Q68EF6 (BEGIN_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Brain-enriched guanylate kinase-associated protein

Gene names

Name:

Begain

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	600 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May sustain the structure of the postsynaptic density (PSD).
Subunit structure	Interacts with DLG4 and DLGAP1 and forms a ternary complex By similarity.
Subcellular location	Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity.
Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR By similarity. Ref.3 Ref.4 Ref.5

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 600	600	Brain-enriched guanylate kinase-associated protein		PRO_0000064905
Amino acid modifications
	Modified residue	137	1	Phosphotyrosine Ref.4
	Modified residue	194	1	Phosphoserine Ref.3
	Modified residue	246	1	Phosphoserine Ref.3
	Modified residue	265	1	Phosphoserine Ref.5
	Modified residue	357	1	Phosphoserine Ref.5
	Modified residue	473	1	Phosphoserine Ref.5
	Modified residue	491	1	Phosphoserine By similarity
	Modified residue	510	1	Phosphoserine By similarity
	Modified residue	570	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q68EF6 [UniParc]. Last modified February 1, 2005. Version 2. Checksum: 0BECA620CF2971D0	FASTA	600	65,309
	10 20 30 40 50 60 MEKLSALQEQ KGELRKRLSY TTHKLEKLET EFDSTRHYLE IELRRAQEEL DKVTEKLRRI 70 80 90 100 110 120 QSNYMALQRI NQELEDKLYR MGQHYEEEKR AMSHEIVALN SHLLEAKVTI DKLSEDNELY 130 140 150 160 170 180 RKDCNLAAQL LQCSQTYGRV HKVSELPSDF QQRVSLHMEK HGCSLPSALC HPAYADSVPT 190 200 210 220 230 240 CVIAKVLEKP DPGSLSSRMS DASARDLGYR DGVEKSGPRP PYKGDIYCSD PALYCPDERE 250 260 270 280 290 300 HARRPSVDTP VTDVGFLRAQ NSTDSAAEEE EEAEAAAFPE AYRREAYQGY AASLPTSSSY 310 320 330 340 350 360 SSFSATSEEK EHAQAGTLTA SQQAIYLSSR DEFFNRKPSA TYGSGPRFAK AASTLGSPLE 370 380 390 400 410 420 AQVAPGFART VSPYPAEPYR YPASPGPQQA LMPPNLWSLR AKPSGNRLAG EDIRGQWRPV 430 440 450 460 470 480 SVEDVGAYSY QAGAAAGRAA SPCNYSERYY GGGGGGGAAG GGSPGDKAEG RASPLYATYK 490 500 510 520 530 540 ADSFSEGDDL SQGHLAEPCF LRAGGDLSLS PSRSADALAG YAASDGDGDR LRVQLCGAGS 550 560 570 580 590 600 SPEPEHGSRE SLEPSSMEAS PEMHPPTRLS PQQAFPRTGG SGLSRKDSLT KAQLYGTLLN

References

[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 35-600. Strain: C57BL/6. Tissue: Brain.
[3]	"Comprehensive identification of phosphorylation sites in postsynaptic density preparations." Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L. Mol. Cell. Proteomics 5:914-922(2006) [PubMed: 16452087] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-194 AND SER-246, MASS SPECTROMETRY. Tissue: Brain.
[4]	"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain." Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P. J. Proteome Res. 7:311-318(2008) [PubMed: 18034455] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-137, MASS SPECTROMETRY. Tissue: Brain.
[5]	"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M. Mol. Cell. Proteomics 6:283-293(2007) [PubMed: 17114649] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-265; SER-357 AND SER-473, MASS SPECTROMETRY. Tissue: Brain cortex.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC140111 Genomic DNA. No translation available. BC080282 mRNA. Translation: AAH80282.1.
IPI	IPI00380950.
RefSeq	NP_001156647.1. NM_001163175.1.
UniGene	Mm.342085.
3D structure databases
ProteinModelPortal	Q68EF6.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q68EF6. 1 interaction.
STRING	Q68EF6.
PTM databases
PhosphoSite	Q68EF6.
Proteomic databases
PRIDE	Q68EF6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	380785.
KEGG	mmu:380785.
UCSC	uc007pal.1. mouse.
Organism-specific databases
CTD	57596.
MGI	MGI:3044626. Begain.
Phylogenomic databases
eggNOG	roNOG11365.
GeneTree	ENSGT00530000063778.
HOGENOM	HBG505527.
HOVERGEN	HBG050683.
InParanoid	Q68EF6.
OMA	QNNYLAL.
OrthoDB	EOG4WQ12D.
Gene expression databases
ArrayExpress	Q68EF6.
Bgee	Q68EF6.
CleanEx	MM_BEGAIN.
Genevestigator	Q68EF6.
GermOnline	ENSMUSG00000040867. Mus musculus.
Family and domain databases
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

BEGIN_MOUSE

Accession

Primary (citable) accession number: Q68EF6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	February 1, 2005
Last modified:	September 21, 2011
This is version 64 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program