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Q68F50 (TWF1_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Twinfilin-1
Gene names
Name:twf1
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin By similarity.

Subunit structure

Interacts with G-actin; ADP-actin form By similarity.

Subcellular location

Cytoplasmcytoskeleton By similarity.

Sequence similarities

Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.

Contains 2 ADF-H domains.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
   DomainRepeat
   LigandActin-binding
Gene Ontology (GO)
   Biological_processnegative regulation of actin filament polymerization

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

cytoskeleton

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 350350Twinfilin-1
PRO_0000232407

Regions

Domain4 – 139136ADF-H 1
Domain177 – 313137ADF-H 2

Sequences

Sequence LengthMass (Da)Tools
Q68F50 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 75654B74886ABA04

FASTA35040,454
        10         20         30         40         50         60 
MSHQTGIQAS EDVLEMFARA RNGKYRLLKL DIEDEQLTVS ACEKPTRSWE QEYDNFILPL 

        70         80         90        100        110        120 
LEDKQPCYIL YRLDSQNAQG FEWIFIAWSP DYSHVRQKML YAATRATVKK EFGGGHIKEE 

       130        140        150        160        170        180 
IFGTVKDDIS LKGYYKYLAC QSAPAPLTTA EEELRQIKIK ETPTDIAVDT KHQTLQGIAF 

       190        200        210        220        230        240 
PIEKAAFQAL EQLREKRLNY VQLKIDIKNE IIILADTTNT EVRDLPKRIP KDAARYHFFL 

       250        260        270        280        290        300 
YKHSHEGDYL DSFVFIYSMP GYTCSIRERM LYSSCKNPLL DAIENRLLME IARKIEIDNG 

       310        320        330        340        350 
DELTPDFLYE EVHPKQHAHK QNFAKPKGPA GKRGIRRLIR GPAEAETAND 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Web resources

Protein Spotlight

Molecular embrace - Issue 73 of August 2006

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC079994 mRNA. Translation: AAH79994.1.
RefSeqNP_001087483.1. NM_001094014.1.
UniGeneXl.15194.

3D structure databases

ProteinModelPortalQ68F50.
SMRQ68F50. Positions 7-138, 161-313.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID447307.
KEGGxla:447307.

Organism-specific databases

CTD5756.
XenbaseXB-GENE-865829. twf1.

Phylogenomic databases

HOVERGENHBG000848.
KOK08870.

Family and domain databases

InterProIPR002108. ADF-H.
IPR028458. Twinfilin.
[Graphical view]
PANTHERPTHR13759. PTHR13759. 1 hit.
PfamPF00241. Cofilin_ADF. 2 hits.
[Graphical view]
SMARTSM00102. ADF. 2 hits.
[Graphical view]
PROSITEPS51263. ADF_H. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTWF1_XENLA
AccessionPrimary (citable) accession number: Q68F50
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 11, 2004
Last modified: April 16, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries