Q68EH7 (HXC8A_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-C8a

Gene names

Name:	hoxc8a
Synonyms:	hoxc8
ORF Names:	si:dkey-81p22.5, zgc:91832

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Danio

Protein attributes

Sequence length	250 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity. UniProtKB P31273
Subcellular location	Nucleus By similarity UniProtKB P31273.
Developmental stage	At the 10-somite stage, expressed in the paraxial mesoderm with an anterior expression limit at somite 7. At the 20-somite stage, expressed in the developing CNS with an anterior expression limit adjacent to somite 4. Ref.4
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	embryonic pectoral fin morphogenesis Inferred from genetic interaction PubMed 15358764. Source: ZFIN endocrine pancreas development Inferred from genetic interaction PubMed 15358764. Source: ZFIN exocrine pancreas development Inferred from genetic interaction PubMed 15358764. Source: ZFIN transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 250	250	Homeobox protein Hox-C8a		PRO_0000248835
Regions
	DNA binding	149 – 208	60	Homeobox
	Motif	138 – 143	6	Antp-type hexapeptide
	Compositional bias	219 – 250	32	Glu-rich

Sequences

	Sequence		Length	Mass (Da)
	Q68EH7 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: E10712DA039D7197	FASTA	250	28,616
	10 20 30 40 50 60 MSSYFVNPLF SKYKGGETLE PTYYDCRFPQ SVARSHTLVY GHGAAAPGFQ HPSHHVQDFF 70 80 90 100 110 120 HHGTTGISNP GYQQNPCALA CHGDATKFYG YEALPRQPLY GTQQEATLAQ YPDCKSSNST 130 140 150 160 170 180 NPGEGQGHLS QNSSPSLMFP WMRPHAPGRR NGRQTYSRYQ TLELEKEFLF NPYLTRKRRI 190 200 210 220 230 240 EVSHALSLTE RQVKIWFQNR RMKWKKENNK DKFPGQRGEA EAEAEEEGNE DGEAEEGEDK 250 ETEEKEESKE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	The Danio rerio sequencing project at the Sanger Institute Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tuebingen.
[2]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Genomic annotation and transcriptome analysis of the zebrafish (Danio rerio) hox complex with description of a novel member, hoxb13a." Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T., de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J., Richardson M.K. Evol. Dev. 7:362-375(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 55-157. Strain: Tuebingen.
[4]	"Zebrafish hox genes: genomic organization and modified colinear expression patterns in the trunk." Prince V.E., Joly L., Ekker M., Ho R.K. Development 125:407-420(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 177-250, DEVELOPMENTAL STAGE. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX005254 Genomic DNA. Translation: CAM16418.1. BC080255 mRNA. Translation: AAH80255.1. DQ060555 mRNA. Translation: AAY67933.1. Y14544 mRNA. Translation: CAA74879.1.
IPI	IPI00489401.
RefSeq	NP_001005771.1. NM_001005771.1.
UniGene	Dr.132201.
3D structure databases
HSSP	HSSP built from PDB template 9ANT based on UniProtKB P02833.
ProteinModelPortal	Q68EH7.
SMR	Q68EH7. Positions 149-215.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000103139; ENSDARP00000093913; ENSDARG00000070346.
GeneID	449648.
KEGG	dre:449648.
Organism-specific databases
CTD	449648.
ZFIN	ZDB-GENE-990415-114. hoxc8a.
Phylogenomic databases
eggNOG	NOG314669.
GeneTree	ENSGT00700000104332.
HOGENOM	HOG000231181.
HOVERGEN	HBG016849.
InParanoid	A2BE64.
KO	K09308.
OMA	HHGTSSI.
OrthoDB	EOG4H464V.
Gene expression databases
Bgee	Q68EH7.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20832749.

Entry information

Entry name

HXC8A_DANRE

Accession

Primary (citable) accession number: Q68EH7
Secondary accession number(s): A2BE64, O57369, Q4PR88

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 5, 2006
Last sequence update:	October 11, 2004
Last modified:	April 3, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program