Q68ED7 (CRTC1_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified April 16, 2014. Version 75. History...
Names and origin
|Protein names||Recommended name:|
CREB-regulated transcription coactivator 1
Mucoepidermoid carcinoma translocated protein 1 homolog
Transducer of regulated cAMP response element-binding protein 1
Short name=Transducer of CREB protein 1
|Organism||Mus musculus (Mouse) [Reference proteome]|
|Taxonomic identifier||10090 [NCBI]|
|Taxonomic lineage||Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus|
|Sequence length||630 AA.|
|Protein existence||Evidence at transcript level|
General annotation (Comments)
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells By similarity. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons. Ref.3 UniProtKB Q6UUV9
Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction. Interaction, via its C-terminal, with TAF4, enhances recruitment of TAF4 to CREB1. Binds HTLV1 Tax.
Cytoplasm. Nucleus. Note: Cytoplasmic when phosphorylated by SIK or AMPK and when sequestered by 14-3-3 proteins By similarity. Translocated to the nucleus on Ser-151 dephosphorylation, instigated by a number of factors including calcium ion and cAMP levels. Ref.3
Highly expressed in specific regions of the brain including the cortex, hippocampus and striatum. Ref.3
Phosphorylation/dephosphorylation states of Ser-151 are required for regulating transduction of CREB activity. TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of phosphorylation is mediated by SIKs (SIK1 and SIK2), is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs by LKB1.
Belongs to the TORC family.
The sequence BAC97983.1 differs from that shown. Reason: Erroneous initiation.
|Technical term||Complete proteome|
|Gene Ontology (GO)|
|Biological_process||membrane hyperpolarizationmemorypositive regulation of CREB transcription factor activity|
Inferred from electronic annotation. Source: InterPropositive regulation of transcription from RNA polymerase II promoter
Inferred from sequence or structural similarity. Source: UniProtKBprotein homotetramerization
Inferred from electronic annotation. Source: InterProtranscription, DNA-templated
Inferred from electronic annotation. Source: UniProtKB-KW
Inferred from sequence or structural similarity. Source: UniProtKBplasma membrane
Inferred from electronic annotation. Source: Ensembl
|Molecular_function||cAMP response element binding protein binding|
Inferred from sequence or structural similarity. Source: UniProtKB
|Complete GO annotation...|
Sequence annotation (Features)
|Feature key||Position(s)||Length||Description||Graphical view||Feature identifier|
|Chain||1 – 630||630||CREB-regulated transcription coactivator 1||PRO_0000096355|
|Motif||242 – 258||17||Nuclear export signal By similarity|
|Compositional bias||295 – 365||71||Ser-rich|
|Site||571||1||Required for ubiquitination and degradation By similarity|
Amino acid modifications
|Modified residue||151||1||Phosphoserine; by SIK1 and SIK2 By similarity|
|Modified residue||161||1||Phosphothreonine By similarity|
|||"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."|
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
|||"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."|
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
|||"TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity."|
Kovacs K.A., Steullet P., Steinmann M., Do K.Q., Magistretti P.J., Halfon O., Cardinaux J.R.
Proc. Natl. Acad. Sci. U.S.A. 104:4700-4705(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
|+||Additional computationally mapped references.|
|BC080308 mRNA. Translation: AAH80308.1.|
AK129173 mRNA. Translation: BAC97983.1. Different initiation.
|RefSeq||NP_001004062.1. NM_001004062.2. |
3D structure databases
|SMR||Q68ED7. Positions 8-35. |
Protein-protein interaction databases
|BioGrid||238211. 1 interaction.|
Protocols and materials databases
Genome annotation databases
|Ensembl||ENSMUST00000076615; ENSMUSP00000075916; ENSMUSG00000003575. |
|UCSC||uc009mae.1. mouse. |
|MGI||MGI:2142523. Crtc1. |
Gene expression databases
Family and domain databases
|InterPro||IPR024786. TORC. |
|PANTHER||PTHR13589. PTHR13589. 1 hit. |
|Pfam||PF12886. TORC_C. 1 hit. |
PF12885. TORC_M. 1 hit.
PF12884. TORC_N. 1 hit.
|Accession||Primary (citable) accession number: Q68ED7|
Secondary accession number(s): Q6ZQ85
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Chordata Protein Annotation Program|