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Protein

Zinc finger protein 772

Gene

ZNF772

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri144 – 166C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri172 – 194C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri266 – 288C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri294 – 316C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri322 – 344C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri350 – 372C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri378 – 400C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri406 – 428C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri434 – 456C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri462 – 484C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 772
Gene namesi
Name:ZNF772
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000197128.11
HGNCiHGNC:33106 ZNF772
neXtProtiNX_Q68DY9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197128
PharmGKBiPA162410356

Polymorphism and mutation databases

BioMutaiZNF772
DMDMi119368827

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002636891 – 489Zinc finger protein 772Add BLAST489

Proteomic databases

PaxDbiQ68DY9
PeptideAtlasiQ68DY9
PRIDEiQ68DY9

PTM databases

iPTMnetiQ68DY9
PhosphoSitePlusiQ68DY9

Expressioni

Gene expression databases

BgeeiENSG00000197128
CleanExiHS_ZNF772
ExpressionAtlasiQ68DY9 baseline and differential

Organism-specific databases

HPAiHPA031312

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PEX5P505423EBI-10249148,EBI-597835

Protein-protein interaction databases

BioGridi134722, 2 interactors
IntActiQ68DY9, 2 interactors
STRINGi9606.ENSP00000341165

Structurei

3D structure databases

ProteinModelPortaliQ68DY9
SMRiQ68DY9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 98KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri144 – 166C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri172 – 194C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri266 – 288C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri294 – 316C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri322 – 344C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri350 – 372C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri378 – 400C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri406 – 428C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri434 – 456C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri462 – 484C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119107
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ68DY9
KOiK09228
OMAiPGCWHGM
OrthoDBiEOG091G02KC
PhylomeDBiQ68DY9
TreeFamiTF342033

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q68DY9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAEPMGPA QVPMNSEVIV DPIQGQVNFE DVFVYFSQEE WVLLDEAQRL
60 70 80 90 100
LYRDVMLENF ALMASLGHTS FMSHIVASLV MGSEPWVPDW VDMTLAVATE
110 120 130 140 150
TPGGSDPGCW HGMEDEEIPF EQSFSIGMSQ IRIPKGGPST QKAYPCGTCG
160 170 180 190 200
LVLKDILHLA EHQETHPGQK PYMCVLCGKQ FCFSANLHQH QKQHSGEKPF
210 220 230 240 250
RSDKSRPFLL NNCAVQSMEM SFVTGEACKD FLASSSIFEH HAPHNEWKPH
260 270 280 290 300
SNTKCEEASH CGKRHYKCSE CGKTFSRKDS LVQHQRVHTG ERPYECGECG
310 320 330 340 350
KTFSRKPILA QHQRIHTGEM PYECGICGKV FNHSSNLIVH QRVHTGARPY
360 370 380 390 400
KCSECGKAYS HKSTLVQHES IHTGERPYEC SECGKYFGHK YRLIKHWSVH
410 420 430 440 450
TGARPYECIA CGKFFSQSSD LIAHQRVHNG EKPYVCSECG KAFSHKHVLV
460 470 480
QHHRIHTGER PYKCSECGKA FRQRASLIRH WKIHTGERP
Length:489
Mass (Da):55,367
Last modified:December 12, 2006 - v2
Checksum:iC5F8E4BA5469C32B
GO
Isoform 2 (identifier: Q68DY9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-112: Missing.

Show »
Length:377
Mass (Da):43,041
Checksum:iCCAFD455FA347038
GO
Isoform 3 (identifier: Q68DY9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-107: Missing.

Note: No experimental confirmation available.
Show »
Length:448
Mass (Da):51,071
Checksum:i66B97C056D575B58
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti369E → G in CAH18081 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029604182C → W1 PublicationCorresponds to variant dbSNP:rs2074060Ensembl.1
Natural variantiVAR_029605218M → L1 PublicationCorresponds to variant dbSNP:rs2074059Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0218821 – 112Missing in isoform 2. 2 PublicationsAdd BLAST112
Alternative sequenceiVSP_04342367 – 107Missing in isoform 3. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK294941 mRNA Translation: BAG58017.1
AK302574 mRNA Translation: BAG63832.1
BX647068 mRNA No translation available.
CR749225 mRNA Translation: CAH18081.1
AC003005 Genomic DNA No translation available.
AC004076 Genomic DNA No translation available.
CCDSiCCDS33133.1 [Q68DY9-1]
CCDS46210.1 [Q68DY9-3]
CCDS82406.1 [Q68DY9-2]
RefSeqiNP_001019767.1, NM_001024596.2 [Q68DY9-1]
NP_001137540.1, NM_001144068.1 [Q68DY9-3]
NP_001317542.1, NM_001330613.1 [Q68DY9-2]
XP_005259001.1, XM_005258944.3 [Q68DY9-2]
UniGeneiHs.388810

Genome annotation databases

EnsembliENST00000343280; ENSP00000341165; ENSG00000197128 [Q68DY9-1]
ENST00000356584; ENSP00000348992; ENSG00000197128 [Q68DY9-3]
ENST00000427512; ENSP00000395967; ENSG00000197128 [Q68DY9-2]
GeneIDi400720
KEGGihsa:400720
UCSCiuc002qot.3 human [Q68DY9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Entry informationi

Entry nameiZN772_HUMAN
AccessioniPrimary (citable) accession number: Q68DY9
Secondary accession number(s): A6NJK9, B4DH56, B4DYS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 12, 2006
Last modified: May 23, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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