHAHK QNFAKPKGPA GKRGIRRLIR GPAEAETAND
Length:350
Mass (Da):40,454
Last modified:October 11, 2004 - v1
Checksum:i75654B74886ABA04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079994 mRNA. Translation: AAH79994.1.
RefSeqiNP_001087483.1. NM_001094014.1.
UniGeneiXl.15194.

Genome annotation databases

GeneIDi447307.
KEGGixla:447307.

Cross-referencesi

Web resourcesi

Protein Spotlight

Molecular embrace - Issue 73 of August 2006

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079994 mRNA. Translation: AAH79994.1.
RefSeqiNP_001087483.1. NM_001094014.1.
UniGeneiXl.15194.

3D structure databases

ProteinModelPortaliQ68F50.
SMRiQ68F50. Positions 7-138, 161-313.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi447307.
KEGGixla:447307.

Organism-specific databases

CTDi5756.
XenbaseiXB-GENE-865829. twf1.

Phylogenomic databases

HOVERGENiHBG000848.
KOiK08870.

Family and domain databases

Gene3Di3.40.20.10. 2 hits.
InterProiIPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR028458. Twinfilin.
[Graphical view]
PANTHERiPTHR13759. PTHR13759. 1 hit.
PfamiPF00241. Cofilin_ADF. 2 hits.
[Graphical view]
SMARTiSM00102. ADF. 2 hits.
[Graphical view]
PROSITEiPS51263. ADF_H. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiTWF1_XENLA
AccessioniPrimary (citable) accession number: Q68F50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 11, 2004
Last modified: January 7, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.