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Q68EH7

- HXC8A_DANRE

UniProt

Q68EH7 - HXC8A_DANRE

Protein

Homeobox protein Hox-C8a

Gene

hoxc8a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi149 – 20860HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. embryonic pectoral fin morphogenesis Source: ZFIN
    2. endocrine pancreas development Source: ZFIN
    3. exocrine pancreas development Source: ZFIN
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-C8a
    Gene namesi
    Name:hoxc8aImported
    Synonyms:hoxc8Imported
    ORF Names:si:dkey-81p22.5, zgc:91832
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 23

    Organism-specific databases

    ZFINiZDB-GENE-990415-114. hoxc8a.

    Subcellular locationi

    Nucleus By similarityPROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 250250Homeobox protein Hox-C8aPRO_0000248835Add
    BLAST

    Expressioni

    Developmental stagei

    At the 10-somite stage, expressed in the paraxial mesoderm with an anterior expression limit at somite 7. At the 20-somite stage, expressed in the developing CNS with an anterior expression limit adjacent to somite 4.1 Publication

    Gene expression databases

    BgeeiQ68EH7.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68EH7.
    SMRiQ68EH7. Positions 149-215.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi138 – 1436Antp-type hexapeptideSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi219 – 25032Glu-richSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Antp homeobox family.Sequence Analysis
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG314669.
    GeneTreeiENSGT00730000110212.
    HOGENOMiHOG000231181.
    HOVERGENiHBG016849.
    InParanoidiA2BE64.
    KOiK09308.
    OMAiHHGTSSI.
    OrthoDBiEOG780RP4.
    PhylomeDBiQ68EH7.
    TreeFamiTF316310.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q68EH7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSYFVNPLF SKYKGGETLE PTYYDCRFPQ SVARSHTLVY GHGAAAPGFQ    50
    HPSHHVQDFF HHGTTGISNP GYQQNPCALA CHGDATKFYG YEALPRQPLY 100
    GTQQEATLAQ YPDCKSSNST NPGEGQGHLS QNSSPSLMFP WMRPHAPGRR 150
    NGRQTYSRYQ TLELEKEFLF NPYLTRKRRI EVSHALSLTE RQVKIWFQNR 200
    RMKWKKENNK DKFPGQRGEA EAEAEEEGNE DGEAEEGEDK ETEEKEESKE 250
    Length:250
    Mass (Da):28,616
    Last modified:October 11, 2004 - v1
    Checksum:iE10712DA039D7197
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX005254 Genomic DNA. Translation: CAM16418.1.
    BC080255 mRNA. Translation: AAH80255.1.
    DQ060555 mRNA. Translation: AAY67933.1.
    Y14544 mRNA. Translation: CAA74879.1.
    RefSeqiNP_001005771.1. NM_001005771.1.
    UniGeneiDr.132201.

    Genome annotation databases

    EnsembliENSDART00000103139; ENSDARP00000093913; ENSDARG00000070346.
    GeneIDi449648.
    KEGGidre:449648.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX005254 Genomic DNA. Translation: CAM16418.1 .
    BC080255 mRNA. Translation: AAH80255.1 .
    DQ060555 mRNA. Translation: AAY67933.1 .
    Y14544 mRNA. Translation: CAA74879.1 .
    RefSeqi NP_001005771.1. NM_001005771.1.
    UniGenei Dr.132201.

    3D structure databases

    ProteinModelPortali Q68EH7.
    SMRi Q68EH7. Positions 149-215.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000103139 ; ENSDARP00000093913 ; ENSDARG00000070346 .
    GeneIDi 449648.
    KEGGi dre:449648.

    Organism-specific databases

    CTDi 449648.
    ZFINi ZDB-GENE-990415-114. hoxc8a.

    Phylogenomic databases

    eggNOGi NOG314669.
    GeneTreei ENSGT00730000110212.
    HOGENOMi HOG000231181.
    HOVERGENi HBG016849.
    InParanoidi A2BE64.
    KOi K09308.
    OMAi HHGTSSI.
    OrthoDBi EOG780RP4.
    PhylomeDBi Q68EH7.
    TreeFami TF316310.

    Miscellaneous databases

    NextBioi 20832749.
    PROi Q68EH7.

    Gene expression databases

    Bgeei Q68EH7.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tuebingen.
    2. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Genomic annotation and transcriptome analysis of the zebrafish (Danio rerio) hox complex with description of a novel member, hoxb13a."
      Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T., de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J., Richardson M.K.
      Evol. Dev. 7:362-375(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 55-157.
      Strain: Tuebingen1 Publication.
    4. "Zebrafish hox genes: genomic organization and modified colinear expression patterns in the trunk."
      Prince V.E., Joly L., Ekker M., Ho R.K.
      Development 125:407-420(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 177-250, DEVELOPMENTAL STAGE.
      Tissue: Embryo1 Publication.

    Entry informationi

    Entry nameiHXC8A_DANRE
    AccessioniPrimary (citable) accession number: Q68EH7
    Secondary accession number(s): A2BE64, O57369, Q4PR88
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3