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Protein

Rho GTPase-activating protein 17

Gene

ARHGAP17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca2+-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-194840. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 17
Alternative name(s):
Rho-type GTPase-activating protein 17
RhoGAP interacting with CIP4 homologs protein 1
Short name:
RICH-1
Gene namesi
Name:ARHGAP17
Synonyms:RICH1
ORF Names:MSTP066, MSTP110
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:18239. ARHGAP17.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Membrane, Tight junction

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi288R → A: Loss of function; leading to defects in tight junction maintenance. 1 Publication1

Organism-specific databases

DisGeNETi55114.
OpenTargetsiENSG00000140750.
PharmGKBiPA134908575.

Polymorphism and mutation databases

BioMutaiARHGAP17.
DMDMi74736331.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002804621 – 881Rho GTPase-activating protein 17Add BLAST881

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei484PhosphoserineCombined sources1
Modified residuei575PhosphoserineCombined sources1
Modified residuei679PhosphothreonineCombined sources1
Modified residuei682PhosphothreonineCombined sources1
Modified residuei702PhosphoserineBy similarity1
Modified residuei704PhosphoserineBy similarity1
Modified residuei753PhosphothreonineBy similarity1
Modified residuei757PhosphothreonineBy similarity1
Modified residuei759PhosphothreonineBy similarity1
Modified residuei762PhosphoserineBy similarity1
Modified residuei763PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ68EM7.
MaxQBiQ68EM7.
PaxDbiQ68EM7.
PeptideAtlasiQ68EM7.
PRIDEiQ68EM7.

PTM databases

iPTMnetiQ68EM7.
PhosphoSitePlusiQ68EM7.

Expressioni

Tissue specificityi

Ubiquitously expressed. Expressed at higher level in heart and placenta.1 Publication

Gene expression databases

BgeeiENSG00000140750.
ExpressionAtlasiQ68EM7. baseline and differential.
GenevisibleiQ68EM7. HS.

Organism-specific databases

HPAiHPA041703.

Interactioni

Subunit structurei

Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, PATJ and PARD3/PAR3. Interacts with SLC9A3R1, FNBP1, TRIP10, CAPZA (CAPZA1, CAPZA2 or CAPZA3), CAPZB, CD2AP and SH3KBP1/CIN85.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AMOTQ4VCS52EBI-1642807,EBI-2511319
AMOTQ4VCS5-24EBI-1642807,EBI-3891843
TRIP10Q156423EBI-1642807,EBI-739936

Protein-protein interaction databases

BioGridi120424. 50 interactors.
IntActiQ68EM7. 9 interactors.
MINTiMINT-195688.
STRINGi9606.ENSP00000289968.

Structurei

3D structure databases

ProteinModelPortaliQ68EM7.
SMRiQ68EM7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 246BARPROSITE-ProRule annotationAdd BLAST233
Domaini252 – 442Rho-GAPPROSITE-ProRule annotationAdd BLAST191

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi753 – 766SH3-bindingSequence analysisAdd BLAST14

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi521 – 816Pro-richAdd BLAST296

Domaini

The BAR domain mediates the interaction with the coiled coil domain of AMOT, leading to its recruitment to tight junctions.1 Publication

