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Q68ED2

- GRM7_MOUSE

UniProt

Q68ED2 - GRM7_MOUSE

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Protein
Metabotropic glutamate receptor 7
Gene
Grm7, Gprc1g, Mglur7
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei159 – 1591Glutamate By similarity
Binding sitei230 – 2301Glutamate By similarity
Binding sitei314 – 3141Glutamate By similarity
Binding sitei407 – 4071Glutamate By similarity

GO - Molecular functioni

  1. PDZ domain binding Source: UniProtKB
  2. adenylate cyclase inhibitor activity Source: Ensembl
  3. calcium channel regulator activity Source: MGI
  4. calcium ion binding Source: Ensembl
  5. glutamate binding Source: Ensembl
  6. glutamate receptor activity Source: UniProtKB
  7. group III metabotropic glutamate receptor activity Source: UniProtKB
  8. serine binding Source: Ensembl
  9. voltage-gated calcium channel activity Source: UniProtKB

GO - Biological processi

  1. adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway Source: UniProtKB
  2. adult behavior Source: MGI
  3. associative learning Source: MGI
  4. behavioral fear response Source: MGI
  5. calcium ion transmembrane transport Source: GOC
  6. conditioned taste aversion Source: MGI
  7. memory Source: MGI
  8. multicellular organismal response to stress Source: MGI
  9. negative regulation of adenylate cyclase activity Source: Ensembl
  10. neurological system process Source: MGI
  11. regulation of neuron death Source: UniProtKB
  12. regulation of synaptic transmission, glutamatergic Source: RefGenome
  13. sensory perception of smell Source: UniProtKB-KW
  14. sensory perception of sound Source: Ensembl
  15. short-term memory Source: MGI
  16. synaptic transmission Source: UniProtKB
  17. transmission of nerve impulse Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Names & Taxonomyi

Protein namesi
Recommended name:
Metabotropic glutamate receptor 7
Short name:
mGluR7
Gene namesi
Name:Grm7
Synonyms:Gprc1g, Mglur7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1351344. Grm7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini35 – 590556Extracellular Reviewed prediction
Add
BLAST
Transmembranei591 – 61525Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini616 – 62712Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei628 – 64821Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini649 – 6546Extracellular Reviewed prediction
Transmembranei655 – 67521Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini676 – 70227Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei703 – 72321Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini724 – 75330Extracellular Reviewed prediction
Add
BLAST
Transmembranei754 – 77522Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini776 – 78813Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei789 – 81022Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini811 – 82515Extracellular Reviewed prediction
Add
BLAST
Transmembranei826 – 85025Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini851 – 91565Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell cortex Source: Ensembl
  2. dendrite Source: Ensembl
  3. integral component of plasma membrane Source: RefGenome
  4. presynaptic active zone membrane Source: UniProtKB
  5. presynaptic membrane Source: UniProtKB
  6. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434 Reviewed prediction
Add
BLAST
Chaini35 – 915881Metabotropic glutamate receptor 7
PRO_0000012939Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi67 ↔ 109 By similarity
Glycosylationi98 – 981N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi249 ↔ 541 By similarity
Disulfide bondi374 ↔ 390 By similarity
Disulfide bondi430 ↔ 437 By similarity
Glycosylationi458 – 4581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi486 – 4861N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi523 ↔ 542 By similarity
Disulfide bondi527 ↔ 545 By similarity
Disulfide bondi548 ↔ 560 By similarity
Disulfide bondi563 ↔ 576 By similarity
Glycosylationi572 – 5721N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ68ED2.
PRIDEiQ68ED2.

PTM databases

PhosphoSiteiQ68ED2.

Expressioni

Gene expression databases

ArrayExpressiQ68ED2.
BgeeiQ68ED2.
CleanExiMM_GRM7.
GenevestigatoriQ68ED2.

Interactioni

Subunit structurei

Interacts with PICK1 By similarity.

Protein-protein interaction databases

DIPiDIP-32216N.
IntActiQ68ED2. 1 interaction.
MINTiMINT-4997427.
STRINGi10090.ENSMUSP00000064404.

Structurei

3D structure databases

ProteinModelPortaliQ68ED2.
SMRiQ68ED2. Positions 40-856.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni180 – 1823Glutamate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG295200.
GeneTreeiENSGT00750000117581.
HOGENOMiHOG000218635.
HOVERGENiHBG107965.
InParanoidiQ68ED2.
KOiK04608.
PhylomeDBiQ68ED2.
TreeFamiTF313240.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001883. GPCR_3_mtglu_rcpt_7.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
PR01057. MTABOTROPC7R.
PR00593. MTABOTROPICR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68ED2-1 [UniParc]FASTAAdd to Basket

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MVQLGKLLRV LTLMKFPCCV LEVLLCVLAA AARGQEMYAP HSIRIEGDVT    50
LGGLFPVHAK GPSGVPCGDI KRENGIHRLE AMLYALDQIN SDPNLLPNVT 100
LGARILDTCS RDTYALEQSL TFVQALIQKD TSDVRCTNGE PPVFVKPEKV 150
VGVIGASGSS VSIMVANILR LFQIPQISYA STAPELSDDR RYDFFSRVVP 200
PDSFQAQAMV DIVKALGWNY VSTLASEGSY GEKGVESFTQ ISKEAGGLCI 250
AQSVRIPQER KDRTIDFDRI IKQLLDTPNS RAVVIFANDE DIKQILAAAK 300
RADQVGHFLW VGSDSWGSKI NPLHQHEDIA EGAITIQPKR ATVEGFDAYF 350
TSRTLENNRR NVWFAEYWEE NFNCKLTISG SKKEDTDRKC TGQERIGKDS 400
NYEQEGKVQF VIDAVYAMAH ALHHMNKDLC ADYRGVCPEM EQAGGKKLLK 450
YIRNVNFNGS AGTPVMFNKN GDAPGRYDIF QYQTTNTTNP GYRLIGQWTD 500
ELQLNIEDMQ WGKGVREIPP SVCTLPCKPG QRKKTQKGTP CCWTCEPCDG 550
YQYQFDEMTC QHCPYDQRPN ENRTGCQNIP IIKLEWHSPW AVIPVFLAML 600
GIIATIFVMA TFIRYNDTPI VRASGRELSY VLLTGIFLCY IITFLMIAKP 650
DVAVCSFRRV FLGLGMCISY AALLTKTNRI YRIFEQGKKS VTAPRLISPT 700
SQLAITSSLI SVQLLGVFIW FGVDPPNIII DYDEHKTMNP EQARGVLKCD 750
ITDLQIICSL GYSILLMVTC TVYAIKTRGV PENFNEAKPI GFTMYTTCIV 800
WLAFIPIFFG TAQSAEKLYI QTTTLTISMN LSASVALGML YMPKVYIIIF 850
HPELNVQKRK RSFKAVVTAA TMSSRLSHKP SDRPNGEAKT ELCENVDPNS 900
PAAKKKYVSY NNLVI 915
Length:915
Mass (Da):102,219
Last modified:October 11, 2004 - v1
Checksum:iF0AF7AEDBFBCCF71
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC080315 mRNA. Translation: AAH80315.1.
CCDSiCCDS39587.1.
RefSeqiNP_796302.2. NM_177328.3.
UniGeneiMm.240881.

Genome annotation databases

EnsembliENSMUST00000172951; ENSMUSP00000133957; ENSMUSG00000056755.
GeneIDi108073.
KEGGimmu:108073.
UCSCiuc009dds.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC080315 mRNA. Translation: AAH80315.1 .
CCDSi CCDS39587.1.
RefSeqi NP_796302.2. NM_177328.3.
UniGenei Mm.240881.

3D structure databases

ProteinModelPortali Q68ED2.
SMRi Q68ED2. Positions 40-856.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-32216N.
IntActi Q68ED2. 1 interaction.
MINTi MINT-4997427.
STRINGi 10090.ENSMUSP00000064404.

Chemistry

BindingDBi Q68ED2.
GuidetoPHARMACOLOGYi 295.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q68ED2.

Proteomic databases

PaxDbi Q68ED2.
PRIDEi Q68ED2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000172951 ; ENSMUSP00000133957 ; ENSMUSG00000056755 .
GeneIDi 108073.
KEGGi mmu:108073.
UCSCi uc009dds.1. mouse.

Organism-specific databases

CTDi 2917.
MGIi MGI:1351344. Grm7.

Phylogenomic databases

eggNOGi NOG295200.
GeneTreei ENSGT00750000117581.
HOGENOMi HOG000218635.
HOVERGENi HBG107965.
InParanoidi Q68ED2.
KOi K04608.
PhylomeDBi Q68ED2.
TreeFami TF313240.

Miscellaneous databases

ChiTaRSi GRM7. mouse.
NextBioi 359996.
PROi Q68ED2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q68ED2.
Bgeei Q68ED2.
CleanExi MM_GRM7.
Genevestigatori Q68ED2.

Family and domain databases

InterProi IPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001883. GPCR_3_mtglu_rcpt_7.
IPR028082. Peripla_BP_I.
[Graphical view ]
Pfami PF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view ]
PRINTSi PR00248. GPCRMGR.
PR01057. MTABOTROPC7R.
PR00593. MTABOTROPICR.
SUPFAMi SSF53822. SSF53822. 1 hit.
PROSITEi PS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiGRM7_MOUSE
AccessioniPrimary (citable) accession number: Q68ED2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 11, 2004
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi