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Protein

Mitoferrin-2B

Gene

slc25a28-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe2+, is then probably delivered to ferrochelatase to catalyze Fe2+ incorporation into protoprophyrin IX to make heme (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processIon transport, Iron transport, Transport
LigandIron

Names & Taxonomyi

Protein namesi
Recommended name:
Mitoferrin-2B
Alternative name(s):
Mitochondrial iron transporter 2-B
Solute carrier family 25 member 28-B
Gene namesi
Name:slc25a28-b
Synonyms:mfrn2-b
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6254008 slc25a28

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei77 – 96Helical; Name=1Sequence analysisAdd BLAST20
Transmembranei137 – 157Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei172 – 185Helical; Name=3Sequence analysisAdd BLAST14

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002352591 – 186Mitoferrin-2BAdd BLAST186

Structurei

3D structure databases

ProteinModelPortaliQ68F18
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati75 – 163SolcarAdd BLAST89

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG081966
KOiK15113

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 1 hit
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 1 hit

Sequencei

Sequence statusi: Complete.

Q68F18-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELEAVLKER TAAAGDPGRV LGAWVRRGWA TAGPGVLESD GGSGGTLAFE
60 70 80 90 100
STSSSRILEL TSDNDPEYEA LPEGSNVTAH MLAGAVAGVM EHCLMYPVDC
110 120 130 140 150
VKTRMQSLQP DPAARYRNVM DALSKIVRTE GFWRPLRGLN VTATGAGPAH
160 170 180
ALYFACYEKL KKTLSDIIHP GGNCHVANGI DNSCPA
Length:186
Mass (Da):19,729
Last modified:October 11, 2004 - v1
Checksum:i165A0D3285FA7B7F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC080028 mRNA Translation: AAH80028.1
RefSeqiNP_001087506.1, NM_001094037.1
UniGeneiXl.80320

Genome annotation databases

GeneIDi447330
KEGGixla:447330

Similar proteinsi

Entry informationi

Entry nameiMFN2B_XENLA
AccessioniPrimary (citable) accession number: Q68F18
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 11, 2004
Last modified: November 22, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health