Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 57

Gene

ZNF57

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri140 – 162C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 218C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 330C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 442C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri476 – 498C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri504 – 526C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 57
Alternative name(s):
Zinc finger protein 424
Gene namesi
Name:ZNF57
Synonyms:ZNF424
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000171970.12.
HGNCiHGNC:13125. ZNF57.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171970.
PharmGKBiPA37699.

Polymorphism and mutation databases

BioMutaiZNF57.
DMDMi143811479.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002748781 – 555Zinc finger protein 57Add BLAST555

Proteomic databases

MaxQBiQ68EA5.
PaxDbiQ68EA5.
PeptideAtlasiQ68EA5.
PRIDEiQ68EA5.

PTM databases

iPTMnetiQ68EA5.
PhosphoSitePlusiQ68EA5.

Expressioni

Gene expression databases

BgeeiENSG00000171970.
CleanExiHS_ZNF57.
ExpressionAtlasiQ68EA5. baseline and differential.
GenevisibleiQ68EA5. HS.

Organism-specific databases

HPAiHPA061915.

Interactioni

Protein-protein interaction databases

BioGridi125974. 1 interactor.
IntActiQ68EA5. 8 interactors.
MINTiMINT-8417745.
STRINGi9606.ENSP00000303696.

Structurei

3D structure databases

ProteinModelPortaliQ68EA5.
SMRiQ68EA5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 76KRABPROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri140 – 162C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 218C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 330C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 442C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri476 – 498C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri504 – 526C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ68EA5.
KOiK09228.
PhylomeDBiQ68EA5.
TreeFamiTF338854.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 9 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.

Sequencei

Sequence statusi: Complete.

Q68EA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSVVFEDVA VDFTLEEWAL LDSAQRDLYR DVMLETFRNL ASVDDGTQFK
60 70 80 90 100
ANGSVSLQDM YGQEKSKEQT IPNFTGNNSC AYTLEKNCEG YGTEDHHKNL
110 120 130 140 150
RNHMVDRFCT HNEGNQYGEA IHQMPDLTLH KKVSAGEKPY ECTKCRTVFT
160 170 180 190 200
HLSSLKRHVK SHCGRKAPPG EECKQACICP SHLHSHGRTD TEEKPYKCQA
210 220 230 240 250
CGQTFQHPRY LSHHVKTHTA EKTYKCEQCR MAFNGFASFT RHVRTHTKDR
260 270 280 290 300
PYKCQECGRA FIYPSTFQRH MTTHTGEKPY KCQHCGKAFT YPQAFQRHEK
310 320 330 340 350
THTGEKPYEC KQCGKTFSWS ETLRVHMRIH TGDKLYKCEH CGKAFTSSRS
360 370 380 390 400
FQGHLRTHTG EKPYECKQCG KAFTWSSTFR EHVRIHTQEQ LYKCEQCGKA
410 420 430 440 450
FTSSRSFRGH LRTHTGEKPY ECKQCGKTFT WSSTFREHVR IHTQEQLHKC
460 470 480 490 500
EHCGKAFTSS RAFQGHLRMH TGEKPYECKQ CGKTFTWSST LHNHVRMHTG
510 520 530 540 550
EKPHKCKQCG MSFKWHSSFR NHLRMHTGQK SHECQSYSKA FSCQVILSKT

SESTH
Length:555
Mass (Da):64,428
Last modified:April 3, 2007 - v3
Checksum:i295DD933C850397F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti198C → R in CAH18455 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052760223T → N. Corresponds to variant dbSNP:rs2288958Ensembl.1
Natural variantiVAR_052761230R → W. Corresponds to variant dbSNP:rs2288957Ensembl.1
Natural variantiVAR_061931357T → M. Corresponds to variant dbSNP:rs55682587Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX537601 mRNA. Translation: CAH18455.2.
BC028974 mRNA. Translation: AAH28974.1.
CCDSiCCDS12098.1.
PIRiB45193.
RefSeqiNP_001306012.1. NM_001319083.1.
NP_775751.1. NM_173480.2.
UniGeneiHs.591378.

Genome annotation databases

EnsembliENST00000306908; ENSP00000303696; ENSG00000171970.
GeneIDi126295.
KEGGihsa:126295.
UCSCiuc002lwr.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZNF57_HUMAN
AccessioniPrimary (citable) accession number: Q68EA5
Secondary accession number(s): Q8N6R9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: April 3, 2007
Last modified: September 27, 2017
This is version 120 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families