Q68DY8 (Q68DY8_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative uncharacterized protein DKFZp686I11137 EMBL CAH18082.1

Gene names

Name:

DKFZp686I11137 EMBL CAH18082.1

Organism

Homo sapiens (Human) EMBL CAH18082.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	667 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein By similarity RuleBase RU003318.

Ontologies

Keywords
Biological process	Cell adhesion RuleBase RU003318 SAAS SAAS020894
Cellular component	Cell membrane SAAS SAAS020894 Membrane
Domain	Repeat SAAS SAAS020894 Transmembrane Transmembrane helix SAAS SAAS020894
Ligand	Calcium RuleBase RU003318 RuleBase RU000484 SAAS SAAS020894
Gene Ontology (GO)
Biological_process	homophilic cell adhesion Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q68DY8 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 0BB91F7401CFB706	FASTA	667	73,331
	10 20 30 40 50 60 MKMITTQFLQ KKLILLQFLK IAEWGTTVGQ VCATDKDEPD TMHTRLKYSI IGQVPPSPTL 70 80 90 100 110 120 FSMHPTTGVI TTTSSQLDRE LIDKYQLKIK VQDMDGQYFG LQTTSTCIIN IDDVNDHLPT 130 140 150 160 170 180 FTRTSYVTSV EENTVDVEIL RVTVEDKDLV NTANWRANYT ILKGNENGNF KIVTDAKTNE 190 200 210 220 230 240 GVLCVVKPLN YEEKQQMILQ IGVVNEAPFS REASPRSAMS TATVTVNVED QDEGPECNPP 250 260 270 280 290 300 IQTVRMKENA EVGTTSNGYK AYDPETRSSS GIRYKKLTDP TGWVTIDENT GSIKVFRSLD 310 320 330 340 350 360 REAETIKNGI YNITVLASDQ GGRTCTGTLG IILQDVNDNS PFIPKKTVII CKPTMSSAEI 370 380 390 400 410 420 VAVDPDEPIH GPPFDFSLES STSEVQRMWR LKAINDTAAR LSYQNDPPFG SYVVPITVRD 430 440 450 460 470 480 RLGMSSVTSL DVTLCDCITE NDCTHRVDPR IGGGGVQLGK WAILAILLGI ALLFCILFTL 490 500 510 520 530 540 VCGASGTSKQ PKVIPDDLAQ QNLIVSNTEA PGDDKVYSAN GFTTQTVGAS AQGVCGTVGS 550 560 570 580 590 600 GIKNGGQETI EMVKGGHQTS ESCRGAGHHH TLDSCRGGHT EVDNCRYTYS EWHSFTQPRL 610 620 630 640 650 660 GEKVYLCNQD ENHKHAQDYV LTYNYEGRGS VAGSVGCCSE RQEEDGLEFL DNLEPKFRTL AEACMKR

References

[1]	The German cDNA Consortium Poustka A., Albert R., Moosmayer P., Schupp I., Wellenreuther R., Mewes H.W., Weil B., Amid C., Osanger A., Fobo G., Han M., Wiemann S. Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Prostate EMBL CAH18082.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR749226 mRNA. Translation: CAH18082.1.
IPI	IPI01009989.
UniGene	Hs.95612.
3D structure databases
ProteinModelPortal	Q68DY8.
SMR	Q68DY8. Positions 7-435, 588-666.
ModBase	Search...
Protein-protein interaction databases
STRING	Q68DY8.
Proteomic databases
PRIDE	Q68DY8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG102801.
Gene expression databases
ArrayExpress	Q68DY8.
Family and domain databases
Gene3D	2.60.40.60. 3 hits.
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR009124. Cadherin/Desmocollin. IPR020894. Cadherin_CS. IPR000233. Cadherin_cytoplasmic-dom. IPR009122. Desmosomal_cadherin. [Graphical view]
PANTHER	PTHR24025. PTHR24025. 1 hit.
Pfam	PF00028. Cadherin. 3 hits. PF01049. Cadherin_C. 1 hit. [Graphical view]
PRINTS	PR00205. CADHERIN. PR01818. DESMOCADHERN. PR01820. DESMOCOLLIN.
SMART	SM00112. CA. 4 hits. [Graphical view]
SUPFAM	SSF49313. Cadherin. 4 hits.
PROSITE	PS00232. CADHERIN_1. 2 hits. PS50268. CADHERIN_2. 4 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q68DY8_HUMAN

Accession

Primary (citable) accession number: Q68DY8
Secondary accession number(s): E9PHQ8

Entry history

Integrated into UniProtKB/TrEMBL:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.