Sequence similaritiesi

Contains 1 BAR domain.PROSITE-ProRule annotation
Contains 1 Rho-GAP domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiKOG4270. Eukaryota.
ENOG410XRR2. LUCA.
GeneTreeiENSGT00760000118863.
HOVERGENiHBG000015.
InParanoidiQ68EM7.
KOiK20638.
OMAiKTLPEMR.
OrthoDBiEOG091G02YP.
PhylomeDBiQ68EM7.
TreeFamiTF350627.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
1.20.1270.60. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF03114. BAR. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00721. BAR. 1 hit.
SM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
PROSITEiPS51021. BAR. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q68EM7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKQFNRMKQ LANQTVGRAE KTEVLSEDLL QIERRLDTVR SICHHSHKRL
60 70 80 90 100
VACFQGQHGT DAERRHKKLP LTALAQNMQE ASTQLEDSLL GKMLETCGDA
110 120 130 140 150
ENQLALELSQ HEVFVEKEIV DPLYGIAEVE IPNIQKQRKQ LARLVLDWDS
160 170 180 190 200
VRARWNQAHK SSGTNFQGLP SKIDTLKEEM DEAGNKVEQC KDQLAADMYN
210 220 230 240 250
FMAKEGEYGK FFVTLLEAQA DYHRKALAVL EKTLPEMRAH QDKWAEKPAF
260 270 280 290 300
GTPLEEHLKR SGREIALPIE ACVMLLLETG MKEEGLFRIG AGASKLKKLK
310 320 330 340 350
AALDCSTSHL DEFYSDPHAV AGALKSYLRE LPEPLMTFNL YEEWTQVASV
360 370 380 390 400
QDQDKKLQDL WRTCQKLPPQ NFVNFRYLIK FLAKLAQTSD VNKMTPSNIA
410 420 430 440 450
IVLGPNLLWA RNEGTLAEMA AATSVHVVAV IEPIIQHADW FFPEEVEFNV
460 470 480 490 500
SEAFVPLTTP SSNHSFHTGN DSDSGTLERK RPASMAVMEG DLVKKESFGV
510 520 530 540 550
KLMDFQAHRR GGTLNRKHIS PAFQPPLPPT DGSTVVPAGP EPPPQSSRAE
560 570 580 590 600
SSSGGGTVPS SAGILEQGPS PGDGSPPKPK DPVSAAVPAP GRNNSQIASG
610 620 630 640 650
QNQPQAAAGS HQLSMGQPHN AAGPSPHTLR RAVKKPAPAP PKPGNPPPGH
660 670 680 690 700
PGGQSSSGTS QHPPSLSPKP PTRSPSPPTQ HTGQPPGQPS APSQLSAPRR
710 720 730 740 750
YSSSLSPIQA PNHPPPQPPT QATPLMHTKP NSQGPPNPMA LPSEHGLEQP
760 770 780 790 800
SHTPPQTPTP PSTPPLGKQN PSLPAPQTLA GGNPETAQPH AGTLPRPRPV
810 820 830 840 850
PKPRNRPSVP PPPQPPGVHS AGDSSLTNTA PTASKIVTDS NSRVSEPHRS
860 870 880
IFPEMHSDSA SKDVPGRILL DIDNDTESTA L
Length:881
Mass (Da):95,437
Last modified:October 11, 2004 - v1
Checksum:i92029DBFFEAD1001
GO
Isoform 2 (identifier: Q68EM7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     497-574: Missing.

Show »
Length:803
Mass (Da):87,609
Checksum:i9F42C390ACBAFADA
GO
Isoform 3 (identifier: Q68EM7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-273: Missing.

Note: No experimental confirmation available.
Show »
Length:608
Mass (Da):64,267
Checksum:i8060364C667A5535
GO
Isoform 4 (identifier: Q68EM7-4) [UniParc]FASTAAdd to basket
Also known as: RICH1B

The sequence of this isoform differs from the canonical sequence as follows:
     215-226: LLEAQADYHRKA → ISGRKNQPLGLP
     227-881: Missing.

Show »
Length:226
Mass (Da):25,760
Checksum:iC849839D16E68AE1
GO
Isoform 5 (identifier: Q68EM7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     839-881: DSNSRVSEPHRSIFPEMHSDSASKDVPGRILLDIDNDTESTAL → GFQNRIAASFLKCTQTQPAKTCLAASCWI

Note: No experimental confirmation available.
Show »
Length:867
Mass (Da):93,855
Checksum:iB2797018F447B1FF
GO
Isoform 6 (identifier: Q68EM7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     840-881: SNSRVSEPHRSIFPEMHSDSASKDVPGRILLDIDNDTESTAL → V

Show »
Length:840
Mass (Da):90,929
Checksum:i333F5437A7222C79
GO
Isoform 7 (identifier: Q68EM7-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-467: Missing.
     468-496: TGNDSDSGTLERKRPASMAVMEGDLVKKE → MCGFNTCGPMGFCLSSLLAWCVDCFFSLC

Note: No experimental confirmation available.
Show »
Length:414
Mass (Da):42,512
Checksum:iB20A13496205E5A8
GO

Sequence cautioni

The sequence AAH01241 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAQ13586 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAQ13632 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti139K → E in BAB55203 (PubMed:14702039).Curated1
Sequence conflicti167Q → R in CAC37948 (PubMed:11431473).Curated1
Sequence conflicti186K → R in CAC37948 (PubMed:11431473).Curated1
Sequence conflicti255E → A in BAB14506 (PubMed:14702039).Curated1
Sequence conflicti404G → A in BAB55203 (PubMed:14702039).Curated1
Sequence conflicti575S → C in BAC86144 (PubMed:14702039).Curated1
Sequence conflicti855M → V in BAB55203 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0236821 – 467Missing in isoform 7. 1 PublicationAdd BLAST467
Alternative sequenceiVSP_0236831 – 273Missing in isoform 3. 1 PublicationAdd BLAST273
Alternative sequenceiVSP_023684215 – 226LLEAQ…YHRKA → ISGRKNQPLGLP in isoform 4. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_023685227 – 881Missing in isoform 4. 1 PublicationAdd BLAST655
Alternative sequenceiVSP_023686468 – 496TGNDS…LVKKE → MCGFNTCGPMGFCLSSLLAW CVDCFFSLC in isoform 7. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_023687497 – 574Missing in isoform 2. 2 PublicationsAdd BLAST78
Alternative sequenceiVSP_023688839 – 881DSNSR…ESTAL → GFQNRIAASFLKCTQTQPAK TCLAASCWI in isoform 5. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_023689840 – 881SNSRV…ESTAL → V in isoform 6. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ306731 mRNA. Translation: CAC37948.1.
AJ306732 mRNA. Translation: CAC37949.1.
AK001170 mRNA. No translation available.
AK023281 mRNA. Translation: BAB14506.1.
AK027567 mRNA. Translation: BAB55203.1.
AK125358 mRNA. Translation: BAC86144.1.
AK291691 mRNA. Translation: BAF84380.1.
AL833975 mRNA. Translation: CAD38819.1.
BC001241 mRNA. Translation: AAH01241.1. Different initiation.
BC080195 mRNA. Translation: AAH80195.1.
AF163257 mRNA. Translation: AAQ13586.1. Different initiation.
AF173885 mRNA. Translation: AAQ13632.1. Different initiation.
CCDSiCCDS32408.1. [Q68EM7-2]
CCDS32409.1. [Q68EM7-1]
PIRiF59433.
RefSeqiNP_001006635.1. NM_001006634.2. [Q68EM7-1]
NP_060524.4. NM_018054.5. [Q68EM7-2]
UniGeneiHs.373793.

