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Q68EH8

- FAD1_DANRE

UniProt

Q68EH8 - FAD1_DANRE

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Protein

FAD synthase

Gene

flad1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.By similarity

Catalytic activityi

ATP + FMN = diphosphate + FAD.

Cofactori

Mg2+By similarity

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. FMN adenylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. FAD biosynthetic process Source: UniProtKB-UniPathway
  2. Mo-molybdopterin cofactor biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

ATP-binding, FAD, Flavoprotein, FMN, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_231582. Vitamin B2 (riboflavin) metabolism.
UniPathwayiUPA00277; UER00407.

Names & Taxonomyi

Protein namesi
Recommended name:
FAD synthase (EC:2.7.7.2)
Alternative name(s):
FAD pyrophosphorylase
FMN adenylyltransferase
Flavin adenine dinucleotide synthase
Including the following 2 domains:
Molybdenum cofactor biosynthesis protein-like region
FAD synthase region
Gene namesi
Name:flad1
ORF Names:zgc:91843
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 16

Organism-specific databases

ZFINiZDB-GENE-040822-44. flad1.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497FAD synthasePRO_0000302740Add
BLAST

Expressioni

Gene expression databases

BgeeiQ68EH8.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000094012.

Structurei

3D structure databases

ProteinModelPortaliQ68EH8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni19 – 11092Molybdenum cofactor biosynthesis protein-likeAdd
BLAST
Regioni308 – 465158FAD synthaseAdd
BLAST

Domaini

The molybdenum cofactor biosynthesis protein-like region may not be functional.

Sequence similaritiesi

In the N-terminal section; belongs to the MoaB/Mog family.Curated
In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.Curated

Phylogenomic databases

eggNOGiCOG0175.
GeneTreeiENSGT00390000007266.
HOGENOMiHOG000007185.
HOVERGENiHBG058211.
InParanoidiQ68EH8.
KOiK00953.
OMAiSFMRINP.
PhylomeDBiQ68EH8.
TreeFamiTF314056.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.40.980.10. 1 hit.
InterProiIPR012183. FAD_synth_Mopterin-bd.
IPR001453. Mopterin-bd_dom.
IPR002500. PAPS_reduct.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00994. MoCF_biosynth. 1 hit.
PF01507. PAPS_reduct. 1 hit.
[Graphical view]
PIRSFiPIRSF036620. MPTbdFAD. 1 hit.
SMARTiSM00852. MoCF_biosynth. 1 hit.
[Graphical view]
SUPFAMiSSF53218. SSF53218. 1 hit.

Sequencei

Sequence statusi: Complete.

Q68EH8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQNCNTSST QKNGSATAAI LIIGDEILKG HTVDTNSAFL CRGLRKLGIT
60 70 80 90 100
VERITVVPDV QEVIAKEVSQ LSSTVTHLIT SGGIGPTHDD VTFESVAMAF
110 120 130 140 150
GEELYAHPEM TKLVEGFFGT VTSDSAPMKL AMVPASAKLN FGIDPQTGQR
160 170 180 190 200
NRFPLVSVHN VYIFPGIPSL LEKSFNGLSH LFSGSGTTFH TREVFVNADE
210 220 230 240 250
TEIAQSLSKL QAGWGKRVSL GSYPDWLSNY HRVRLVLDTD SVEEVERART
260 270 280 290 300
QLIEELPKGS VVPLVTDPIS VAAQEVYSLS KSETQLGKKV AAALGTIEMA
310 320 330 340 350
LDKYSVNEIC VGFNGGKDCT ALLHLYYAAL KRRYPDGKDR LKALYIRIVS
360 370 380 390 400
PFPEMERFLQ DTIKRYDLEL FSVEGSIRQA LNEVKERRPD LRAVLMGTRR
410 420 430 440 450
TDPYSHTLTP FCPTDPGWPD YMRVNPLLEW TYHDIWSFLR TLYVPYCILY
460 470 480 490
DKGYTSLGSM DNSYRNPSLK MVDERGATRY KPAYMLENEE EERNSRE
Length:497
Mass (Da):55,610
Last modified:October 11, 2004 - v1
Checksum:iD71C34BE8FA99DFF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC080254 mRNA. Translation: AAH80254.1.
RefSeqiNP_001003997.1. NM_001003997.1.
UniGeneiDr.76199.

Genome annotation databases

EnsembliENSDART00000103235; ENSDARP00000094012; ENSDARG00000070390.
GeneIDi445492.
KEGGidre:445492.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC080254 mRNA. Translation: AAH80254.1 .
RefSeqi NP_001003997.1. NM_001003997.1.
UniGenei Dr.76199.

3D structure databases

ProteinModelPortali Q68EH8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000094012.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000103235 ; ENSDARP00000094012 ; ENSDARG00000070390 .
GeneIDi 445492.
KEGGi dre:445492.

Organism-specific databases

CTDi 80308.
ZFINi ZDB-GENE-040822-44. flad1.

Phylogenomic databases

eggNOGi COG0175.
GeneTreei ENSGT00390000007266.
HOGENOMi HOG000007185.
HOVERGENi HBG058211.
InParanoidi Q68EH8.
KOi K00953.
OMAi SFMRINP.
PhylomeDBi Q68EH8.
TreeFami TF314056.

Enzyme and pathway databases

UniPathwayi UPA00277 ; UER00407 .
Reactomei REACT_231582. Vitamin B2 (riboflavin) metabolism.

Miscellaneous databases

NextBioi 20832162.
PROi Q68EH8.

Gene expression databases

Bgeei Q68EH8.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.40.980.10. 1 hit.
InterProi IPR012183. FAD_synth_Mopterin-bd.
IPR001453. Mopterin-bd_dom.
IPR002500. PAPS_reduct.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00994. MoCF_biosynth. 1 hit.
PF01507. PAPS_reduct. 1 hit.
[Graphical view ]
PIRSFi PIRSF036620. MPTbdFAD. 1 hit.
SMARTi SM00852. MoCF_biosynth. 1 hit.
[Graphical view ]
SUPFAMi SSF53218. SSF53218. 1 hit.
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiFAD1_DANRE
AccessioniPrimary (citable) accession number: Q68EH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 11, 2004
Last modified: November 26, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3