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Protein

Metabotropic glutamate receptor 7

Gene

Grm7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei159 – 1591GlutamateBy similarity
Binding sitei230 – 2301GlutamateBy similarity
Binding sitei314 – 3141GlutamateBy similarity
Binding sitei407 – 4071GlutamateBy similarity

GO - Molecular functioni

  1. adenylate cyclase inhibitor activity Source: MGI
  2. calcium channel regulator activity Source: MGI
  3. calcium ion binding Source: MGI
  4. glutamate binding Source: MGI
  5. glutamate receptor activity Source: UniProtKB
  6. group III metabotropic glutamate receptor activity Source: UniProtKB
  7. PDZ domain binding Source: UniProtKB
  8. serine binding Source: MGI
  9. voltage-gated calcium channel activity Source: UniProtKB

GO - Biological processi

  1. adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway Source: UniProtKB
  2. adult behavior Source: MGI
  3. associative learning Source: MGI
  4. behavioral fear response Source: MGI
  5. calcium ion transmembrane transport Source: GOC
  6. conditioned taste aversion Source: MGI
  7. memory Source: MGI
  8. multicellular organismal response to stress Source: MGI
  9. negative regulation of adenylate cyclase activity Source: MGI
  10. negative regulation of cAMP biosynthetic process Source: MGI
  11. neurological system process Source: MGI
  12. regulation of cyclase activity Source: MGI
  13. regulation of neuron death Source: UniProtKB
  14. regulation of synaptic transmission, glutamatergic Source: GO_Central
  15. sensory perception of smell Source: UniProtKB-KW
  16. sensory perception of sound Source: MGI
  17. short-term memory Source: MGI
  18. synaptic transmission Source: UniProtKB
  19. transmission of nerve impulse Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_250376. G alpha (i) signalling events.
REACT_262510. Class C/3 (Metabotropic glutamate/pheromone receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Metabotropic glutamate receptor 7
Short name:
mGluR7
Gene namesi
Name:Grm7
Synonyms:Gprc1g, Mglur7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1351344. Grm7.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini35 – 590556ExtracellularSequence AnalysisAdd
BLAST
Transmembranei591 – 61525Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini616 – 62712CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei628 – 64821Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini649 – 6546ExtracellularSequence Analysis
Transmembranei655 – 67521Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini676 – 70227CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei703 – 72321Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini724 – 75330ExtracellularSequence AnalysisAdd
BLAST
Transmembranei754 – 77522Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini776 – 78813CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei789 – 81022Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini811 – 82515ExtracellularSequence AnalysisAdd
BLAST
Transmembranei826 – 85025Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini851 – 91565CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell cortex Source: MGI
  2. dendrite Source: MGI
  3. integral component of membrane Source: MGI
  4. integral component of plasma membrane Source: GO_Central
  5. presynaptic active zone membrane Source: UniProtKB
  6. presynaptic membrane Source: UniProtKB
  7. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Sequence AnalysisAdd
BLAST
Chaini35 – 915881Metabotropic glutamate receptor 7PRO_0000012939Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi67 ↔ 109By similarity
Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi249 ↔ 541By similarity
Disulfide bondi374 ↔ 390By similarity
Disulfide bondi430 ↔ 437By similarity
Glycosylationi458 – 4581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi486 – 4861N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi523 ↔ 542By similarity
Disulfide bondi527 ↔ 545By similarity
Disulfide bondi548 ↔ 560By similarity
Disulfide bondi563 ↔ 576By similarity
Glycosylationi572 – 5721N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ68ED2.
PaxDbiQ68ED2.
PRIDEiQ68ED2.

PTM databases

PhosphoSiteiQ68ED2.

Expressioni

Gene expression databases

BgeeiQ68ED2.
CleanExiMM_GRM7.
ExpressionAtlasiQ68ED2. baseline and differential.
GenevestigatoriQ68ED2.

Interactioni

Subunit structurei

Interacts with PICK1.By similarity

Protein-protein interaction databases

DIPiDIP-32216N.
IntActiQ68ED2. 1 interaction.
MINTiMINT-4997427.
STRINGi10090.ENSMUSP00000064404.

