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Protein

Mitoferrin-2B

Gene

slc25a28-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe2+, is then probably delivered to ferrochelatase to catalyze Fe2+ incorporation into protoprophyrin IX to make heme (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processIon transport, Iron transport, Transport
LigandIron

Names & Taxonomyi

Protein namesi
Recommended name:
Mitoferrin-2B
Alternative name(s):
Mitochondrial iron transporter 2-B
Solute carrier family 25 member 28-B
Gene namesi
Name:slc25a28-b
Synonyms:mfrn2-b
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6254008. slc25a28.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei77 – 96Helical; Name=1Sequence analysisAdd BLAST20
Transmembranei137 – 157Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei172 – 185Helical; Name=3Sequence analysisAdd BLAST14

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002352591 – 186Mitoferrin-2BAdd BLAST186

Structurei

3D structure databases

ProteinModelPortaliQ68F18.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati75 – 163SolcarAdd BLAST89

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG081966.
KOiK15113.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiView protein in InterPro
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
PfamiView protein in Pfam
PF00153. Mito_carr. 1 hit.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 1 hit.

Sequencei

Sequence statusi: Complete.

Q68F18-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELEAVLKER TAAAGDPGRV LGAWVRRGWA TAGPGVLESD GGSGGTLAFE
60 70 80 90 100
STSSSRILEL TSDNDPEYEA LPEGSNVTAH MLAGAVAGVM EHCLMYPVDC
110 120 130 140 150
VKTRMQSLQP DPAARYRNVM DALSKIVRTE GFWRPLRGLN VTATGAGPAH
160 170 180
ALYFACYEKL KKTLSDIIHP GGNCHVANGI DNSCPA
Length:186
Mass (Da):19,729
Last modified:October 11, 2004 - v1
Checksum:i165A0D3285FA7B7F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC080028 mRNA. Translation: AAH80028.1.
RefSeqiNP_001087506.1. NM_001094037.1.
UniGeneiXl.80320.

Genome annotation databases

GeneIDi447330.
KEGGixla:447330.

Similar proteinsi

Entry informationi

Entry nameiMFN2B_XENLA
AccessioniPrimary (citable) accession number: Q68F18
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 11, 2004
Last modified: April 12, 2017
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families