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Protein

CREB-regulated transcription coactivator 1

Gene

Crtc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells (By similarity). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons. In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock.By similarity3 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei571 – 5711Required for ubiquitination and degradationBy similarity

GO - Molecular functioni

GO - Biological processi

  • entrainment of circadian clock by photoperiod Source: UniProtKB
  • membrane hyperpolarization Source: MGI
  • memory Source: MGI
  • positive regulation of CREB transcription factor activity Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • protein homotetramerization Source: InterPro
  • rhythmic process Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
CREB-regulated transcription coactivator 1
Alternative name(s):
Mucoepidermoid carcinoma translocated protein 1 homolog
Transducer of regulated cAMP response element-binding protein 1
Short name:
TORC-1
Short name:
Transducer of CREB protein 1
Gene namesi
Name:Crtc1Imported
Synonyms:Kiaa0616Imported, Mect1Imported, Torc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2142523. Crtc1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleoplasm Source: MGI
  • nucleus Source: UniProtKB
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 630630CREB-regulated transcription coactivator 1PRO_0000096355Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei151 – 1511Phosphoserine; by SIK1 and SIK2By similarity
Modified residuei161 – 1611PhosphothreonineBy similarity

Post-translational modificationi

Phosphorylation/dephosphorylation states of Ser-151 are required for regulating transduction of CREB activity. TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of phosphorylation is mediated by SIKs (SIK1 and SIK2), is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs by LKB1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ68ED7.
PaxDbiQ68ED7.
PRIDEiQ68ED7.

PTM databases

PhosphoSiteiQ68ED7.

Expressioni

Tissue specificityi

Highly expressed in specific regions of the brain including the cortex, hippocampus and striatum.1 Publication

Inductioni

Expressed in a circadian manner in the suprachiasmatic nucleus (SCN) of the brain. Expression is highest during the day and reaches a nadir during the early subjective night.1 Publication

Gene expression databases

BgeeiQ68ED7.
CleanExiMM_CRTC1.
GenevestigatoriQ68ED7.

Interactioni

Subunit structurei

Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction. Interaction, via its C-terminal, with TAF4, enhances recruitment of TAF4 to CREB1. Binds HTLV1 Tax.

Protein-protein interaction databases

BioGridi238211. 1 interaction.
STRINGi10090.ENSMUSP00000075916.

Structurei

3D structure databases

ProteinModelPortaliQ68ED7.
SMRiQ68ED7. Positions 8-35.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi242 – 25817Nuclear export signalBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi295 – 36571Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the TORC family.Curated

Phylogenomic databases

eggNOGiNOG85958.
GeneTreeiENSGT00390000010652.
HOGENOMiHOG000111980.
HOVERGENiHBG058314.
InParanoidiQ68ED7.
KOiK15309.
OMAiIPQSPPG.
OrthoDBiEOG7MKW5P.
PhylomeDBiQ68ED7.
TreeFamiTF321571.

Family and domain databases

InterProiIPR024786. TORC.
IPR024785. TORC_C.
IPR024784. TORC_M.
IPR024783. TORC_N.
[Graphical view]
PANTHERiPTHR13589. PTHR13589. 1 hit.
PfamiPF12886. TORC_C. 1 hit.
PF12885. TORC_M. 1 hit.
PF12884. TORC_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68ED7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSNNPRKF SEKIALHNQK QAEETAAFEE VMKDLSLTRA ARLQLQKSQY
60 70 80 90 100
LQLGPSRGQY YGGSLPNVNQ IGSSSVDLAF QTPFQSSGLD TSRTTRHHGL
110 120 130 140 150
VDRVYRERGR LGSPHRRPLS VDKHGRQADS CPYGTVYLSP PADTSWRRTN
160 170 180 190 200
SDSALHQSTM TPSQAESFTG GSQDAHQKRV LLLTVPGMED TGAETDKTLS
210 220 230 240 250
KQSWDSKKAG SRPKSCEVPG INIFPSADQE NTTALIPATH NTGGSLPDLT
260 270 280 290 300
NIHFPSPLPT PLDPEEPPFP ALTSSSSTGS LAHLGVGGAG QGMNTPSSSP
310 320 330 340 350
QHRPAVVSPL SLSTEARRQQ AQQVSPTLSP LSPITQAVAM DALSLEQQLP
360 370 380 390 400
YAFFTQTGSQ QPPPQPQPPP PPPPVSQQQP PPPQVSVGLP QGGPLLPSAS
410 420 430 440 450
LTRGPQLPPL SVTVPSTLPQ SPTENPGQSP MGIDATSAPA LQYRTSAGSP
460 470 480 490 500
ATQSPTSPVS NQGFSPGSSP QHTSTLGSVF GDAYYEQQMT ARQANALSRQ
510 520 530 540 550
LEQFNMMENA ISSSSLYNPG STLNYSQAAM MGLSGSHGGL QDPQQLGYTG
560 570 580 590 600
HGGIPNIILT VTGESPPSLS KELSSTLAGV SDVSFDSDHQ FPLDELKIDP
610 620 630
LTLDGLHMLN DPDMVLADPA TEDTFRMDRL
Length:630
Mass (Da):66,945
Last modified:October 11, 2004 - v1
Checksum:iFD0C37B48301471C
GO

