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Protein

Rab-3A-interacting protein

Gene

Rab3ip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity).By similarity

GO - Molecular functioni

  1. Rab guanyl-nucleotide exchange factor activity Source: UniProtKB

GO - Biological processi

  1. cilium assembly Source: MGI
  2. positive regulation of Rab GTPase activity Source: MGI
  3. protein localization to organelle Source: MGI
  4. protein targeting to membrane Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Rab-3A-interacting protein
Short name:
Rab3A-interacting protein
Alternative name(s):
Rabin-3
SSX2-interacting protein
Gene namesi
Name:Rab3ipImported
Synonyms:Rabin8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:105933. Rab3ip.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity. Cytoplasmcytoskeleton By similarity. Cell projectionlamellipodium By similarity
Note: Predominantly cytoplasmic but a small proportion colocalizes with SSX2 in the nucleus. Activation of protein kinase C results in redistribution to the periphery of lamellipodia. In the cytoskeleton, localizes to cortical actin (By similarity).By similarity

GO - Cellular componenti

  1. centrosome Source: MGI
  2. cytoplasm Source: MGI
  3. cytosol Source: UniProtKB
  4. lamellipodium Source: UniProtKB-SubCell
  5. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428Rab-3A-interacting proteinPRO_0000097145Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei147 – 1471PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ68EF0.
PaxDbiQ68EF0.
PRIDEiQ68EF0.

PTM databases

PhosphoSiteiQ68EF0.

Expressioni

Gene expression databases

BgeeiQ68EF0.
CleanExiMM_RAB3IP.
ExpressionAtlasiQ68EF0. baseline and differential.
GenevestigatoriQ68EF0.

Interactioni

Subunit structurei

Interacts with the N-terminal region of SSX2. Interacts with the GDP-bound forms of RAB3A, RAB3D, RAB8A and RAB8B (By similarity).By similarity

Protein-protein interaction databases

BioGridi229736. 1 interaction.
STRINGi10090.ENSMUSP00000020375.

Structurei

3D structure databases

ProteinModelPortaliQ68EF0.
SMRiQ68EF0. Positions 152-198.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili149 – 21264Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the SEC2 family.Sequence Analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG243791.
GeneTreeiENSGT00390000009036.
HOGENOMiHOG000220814.
HOVERGENiHBG057034.
InParanoidiQ68EF0.
KOiK16779.
OMAiCSAPIQA.
OrthoDBiEOG7KSX8Q.
PhylomeDBiQ68EF0.
TreeFamiTF313748.

Family and domain databases

InterProiIPR009449. Sec2p.
[Graphical view]
PfamiPF06428. Sec2p. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68EF0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANDPLEGFH EVNLASPTSP DLLGVCDPGT QEQTTSPSVI YRPHPSTLCA
60 70 80 90 100
APLQANALDL SDLPTQPVYS SPRHFNCAEV SNISAHAPDP ASSVPSAVAS
110 120 130 140 150
GLTKLTSRKD SCNAEREFLQ GATITEASAG NDDIFGLSTD SLSRLRSPSV
160 170 180 190 200
LEVREKGYER LKEELAKAQR EAHKMVREAN VKQATAEKQL KEAQGKIDVL
210 220 230 240 250
QAEVAALKTL VLSSSPTSPT QEPLAAAKTP FKRGHTRNKS TSSAMGGSHQ
260 270 280 290 300
DLSVIQPIVK DCKEADLSLY NEFRSWKDEP TMDRTCPFLD KIYQEDIFPC
310 320 330 340 350
LTFAKSELAS AVLEAVENNT LSIEPVGLQP IRFVKASAVE CGGPKKCALT
360 370 380 390 400
GQSKPCRHRI RLGDSSCCYY ISPFCRYRIT SVCNFFTYIR YIQQGLVKQQ
410 420
DVDQMFWEVM QLRKEMSLAK LGYFKEEL
Length:428
Mass (Da):47,133
Last modified:October 11, 2004 - v1
Checksum:i443F79CDDACD9D3F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC080289 mRNA. Translation: AAH80289.1.
CCDSiCCDS24186.1.
RefSeqiNP_001003950.1. NM_001003950.2.
UniGeneiMm.336394.

Genome annotation databases

EnsembliENSMUST00000020375; ENSMUSP00000020375; ENSMUSG00000064181.
GeneIDi216363.
KEGGimmu:216363.
UCSCiuc007hcj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC080289 mRNA. Translation: AAH80289.1.
CCDSiCCDS24186.1.
RefSeqiNP_001003950.1. NM_001003950.2.
UniGeneiMm.336394.

3D structure databases

ProteinModelPortaliQ68EF0.
SMRiQ68EF0. Positions 152-198.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229736. 1 interaction.
STRINGi10090.ENSMUSP00000020375.

PTM databases

PhosphoSiteiQ68EF0.

Proteomic databases

MaxQBiQ68EF0.
PaxDbiQ68EF0.
PRIDEiQ68EF0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020375; ENSMUSP00000020375; ENSMUSG00000064181.
GeneIDi216363.
KEGGimmu:216363.
UCSCiuc007hcj.1. mouse.

Organism-specific databases

CTDi117177.
MGIiMGI:105933. Rab3ip.

Phylogenomic databases

eggNOGiNOG243791.
GeneTreeiENSGT00390000009036.
HOGENOMiHOG000220814.
HOVERGENiHBG057034.
InParanoidiQ68EF0.
KOiK16779.
OMAiCSAPIQA.
OrthoDBiEOG7KSX8Q.
PhylomeDBiQ68EF0.
TreeFamiTF313748.

Miscellaneous databases

ChiTaRSiRab3ip. mouse.
NextBioi375123.
PROiQ68EF0.
SOURCEiSearch...

Gene expression databases

BgeeiQ68EF0.
CleanExiMM_RAB3IP.
ExpressionAtlasiQ68EF0. baseline and differential.
GenevestigatoriQ68EF0.

Family and domain databases

InterProiIPR009449. Sec2p.
[Graphical view]
PfamiPF06428. Sec2p. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6Imported.
    Tissue: BrainImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiRAB3I_MOUSE
AccessioniPrimary (citable) accession number: Q68EF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 11, 2004
Last modified: February 4, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.