Q68F50 (TWF1_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Twinfilin-1

Gene names

Name:

twf1

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin By similarity.
Subunit structure	Interacts with G-actin; ADP-actin form By similarity.
Subcellular location	Cytoplasm › cytoskeleton By similarity.
Sequence similarities	Belongs to the actin-binding proteins ADF family. Twinfilin subfamily. Contains 2 ADF-H domains.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Domain	Repeat
Ligand	Actin-binding
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 350	350	Twinfilin-1		PRO_0000232407
Regions
	Domain	4 – 139	136	ADF-H 1
	Domain	177 – 313	137	ADF-H 2

Sequences

	Sequence		Length	Mass (Da)
	Q68F50 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 75654B74886ABA04	FASTA	350	40,454
	10 20 30 40 50 60 MSHQTGIQAS EDVLEMFARA RNGKYRLLKL DIEDEQLTVS ACEKPTRSWE QEYDNFILPL 70 80 90 100 110 120 LEDKQPCYIL YRLDSQNAQG FEWIFIAWSP DYSHVRQKML YAATRATVKK EFGGGHIKEE 130 140 150 160 170 180 IFGTVKDDIS LKGYYKYLAC QSAPAPLTTA EEELRQIKIK ETPTDIAVDT KHQTLQGIAF 190 200 210 220 230 240 PIEKAAFQAL EQLREKRLNY VQLKIDIKNE IIILADTTNT EVRDLPKRIP KDAARYHFFL 250 260 270 280 290 300 YKHSHEGDYL DSFVFIYSMP GYTCSIRERM LYSSCKNPLL DAIENRLLME IARKIEIDNG 310 320 330 340 350 DELTPDFLYE EVHPKQHAHK QNFAKPKGPA GKRGIRRLIR GPAEAETAND

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Web resources

Protein Spotlight

Molecular embrace - Issue 73 of August 2006

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC079994 mRNA. Translation: AAH79994.1.
RefSeq	NP_001087483.1. NM_001094014.1.
UniGene	Xl.15194.
3D structure databases
ProteinModelPortal	Q68F50.
SMR	Q68F50. Positions 7-138, 161-313.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	447307.
KEGG	xla:447307.
Organism-specific databases
CTD	5756.
Xenbase	XB-GENE-865829. twf1.
Phylogenomic databases
HOVERGEN	HBG000848.
KO	K08870.
Family and domain databases
InterPro	IPR002108. Actin-bd_cofilin/tropomyosin. [Graphical view]
Pfam	PF00241. Cofilin_ADF. 2 hits. [Graphical view]
SMART	SM00102. ADF. 2 hits. [Graphical view]
PROSITE	PS51263. ADF_H. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TWF1_XENLA

Accession

Primary (citable) accession number: Q68F50

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	October 11, 2004
Last modified:	July 11, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program