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Q68EH8

- FAD1_DANRE

UniProt

Q68EH8 - FAD1_DANRE

Protein

FAD synthase

Gene

flad1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.By similarity

    Catalytic activityi

    ATP + FMN = diphosphate + FAD.

    Cofactori

    Magnesium.By similarity

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. FMN adenylyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. FAD biosynthetic process Source: UniProtKB-UniPathway
    2. Mo-molybdopterin cofactor biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    ATP-binding, FAD, Flavoprotein, FMN, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00277; UER00407.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    FAD synthase (EC:2.7.7.2)
    Alternative name(s):
    FAD pyrophosphorylase
    FMN adenylyltransferase
    Flavin adenine dinucleotide synthase
    Including the following 2 domains:
    Molybdenum cofactor biosynthesis protein-like region
    FAD synthase region
    Gene namesi
    Name:flad1
    ORF Names:zgc:91843
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 16

    Organism-specific databases

    ZFINiZDB-GENE-040822-44. flad1.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 497497FAD synthasePRO_0000302740Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiQ68EH8.

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000094012.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68EH8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni19 – 11092Molybdenum cofactor biosynthesis protein-likeAdd
    BLAST
    Regioni308 – 465158FAD synthaseAdd
    BLAST

    Domaini

    The molybdenum cofactor biosynthesis protein-like region may not be functional.

    Sequence similaritiesi

    In the N-terminal section; belongs to the MoaB/Mog family.Curated
    In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0175.
    GeneTreeiENSGT00390000007266.
    HOGENOMiHOG000007185.
    HOVERGENiHBG058211.
    InParanoidiQ68EH8.
    KOiK00953.
    OMAiSFMRINP.
    PhylomeDBiQ68EH8.
    TreeFamiTF314056.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.40.980.10. 1 hit.
    InterProiIPR012183. FAD_synth_Mopterin-bd.
    IPR001453. Mopterin-bd_dom.
    IPR002500. PAPS_reduct.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00994. MoCF_biosynth. 1 hit.
    PF01507. PAPS_reduct. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036620. MPTbdFAD. 1 hit.
    SMARTiSM00852. MoCF_biosynth. 1 hit.
    [Graphical view]
    SUPFAMiSSF53218. SSF53218. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q68EH8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQNCNTSST QKNGSATAAI LIIGDEILKG HTVDTNSAFL CRGLRKLGIT    50
    VERITVVPDV QEVIAKEVSQ LSSTVTHLIT SGGIGPTHDD VTFESVAMAF 100
    GEELYAHPEM TKLVEGFFGT VTSDSAPMKL AMVPASAKLN FGIDPQTGQR 150
    NRFPLVSVHN VYIFPGIPSL LEKSFNGLSH LFSGSGTTFH TREVFVNADE 200
    TEIAQSLSKL QAGWGKRVSL GSYPDWLSNY HRVRLVLDTD SVEEVERART 250
    QLIEELPKGS VVPLVTDPIS VAAQEVYSLS KSETQLGKKV AAALGTIEMA 300
    LDKYSVNEIC VGFNGGKDCT ALLHLYYAAL KRRYPDGKDR LKALYIRIVS 350
    PFPEMERFLQ DTIKRYDLEL FSVEGSIRQA LNEVKERRPD LRAVLMGTRR 400
    TDPYSHTLTP FCPTDPGWPD YMRVNPLLEW TYHDIWSFLR TLYVPYCILY 450
    DKGYTSLGSM DNSYRNPSLK MVDERGATRY KPAYMLENEE EERNSRE 497
    Length:497
    Mass (Da):55,610
    Last modified:October 11, 2004 - v1
    Checksum:iD71C34BE8FA99DFF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC080254 mRNA. Translation: AAH80254.1.
    RefSeqiNP_001003997.1. NM_001003997.1.
    UniGeneiDr.76199.

    Genome annotation databases

    EnsembliENSDART00000103235; ENSDARP00000094012; ENSDARG00000070390.
    GeneIDi445492.
    KEGGidre:445492.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC080254 mRNA. Translation: AAH80254.1 .
    RefSeqi NP_001003997.1. NM_001003997.1.
    UniGenei Dr.76199.

    3D structure databases

    ProteinModelPortali Q68EH8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000094012.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000103235 ; ENSDARP00000094012 ; ENSDARG00000070390 .
    GeneIDi 445492.
    KEGGi dre:445492.

    Organism-specific databases

    CTDi 80308.
    ZFINi ZDB-GENE-040822-44. flad1.

    Phylogenomic databases

    eggNOGi COG0175.
    GeneTreei ENSGT00390000007266.
    HOGENOMi HOG000007185.
    HOVERGENi HBG058211.
    InParanoidi Q68EH8.
    KOi K00953.
    OMAi SFMRINP.
    PhylomeDBi Q68EH8.
    TreeFami TF314056.

    Enzyme and pathway databases

    UniPathwayi UPA00277 ; UER00407 .

    Miscellaneous databases

    NextBioi 20832162.
    PROi Q68EH8.

    Gene expression databases

    Bgeei Q68EH8.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.40.980.10. 1 hit.
    InterProi IPR012183. FAD_synth_Mopterin-bd.
    IPR001453. Mopterin-bd_dom.
    IPR002500. PAPS_reduct.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00994. MoCF_biosynth. 1 hit.
    PF01507. PAPS_reduct. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036620. MPTbdFAD. 1 hit.
    SMARTi SM00852. MoCF_biosynth. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53218. SSF53218. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiFAD1_DANRE
    AccessioniPrimary (citable) accession number: Q68EH8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3