Genome annotation databases

EnsembliENST00000289968; ENSP00000289968; ENSG00000140750. [Q68EM7-1]
ENST00000303665; ENSP00000303130; ENSG00000140750. [Q68EM7-2]
GeneIDi55114.
KEGGihsa:55114.
UCSCiuc002dnb.5. human. [Q68EM7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ306731 mRNA. Translation: CAC37948.1.
AJ306732 mRNA. Translation: CAC37949.1.
AK001170 mRNA. No translation available.
AK023281 mRNA. Translation: BAB14506.1.
AK027567 mRNA. Translation: BAB55203.1.
AK125358 mRNA. Translation: BAC86144.1.
AK291691 mRNA. Translation: BAF84380.1.
AL833975 mRNA. Translation: CAD38819.1.
BC001241 mRNA. Translation: AAH01241.1. Different initiation.
BC080195 mRNA. Translation: AAH80195.1.
AF163257 mRNA. Translation: AAQ13586.1. Different initiation.
AF173885 mRNA. Translation: AAQ13632.1. Different initiation.
CCDSiCCDS32408.1. [Q68EM7-2]
CCDS32409.1. [Q68EM7-1]
PIRiF59433.
RefSeqiNP_001006635.1. NM_001006634.2. [Q68EM7-1]
NP_060524.4. NM_018054.5. [Q68EM7-2]
UniGeneiHs.373793.

3D structure databases

ProteinModelPortaliQ68EM7.
SMRiQ68EM7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120424. 50 interactors.
IntActiQ68EM7. 9 interactors.
MINTiMINT-195688.
STRINGi9606.ENSP00000289968.

PTM databases

iPTMnetiQ68EM7.
PhosphoSitePlusiQ68EM7.

Polymorphism and mutation databases

BioMutaiARHGAP17.
DMDMi74736331.

Proteomic databases

EPDiQ68EM7.
MaxQBiQ68EM7.
PaxDbiQ68EM7.
PeptideAtlasiQ68EM7.
PRIDEiQ68EM7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289968; ENSP00000289968; ENSG00000140750. [Q68EM7-1]
ENST00000303665; ENSP00000303130; ENSG00000140750. [Q68EM7-2]
GeneIDi55114.
KEGGihsa:55114.
UCSCiuc002dnb.5. human. [Q68EM7-1]

Organism-specific databases

CTDi55114.
DisGeNETi55114.
GeneCardsiARHGAP17.
HGNCiHGNC:18239. ARHGAP17.
HPAiHPA041703.
MIMi608293. gene.
neXtProtiNX_Q68EM7.
OpenTargetsiENSG00000140750.
PharmGKBiPA134908575.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4270. Eukaryota.
ENOG410XRR2. LUCA.
GeneTreeiENSGT00760000118863.
HOVERGENiHBG000015.
InParanoidiQ68EM7.
KOiK20638.
OMAiKTLPEMR.
OrthoDBiEOG091G02YP.
PhylomeDBiQ68EM7.
TreeFamiTF350627.

Enzyme and pathway databases

ReactomeiR-HSA-194840. Rho GTPase cycle.

Miscellaneous databases

ChiTaRSiARHGAP17. human.
GenomeRNAii55114.
PROiQ68EM7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140750.
ExpressionAtlasiQ68EM7. baseline and differential.
GenevisibleiQ68EM7. HS.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
1.20.1270.60. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF03114. BAR. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00721. BAR. 1 hit.
SM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
PROSITEiPS51021. BAR. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRHG17_HUMAN
AccessioniPrimary (citable) accession number: Q68EM7
Secondary accession number(s): A8K6M6
, Q6ZUS4, Q7Z2F2, Q8NDG2, Q96KS2, Q96KS3, Q96SS8, Q9BVF6, Q9H8U5, Q9NW54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.