Sequence cautioni

The sequence BAC97983.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC080308 mRNA. Translation: AAH80308.1.
AK129173 mRNA. Translation: BAC97983.1. Different initiation.
CCDSiCCDS40372.1.
RefSeqiNP_001004062.1. NM_001004062.2.
UniGeneiMm.227767.

Genome annotation databases

EnsembliENSMUST00000076615; ENSMUSP00000075916; ENSMUSG00000003575.
GeneIDi382056.
KEGGimmu:382056.
UCSCiuc009mae.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC080308 mRNA. Translation: AAH80308.1.
AK129173 mRNA. Translation: BAC97983.1. Different initiation.
CCDSiCCDS40372.1.
RefSeqiNP_001004062.1. NM_001004062.2.
UniGeneiMm.227767.

3D structure databases

ProteinModelPortaliQ68ED7.
SMRiQ68ED7. Positions 8-35.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi238211. 1 interaction.
STRINGi10090.ENSMUSP00000075916.

PTM databases

PhosphoSiteiQ68ED7.

Proteomic databases

MaxQBiQ68ED7.
PaxDbiQ68ED7.
PRIDEiQ68ED7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000076615; ENSMUSP00000075916; ENSMUSG00000003575.
GeneIDi382056.
KEGGimmu:382056.
UCSCiuc009mae.1. mouse.

Organism-specific databases

CTDi23373.
MGIiMGI:2142523. Crtc1.
RougeiSearch...

Phylogenomic databases

eggNOGiNOG85958.
GeneTreeiENSGT00390000010652.
HOGENOMiHOG000111980.
HOVERGENiHBG058314.
InParanoidiQ68ED7.
KOiK15309.
OMAiIPQSPPG.
OrthoDBiEOG7MKW5P.
PhylomeDBiQ68ED7.
TreeFamiTF321571.

Miscellaneous databases

NextBioi402921.
PROiQ68ED7.
SOURCEiSearch...

Gene expression databases

BgeeiQ68ED7.
CleanExiMM_CRTC1.
GenevestigatoriQ68ED7.

Family and domain databases

InterProiIPR024786. TORC.
IPR024785. TORC_C.
IPR024784. TORC_M.
IPR024783. TORC_N.
[Graphical view]
PANTHERiPTHR13589. PTHR13589. 1 hit.
PfamiPF12886. TORC_C. 1 hit.
PF12885. TORC_M. 1 hit.
PF12884. TORC_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6Imported.
    Tissue: BrainImported.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  3. "TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity."
    Kovacs K.A., Steullet P., Steinmann M., Do K.Q., Magistretti P.J., Halfon O., Cardinaux J.R.
    Proc. Natl. Acad. Sci. U.S.A. 104:4700-4705(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  4. Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION.
  5. "Clock and light regulation of the CREB coactivator CRTC1 in the suprachiasmatic circadian clock."
    Sakamoto K., Norona F.E., Alzate-Correa D., Scarberry D., Hoyt K.R., Obrietan K.
    J. Neurosci. 33:9021-9027(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiCRTC1_MOUSE
AccessioniPrimary (citable) accession number: Q68ED7
Secondary accession number(s): Q6ZQ85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 11, 2004
Last modified: March 4, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.