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Q68EF0

- RAB3I_MOUSE

UniProt

Q68EF0 - RAB3I_MOUSE

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Protein

Rab-3A-interacting protein

Gene

Rab3ip

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity).By similarity

GO - Molecular functioni

  1. Rab guanyl-nucleotide exchange factor activity Source: UniProtKB

GO - Biological processi

  1. positive regulation of Rab GTPase activity Source: GOC
  2. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Rab-3A-interacting protein
Short name:
Rab3A-interacting protein
Alternative name(s):
Rabin-3
SSX2-interacting protein
Gene namesi
Name:Rab3ipImported
Synonyms:Rabin8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:105933. Rab3ip.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity. Cytoplasmcytoskeleton By similarity. Cell projectionlamellipodium By similarity
Note: Predominantly cytoplasmic but a small proportion colocalizes with SSX2 in the nucleus. Activation of protein kinase C results in redistribution to the periphery of lamellipodia. In the cytoskeleton, localizes to cortical actin (By similarity).By similarity

GO - Cellular componenti

  1. cell projection Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-KW
  3. cytosol Source: UniProtKB
  4. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428Rab-3A-interacting proteinPRO_0000097145Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei147 – 1471PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ68EF0.
PaxDbiQ68EF0.
PRIDEiQ68EF0.

PTM databases

PhosphoSiteiQ68EF0.

Expressioni

Gene expression databases

BgeeiQ68EF0.
CleanExiMM_RAB3IP.
ExpressionAtlasiQ68EF0. baseline and differential.
GenevestigatoriQ68EF0.

Interactioni

Subunit structurei

Interacts with the N-terminal region of SSX2. Interacts with the GDP-bound forms of RAB3A, RAB3D, RAB8A and RAB8B (By similarity).By similarity

Protein-protein interaction databases

BioGridi229736. 1 interaction.
STRINGi10090.ENSMUSP00000020375.

Structurei

3D structure databases

ProteinModelPortaliQ68EF0.
SMRiQ68EF0. Positions 152-198.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili149 – 21264Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the SEC2 family.Sequence Analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG243791.
GeneTreeiENSGT00390000009036.
HOGENOMiHOG000220814.
HOVERGENiHBG057034.
InParanoidiQ68EF0.
KOiK16779.
OMAiAPIQANA.
OrthoDBiEOG7KSX8Q.
PhylomeDBiQ68EF0.
TreeFamiTF313748.

Family and domain databases

InterProiIPR009449. Sec2p.
[Graphical view]
PfamiPF06428. Sec2p. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68EF0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANDPLEGFH EVNLASPTSP DLLGVCDPGT QEQTTSPSVI YRPHPSTLCA
60 70 80 90 100
APLQANALDL SDLPTQPVYS SPRHFNCAEV SNISAHAPDP ASSVPSAVAS
110 120 130 140 150
GLTKLTSRKD SCNAEREFLQ GATITEASAG NDDIFGLSTD SLSRLRSPSV
160 170 180 190 200
LEVREKGYER LKEELAKAQR EAHKMVREAN VKQATAEKQL KEAQGKIDVL
210 220 230 240 250
QAEVAALKTL VLSSSPTSPT QEPLAAAKTP FKRGHTRNKS TSSAMGGSHQ
260 270 280 290 300
DLSVIQPIVK DCKEADLSLY NEFRSWKDEP TMDRTCPFLD KIYQEDIFPC
310 320 330 340 350
LTFAKSELAS AVLEAVENNT LSIEPVGLQP IRFVKASAVE CGGPKKCALT
360 370 380 390 400
GQSKPCRHRI RLGDSSCCYY ISPFCRYRIT SVCNFFTYIR YIQQGLVKQQ
410 420
DVDQMFWEVM QLRKEMSLAK LGYFKEEL
Length:428
Mass (Da):47,133
Last modified:October 11, 2004 - v1
Checksum:i443F79CDDACD9D3F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC080289 mRNA. Translation: AAH80289.1.
CCDSiCCDS24186.1.
RefSeqiNP_001003950.1. NM_001003950.2.
UniGeneiMm.336394.

Genome annotation databases

EnsembliENSMUST00000020375; ENSMUSP00000020375; ENSMUSG00000064181.
GeneIDi216363.
KEGGimmu:216363.
UCSCiuc007hcj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC080289 mRNA. Translation: AAH80289.1 .
CCDSi CCDS24186.1.
RefSeqi NP_001003950.1. NM_001003950.2.
UniGenei Mm.336394.

3D structure databases

ProteinModelPortali Q68EF0.
SMRi Q68EF0. Positions 152-198.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 229736. 1 interaction.
STRINGi 10090.ENSMUSP00000020375.

PTM databases

PhosphoSitei Q68EF0.

Proteomic databases

MaxQBi Q68EF0.
PaxDbi Q68EF0.
PRIDEi Q68EF0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020375 ; ENSMUSP00000020375 ; ENSMUSG00000064181 .
GeneIDi 216363.
KEGGi mmu:216363.
UCSCi uc007hcj.1. mouse.

Organism-specific databases

CTDi 117177.
MGIi MGI:105933. Rab3ip.

Phylogenomic databases

eggNOGi NOG243791.
GeneTreei ENSGT00390000009036.
HOGENOMi HOG000220814.
HOVERGENi HBG057034.
InParanoidi Q68EF0.
KOi K16779.
OMAi APIQANA.
OrthoDBi EOG7KSX8Q.
PhylomeDBi Q68EF0.
TreeFami TF313748.

Miscellaneous databases

ChiTaRSi Rab3ip. mouse.
NextBioi 375123.
PROi Q68EF0.
SOURCEi Search...

Gene expression databases

Bgeei Q68EF0.
CleanExi MM_RAB3IP.
ExpressionAtlasi Q68EF0. baseline and differential.
Genevestigatori Q68EF0.

Family and domain databases

InterProi IPR009449. Sec2p.
[Graphical view ]
Pfami PF06428. Sec2p. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6Imported.
    Tissue: BrainImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiRAB3I_MOUSE
AccessioniPrimary (citable) accession number: Q68EF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 11, 2004
Last modified: November 26, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3