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Protein

Metabotropic glutamate receptor 7

Gene

Grm7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei159GlutamateBy similarity1
Binding sitei230GlutamateBy similarity1
Binding sitei314GlutamateBy similarity1
Binding sitei407GlutamateBy similarity1

GO - Molecular functioni

  • adenylate cyclase inhibitor activity Source: MGI
  • calcium channel regulator activity Source: MGI
  • glutamate receptor activity Source: UniProtKB
  • group III metabotropic glutamate receptor activity Source: UniProtKB
  • PDZ domain binding Source: UniProtKB
  • serine binding Source: MGI
  • voltage-gated calcium channel activity Source: UniProtKB

GO - Biological processi

  • adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway Source: UniProtKB
  • adult behavior Source: MGI
  • associative learning Source: MGI
  • behavioral fear response Source: MGI
  • chemical synaptic transmission Source: UniProtKB
  • conditioned taste aversion Source: MGI
  • memory Source: MGI
  • multicellular organismal response to stress Source: MGI
  • negative regulation of cAMP biosynthetic process Source: MGI
  • neurological system process Source: MGI
  • regulation of neuron death Source: UniProtKB
  • regulation of synaptic transmission, glutamatergic Source: GO_Central
  • sensory perception of smell Source: UniProtKB-KW
  • sensory perception of sound Source: MGI
  • short-term memory Source: MGI
  • transmission of nerve impulse Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-MMU-418594. G alpha (i) signalling events.
R-MMU-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Metabotropic glutamate receptor 7
Short name:
mGluR7
Gene namesi
Name:Grm7
Synonyms:Gprc1g, Mglur7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1351344. Grm7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini35 – 590ExtracellularSequence analysisAdd BLAST556
Transmembranei591 – 615Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini616 – 627CytoplasmicSequence analysisAdd BLAST12
Transmembranei628 – 648Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini649 – 654ExtracellularSequence analysis6
Transmembranei655 – 675Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini676 – 702CytoplasmicSequence analysisAdd BLAST27
Transmembranei703 – 723Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini724 – 753ExtracellularSequence analysisAdd BLAST30
Transmembranei754 – 775Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini776 – 788CytoplasmicSequence analysisAdd BLAST13
Transmembranei789 – 810Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini811 – 825ExtracellularSequence analysisAdd BLAST15
Transmembranei826 – 850Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini851 – 915CytoplasmicSequence analysisAdd BLAST65

GO - Cellular componenti

  • cell cortex Source: MGI
  • dendrite Source: MGI
  • integral component of membrane Source: MGI
  • integral component of plasma membrane Source: GO_Central
  • presynaptic active zone membrane Source: UniProtKB
  • presynaptic membrane Source: UniProtKB
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000001293935 – 915Metabotropic glutamate receptor 7Add BLAST881

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi67 ↔ 109By similarity
Glycosylationi98N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi249 ↔ 541By similarity
Disulfide bondi374 ↔ 390By similarity
Disulfide bondi430 ↔ 437By similarity
Glycosylationi458N-linked (GlcNAc...)Sequence analysis1
Glycosylationi486N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi523 ↔ 542By similarity
Disulfide bondi527 ↔ 545By similarity
Disulfide bondi548 ↔ 560By similarity
Disulfide bondi563 ↔ 576By similarity
Glycosylationi572N-linked (GlcNAc...)Sequence analysis1
Modified residuei900PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ68ED2.
PaxDbiQ68ED2.
PRIDEiQ68ED2.

PTM databases

iPTMnetiQ68ED2.
PhosphoSitePlusiQ68ED2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000056755.
CleanExiMM_GRM7.
ExpressionAtlasiQ68ED2. baseline and differential.
GenevisibleiQ68ED2. MM.

Interactioni

Subunit structurei

Interacts with PICK1.By similarity

GO - Molecular functioni

  • PDZ domain binding Source: UniProtKB

Protein-protein interaction databases

BioGridi223811. 1 interactor.
DIPiDIP-32216N.
IntActiQ68ED2. 1 interactor.
MINTiMINT-4997427.
STRINGi10090.ENSMUSP00000133957.

Structurei

3D structure databases

ProteinModelPortaliQ68ED2.
SMRiQ68ED2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni180 – 182Glutamate bindingBy similarity3

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
GeneTreeiENSGT00760000118884.
HOGENOMiHOG000218635.
HOVERGENiHBG107965.
InParanoidiQ68ED2.
KOiK04608.
PhylomeDBiQ68ED2.
TreeFamiTF313240.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001883. GPCR_3_mtglu_rcpt_7.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
PR01057. MTABOTROPC7R.
PR00593. MTABOTROPICR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68ED2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQLGKLLRV LTLMKFPCCV LEVLLCVLAA AARGQEMYAP HSIRIEGDVT
60 70 80 90 100
LGGLFPVHAK GPSGVPCGDI KRENGIHRLE AMLYALDQIN SDPNLLPNVT
110 120 130 140 150
LGARILDTCS RDTYALEQSL TFVQALIQKD TSDVRCTNGE PPVFVKPEKV
160 170 180 190 200
VGVIGASGSS VSIMVANILR LFQIPQISYA STAPELSDDR RYDFFSRVVP
210 220 230 240 250
PDSFQAQAMV DIVKALGWNY VSTLASEGSY GEKGVESFTQ ISKEAGGLCI
260 270 280 290 300
AQSVRIPQER KDRTIDFDRI IKQLLDTPNS RAVVIFANDE DIKQILAAAK
310 320 330 340 350
RADQVGHFLW VGSDSWGSKI NPLHQHEDIA EGAITIQPKR ATVEGFDAYF
360 370 380 390 400
TSRTLENNRR NVWFAEYWEE NFNCKLTISG SKKEDTDRKC TGQERIGKDS
410 420 430 440 450
NYEQEGKVQF VIDAVYAMAH ALHHMNKDLC ADYRGVCPEM EQAGGKKLLK
460 470 480 490 500
YIRNVNFNGS AGTPVMFNKN GDAPGRYDIF QYQTTNTTNP GYRLIGQWTD
510 520 530 540 550
ELQLNIEDMQ WGKGVREIPP SVCTLPCKPG QRKKTQKGTP CCWTCEPCDG
560 570 580 590 600
YQYQFDEMTC QHCPYDQRPN ENRTGCQNIP IIKLEWHSPW AVIPVFLAML
610 620 630 640 650
GIIATIFVMA TFIRYNDTPI VRASGRELSY VLLTGIFLCY IITFLMIAKP
660 670 680 690 700
DVAVCSFRRV FLGLGMCISY AALLTKTNRI YRIFEQGKKS VTAPRLISPT
710 720 730 740 750
SQLAITSSLI SVQLLGVFIW FGVDPPNIII DYDEHKTMNP EQARGVLKCD
760 770 780 790 800
ITDLQIICSL GYSILLMVTC TVYAIKTRGV PENFNEAKPI GFTMYTTCIV
810 820 830 840 850
WLAFIPIFFG TAQSAEKLYI QTTTLTISMN LSASVALGML YMPKVYIIIF
860 870 880 890 900
HPELNVQKRK RSFKAVVTAA TMSSRLSHKP SDRPNGEAKT ELCENVDPNS
910
PAAKKKYVSY NNLVI
Length:915
Mass (Da):102,219
Last modified:October 11, 2004 - v1
Checksum:iF0AF7AEDBFBCCF71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC080315 mRNA. Translation: AAH80315.1.
CCDSiCCDS39587.1.
RefSeqiNP_796302.2. NM_177328.3.
UniGeneiMm.240881.

Genome annotation databases

EnsembliENSMUST00000172951; ENSMUSP00000133957; ENSMUSG00000056755.
GeneIDi108073.
KEGGimmu:108073.
UCSCiuc009dds.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC080315 mRNA. Translation: AAH80315.1.
CCDSiCCDS39587.1.
RefSeqiNP_796302.2. NM_177328.3.
UniGeneiMm.240881.

3D structure databases

ProteinModelPortaliQ68ED2.
SMRiQ68ED2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi223811. 1 interactor.
DIPiDIP-32216N.
IntActiQ68ED2. 1 interactor.
MINTiMINT-4997427.
STRINGi10090.ENSMUSP00000133957.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ68ED2.
PhosphoSitePlusiQ68ED2.

Proteomic databases

MaxQBiQ68ED2.
PaxDbiQ68ED2.
PRIDEiQ68ED2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000172951; ENSMUSP00000133957; ENSMUSG00000056755.
GeneIDi108073.
KEGGimmu:108073.
UCSCiuc009dds.1. mouse.

Organism-specific databases

CTDi2917.
MGIiMGI:1351344. Grm7.

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
GeneTreeiENSGT00760000118884.
HOGENOMiHOG000218635.
HOVERGENiHBG107965.
InParanoidiQ68ED2.
KOiK04608.
PhylomeDBiQ68ED2.
TreeFamiTF313240.

Enzyme and pathway databases

ReactomeiR-MMU-418594. G alpha (i) signalling events.
R-MMU-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Miscellaneous databases

PROiQ68ED2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000056755.
CleanExiMM_GRM7.
ExpressionAtlasiQ68ED2. baseline and differential.
GenevisibleiQ68ED2. MM.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001883. GPCR_3_mtglu_rcpt_7.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
PR01057. MTABOTROPC7R.
PR00593. MTABOTROPICR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGRM7_MOUSE
AccessioniPrimary (citable) accession number: Q68ED2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.