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Protein

Homeobox protein Hox-C8a

Gene

hoxc8a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi149 – 208HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • embryonic pectoral fin morphogenesis Source: ZFIN
  • endocrine pancreas development Source: ZFIN
  • exocrine pancreas development Source: ZFIN
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C8a
Gene namesi
Name:hoxc8aImported
Synonyms:hoxc8Imported
ORF Names:si:dkey-81p22.5, zgc:91832
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 23

Organism-specific databases

ZFINiZDB-GENE-990415-114. hoxc8a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002488351 – 250Homeobox protein Hox-C8aAdd BLAST250

Proteomic databases

PaxDbiQ68EH7.

Expressioni

Developmental stagei

At the 10-somite stage, expressed in the paraxial mesoderm with an anterior expression limit at somite 7. At the 20-somite stage, expressed in the developing CNS with an anterior expression limit adjacent to somite 4.1 Publication

Gene expression databases

BgeeiENSDARG00000070346.
ExpressionAtlasiQ68EH7. baseline.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000093913.

Structurei

3D structure databases

ProteinModelPortaliQ68EH7.
SMRiQ68EH7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi138 – 143Antp-type hexapeptideSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi219 – 250Glu-richSequence analysisAdd BLAST32

Sequence similaritiesi

Belongs to the Antp homeobox family.Sequence analysis

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiQ68EH7.
KOiK09308.
OMAiFHHGTSS.
OrthoDBiEOG091G09XD.
PhylomeDBiQ68EH7.
TreeFamiTF316310.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q68EH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSYFVNPLF SKYKGGETLE PTYYDCRFPQ SVARSHTLVY GHGAAAPGFQ
60 70 80 90 100
HPSHHVQDFF HHGTTGISNP GYQQNPCALA CHGDATKFYG YEALPRQPLY
110 120 130 140 150
GTQQEATLAQ YPDCKSSNST NPGEGQGHLS QNSSPSLMFP WMRPHAPGRR
160 170 180 190 200
NGRQTYSRYQ TLELEKEFLF NPYLTRKRRI EVSHALSLTE RQVKIWFQNR
210 220 230 240 250
RMKWKKENNK DKFPGQRGEA EAEAEEEGNE DGEAEEGEDK ETEEKEESKE
Length:250
Mass (Da):28,616
Last modified:October 11, 2004 - v1
Checksum:iE10712DA039D7197
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX005254 Genomic DNA. Translation: CAM16418.1.
BC080255 mRNA. Translation: AAH80255.1.
DQ060555 mRNA. Translation: AAY67933.1.
Y14544 mRNA. Translation: CAA74879.1.
RefSeqiNP_001005771.1. NM_001005771.1.
UniGeneiDr.132201.

Genome annotation databases

EnsembliENSDART00000103139; ENSDARP00000093913; ENSDARG00000070346.
GeneIDi449648.
KEGGidre:449648.

Similar proteinsi

Entry informationi

Entry nameiHXC8A_DANRE
AccessioniPrimary (citable) accession number: Q68EH7
Secondary accession number(s): A2BE64, O57369, Q4PR88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: October 11, 2004
Last modified: September 27, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families