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Q68ED2 (GRM7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Metabotropic glutamate receptor 7

Short name=mGluR7
Gene names
Name:Grm7
Synonyms:Gprc1g, Mglur7
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length915 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity By similarity.

Subunit structure

Interacts with PICK1 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 3 family.

Ontologies

Keywords
   Biological processOlfaction
Sensory transduction
   Cellular componentCell membrane
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

adult behavior

Inferred from mutant phenotype PubMed 12814372. Source: MGI

associative learning

Inferred from mutant phenotype PubMed 16775145. Source: MGI

behavioral fear response

Inferred from mutant phenotype PubMed 9920659. Source: MGI

calcium ion transmembrane transport

Inferred from direct assay PubMed 12065412. Source: GOC

conditioned taste aversion

Inferred from mutant phenotype PubMed 9920659. Source: MGI

memory

Inferred from mutant phenotype PubMed 16204199PubMed 16775145. Source: MGI

multicellular organismal response to stress

Inferred from mutant phenotype PubMed 12814372. Source: MGI

negative regulation of adenylate cyclase activity

Inferred from electronic annotation. Source: Ensembl

neurological system process

Inferred from mutant phenotype PubMed 16204199. Source: MGI

regulation of neuron death

Traceable author statement PubMed 12065412. Source: UniProtKB

sensory perception of smell

Inferred from electronic annotation. Source: UniProtKB-KW

sensory perception of sound

Inferred from electronic annotation. Source: Ensembl

short-term memory

Inferred from mutant phenotype PubMed 15313036. Source: MGI

synaptic transmission

Inferred from direct assay PubMed 12065412. Source: UniProtKB

transmission of nerve impulse

Inferred from mutant phenotype PubMed 11698585. Source: MGI

   Cellular_componentcell cortex

Inferred from electronic annotation. Source: Ensembl

dendrite

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

presynaptic active zone membrane

Traceable author statement PubMed 12065412. Source: UniProtKB

presynaptic membrane

Inferred from direct assay PubMed 12065412. Source: UniProtKB

receptor complex

Inferred from sequence orthology PubMed 23382219. Source: MGI

   Molecular_functionPDZ domain binding

Traceable author statement PubMed 12065412. Source: UniProtKB

adenylate cyclase inhibitor activity

Inferred from electronic annotation. Source: Ensembl

calcium channel regulator activity

Inferred from direct assay PubMed 11584003. Source: MGI

calcium ion binding

Inferred from electronic annotation. Source: Ensembl

glutamate binding

Inferred from electronic annotation. Source: Ensembl

glutamate receptor activity

Inferred from sequence or structural similarity. Source: UniProtKB

group III metabotropic glutamate receptor activity

Inferred from sequence or structural similarity. Source: UniProtKB

serine binding

Inferred from electronic annotation. Source: Ensembl

voltage-gated calcium channel activity

Inferred from direct assay PubMed 12065412. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3434 Potential
Chain35 – 915881Metabotropic glutamate receptor 7
PRO_0000012939

Regions

Topological domain35 – 590556Extracellular Potential
Transmembrane591 – 61525Helical; Name=1; Potential
Topological domain616 – 62712Cytoplasmic Potential
Transmembrane628 – 64821Helical; Name=2; Potential
Topological domain649 – 6546Extracellular Potential
Transmembrane655 – 67521Helical; Name=3; Potential
Topological domain676 – 70227Cytoplasmic Potential
Transmembrane703 – 72321Helical; Name=4; Potential
Topological domain724 – 75330Extracellular Potential
Transmembrane754 – 77522Helical; Name=5; Potential
Topological domain776 – 78813Cytoplasmic Potential
Transmembrane789 – 81022Helical; Name=6; Potential
Topological domain811 – 82515Extracellular Potential
Transmembrane826 – 85025Helical; Name=7; Potential
Topological domain851 – 91565Cytoplasmic Potential
Region180 – 1823Glutamate binding By similarity

Sites

Binding site1591Glutamate By similarity
Binding site2301Glutamate By similarity
Binding site3141Glutamate By similarity
Binding site4071Glutamate By similarity

Amino acid modifications

Glycosylation981N-linked (GlcNAc...) Potential
Glycosylation4581N-linked (GlcNAc...) Potential
Glycosylation4861N-linked (GlcNAc...) Potential
Glycosylation5721N-linked (GlcNAc...) Potential
Disulfide bond67 ↔ 109 By similarity
Disulfide bond249 ↔ 541 By similarity
Disulfide bond374 ↔ 390 By similarity
Disulfide bond430 ↔ 437 By similarity
Disulfide bond523 ↔ 542 By similarity
Disulfide bond527 ↔ 545 By similarity
Disulfide bond548 ↔ 560 By similarity
Disulfide bond563 ↔ 576 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q68ED2 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: F0AF7AEDBFBCCF71

