Reviewed, UniProtKB/Swiss-Prot Q68EQ1 (GMPPB_XENTR)

Names and origin

Protein names

Recommended name:
    Mannose-1-phosphate guanyltransferase beta
    EC=2.7.7.13
Alternative name(s):
    GTP-mannose-1-phosphate guanylyltransferase beta
    GDP-mannose pyrophosphorylase B

Gene names

Name:	gmppb
ORF Names:	TGas135o02.1

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	360 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.
Pathway	Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.
Sequence similarities	Belongs to the transferase hexapeptide repeat family.

Ontologies

Keywords
Ligand	GTP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW mannose-1-phosphate guanylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 360	360	Mannose-1-phosphate guanyltransferase beta		PRO_0000307168

Sequences

	Sequence		Length	Mass (Da)
	Q68EQ1-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: AE6206C213A961C8	FASTA	360	40,161
	10 20 30 40 50 60 MKALILVGGY GTRLRPLTLS VPKPLVDFCN KPILLHQVEA LVKAGVNHVI LAVSYMSDML 70 80 90 100 110 120 EKEMKEQEKR LGIRISMSHE KEPLGTAGPL ALARELLTEN SDPFFVLNSD VICDFPFEEM 130 140 150 160 170 180 VRFHKHHGKE GTIVVTKVEE PSKYGVVVYE AESGQIQRFV EKPQVFVSNK INSGLYIFSP 190 200 210 220 230 240 AVLDRIQLRP TSIEKEIFPA MAQEGQLFAM ELQGFWMDIG QPKDFLTGMC MYLQSVRQKH 250 260 270 280 290 300 PEWLHVGPGF IGNVLVDPTA KIGQNCSIGP NVTIGPGVTV EDGVRIKRCT IMKGSRLHSH 310 320 330 340 350 360 SWLESSIVGW SSSVGQWVRM ENVTVLGEDV IVNDELYLNG ANVLPHKCIS ESVPEPRIIM

References

[1]	Sanger Xenopus tropicalis EST/cDNA project Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Gastrula.
[2]	NIH - Xenopus Gene Collection (XGC) project Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR760719 mRNA. Translation: CAJ83390.1. BC080150 mRNA. Translation: AAH80150.1.
RefSeq	NP_001008434.1.
UniGene	Str.66834
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q68EQ1.
Genome annotation databases
Ensembl	ENSXETT00000013087; ENSXETP00000013087; ENSXETG00000005954; Xenopus tropicalis. [Genome view]
GeneID	493267.
KEGG	xtr:493267.
Organism-specific databases
CTD	493267.
Xenbase	XB-FEAT-922649. gmppb.
Phylogenomic databases
HOGENOM	Q68EQ1.
HOVERGEN	Q68EQ1.
OMA	RRIQLQP.
Enzyme and pathway databases
BRENDA	2.7.7.13. 279072.
Family and domain databases
InterPro	IPR001451. Hexapep_transf. IPR018357. Hexapep_transf_CS. IPR005835. NTP_transferase. [Graphical view]
Pfam	PF00132. Hexapep. 2 hits. PF00483. NTP_transferase. 1 hit. [Graphical view]
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GMPPB_XENTR

Accession

Primary (citable) accession number: Q68EQ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	October 11, 2004
Last modified:	November 3, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project