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Q68ED7 (CRTC1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CREB-regulated transcription coactivator 1
Alternative name(s):
Mucoepidermoid carcinoma translocated protein 1 homolog
Transducer of regulated cAMP response element-binding protein 1
Short name=TORC-1
Short name=Transducer of CREB protein 1
Gene names
Name:Crtc1
Synonyms:Kiaa0616, Mect1, Torc1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length630 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells By similarity. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons. Ref.3 UniProtKB Q6UUV9

Subunit structure

Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction. Interaction, via its C-terminal, with TAF4, enhances recruitment of TAF4 to CREB1. Binds HTLV1 Tax.

Subcellular location

Cytoplasm. Nucleus. Note: Cytoplasmic when phosphorylated by SIK or AMPK and when sequestered by 14-3-3 proteins By similarity. Translocated to the nucleus on Ser-151 dephosphorylation, instigated by a number of factors including calcium ion and cAMP levels. Ref.3

Tissue specificity

Highly expressed in specific regions of the brain including the cortex, hippocampus and striatum. Ref.3

Post-translational modification

Phosphorylation/dephosphorylation states of Ser-151 are required for regulating transduction of CREB activity. TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of phosphorylation is mediated by SIKs (SIK1 and SIK2), is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs by LKB1.

Sequence similarities

Belongs to the TORC family.

Sequence caution

The sequence BAC97983.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 630630CREB-regulated transcription coactivator 1
PRO_0000096355

Regions

Motif242 – 25817Nuclear export signal By similarity
Compositional bias295 – 36571Ser-rich

Sites

Site5711Required for ubiquitination and degradation By similarity

Amino acid modifications

Modified residue1511Phosphoserine; by SIK1 and SIK2 By similarity
Modified residue1611Phosphothreonine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q68ED7 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: FD0C37B48301471C

FASTA63066,945
        10         20         30         40         50         60 
MATSNNPRKF SEKIALHNQK QAEETAAFEE VMKDLSLTRA ARLQLQKSQY LQLGPSRGQY 

        70         80         90        100        110        120 
YGGSLPNVNQ IGSSSVDLAF QTPFQSSGLD TSRTTRHHGL VDRVYRERGR LGSPHRRPLS 

       130        140        150        160        170        180 
VDKHGRQADS CPYGTVYLSP PADTSWRRTN SDSALHQSTM TPSQAESFTG GSQDAHQKRV 

       190        200        210        220        230        240 
LLLTVPGMED TGAETDKTLS KQSWDSKKAG SRPKSCEVPG INIFPSADQE NTTALIPATH 

       250        260        270        280        290        300 
NTGGSLPDLT NIHFPSPLPT PLDPEEPPFP ALTSSSSTGS LAHLGVGGAG QGMNTPSSSP 

       310        320        330        340        350        360 
QHRPAVVSPL SLSTEARRQQ AQQVSPTLSP LSPITQAVAM DALSLEQQLP YAFFTQTGSQ 

       370        380        390        400        410        420 
QPPPQPQPPP PPPPVSQQQP PPPQVSVGLP QGGPLLPSAS LTRGPQLPPL SVTVPSTLPQ 

       430        440        450        460        470        480 
SPTENPGQSP MGIDATSAPA LQYRTSAGSP ATQSPTSPVS NQGFSPGSSP QHTSTLGSVF 

       490        500        510        520        530        540 
GDAYYEQQMT ARQANALSRQ LEQFNMMENA ISSSSLYNPG STLNYSQAAM MGLSGSHGGL 

       550        560        570        580        590        600 
QDPQQLGYTG HGGIPNIILT VTGESPPSLS KELSSTLAGV SDVSFDSDHQ FPLDELKIDP 

       610        620        630 
LTLDGLHMLN DPDMVLADPA TEDTFRMDRL 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[2]"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity."
Kovacs K.A., Steullet P., Steinmann M., Do K.Q., Magistretti P.J., Halfon O., Cardinaux J.R.
Proc. Natl. Acad. Sci. U.S.A. 104:4700-4705(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC080308 mRNA. Translation: AAH80308.1.
AK129173 mRNA. Translation: BAC97983.1. Different initiation.
CCDSCCDS40372.1.
RefSeqNP_001004062.1. NM_001004062.2.
UniGeneMm.227767.

3D structure databases

ProteinModelPortalQ68ED7.
SMRQ68ED7. Positions 8-35.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid238211. 1 interaction.
STRING10090.ENSMUSP00000075916.

PTM databases

PhosphoSiteQ68ED7.

Proteomic databases

MaxQBQ68ED7.
PaxDbQ68ED7.
PRIDEQ68ED7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000076615; ENSMUSP00000075916; ENSMUSG00000003575.
GeneID382056.
KEGGmmu:382056.
UCSCuc009mae.1. mouse.

Organism-specific databases

CTD23373.
MGIMGI:2142523. Crtc1.
RougeSearch...

Phylogenomic databases

eggNOGNOG85958.
GeneTreeENSGT00390000010652.
HOGENOMHOG000111980.
HOVERGENHBG058314.
InParanoidQ68ED7.
KOK15309.
OMAPQHSSTL.
OrthoDBEOG7MKW5P.
PhylomeDBQ68ED7.
TreeFamTF321571.

Gene expression databases

BgeeQ68ED7.
CleanExMM_CRTC1.
GenevestigatorQ68ED7.

Family and domain databases

InterProIPR024786. TORC.
IPR024785. TORC_C.
IPR024784. TORC_M.
IPR024783. TORC_N.
[Graphical view]
PANTHERPTHR13589. PTHR13589. 1 hit.
PfamPF12886. TORC_C. 1 hit.
PF12885. TORC_M. 1 hit.
PF12884. TORC_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio402921.
PROQ68ED7.
SOURCESearch...

Entry information

Entry nameCRTC1_MOUSE
AccessionPrimary (citable) accession number: Q68ED7
Secondary accession number(s): Q6ZQ85
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 11, 2004
Last modified: July 9, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot