CREB-regulated transcription coactivator 1

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Q68ED7 (CRTC1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 67. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
CREB-regulated transcription coactivator 1

Alternative name(s):
Mucoepidermoid carcinoma translocated protein 1 homolog
Transducer of regulated cAMP response element-binding protein 1
Short name=TORC-1
Short name=Transducer of CREB protein 1

Gene names

Name:	Crtc1
Synonyms:	Kiaa0616, Mect1, Torc1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	630 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells By similarity. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons. Ref.3 UniProtKB Q6UUV9
Subunit structure	Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction. Interaction, via its C-terminal, with TAF4, enhances recruitment of TAF4 to CREB1. Binds HTLV1 Tax.
Subcellular location	Cytoplasm. Nucleus. Note: Cytoplasmic when phosphorylated by SIK or AMPK and when sequestered by 14-3-3 proteins By similarity. Translocated to the nucleus on Ser-151 dephosphorylation, instigated by a number of factors including calcium ion and cAMP levels. Ref.3
Tissue specificity	Highly expressed in specific regions of the brain including the cortex, hippocampus and striatum. Ref.3
Post-translational modification	Phosphorylation/dephosphorylation states of Ser-151 are required for regulating transduction of CREB activity. TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of phosphorylation is mediated by SIKs (SIK1 and SIK2), is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs by LKB1.
Sequence similarities	Belongs to the TORC family.
Sequence caution	The sequence BAC97983.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Molecular function	Activator
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of CREB transcription factor activity Inferred from electronic annotation. Source: InterPro positive regulation of transcription from RNA polymerase II promoter Inferred from sequence or structural similarity. Source: UniProtKB protein homotetramerization Inferred from electronic annotation. Source: InterPro transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from sequence or structural similarity. Source: UniProtKB plasma membrane Inferred from electronic annotation. Source: Compara
Molecular_function	cAMP response element binding protein binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 630

630

CREB-regulated transcription coactivator 1

PRO_0000096355

Regions

Motif

242 – 258

Nuclear export signal By similarity

Compositional bias

295 – 365

Ser-rich

Sites

Site

571

Required for ubiquitination and degradation By similarity

Amino acid modifications

Modified residue

151

Phosphoserine; by SIK1 and SIK2 By similarity

Modified residue

161

Phosphothreonine By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q68ED7 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: FD0C37B48301471C
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FASTA

630

66,945

        10         20         30         40         50         60 
MATSNNPRKF SEKIALHNQK QAEETAAFEE VMKDLSLTRA ARLQLQKSQY LQLGPSRGQY 

        70         80         90        100        110        120 
YGGSLPNVNQ IGSSSVDLAF QTPFQSSGLD TSRTTRHHGL VDRVYRERGR LGSPHRRPLS 

       130        140        150        160        170        180 
VDKHGRQADS CPYGTVYLSP PADTSWRRTN SDSALHQSTM TPSQAESFTG GSQDAHQKRV 

       190        200        210        220        230        240 
LLLTVPGMED TGAETDKTLS KQSWDSKKAG SRPKSCEVPG INIFPSADQE NTTALIPATH 

       250        260        270        280        290        300 
NTGGSLPDLT NIHFPSPLPT PLDPEEPPFP ALTSSSSTGS LAHLGVGGAG QGMNTPSSSP 

       310        320        330        340        350        360 
QHRPAVVSPL SLSTEARRQQ AQQVSPTLSP LSPITQAVAM DALSLEQQLP YAFFTQTGSQ 

       370        380        390        400        410        420 
QPPPQPQPPP PPPPVSQQQP PPPQVSVGLP QGGPLLPSAS LTRGPQLPPL SVTVPSTLPQ 

       430        440        450        460        470        480 
SPTENPGQSP MGIDATSAPA LQYRTSAGSP ATQSPTSPVS NQGFSPGSSP QHTSTLGSVF 

       490        500        510        520        530        540 
GDAYYEQQMT ARQANALSRQ LEQFNMMENA ISSSSLYNPG STLNYSQAAM MGLSGSHGGL 

       550        560        570        580        590        600 
QDPQQLGYTG HGGIPNIILT VTGESPPSLS KELSSTLAGV SDVSFDSDHQ FPLDELKIDP 

       610        620        630 
LTLDGLHMLN DPDMVLADPA TEDTFRMDRL

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Brain.
[2]	"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H. DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity." Kovacs K.A., Steullet P., Steinmann M., Do K.Q., Magistretti P.J., Halfon O., Cardinaux J.R. Proc. Natl. Acad. Sci. U.S.A. 104:4700-4705(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC080308 mRNA. Translation: AAH80308.1. AK129173 mRNA. Translation: BAC97983.1. Different initiation.
IPI	IPI00469761.
RefSeq	NP_001004062.1. NM_001004062.2.
UniGene	Mm.227767.
3D structure databases
SMR	Q68ED7. Positions 8-35.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000075916.
PTM databases
PhosphoSite	Q68ED7.
Proteomic databases
PaxDb	Q68ED7.
PRIDE	Q68ED7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000076615; ENSMUSP00000075916; ENSMUSG00000003575.
GeneID	382056.
KEGG	mmu:382056.
UCSC	uc009mae.1. mouse.
Organism-specific databases
CTD	23373.
MGI	MGI:2142523. Crtc1.
Rouge	Search...
Phylogenomic databases
eggNOG	NOG85958.
GeneTree	ENSGT00390000010652.
HOGENOM	HOG000111980.
HOVERGEN	HBG058314.
InParanoid	Q68ED7.
KO	K15309.
OMA	MAARQAN.
OrthoDB	EOG437RDM.
Gene expression databases
Bgee	Q68ED7.
CleanEx	MM_CRTC1.
Genevestigator	Q68ED7.
GermOnline	ENSMUSG00000003575. Mus musculus.
Family and domain databases
InterPro	IPR024786. TORC. IPR024785. TORC_C. IPR024784. TORC_M. IPR024783. TORC_N. [Graphical view]
PANTHER	PTHR13589. PTHR13589. 1 hit.
Pfam	PF12886. TORC_C. 1 hit. PF12885. TORC_M. 1 hit. PF12884. TORC_N. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	402921.
SOURCE	Search...

Entry information

Entry name

CRTC1_MOUSE

Accession

Primary (citable) accession number: Q68ED7
Secondary accession number(s): Q6ZQ85

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents