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Q68EF0 (RAB3I_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Rab-3A-interacting protein

Short name=Rab3A-interacting protein
Alternative name(s):
Rabin-3
SSX2-interacting protein
Gene names
Name:Rab3ip
Synonyms:Rabin8
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length428 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis By similarity.

Subunit structure

Interacts with the N-terminal region of SSX2. Interacts with the GDP-bound forms of RAB3A, RAB3D, RAB8A and RAB8B By similarity. UniProtKB Q96QF0 UniProtKB Q62739

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Cytoplasmcytoskeleton By similarity. Cell projectionlamellipodium By similarity. Note: Predominantly cytoplasmic but a small proportion colocalizes with SSX2 in the nucleus. Activation of protein kinase C results in redistribution to the periphery of lamellipodia. In the cytoskeleton, localizes to cortical actin By similarity.

Sequence similarities

Belongs to the SEC2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 428428Rab-3A-interacting protein
PRO_0000097145

Regions

Coiled coil149 – 21264 Potential

Amino acid modifications

Modified residue1471Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q68EF0 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 443F79CDDACD9D3F

FASTA42847,133
        10         20         30         40         50         60 
MANDPLEGFH EVNLASPTSP DLLGVCDPGT QEQTTSPSVI YRPHPSTLCA APLQANALDL 

        70         80         90        100        110        120 
SDLPTQPVYS SPRHFNCAEV SNISAHAPDP ASSVPSAVAS GLTKLTSRKD SCNAEREFLQ 

       130        140        150        160        170        180 
GATITEASAG NDDIFGLSTD SLSRLRSPSV LEVREKGYER LKEELAKAQR EAHKMVREAN 

       190        200        210        220        230        240 
VKQATAEKQL KEAQGKIDVL QAEVAALKTL VLSSSPTSPT QEPLAAAKTP FKRGHTRNKS 

       250        260        270        280        290        300 
TSSAMGGSHQ DLSVIQPIVK DCKEADLSLY NEFRSWKDEP TMDRTCPFLD KIYQEDIFPC 

       310        320        330        340        350        360 
LTFAKSELAS AVLEAVENNT LSIEPVGLQP IRFVKASAVE CGGPKKCALT GQSKPCRHRI 

       370        380        390        400        410        420 
RLGDSSCCYY ISPFCRYRIT SVCNFFTYIR YIQQGLVKQQ DVDQMFWEVM QLRKEMSLAK 


LGYFKEEL 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[2]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC080289 mRNA. Translation: AAH80289.1.
RefSeqNP_001003950.1. NM_001003950.2.
UniGeneMm.336394.

3D structure databases

ProteinModelPortalQ68EF0.
SMRQ68EF0. Positions 152-198.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid229736. 1 interaction.
STRING10090.ENSMUSP00000020375.

PTM databases

PhosphoSiteQ68EF0.

Proteomic databases

PaxDbQ68EF0.
PRIDEQ68EF0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000020375; ENSMUSP00000020375; ENSMUSG00000064181.
GeneID216363.
KEGGmmu:216363.
UCSCuc007hcj.1. mouse.

Organism-specific databases

CTD117177.
MGIMGI:105933. Rab3ip.

Phylogenomic databases

eggNOGNOG243791.
GeneTreeENSGT00390000009036.
HOGENOMHOG000220814.
HOVERGENHBG057034.
InParanoidQ68EF0.
KOK16779.
OMAAPIQANA.
OrthoDBEOG7KSX8Q.
TreeFamTF313748.

Gene expression databases

ArrayExpressQ68EF0.
BgeeQ68EF0.
CleanExMM_RAB3IP.
GenevestigatorQ68EF0.

Family and domain databases

InterProIPR009449. Sec2p.
[Graphical view]
PfamPF06428. Sec2p. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRAB3IP. mouse.
NextBio375123.
PROQ68EF0.
SOURCESearch...

Entry information

Entry nameRAB3I_MOUSE
AccessionPrimary (citable) accession number: Q68EF0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 11, 2004
Last modified: March 19, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot