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Q68EH8 (FAD1_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
FAD synthase

EC=2.7.7.2
Alternative name(s):
FAD pyrophosphorylase
FMN adenylyltransferase
Flavin adenine dinucleotide synthase

Including the following 2 domains:

  1. Molybdenum cofactor biosynthesis protein-like region
  2. FAD synthase region
Gene names
Name:flad1
ORF Names:zgc:91843
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme By similarity.

Catalytic activity

ATP + FMN = diphosphate + FAD.

Cofactor

Magnesium By similarity.

Pathway

Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.

Subcellular location

Cytoplasm By similarity.

Domain

The molybdenum cofactor biosynthesis protein-like region may not be functional.

Sequence similarities

In the N-terminal section; belongs to the MoaB/Mog family.

In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 497497FAD synthase
PRO_0000302740

Regions

Region19 – 11092Molybdenum cofactor biosynthesis protein-like
Region308 – 465158FAD synthase

Sequences

Sequence LengthMass (Da)Tools
Q68EH8 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: D71C34BE8FA99DFF

FASTA49755,610
        10         20         30         40         50         60 
MAQNCNTSST QKNGSATAAI LIIGDEILKG HTVDTNSAFL CRGLRKLGIT VERITVVPDV 

        70         80         90        100        110        120 
QEVIAKEVSQ LSSTVTHLIT SGGIGPTHDD VTFESVAMAF GEELYAHPEM TKLVEGFFGT 

       130        140        150        160        170        180 
VTSDSAPMKL AMVPASAKLN FGIDPQTGQR NRFPLVSVHN VYIFPGIPSL LEKSFNGLSH 

       190        200        210        220        230        240 
LFSGSGTTFH TREVFVNADE TEIAQSLSKL QAGWGKRVSL GSYPDWLSNY HRVRLVLDTD 

       250        260        270        280        290        300 
SVEEVERART QLIEELPKGS VVPLVTDPIS VAAQEVYSLS KSETQLGKKV AAALGTIEMA 

       310        320        330        340        350        360 
LDKYSVNEIC VGFNGGKDCT ALLHLYYAAL KRRYPDGKDR LKALYIRIVS PFPEMERFLQ 

       370        380        390        400        410        420 
DTIKRYDLEL FSVEGSIRQA LNEVKERRPD LRAVLMGTRR TDPYSHTLTP FCPTDPGWPD 

       430        440        450        460        470        480 
YMRVNPLLEW TYHDIWSFLR TLYVPYCILY DKGYTSLGSM DNSYRNPSLK MVDERGATRY 

       490 
KPAYMLENEE EERNSRE 

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC080254 mRNA. Translation: AAH80254.1.
RefSeqNP_001003997.1. NM_001003997.1.
UniGeneDr.76199.

3D structure databases

ProteinModelPortalQ68EH8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000094012.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000103235; ENSDARP00000094012; ENSDARG00000070390.
GeneID445492.
KEGGdre:445492.

Organism-specific databases

CTD80308.
ZFINZDB-GENE-040822-44. flad1.

Phylogenomic databases

eggNOGCOG0175.
GeneTreeENSGT00390000007266.
HOGENOMHOG000007185.
HOVERGENHBG058211.
InParanoidQ68EH8.
KOK00953.
OMASFMRINP.
PhylomeDBQ68EH8.
TreeFamTF314056.

Enzyme and pathway databases

UniPathwayUPA00277; UER00407.

Gene expression databases

BgeeQ68EH8.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
3.40.980.10. 1 hit.
InterProIPR012183. FAD_synth_Mopterin-bd.
IPR001453. Mopterin-bd_dom.
IPR002500. PAPS_reduct.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamPF00994. MoCF_biosynth. 1 hit.
PF01507. PAPS_reduct. 1 hit.
[Graphical view]
PIRSFPIRSF036620. MPTbdFAD. 1 hit.
SMARTSM00852. MoCF_biosynth. 1 hit.
[Graphical view]
SUPFAMSSF53218. SSF53218. 1 hit.
ProtoNetSearch...

Other

NextBio20832162.
PROQ68EH8.

Entry information

Entry nameFAD1_DANRE
AccessionPrimary (citable) accession number: Q68EH8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 11, 2004
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways