Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Ccnb1 protein

Gene

Ccnb1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. kinase activity Source: MGI
  2. patched binding Source: MGI
  3. protein kinase binding Source: MGI

GO - Biological processi

  1. histone H3-S10 phosphorylation involved in chromosome condensation Source: MGI
  2. in utero embryonic development Source: MGI
  3. mitotic metaphase plate congression Source: MGI
  4. mitotic spindle stabilization Source: MGI
  5. positive regulation of attachment of spindle microtubules to kinetochore Source: MGI
  6. positive regulation of cell cycle Source: MGI
  7. positive regulation of fibroblast proliferation Source: MGI
  8. positive regulation of mitotic cell cycle Source: MGI
  9. protein phosphorylation Source: MGI
  10. regulation of mitotic cell cycle spindle assembly checkpoint Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

CyclinUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Ccnb1 proteinImported
Submitted name:
G2/mitotic-specific cyclin-B1Imported
Gene namesi
Name:Ccnb1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:88302. Ccnb1.

Subcellular locationi

GO - Cellular componenti

  1. centrosome Source: MGI
  2. condensed nuclear chromosome outer kinetochore Source: MGI
  3. cytoplasm Source: MGI
  4. membrane Source: MGI
  5. nucleus Source: MGI
  6. spindle pole Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ68EM3.

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000118939.
HOVERGENiHBG061650.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68EM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRVTRNTK INAENKAKVS MAGAKRVPVT VTAASKPGLR PRTALGDIGN
60 70 80 90 100
KVSEELQARV PLKREAKTLG TGKGTVKALP KPVEKVPVCE PEVELAEPEP
110 120 130 140 150
EPELEHVREE KLSPEPILEE QSVRPKYLQG REVTGNMRAI LIDWLIQVQM
160 170 180 190 200
KFRLLQETMY MTVSIIDRFM QNSCVPKKML QLVGVTAMFI ASKYEEMYPP
210 220 230 240 250
EIGDFAFVTN NTYTKHQIRQ MEMKILRVLN FSLGRPLPLH FLRRASKVGE
260 270 280 290 300
VDVEQHTLAK YLMELSMLDY DMVHFAPSQI AAGAFCLALK ILDNGEWTPT
310 320 330 340 350
LQHYLSYSED SLLPVMQHLA KNVVMVNCGL TKHMTVKNKY AASKHAKIST
360
LAQLNCTLVQ NLSKAVTKA
Length:369
Mass (Da):41,468
Last modified:October 11, 2004 - v1
Checksum:iD4FDE1A1A964600E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112701 Genomic DNA. No translation available.
BC080202 mRNA. Translation: AAH80202.1.
UniGeneiMm.260114.
Mm.380027.
Mm.482545.

Genome annotation databases

EnsembliENSMUST00000091295; ENSMUSP00000088841; ENSMUSG00000041431.
UCSCiuc007rrp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112701 Genomic DNA. No translation available.
BC080202 mRNA. Translation: AAH80202.1.
UniGeneiMm.260114.
Mm.380027.
Mm.482545.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000091295; ENSMUSP00000088841; ENSMUSG00000041431.
UCSCiuc007rrp.1. mouse.

Organism-specific databases

MGIiMGI:88302. Ccnb1.

Phylogenomic databases

GeneTreeiENSGT00760000118939.
HOVERGENiHBG061650.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

GenevestigatoriQ68EM3.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: Mammary tumor. C3Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ68EM3_MOUSE
AccessioniPrimary (citable) accession number: Q68EM3
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2004
Last sequence update: October 11, 2004
Last modified: April 29, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.