Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q68ED7

- CRTC1_MOUSE

UniProt

Q68ED7 - CRTC1_MOUSE

Protein

CREB-regulated transcription coactivator 1

Gene

Crtc1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells By similarity. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons.By similarity1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei571 – 5711Required for ubiquitination and degradationBy similarity

    GO - Molecular functioni

    1. cAMP response element binding protein binding Source: UniProtKB

    GO - Biological processi

    1. membrane hyperpolarization Source: MGI
    2. memory Source: MGI
    3. positive regulation of CREB transcription factor activity Source: InterPro
    4. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    5. protein homotetramerization Source: InterPro
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CREB-regulated transcription coactivator 1
    Alternative name(s):
    Mucoepidermoid carcinoma translocated protein 1 homolog
    Transducer of regulated cAMP response element-binding protein 1
    Short name:
    TORC-1
    Short name:
    Transducer of CREB protein 1
    Gene namesi
    Name:Crtc1Imported
    Synonyms:Kiaa0616Imported, Mect1Imported, Torc1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:2142523. Crtc1.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication
    Note: Cytoplasmic when phosphorylated by SIK or AMPK and when sequestered by 14-3-3 proteins By similarity. Translocated to the nucleus on Ser-151 dephosphorylation, instigated by a number of factors including calcium ion and cAMP levels.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. nucleus Source: UniProtKB
    3. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 630630CREB-regulated transcription coactivator 1PRO_0000096355Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei151 – 1511Phosphoserine; by SIK1 and SIK2By similarity
    Modified residuei161 – 1611PhosphothreonineBy similarity

    Post-translational modificationi

    Phosphorylation/dephosphorylation states of Ser-151 are required for regulating transduction of CREB activity. TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of phosphorylation is mediated by SIKs (SIK1 and SIK2), is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs by LKB1.

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ68ED7.
    PaxDbiQ68ED7.
    PRIDEiQ68ED7.

    PTM databases

    PhosphoSiteiQ68ED7.

    Expressioni

    Tissue specificityi

    Highly expressed in specific regions of the brain including the cortex, hippocampus and striatum.1 Publication

    Gene expression databases

    BgeeiQ68ED7.
    CleanExiMM_CRTC1.
    GenevestigatoriQ68ED7.

    Interactioni

    Subunit structurei

    Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction. Interaction, via its C-terminal, with TAF4, enhances recruitment of TAF4 to CREB1. Binds HTLV1 Tax.

    Protein-protein interaction databases

    BioGridi238211. 1 interaction.
    STRINGi10090.ENSMUSP00000075916.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68ED7.
    SMRiQ68ED7. Positions 8-35.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi242 – 25817Nuclear export signalBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi295 – 36571Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TORC family.Curated

    Phylogenomic databases

    eggNOGiNOG85958.
    GeneTreeiENSGT00390000010652.
    HOGENOMiHOG000111980.
    HOVERGENiHBG058314.
    InParanoidiQ68ED7.
    KOiK15309.
    OMAiPQHSSTL.
    OrthoDBiEOG7MKW5P.
    PhylomeDBiQ68ED7.
    TreeFamiTF321571.

    Family and domain databases

    InterProiIPR024786. TORC.
    IPR024785. TORC_C.
    IPR024784. TORC_M.
    IPR024783. TORC_N.
    [Graphical view]
    PANTHERiPTHR13589. PTHR13589. 1 hit.
    PfamiPF12886. TORC_C. 1 hit.
    PF12885. TORC_M. 1 hit.
    PF12884. TORC_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q68ED7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATSNNPRKF SEKIALHNQK QAEETAAFEE VMKDLSLTRA ARLQLQKSQY    50
    LQLGPSRGQY YGGSLPNVNQ IGSSSVDLAF QTPFQSSGLD TSRTTRHHGL 100
    VDRVYRERGR LGSPHRRPLS VDKHGRQADS CPYGTVYLSP PADTSWRRTN 150
    SDSALHQSTM TPSQAESFTG GSQDAHQKRV LLLTVPGMED TGAETDKTLS 200
    KQSWDSKKAG SRPKSCEVPG INIFPSADQE NTTALIPATH NTGGSLPDLT 250
    NIHFPSPLPT PLDPEEPPFP ALTSSSSTGS LAHLGVGGAG QGMNTPSSSP 300
    QHRPAVVSPL SLSTEARRQQ AQQVSPTLSP LSPITQAVAM DALSLEQQLP 350
    YAFFTQTGSQ QPPPQPQPPP PPPPVSQQQP PPPQVSVGLP QGGPLLPSAS 400
    LTRGPQLPPL SVTVPSTLPQ SPTENPGQSP MGIDATSAPA LQYRTSAGSP 450
    ATQSPTSPVS NQGFSPGSSP QHTSTLGSVF GDAYYEQQMT ARQANALSRQ 500
    LEQFNMMENA ISSSSLYNPG STLNYSQAAM MGLSGSHGGL QDPQQLGYTG 550
    HGGIPNIILT VTGESPPSLS KELSSTLAGV SDVSFDSDHQ FPLDELKIDP 600
    LTLDGLHMLN DPDMVLADPA TEDTFRMDRL 630
    Length:630
    Mass (Da):66,945
    Last modified:October 11, 2004 - v1
    Checksum:iFD0C37B48301471C
    GO

    Sequence cautioni

    The sequence BAC97983.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC080308 mRNA. Translation: AAH80308.1.
    AK129173 mRNA. Translation: BAC97983.1. Different initiation.
    CCDSiCCDS40372.1.
    RefSeqiNP_001004062.1. NM_001004062.2.
    UniGeneiMm.227767.

    Genome annotation databases

    EnsembliENSMUST00000076615; ENSMUSP00000075916; ENSMUSG00000003575.
    GeneIDi382056.
    KEGGimmu:382056.
    UCSCiuc009mae.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC080308 mRNA. Translation: AAH80308.1 .
    AK129173 mRNA. Translation: BAC97983.1 . Different initiation.
    CCDSi CCDS40372.1.
    RefSeqi NP_001004062.1. NM_001004062.2.
    UniGenei Mm.227767.

    3D structure databases

    ProteinModelPortali Q68ED7.
    SMRi Q68ED7. Positions 8-35.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 238211. 1 interaction.
    STRINGi 10090.ENSMUSP00000075916.

    PTM databases

    PhosphoSitei Q68ED7.

    Proteomic databases

    MaxQBi Q68ED7.
    PaxDbi Q68ED7.
    PRIDEi Q68ED7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000076615 ; ENSMUSP00000075916 ; ENSMUSG00000003575 .
    GeneIDi 382056.
    KEGGi mmu:382056.
    UCSCi uc009mae.1. mouse.

    Organism-specific databases

    CTDi 23373.
    MGIi MGI:2142523. Crtc1.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG85958.
    GeneTreei ENSGT00390000010652.
    HOGENOMi HOG000111980.
    HOVERGENi HBG058314.
    InParanoidi Q68ED7.
    KOi K15309.
    OMAi PQHSSTL.
    OrthoDBi EOG7MKW5P.
    PhylomeDBi Q68ED7.
    TreeFami TF321571.

    Miscellaneous databases

    NextBioi 402921.
    PROi Q68ED7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q68ED7.
    CleanExi MM_CRTC1.
    Genevestigatori Q68ED7.

    Family and domain databases

    InterProi IPR024786. TORC.
    IPR024785. TORC_C.
    IPR024784. TORC_M.
    IPR024783. TORC_N.
    [Graphical view ]
    PANTHERi PTHR13589. PTHR13589. 1 hit.
    Pfami PF12886. TORC_C. 1 hit.
    PF12885. TORC_M. 1 hit.
    PF12884. TORC_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6Imported.
      Tissue: BrainImported.
    2. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
      DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: BrainImported.
    3. "TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity."
      Kovacs K.A., Steullet P., Steinmann M., Do K.Q., Magistretti P.J., Halfon O., Cardinaux J.R.
      Proc. Natl. Acad. Sci. U.S.A. 104:4700-4705(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiCRTC1_MOUSE
    AccessioniPrimary (citable) accession number: Q68ED7
    Secondary accession number(s): Q6ZQ85
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3