FASTA915102,219
        10         20         30         40         50         60 
MVQLGKLLRV LTLMKFPCCV LEVLLCVLAA AARGQEMYAP HSIRIEGDVT LGGLFPVHAK 

        70         80         90        100        110        120 
GPSGVPCGDI KRENGIHRLE AMLYALDQIN SDPNLLPNVT LGARILDTCS RDTYALEQSL 

       130        140        150        160        170        180 
TFVQALIQKD TSDVRCTNGE PPVFVKPEKV VGVIGASGSS VSIMVANILR LFQIPQISYA 

       190        200        210        220        230        240 
STAPELSDDR RYDFFSRVVP PDSFQAQAMV DIVKALGWNY VSTLASEGSY GEKGVESFTQ 

       250        260        270        280        290        300 
ISKEAGGLCI AQSVRIPQER KDRTIDFDRI IKQLLDTPNS RAVVIFANDE DIKQILAAAK 

       310        320        330        340        350        360 
RADQVGHFLW VGSDSWGSKI NPLHQHEDIA EGAITIQPKR ATVEGFDAYF TSRTLENNRR 

       370        380        390        400        410        420 
NVWFAEYWEE NFNCKLTISG SKKEDTDRKC TGQERIGKDS NYEQEGKVQF VIDAVYAMAH 

       430        440        450        460        470        480 
ALHHMNKDLC ADYRGVCPEM EQAGGKKLLK YIRNVNFNGS AGTPVMFNKN GDAPGRYDIF 

       490        500        510        520        530        540 
QYQTTNTTNP GYRLIGQWTD ELQLNIEDMQ WGKGVREIPP SVCTLPCKPG QRKKTQKGTP 

       550        560        570        580        590        600 
CCWTCEPCDG YQYQFDEMTC QHCPYDQRPN ENRTGCQNIP IIKLEWHSPW AVIPVFLAML 

       610        620        630        640        650        660 
GIIATIFVMA TFIRYNDTPI VRASGRELSY VLLTGIFLCY IITFLMIAKP DVAVCSFRRV 

       670        680        690        700        710        720 
FLGLGMCISY AALLTKTNRI YRIFEQGKKS VTAPRLISPT SQLAITSSLI SVQLLGVFIW 

       730        740        750        760        770        780 
FGVDPPNIII DYDEHKTMNP EQARGVLKCD ITDLQIICSL GYSILLMVTC TVYAIKTRGV 

       790        800        810        820        830        840 
PENFNEAKPI GFTMYTTCIV WLAFIPIFFG TAQSAEKLYI QTTTLTISMN LSASVALGML 

       850        860        870        880        890        900 
YMPKVYIIIF HPELNVQKRK RSFKAVVTAA TMSSRLSHKP SDRPNGEAKT ELCENVDPNS 

       910 
PAAKKKYVSY NNLVI 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC080315 mRNA. Translation: AAH80315.1.
RefSeqNP_796302.2. NM_177328.3.
UniGeneMm.240881.

3D structure databases

ProteinModelPortalQ68ED2.
SMRQ68ED2. Positions 40-580.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-32216N.
IntActQ68ED2. 1 interaction.
MINTMINT-4997427.
STRING10090.ENSMUSP00000064404.

Chemistry

BindingDBQ68ED2.
GuidetoPHARMACOLOGY295.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ68ED2.

Proteomic databases

PaxDbQ68ED2.
PRIDEQ68ED2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000172951; ENSMUSP00000133957; ENSMUSG00000056755.
GeneID108073.
KEGGmmu:108073.
UCSCuc009dds.1. mouse.

Organism-specific databases

CTD2917.
MGIMGI:1351344. Grm7.

Phylogenomic databases

eggNOGNOG295200.
GeneTreeENSGT00750000117581.
HOGENOMHOG000218635.
HOVERGENHBG107965.
InParanoidQ68ED2.
KOK04608.
PhylomeDBQ68ED2.
TreeFamTF313240.

Gene expression databases

ArrayExpressQ68ED2.
BgeeQ68ED2.
CleanExMM_GRM7.
GenevestigatorQ68ED2.

Family and domain databases

InterProIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001883. GPCR_3_mtglu_rcpt_7.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSPR00248. GPCRMGR.
PR01057. MTABOTROPC7R.
PR00593. MTABOTROPICR.
SUPFAMSSF53822. SSF53822. 1 hit.
PROSITEPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSGRM7. mouse.
NextBio359996.
PROQ68ED2.
SOURCESearch...

Entry information

Entry nameGRM7_MOUSE
AccessionPrimary (citable) accession number: Q68ED2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 11, 2004
Last modified: April 16, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries