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Q68EF4

- GRM4_MOUSE

UniProt

Q68EF4 - GRM4_MOUSE

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Protein
Metabotropic glutamate receptor 4
Gene
Grm4, Gprc1d, Mglur4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei159 – 1591Glutamate By similarity
Binding sitei230 – 2301Glutamate By similarity
Binding sitei312 – 3121Glutamate By similarity
Binding sitei405 – 4051Glutamate By similarity

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB
  2. glutamate receptor activity Source: UniProtKB
  3. group III metabotropic glutamate receptor activity Source: RefGenome

GO - Biological processi

  1. activation of MAPK activity Source: Ensembl
  2. adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway Source: UniProtKB
  3. learning Source: MGI
  4. regulation of synaptic transmission, glutamatergic Source: RefGenome
  5. synaptic transmission Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Metabotropic glutamate receptor 4
Short name:
mGluR4
Gene namesi
Name:Grm4
Synonyms:Gprc1d, Mglur4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17, UP000000589: Chromosome Y

Organism-specific databases

MGIiMGI:1351341. Grm4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini33 – 586554Extracellular Reviewed prediction
Add
BLAST
Transmembranei587 – 60721Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini608 – 62417Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei625 – 64521Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini646 – 6538Extracellular Reviewed prediction
Transmembranei654 – 67118Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini672 – 69928Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei700 – 72021Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini721 – 75131Extracellular Reviewed prediction
Add
BLAST
Transmembranei752 – 77221Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini773 – 78614Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei787 – 80721Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini808 – 82619Extracellular Reviewed prediction
Add
BLAST
Transmembranei827 – 84721Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini848 – 91265Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cytoplasmic vesicle Source: Ensembl
  2. dendritic shaft Source: Ensembl
  3. integral component of plasma membrane Source: RefGenome
  4. neuron projection Source: BHF-UCL
  5. presynaptic active zone membrane Source: Ensembl
  6. presynaptic membrane Source: RefGenome
  7. terminal bouton Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232 Reviewed prediction
Add
BLAST
Chaini33 – 912880Metabotropic glutamate receptor 4
PRO_0000306852Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi67 ↔ 109 By similarity
Glycosylationi98 – 981N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi249 ↔ 538 By similarity
Glycosylationi301 – 3011N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi372 ↔ 388 By similarity
Disulfide bondi428 ↔ 435 By similarity
Disulfide bondi520 ↔ 539 By similarity
Disulfide bondi524 ↔ 542 By similarity
Disulfide bondi545 ↔ 557 By similarity
Disulfide bondi560 ↔ 573 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ68EF4.
PRIDEiQ68EF4.

PTM databases

PhosphoSiteiQ68EF4.

Expressioni

Gene expression databases

BgeeiQ68EF4.
CleanExiMM_GRM4.
GenevestigatoriQ68EF4.

Interactioni

Subunit structurei

Interacts with PICK1 By similarity.

Protein-protein interaction databases

DIPiDIP-49002N.
STRINGi10090.ENSMUSP00000113819.

Structurei

3D structure databases

ProteinModelPortaliQ68EF4.
SMRiQ68EF4. Positions 38-853.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni180 – 1823Glutamate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG295200.
GeneTreeiENSGT00750000117581.
HOGENOMiHOG000218635.
HOVERGENiHBG107965.
InParanoidiQ68EF4.
KOiK04607.
PhylomeDBiQ68EF4.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001786. GPCR_3_mtglu_rcpt_4.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
PR01054. MTABOTROPC4R.
PR00593. MTABOTROPICR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q68EF4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSGKGGWAWW WARLPLCLLL SLYGSWVPSS LGKPKGHPHM NSIRIDGDIT    50
LGGLFPVHGR GSEGKACGEL KKEKGIHRLE AMLFALDRIN NDPDLLPNIT 100
LGARILDTCS RDTHALEQSL TFVQALIEKD GTEVRCGSGG PPIITKPERV 150
VGVIGASGSS VSIMVANILR LFKIPQISYA STAPDLSDNS RYDFFSRVVP 200
SDTYQAQAMV DIVRALKWNY VSTLASEGSY GESGVEAFIQ KSRENGGVCI 250
AQSVKIPREP KTGEFDKIIK RLLETSNARA IIIFANEDDI RRVLEAARRA 300
NQTGHFFWMG SDSWGSKSAP VLRLEEVAEG AVTILPKRTS VRGFDRYFSS 350
RTLDNNRRNI WFAEFWEDNF HCKLSRHALK KGSHIKKCTN RERIGQDSAY 400
EQEGKVQFVI DAVYAMGHAL HAMHRDLCPG RVGLCPRMDP VDGTQLLKYI 450
RNVNFSGIAG NPVTFNENGD APGRYDIYQY QRRNGSAEYK VIGSWTDHLH 500
LRIERMQWPG SGQQLPRSIC SLPCQPGERK KTVKGMACCW HCEPCTGYQY 550
QVDRYTCKTC PYDMRPTENR TSCQPIPIVK LEWDSPWAVL PLFLAVVGIA 600
ATLFVVVTFV RYNDTPIVKA SGRELSYVLL AGIFLCYATT FLMIAEPDLG 650
TCSLRRIFLG LGMSISYAAL LTKTNRIYRI FEQGKRSVSA PRFISPASQL 700
AITFVLISLQ LLCICVWFVV DPSHSVVDFQ DQRTLDPRFA RGVLKCDISD 750
LSLICLLGYS MLLMVTCTVY AIKTRGVPET FNEAKPIGFT MYTTCIVWLA 800
FIPIFFGTSQ SADKLYIQTT TLTVSVSLSA SVSLGMLYMP KVYIILFHPE 850
QNVPKRKRSL KAVVTAATMS NKFTQKGNFR PNGEAKSELC ENLEAPALAT 900
KQTYVTYTNH AI 912
Length:912
Mass (Da):101,824
Last modified:October 2, 2007 - v2
Checksum:i5D73C6423CF4E38C
GO
Isoform 2 (identifier: Q68EF4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     815-832: LYIQTTTLTVSVSLSASV → VTSEALPVEFSPPLLAHN
     833-912: Missing.

Show »
Length:832
Mass (Da):92,879
Checksum:i3B94570F77821FB2
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei815 – 83218LYIQT…LSASV → VTSEALPVEFSPPLLAHN in isoform 2.
VSP_028517Add
BLAST
Alternative sequencei833 – 91280Missing in isoform 2.
VSP_028518Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti713 – 7131C → G in AAH80284. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC072635 mRNA. No translation available.
BC080284 mRNA. Translation: AAH80284.1.
AY255558 mRNA. Translation: AAO85070.1.
CCDSiCCDS28563.1. [Q68EF4-2]
CCDS70775.1. [Q68EF4-1]
RefSeqiNP_001013403.1. NM_001013385.2.
UniGeneiMm.358940.

Genome annotation databases

EnsembliENSMUST00000118489; ENSMUSP00000112578; ENSMUSG00000063239.
GeneIDi268934.
KEGGimmu:268934.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC072635 mRNA. No translation available.
BC080284 mRNA. Translation: AAH80284.1 .
AY255558 mRNA. Translation: AAO85070.1 .
CCDSi CCDS28563.1. [Q68EF4-2 ]
CCDS70775.1. [Q68EF4-1 ]
RefSeqi NP_001013403.1. NM_001013385.2.
UniGenei Mm.358940.

3D structure databases

ProteinModelPortali Q68EF4.
SMRi Q68EF4. Positions 38-853.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-49002N.
STRINGi 10090.ENSMUSP00000113819.

Chemistry

GuidetoPHARMACOLOGYi 292.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q68EF4.

Proteomic databases

PaxDbi Q68EF4.
PRIDEi Q68EF4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000118489 ; ENSMUSP00000112578 ; ENSMUSG00000063239 .
GeneIDi 268934.
KEGGi mmu:268934.

Organism-specific databases

CTDi 2914.
MGIi MGI:1351341. Grm4.

Phylogenomic databases

eggNOGi NOG295200.
GeneTreei ENSGT00750000117581.
HOGENOMi HOG000218635.
HOVERGENi HBG107965.
InParanoidi Q68EF4.
KOi K04607.
PhylomeDBi Q68EF4.

Miscellaneous databases

NextBioi 392591.
PROi Q68EF4.
SOURCEi Search...

Gene expression databases

Bgeei Q68EF4.
CleanExi MM_GRM4.
Genevestigatori Q68EF4.

Family and domain databases

InterProi IPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001786. GPCR_3_mtglu_rcpt_4.
IPR028082. Peripla_BP_I.
[Graphical view ]
Pfami PF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view ]
PRINTSi PR00248. GPCRMGR.
PR01054. MTABOTROPC4R.
PR00593. MTABOTROPICR.
SUPFAMi SSF53822. SSF53822. 1 hit.
PROSITEi PS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 528-642.

Entry informationi

Entry nameiGRM4_MOUSE
AccessioniPrimary (citable) accession number: Q68EF4
Secondary accession number(s): Q80UC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: September 3, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi