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Protein

Twinfilin-1

Gene

twf1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Twinfilin-1
Gene namesi
Name:twf1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-865829. twf1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002324071 – 350Twinfilin-1Add BLAST350

Interactioni

Subunit structurei

Interacts with G-actin; ADP-actin form.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ68F50.
SMRiQ68F50.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 139ADF-H 1PROSITE-ProRule annotationAdd BLAST136
Domaini177 – 313ADF-H 2PROSITE-ProRule annotationAdd BLAST137

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG000848.
KOiK08870.

Family and domain databases

Gene3Di3.40.20.10. 2 hits.
InterProiView protein in InterPro
IPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR028458. Twinfilin.
PANTHERiPTHR13759. PTHR13759. 1 hit.
PfamiView protein in Pfam
PF00241. Cofilin_ADF. 2 hits.
SMARTiView protein in SMART
SM00102. ADF. 2 hits.
PROSITEiView protein in PROSITE
PS51263. ADF_H. 2 hits.

Sequencei

Sequence statusi: Complete.

Q68F50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHQTGIQAS EDVLEMFARA RNGKYRLLKL DIEDEQLTVS ACEKPTRSWE
60 70 80 90 100
QEYDNFILPL LEDKQPCYIL YRLDSQNAQG FEWIFIAWSP DYSHVRQKML
110 120 130 140 150
YAATRATVKK EFGGGHIKEE IFGTVKDDIS LKGYYKYLAC QSAPAPLTTA
160 170 180 190 200
EEELRQIKIK ETPTDIAVDT KHQTLQGIAF PIEKAAFQAL EQLREKRLNY
210 220 230 240 250
VQLKIDIKNE IIILADTTNT EVRDLPKRIP KDAARYHFFL YKHSHEGDYL
260 270 280 290 300
DSFVFIYSMP GYTCSIRERM LYSSCKNPLL DAIENRLLME IARKIEIDNG
310 320 330 340 350
DELTPDFLYE EVHPKQHAHK QNFAKPKGPA GKRGIRRLIR GPAEAETAND
Length:350
Mass (Da):40,454
Last modified:October 11, 2004 - v1
Checksum:i75654B74886ABA04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079994 mRNA. Translation: AAH79994.1.
RefSeqiNP_001087483.1. NM_001094014.1.
UniGeneiXl.15194.

Genome annotation databases

GeneIDi447307.
KEGGixla:447307.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTWF1_XENLA
AccessioniPrimary (citable) accession number: Q68F50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 11, 2004
Last modified: May 10, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families