Structurei

3D structure databases

ProteinModelPortaliQ68ED2.
SMRiQ68ED2. Positions 40-691, 701-855.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni180 – 1823Glutamate bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG295200.
GeneTreeiENSGT00760000118884.
HOGENOMiHOG000218635.
HOVERGENiHBG107965.
InParanoidiQ68ED2.
KOiK04608.
PhylomeDBiQ68ED2.
TreeFamiTF313240.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001883. GPCR_3_mtglu_rcpt_7.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
PR01057. MTABOTROPC7R.
PR00593. MTABOTROPICR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68ED2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVQLGKLLRV LTLMKFPCCV LEVLLCVLAA AARGQEMYAP HSIRIEGDVT
60 70 80 90 100
LGGLFPVHAK GPSGVPCGDI KRENGIHRLE AMLYALDQIN SDPNLLPNVT
110 120 130 140 150
LGARILDTCS RDTYALEQSL TFVQALIQKD TSDVRCTNGE PPVFVKPEKV
160 170 180 190 200
VGVIGASGSS VSIMVANILR LFQIPQISYA STAPELSDDR RYDFFSRVVP
210 220 230 240 250
PDSFQAQAMV DIVKALGWNY VSTLASEGSY GEKGVESFTQ ISKEAGGLCI
260 270 280 290 300
AQSVRIPQER KDRTIDFDRI IKQLLDTPNS RAVVIFANDE DIKQILAAAK
310 320 330 340 350
RADQVGHFLW VGSDSWGSKI NPLHQHEDIA EGAITIQPKR ATVEGFDAYF
360 370 380 390 400
TSRTLENNRR NVWFAEYWEE NFNCKLTISG SKKEDTDRKC TGQERIGKDS
410 420 430 440 450
NYEQEGKVQF VIDAVYAMAH ALHHMNKDLC ADYRGVCPEM EQAGGKKLLK
460 470 480 490 500
YIRNVNFNGS AGTPVMFNKN GDAPGRYDIF QYQTTNTTNP GYRLIGQWTD
510 520 530 540 550
ELQLNIEDMQ WGKGVREIPP SVCTLPCKPG QRKKTQKGTP CCWTCEPCDG
560 570 580 590 600
YQYQFDEMTC QHCPYDQRPN ENRTGCQNIP IIKLEWHSPW AVIPVFLAML
610 620 630 640 650
GIIATIFVMA TFIRYNDTPI VRASGRELSY VLLTGIFLCY IITFLMIAKP
660 670 680 690 700
DVAVCSFRRV FLGLGMCISY AALLTKTNRI YRIFEQGKKS VTAPRLISPT
710 720 730 740 750
SQLAITSSLI SVQLLGVFIW FGVDPPNIII DYDEHKTMNP EQARGVLKCD
760 770 780 790 800
ITDLQIICSL GYSILLMVTC TVYAIKTRGV PENFNEAKPI GFTMYTTCIV
810 820 830 840 850
WLAFIPIFFG TAQSAEKLYI QTTTLTISMN LSASVALGML YMPKVYIIIF
860 870 880 890 900
HPELNVQKRK RSFKAVVTAA TMSSRLSHKP SDRPNGEAKT ELCENVDPNS
910
PAAKKKYVSY NNLVI
Length:915
Mass (Da):102,219
Last modified:October 11, 2004 - v1
Checksum:iF0AF7AEDBFBCCF71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC080315 mRNA. Translation: AAH80315.1.
CCDSiCCDS39587.1.
RefSeqiNP_796302.2. NM_177328.3.
UniGeneiMm.240881.

Genome annotation databases

EnsembliENSMUST00000172951; ENSMUSP00000133957; ENSMUSG00000056755.
GeneIDi108073.
KEGGimmu:108073.
UCSCiuc009dds.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC080315 mRNA. Translation: AAH80315.1.
CCDSiCCDS39587.1.
RefSeqiNP_796302.2. NM_177328.3.
UniGeneiMm.240881.

3D structure databases

ProteinModelPortaliQ68ED2.
SMRiQ68ED2. Positions 40-691, 701-855.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-32216N.
IntActiQ68ED2. 1 interaction.
MINTiMINT-4997427.
STRINGi10090.ENSMUSP00000064404.

Chemistry

GuidetoPHARMACOLOGYi295.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ68ED2.

Proteomic databases

MaxQBiQ68ED2.
PaxDbiQ68ED2.
PRIDEiQ68ED2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000172951; ENSMUSP00000133957; ENSMUSG00000056755.
GeneIDi108073.
KEGGimmu:108073.
UCSCiuc009dds.1. mouse.

Organism-specific databases

CTDi2917.
MGIiMGI:1351344. Grm7.

Phylogenomic databases

eggNOGiNOG295200.
GeneTreeiENSGT00760000118884.
HOGENOMiHOG000218635.
HOVERGENiHBG107965.
InParanoidiQ68ED2.
KOiK04608.
PhylomeDBiQ68ED2.
TreeFamiTF313240.

Enzyme and pathway databases

ReactomeiREACT_250376. G alpha (i) signalling events.
REACT_262510. Class C/3 (Metabotropic glutamate/pheromone receptors).

Miscellaneous databases

NextBioi359996.
PROiQ68ED2.
SOURCEiSearch...

Gene expression databases

BgeeiQ68ED2.
CleanExiMM_GRM7.
ExpressionAtlasiQ68ED2. baseline and differential.
GenevestigatoriQ68ED2.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001883. GPCR_3_mtglu_rcpt_7.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
PR01057. MTABOTROPC7R.
PR00593. MTABOTROPICR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiGRM7_MOUSE
AccessioniPrimary (citable) accession number: Q68ED2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 11, 2004
Last modified: February 4, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.