Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q68EF0

- RAB3I_MOUSE

UniProt

Q68EF0 - RAB3I_MOUSE

Protein

Rab-3A-interacting protein

Gene

Rab3ip

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis By similarity.By similarity

    GO - Molecular functioni

    1. Rab guanyl-nucleotide exchange factor activity Source: UniProtKB

    GO - Biological processi

    1. positive regulation of Rab GTPase activity Source: GOC
    2. protein transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rab-3A-interacting protein
    Short name:
    Rab3A-interacting protein
    Alternative name(s):
    Rabin-3
    SSX2-interacting protein
    Gene namesi
    Name:Rab3ipImported
    Synonyms:Rabin8
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:105933. Rab3ip.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity. Cytoplasmcytoskeleton By similarity. Cell projectionlamellipodium By similarity
    Note: Predominantly cytoplasmic but a small proportion colocalizes with SSX2 in the nucleus. Activation of protein kinase C results in redistribution to the periphery of lamellipodia. In the cytoskeleton, localizes to cortical actin By similarity.By similarity

    GO - Cellular componenti

    1. cytoskeleton Source: UniProtKB-SubCell
    2. cytosol Source: UniProtKB
    3. lamellipodium Source: UniProtKB-SubCell
    4. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cell projection, Cytoplasm, Cytoskeleton, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 428428Rab-3A-interacting proteinPRO_0000097145Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei147 – 1471PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ68EF0.
    PaxDbiQ68EF0.
    PRIDEiQ68EF0.

    PTM databases

    PhosphoSiteiQ68EF0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ68EF0.
    BgeeiQ68EF0.
    CleanExiMM_RAB3IP.
    GenevestigatoriQ68EF0.

    Interactioni

    Subunit structurei

    Interacts with the N-terminal region of SSX2. Interacts with the GDP-bound forms of RAB3A, RAB3D, RAB8A and RAB8B By similarity.By similarity

    Protein-protein interaction databases

    BioGridi229736. 1 interaction.
    STRINGi10090.ENSMUSP00000020375.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68EF0.
    SMRiQ68EF0. Positions 152-198.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili149 – 21264Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SEC2 family.Sequence Analysis

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG243791.
    GeneTreeiENSGT00390000009036.
    HOGENOMiHOG000220814.
    HOVERGENiHBG057034.
    InParanoidiQ68EF0.
    KOiK16779.
    OMAiAPIQANA.
    OrthoDBiEOG7KSX8Q.
    PhylomeDBiQ68EF0.
    TreeFamiTF313748.

    Family and domain databases

    InterProiIPR009449. Sec2p.
    [Graphical view]
    PfamiPF06428. Sec2p. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q68EF0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANDPLEGFH EVNLASPTSP DLLGVCDPGT QEQTTSPSVI YRPHPSTLCA    50
    APLQANALDL SDLPTQPVYS SPRHFNCAEV SNISAHAPDP ASSVPSAVAS 100
    GLTKLTSRKD SCNAEREFLQ GATITEASAG NDDIFGLSTD SLSRLRSPSV 150
    LEVREKGYER LKEELAKAQR EAHKMVREAN VKQATAEKQL KEAQGKIDVL 200
    QAEVAALKTL VLSSSPTSPT QEPLAAAKTP FKRGHTRNKS TSSAMGGSHQ 250
    DLSVIQPIVK DCKEADLSLY NEFRSWKDEP TMDRTCPFLD KIYQEDIFPC 300
    LTFAKSELAS AVLEAVENNT LSIEPVGLQP IRFVKASAVE CGGPKKCALT 350
    GQSKPCRHRI RLGDSSCCYY ISPFCRYRIT SVCNFFTYIR YIQQGLVKQQ 400
    DVDQMFWEVM QLRKEMSLAK LGYFKEEL 428
    Length:428
    Mass (Da):47,133
    Last modified:October 11, 2004 - v1
    Checksum:i443F79CDDACD9D3F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC080289 mRNA. Translation: AAH80289.1.
    CCDSiCCDS24186.1.
    RefSeqiNP_001003950.1. NM_001003950.2.
    UniGeneiMm.336394.

    Genome annotation databases

    EnsembliENSMUST00000020375; ENSMUSP00000020375; ENSMUSG00000064181.
    GeneIDi216363.
    KEGGimmu:216363.
    UCSCiuc007hcj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC080289 mRNA. Translation: AAH80289.1 .
    CCDSi CCDS24186.1.
    RefSeqi NP_001003950.1. NM_001003950.2.
    UniGenei Mm.336394.

    3D structure databases

    ProteinModelPortali Q68EF0.
    SMRi Q68EF0. Positions 152-198.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 229736. 1 interaction.
    STRINGi 10090.ENSMUSP00000020375.

    PTM databases

    PhosphoSitei Q68EF0.

    Proteomic databases

    MaxQBi Q68EF0.
    PaxDbi Q68EF0.
    PRIDEi Q68EF0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020375 ; ENSMUSP00000020375 ; ENSMUSG00000064181 .
    GeneIDi 216363.
    KEGGi mmu:216363.
    UCSCi uc007hcj.1. mouse.

    Organism-specific databases

    CTDi 117177.
    MGIi MGI:105933. Rab3ip.

    Phylogenomic databases

    eggNOGi NOG243791.
    GeneTreei ENSGT00390000009036.
    HOGENOMi HOG000220814.
    HOVERGENi HBG057034.
    InParanoidi Q68EF0.
    KOi K16779.
    OMAi APIQANA.
    OrthoDBi EOG7KSX8Q.
    PhylomeDBi Q68EF0.
    TreeFami TF313748.

    Miscellaneous databases

    ChiTaRSi RAB3IP. mouse.
    NextBioi 375123.
    PROi Q68EF0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q68EF0.
    Bgeei Q68EF0.
    CleanExi MM_RAB3IP.
    Genevestigatori Q68EF0.

    Family and domain databases

    InterProi IPR009449. Sec2p.
    [Graphical view ]
    Pfami PF06428. Sec2p. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6Imported.
      Tissue: BrainImported.
    2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiRAB3I_MOUSE
    AccessioniPrimary (citable) accession number: Q68EF0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3