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Protein

Zinc finger protein 772

Gene

ZNF772

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri144 – 16623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri172 – 19423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri266 – 28823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri294 – 31623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri322 – 34423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri350 – 37223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri378 – 40023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri406 – 42823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri434 – 45623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri462 – 48423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 772
Gene namesi
Name:ZNF772
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:33106. ZNF772.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410356.

Polymorphism and mutation databases

BioMutaiZNF772.
DMDMi119368827.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 489489Zinc finger protein 772PRO_0000263689Add
BLAST

Proteomic databases

PaxDbiQ68DY9.
PeptideAtlasiQ68DY9.
PRIDEiQ68DY9.

PTM databases

iPTMnetiQ68DY9.
PhosphoSiteiQ68DY9.

Expressioni

Gene expression databases

BgeeiQ68DY9.
CleanExiHS_ZNF772.
ExpressionAtlasiQ68DY9. baseline and differential.

Organism-specific databases

HPAiHPA031312.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PEX5P505423EBI-10249148,EBI-597835

Protein-protein interaction databases

BioGridi134722. 2 interactions.
IntActiQ68DY9. 1 interaction.
STRINGi9606.ENSP00000341165.

Structurei

3D structure databases

ProteinModelPortaliQ68DY9.
SMRiQ68DY9. Positions 140-489.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 9872KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri144 – 16623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri172 – 19423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri266 – 28823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri294 – 31623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri322 – 34423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri350 – 37223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri378 – 40023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri406 – 42823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri434 – 45623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri462 – 48423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ68DY9.
KOiK09228.
OMAiVMGSEPW.
PhylomeDBiQ68DY9.
TreeFamiTF342033.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q68DY9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAEPMGPA QVPMNSEVIV DPIQGQVNFE DVFVYFSQEE WVLLDEAQRL
60 70 80 90 100
LYRDVMLENF ALMASLGHTS FMSHIVASLV MGSEPWVPDW VDMTLAVATE
110 120 130 140 150
TPGGSDPGCW HGMEDEEIPF EQSFSIGMSQ IRIPKGGPST QKAYPCGTCG
160 170 180 190 200
LVLKDILHLA EHQETHPGQK PYMCVLCGKQ FCFSANLHQH QKQHSGEKPF
210 220 230 240 250
RSDKSRPFLL NNCAVQSMEM SFVTGEACKD FLASSSIFEH HAPHNEWKPH
260 270 280 290 300
SNTKCEEASH CGKRHYKCSE CGKTFSRKDS LVQHQRVHTG ERPYECGECG
310 320 330 340 350
KTFSRKPILA QHQRIHTGEM PYECGICGKV FNHSSNLIVH QRVHTGARPY
360 370 380 390 400
KCSECGKAYS HKSTLVQHES IHTGERPYEC SECGKYFGHK YRLIKHWSVH
410 420 430 440 450
TGARPYECIA CGKFFSQSSD LIAHQRVHNG EKPYVCSECG KAFSHKHVLV
460 470 480
QHHRIHTGER PYKCSECGKA FRQRASLIRH WKIHTGERP
Length:489
Mass (Da):55,367
Last modified:December 12, 2006 - v2
Checksum:iC5F8E4BA5469C32B
GO
Isoform 2 (identifier: Q68DY9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-112: Missing.

Show »
Length:377
Mass (Da):43,041
Checksum:iCCAFD455FA347038
GO
Isoform 3 (identifier: Q68DY9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-107: Missing.

