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Protein

Zinc finger protein 57

Gene

ZNF57

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri140 – 16223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri196 – 21823C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri224 – 24623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri252 – 27423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri280 – 30223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri308 – 33023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri336 – 35823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri364 – 38623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri392 – 41423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri420 – 44223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri448 – 47023C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri476 – 49823C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri504 – 52623C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 57
Alternative name(s):
Zinc finger protein 424
Gene namesi
Name:ZNF57
Synonyms:ZNF424
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13125. ZNF57.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37699.

Polymorphism and mutation databases

BioMutaiZNF57.
DMDMi143811479.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Zinc finger protein 57PRO_0000274878Add
BLAST

Proteomic databases

MaxQBiQ68EA5.
PaxDbiQ68EA5.
PRIDEiQ68EA5.

PTM databases

PhosphoSiteiQ68EA5.

Expressioni

Gene expression databases

BgeeiQ68EA5.
CleanExiHS_ZNF57.
ExpressionAtlasiQ68EA5. baseline and differential.
GenevisibleiQ68EA5. HS.

Interactioni

Protein-protein interaction databases

BioGridi125974. 1 interaction.
IntActiQ68EA5. 5 interactions.
MINTiMINT-8417745.
STRINGi9606.ENSP00000303696.

Structurei

3D structure databases

ProteinModelPortaliQ68EA5.
SMRiQ68EA5. Positions 4-43, 137-527.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 7673KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri140 – 16223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri196 – 21823C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri224 – 24623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri252 – 27423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri280 – 30223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri308 – 33023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri336 – 35823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri364 – 38623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri392 – 41423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri420 – 44223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri448 – 47023C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri476 – 49823C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri504 – 52623C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ68EA5.
KOiK09228.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ68EA5.
TreeFamiTF338854.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68EA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSVVFEDVA VDFTLEEWAL LDSAQRDLYR DVMLETFRNL ASVDDGTQFK
60 70 80 90 100
ANGSVSLQDM YGQEKSKEQT IPNFTGNNSC AYTLEKNCEG YGTEDHHKNL
110 120 130 140 150
RNHMVDRFCT HNEGNQYGEA IHQMPDLTLH KKVSAGEKPY ECTKCRTVFT
160 170 180 190 200
HLSSLKRHVK SHCGRKAPPG EECKQACICP SHLHSHGRTD TEEKPYKCQA
210 220 230 240 250
CGQTFQHPRY LSHHVKTHTA EKTYKCEQCR MAFNGFASFT RHVRTHTKDR
260 270 280 290 300
PYKCQECGRA FIYPSTFQRH MTTHTGEKPY KCQHCGKAFT YPQAFQRHEK
310 320 330 340 350
THTGEKPYEC KQCGKTFSWS ETLRVHMRIH TGDKLYKCEH CGKAFTSSRS
360 370 380 390 400
FQGHLRTHTG EKPYECKQCG KAFTWSSTFR EHVRIHTQEQ LYKCEQCGKA
410 420 430 440 450
FTSSRSFRGH LRTHTGEKPY ECKQCGKTFT WSSTFREHVR IHTQEQLHKC
460 470 480 490 500
EHCGKAFTSS RAFQGHLRMH TGEKPYECKQ CGKTFTWSST LHNHVRMHTG
510 520 530 540 550
EKPHKCKQCG MSFKWHSSFR NHLRMHTGQK SHECQSYSKA FSCQVILSKT

SESTH
Length:555
Mass (Da):64,428
Last modified:April 3, 2007 - v3
Checksum:i295DD933C850397F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti198 – 1981C → R in CAH18455 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti223 – 2231T → N.
Corresponds to variant rs2288958 [ dbSNP | Ensembl ].
VAR_052760
Natural varianti230 – 2301R → W.
Corresponds to variant rs2288957 [ dbSNP | Ensembl ].
VAR_052761
Natural varianti357 – 3571T → M.
Corresponds to variant rs55682587 [ dbSNP | Ensembl ].
VAR_061931

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX537601 mRNA. Translation: CAH18455.2.
BC028974 mRNA. Translation: AAH28974.1.
CCDSiCCDS12098.1.
PIRiB45193.
RefSeqiNP_001306012.1. NM_001319083.1.
NP_775751.1. NM_173480.2.
UniGeneiHs.591378.

Genome annotation databases

EnsembliENST00000306908; ENSP00000303696; ENSG00000171970.
GeneIDi126295.
KEGGihsa:126295.
UCSCiuc002lwr.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX537601 mRNA. Translation: CAH18455.2.
BC028974 mRNA. Translation: AAH28974.1.
CCDSiCCDS12098.1.
PIRiB45193.
RefSeqiNP_001306012.1. NM_001319083.1.
NP_775751.1. NM_173480.2.
UniGeneiHs.591378.

3D structure databases

ProteinModelPortaliQ68EA5.
SMRiQ68EA5. Positions 4-43, 137-527.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125974. 1 interaction.
IntActiQ68EA5. 5 interactions.
MINTiMINT-8417745.
STRINGi9606.ENSP00000303696.

PTM databases

PhosphoSiteiQ68EA5.

Polymorphism and mutation databases

BioMutaiZNF57.
DMDMi143811479.

Proteomic databases

MaxQBiQ68EA5.
PaxDbiQ68EA5.
PRIDEiQ68EA5.

Protocols and materials databases

DNASUi126295.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306908; ENSP00000303696; ENSG00000171970.
GeneIDi126295.
KEGGihsa:126295.
UCSCiuc002lwr.3. human.

Organism-specific databases

CTDi126295.
GeneCardsiZNF57.
HGNCiHGNC:13125. ZNF57.
neXtProtiNX_Q68EA5.
PharmGKBiPA37699.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ68EA5.
KOiK09228.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ68EA5.
TreeFamiTF338854.

Miscellaneous databases

GenomeRNAii126295.
NextBioi81753.
PROiQ68EA5.

Gene expression databases

BgeeiQ68EA5.
CleanExiHS_ZNF57.
ExpressionAtlasiQ68EA5. baseline and differential.
GenevisibleiQ68EA5. HS.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Endometrium.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix.

Entry informationi

Entry nameiZNF57_HUMAN
AccessioniPrimary (citable) accession number: Q68EA5
Secondary accession number(s): Q8N6R9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: April 3, 2007
Last modified: May 11, 2016
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.