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Q68ED2

- GRM7_MOUSE

UniProt

Q68ED2 - GRM7_MOUSE

Protein

Metabotropic glutamate receptor 7

Gene

Grm7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei159 – 1591GlutamateBy similarity
    Binding sitei230 – 2301GlutamateBy similarity
    Binding sitei314 – 3141GlutamateBy similarity
    Binding sitei407 – 4071GlutamateBy similarity

    GO - Molecular functioni

    1. adenylate cyclase inhibitor activity Source: Ensembl
    2. calcium channel regulator activity Source: MGI
    3. calcium ion binding Source: Ensembl
    4. glutamate binding Source: Ensembl
    5. glutamate receptor activity Source: UniProtKB
    6. group III metabotropic glutamate receptor activity Source: UniProtKB
    7. PDZ domain binding Source: UniProtKB
    8. serine binding Source: Ensembl
    9. voltage-gated calcium channel activity Source: UniProtKB

    GO - Biological processi

    1. adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway Source: UniProtKB
    2. adult behavior Source: MGI
    3. associative learning Source: MGI
    4. behavioral fear response Source: MGI
    5. calcium ion transmembrane transport Source: GOC
    6. conditioned taste aversion Source: MGI
    7. memory Source: MGI
    8. multicellular organismal response to stress Source: MGI
    9. negative regulation of adenylate cyclase activity Source: Ensembl
    10. neurological system process Source: MGI
    11. regulation of neuron death Source: UniProtKB
    12. regulation of synaptic transmission, glutamatergic Source: RefGenome
    13. sensory perception of smell Source: UniProtKB-KW
    14. sensory perception of sound Source: Ensembl
    15. short-term memory Source: MGI
    16. synaptic transmission Source: UniProtKB
    17. transmission of nerve impulse Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metabotropic glutamate receptor 7
    Short name:
    mGluR7
    Gene namesi
    Name:Grm7
    Synonyms:Gprc1g, Mglur7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1351344. Grm7.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. cell cortex Source: Ensembl
    2. dendrite Source: Ensembl
    3. integral component of plasma membrane Source: RefGenome
    4. presynaptic active zone membrane Source: UniProtKB
    5. presynaptic membrane Source: UniProtKB
    6. receptor complex Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3434Sequence AnalysisAdd
    BLAST
    Chaini35 – 915881Metabotropic glutamate receptor 7PRO_0000012939Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi67 ↔ 109By similarity
    Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi249 ↔ 541By similarity
    Disulfide bondi374 ↔ 390By similarity
    Disulfide bondi430 ↔ 437By similarity
    Glycosylationi458 – 4581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi486 – 4861N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi523 ↔ 542By similarity
    Disulfide bondi527 ↔ 545By similarity
    Disulfide bondi548 ↔ 560By similarity
    Disulfide bondi563 ↔ 576By similarity
    Glycosylationi572 – 5721N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ68ED2.
    PRIDEiQ68ED2.

    PTM databases

    PhosphoSiteiQ68ED2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ68ED2.
    BgeeiQ68ED2.
    CleanExiMM_GRM7.
    GenevestigatoriQ68ED2.

    Interactioni

    Subunit structurei

    Interacts with PICK1.By similarity

    Protein-protein interaction databases

    DIPiDIP-32216N.
    IntActiQ68ED2. 1 interaction.
    MINTiMINT-4997427.
    STRINGi10090.ENSMUSP00000064404.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68ED2.
    SMRiQ68ED2. Positions 40-856.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini35 – 590556ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini616 – 62712CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini649 – 6546ExtracellularSequence Analysis
    Topological domaini676 – 70227CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini724 – 75330ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini776 – 78813CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini811 – 82515ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini851 – 91565CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei591 – 61525Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei628 – 64821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei655 – 67521Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei703 – 72321Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei754 – 77522Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei789 – 81022Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei826 – 85025Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni180 – 1823Glutamate bindingBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG295200.
    GeneTreeiENSGT00750000117581.
    HOGENOMiHOG000218635.
    HOVERGENiHBG107965.
    InParanoidiQ68ED2.
    KOiK04608.
    PhylomeDBiQ68ED2.
    TreeFamiTF313240.

    Family and domain databases

    InterProiIPR001828. ANF_lig-bd_rcpt.
    IPR000337. GPCR_3.
    IPR011500. GPCR_3_9-Cys_dom.
    IPR017978. GPCR_3_C.
    IPR017979. GPCR_3_CS.
    IPR000162. GPCR_3_mtglu_rcpt.
    IPR001883. GPCR_3_mtglu_rcpt_7.
    IPR028082. Peripla_BP_I.
    [Graphical view]
    PfamiPF00003. 7tm_3. 1 hit.
    PF01094. ANF_receptor. 1 hit.
    PF07562. NCD3G. 1 hit.
    [Graphical view]
    PRINTSiPR00248. GPCRMGR.
    PR01057. MTABOTROPC7R.
    PR00593. MTABOTROPICR.
    SUPFAMiSSF53822. SSF53822. 1 hit.
    PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
    PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
    PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
    PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q68ED2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVQLGKLLRV LTLMKFPCCV LEVLLCVLAA AARGQEMYAP HSIRIEGDVT    50
    LGGLFPVHAK GPSGVPCGDI KRENGIHRLE AMLYALDQIN SDPNLLPNVT 100
    LGARILDTCS RDTYALEQSL TFVQALIQKD TSDVRCTNGE PPVFVKPEKV 150
    VGVIGASGSS VSIMVANILR LFQIPQISYA STAPELSDDR RYDFFSRVVP 200
    PDSFQAQAMV DIVKALGWNY VSTLASEGSY GEKGVESFTQ ISKEAGGLCI 250
    AQSVRIPQER KDRTIDFDRI IKQLLDTPNS RAVVIFANDE DIKQILAAAK 300
    RADQVGHFLW VGSDSWGSKI NPLHQHEDIA EGAITIQPKR ATVEGFDAYF 350
    TSRTLENNRR NVWFAEYWEE NFNCKLTISG SKKEDTDRKC TGQERIGKDS 400
    NYEQEGKVQF VIDAVYAMAH ALHHMNKDLC ADYRGVCPEM EQAGGKKLLK 450
    YIRNVNFNGS AGTPVMFNKN GDAPGRYDIF QYQTTNTTNP GYRLIGQWTD 500
    ELQLNIEDMQ WGKGVREIPP SVCTLPCKPG QRKKTQKGTP CCWTCEPCDG 550
    YQYQFDEMTC QHCPYDQRPN ENRTGCQNIP IIKLEWHSPW AVIPVFLAML 600
    GIIATIFVMA TFIRYNDTPI VRASGRELSY VLLTGIFLCY IITFLMIAKP 650
    DVAVCSFRRV FLGLGMCISY AALLTKTNRI YRIFEQGKKS VTAPRLISPT 700
    SQLAITSSLI SVQLLGVFIW FGVDPPNIII DYDEHKTMNP EQARGVLKCD 750
    ITDLQIICSL GYSILLMVTC TVYAIKTRGV PENFNEAKPI GFTMYTTCIV 800
    WLAFIPIFFG TAQSAEKLYI QTTTLTISMN LSASVALGML YMPKVYIIIF 850
    HPELNVQKRK RSFKAVVTAA TMSSRLSHKP SDRPNGEAKT ELCENVDPNS 900
    PAAKKKYVSY NNLVI 915
    Length:915
    Mass (Da):102,219
    Last modified:October 11, 2004 - v1
    Checksum:iF0AF7AEDBFBCCF71
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC080315 mRNA. Translation: AAH80315.1.
    CCDSiCCDS39587.1.
    RefSeqiNP_796302.2. NM_177328.3.
    UniGeneiMm.240881.

    Genome annotation databases

    EnsembliENSMUST00000172951; ENSMUSP00000133957; ENSMUSG00000056755.
    GeneIDi108073.
    KEGGimmu:108073.
    UCSCiuc009dds.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC080315 mRNA. Translation: AAH80315.1 .
    CCDSi CCDS39587.1.
    RefSeqi NP_796302.2. NM_177328.3.
    UniGenei Mm.240881.

    3D structure databases

    ProteinModelPortali Q68ED2.
    SMRi Q68ED2. Positions 40-856.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-32216N.
    IntActi Q68ED2. 1 interaction.
    MINTi MINT-4997427.
    STRINGi 10090.ENSMUSP00000064404.

    Chemistry

    BindingDBi Q68ED2.
    GuidetoPHARMACOLOGYi 295.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q68ED2.

    Proteomic databases

    PaxDbi Q68ED2.
    PRIDEi Q68ED2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000172951 ; ENSMUSP00000133957 ; ENSMUSG00000056755 .
    GeneIDi 108073.
    KEGGi mmu:108073.
    UCSCi uc009dds.1. mouse.

    Organism-specific databases

    CTDi 2917.
    MGIi MGI:1351344. Grm7.

    Phylogenomic databases

    eggNOGi NOG295200.
    GeneTreei ENSGT00750000117581.
    HOGENOMi HOG000218635.
    HOVERGENi HBG107965.
    InParanoidi Q68ED2.
    KOi K04608.
    PhylomeDBi Q68ED2.
    TreeFami TF313240.

    Miscellaneous databases

    ChiTaRSi GRM7. mouse.
    NextBioi 359996.
    PROi Q68ED2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q68ED2.
    Bgeei Q68ED2.
    CleanExi MM_GRM7.
    Genevestigatori Q68ED2.

    Family and domain databases

    InterProi IPR001828. ANF_lig-bd_rcpt.
    IPR000337. GPCR_3.
    IPR011500. GPCR_3_9-Cys_dom.
    IPR017978. GPCR_3_C.
    IPR017979. GPCR_3_CS.
    IPR000162. GPCR_3_mtglu_rcpt.
    IPR001883. GPCR_3_mtglu_rcpt_7.
    IPR028082. Peripla_BP_I.
    [Graphical view ]
    Pfami PF00003. 7tm_3. 1 hit.
    PF01094. ANF_receptor. 1 hit.
    PF07562. NCD3G. 1 hit.
    [Graphical view ]
    PRINTSi PR00248. GPCRMGR.
    PR01057. MTABOTROPC7R.
    PR00593. MTABOTROPICR.
    SUPFAMi SSF53822. SSF53822. 1 hit.
    PROSITEi PS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
    PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
    PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
    PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiGRM7_MOUSE
    AccessioniPrimary (citable) accession number: Q68ED2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3