Note: No experimental confirmation available.
Show »
Length:448
Mass (Da):51,071
Checksum:i66B97C056D575B58
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti369 – 3691E → G in CAH18081 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti182 – 1821C → W.1 Publication
Corresponds to variant rs2074060 [ dbSNP | Ensembl ].
VAR_029604
Natural varianti218 – 2181M → L.1 Publication
Corresponds to variant rs2074059 [ dbSNP | Ensembl ].
VAR_029605

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 112112Missing in isoform 2. 2 PublicationsVSP_021882Add
BLAST
Alternative sequencei67 – 10741Missing in isoform 3. 1 PublicationVSP_043423Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK294941 mRNA. Translation: BAG58017.1.
AK302574 mRNA. Translation: BAG63832.1.
BX647068 mRNA. No translation available.
CR749225 mRNA. Translation: CAH18081.1.
AC003005 Genomic DNA. No translation available.
AC004076 Genomic DNA. No translation available.
CCDSiCCDS33133.1. [Q68DY9-1]
CCDS46210.1. [Q68DY9-3]
RefSeqiNP_001019767.1. NM_001024596.2. [Q68DY9-1]
NP_001137540.1. NM_001144068.1. [Q68DY9-3]
XP_005259000.1. XM_005258943.3. [Q68DY9-2]
XP_005259001.1. XM_005258944.2. [Q68DY9-2]
UniGeneiHs.388810.

Genome annotation databases

EnsembliENST00000343280; ENSP00000341165; ENSG00000197128. [Q68DY9-1]
ENST00000356584; ENSP00000348992; ENSG00000197128. [Q68DY9-3]
ENST00000427512; ENSP00000395967; ENSG00000197128. [Q68DY9-2]
GeneIDi400720.
KEGGihsa:400720.
UCSCiuc002qot.3. human. [Q68DY9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK294941 mRNA. Translation: BAG58017.1.
AK302574 mRNA. Translation: BAG63832.1.
BX647068 mRNA. No translation available.
CR749225 mRNA. Translation: CAH18081.1.
AC003005 Genomic DNA. No translation available.
AC004076 Genomic DNA. No translation available.
CCDSiCCDS33133.1. [Q68DY9-1]
CCDS46210.1. [Q68DY9-3]
RefSeqiNP_001019767.1. NM_001024596.2. [Q68DY9-1]
NP_001137540.1. NM_001144068.1. [Q68DY9-3]
XP_005259000.1. XM_005258943.3. [Q68DY9-2]
XP_005259001.1. XM_005258944.2. [Q68DY9-2]
UniGeneiHs.388810.

3D structure databases

ProteinModelPortaliQ68DY9.
SMRiQ68DY9. Positions 140-489.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi134722. 2 interactions.
IntActiQ68DY9. 1 interaction.
STRINGi9606.ENSP00000341165.

PTM databases

iPTMnetiQ68DY9.
PhosphoSiteiQ68DY9.

Polymorphism and mutation databases

BioMutaiZNF772.
DMDMi119368827.

Proteomic databases

PaxDbiQ68DY9.
PeptideAtlasiQ68DY9.
PRIDEiQ68DY9.

Protocols and materials databases

DNASUi400720.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343280; ENSP00000341165; ENSG00000197128. [Q68DY9-1]
ENST00000356584; ENSP00000348992; ENSG00000197128. [Q68DY9-3]
ENST00000427512; ENSP00000395967; ENSG00000197128. [Q68DY9-2]
GeneIDi400720.
KEGGihsa:400720.
UCSCiuc002qot.3. human. [Q68DY9-1]

Organism-specific databases

CTDi400720.
GeneCardsiZNF772.
HGNCiHGNC:33106. ZNF772.
HPAiHPA031312.
neXtProtiNX_Q68DY9.
PharmGKBiPA162410356.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ68DY9.
KOiK09228.
OMAiVMGSEPW.
PhylomeDBiQ68DY9.
TreeFamiTF342033.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii400720.
PROiQ68DY9.

Gene expression databases

BgeeiQ68DY9.
CleanExiHS_ZNF772.
ExpressionAtlasiQ68DY9. baseline and differential.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Brain and Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS TRP-182 AND LEU-218.
    Tissue: Endometrial tumor and Fetal kidney.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiZN772_HUMAN
AccessioniPrimary (citable) accession number: Q68DY9
Secondary accession number(s): A6NJK9, B4DH56, B4DYS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 12, 2006
Last modified: July 6, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.