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Protein

Zinc finger protein 626

Gene

ZNF626

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri173 – 19523C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri201 – 22323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri229 – 25123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri257 – 27923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 30723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri313 – 33523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri341 – 36323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri369 – 39123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri397 – 41923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri425 – 44723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri453 – 47523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri481 – 50323C2H2-type 12; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 626
Gene namesi
Name:ZNF626
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:30461. ZNF626.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134875370.

Polymorphism and mutation databases

BioMutaiZNF626.
DMDMi215273916.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 528528Zinc finger protein 626PRO_0000270994Add
BLAST

Proteomic databases

PaxDbiQ68DY1.
PRIDEiQ68DY1.

PTM databases

iPTMnetiQ68DY1.
PhosphoSiteiQ68DY1.

Expressioni

Gene expression databases

BgeeiQ68DY1.
CleanExiHS_ZNF626.
ExpressionAtlasiQ68DY1. baseline and differential.
GenevisibleiQ68DY1. HS.

Organism-specific databases

HPAiHPA045631.

Interactioni

Protein-protein interaction databases

BioGridi128273. 2 interactions.
IntActiQ68DY1. 3 interactions.
STRINGi9606.ENSP00000469958.

Structurei

3D structure databases

ProteinModelPortaliQ68DY1.
SMRiQ68DY1. Positions 138-510.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 7572KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri173 – 19523C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri201 – 22323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri229 – 25123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri257 – 27923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 30723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri313 – 33523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri341 – 36323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri369 – 39123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri397 – 41923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri425 – 44723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri453 – 47523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri481 – 50323C2H2-type 12; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000231475.
HOVERGENiHBG018163.
InParanoidiQ68DY1.
PhylomeDBiQ68DY1.
TreeFamiTF342117.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q68DY1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPLQFRDVA IEFSLEEWHC LDTAQRNLYR NVMLENYSNL VFLGITVSKP
60 70 80 90 100
DLITCLEQGR KPLTMKRNEM IAKPSVMCSH FAQDLWPEQS MKDSFQKVVL
110 120 130 140 150
RRYEKCEHDN LQLKKGCISV DECKVHKEGY NELNQCLTTT PRKICQCDKY
160 170 180 190 200
VKVLHQFPNS NGQKRGHTGK KPFKYIECGK AFKQFSTLTT HKKIHTGGKP
210 220 230 240 250
YKCEECGKAF NHSCSLTRHK KIHTGEKPYK CEECGKAFKH SSTLTTHKRN
260 270 280 290 300
HTGEKPYKCD KCGKAFMSSS TLSKHEIIHT EKKPYKCEEC GKAFNRSSTL
310 320 330 340 350
TTHKIIHTGE KPYKCEECDK AFKYSYTLTT HKRIHTEDKP YKCEECGKAF
360 370 380 390 400
KYSSTLTTHK RIHTGEKPYK CEECGKAFKR SSDLTTHKII HTGEKPYKCE
410 420 430 440 450
ECGKAFKYSS NLTTHKKIHT GERPYKCEEC GKAFNQSSIL TTHRRIHTGE
460 470 480 490 500
KFYKCEECGK AFKCSSNLTT HKKIHTGERP YKCEECGKAF NQSSILTTHE
510 520
RIILERNSTN VKNVAKPSSG PHTLLHIR
Length:528
Mass (Da):60,893
Last modified:November 25, 2008 - v2
Checksum:i4F631D271B872653
GO
Isoform 2 (identifier: Q68DY1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.

Note: No experimental confirmation available.
Show »
Length:452
Mass (Da):52,097
Checksum:iBEBB1EE32FB68C7B
GO
Isoform 3 (identifier: Q68DY1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-92: MCSHFAQDLWPEQSMK → SFLQVHSESQSPLHDI
     93-528: Missing.

Note: No experimental confirmation available.
Show »
Length:92
Mass (Da):10,620
Checksum:i5F8BE284A21A4213
GO

Sequence cautioni

The sequence BAC04729.1 differs from that shown.Intron-exon boundaries of the last intron are not canonical, they have a CT-AG boundary.Curated
The sequence CAH18089.1 differs from that shown.Intron-exon boundaries of the last intron are not canonical, they have a CT-AG boundary.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti31 – 311N → D.
Corresponds to variant rs3206157 [ dbSNP | Ensembl ].
VAR_029836
Natural varianti65 – 651M → T.
Corresponds to variant rs8106117 [ dbSNP | Ensembl ].
VAR_047338
Natural varianti68 – 681N → H.
Corresponds to variant rs3209058 [ dbSNP | Ensembl ].
VAR_029837
Natural varianti89 – 891Q → E.
Corresponds to variant rs8111015 [ dbSNP | Ensembl ].
VAR_047339
Natural varianti90 – 901S → N.
Corresponds to variant rs8110802 [ dbSNP | Ensembl ].
VAR_047340
Natural varianti464 – 4641C → Y.
Corresponds to variant rs4809072 [ dbSNP | Ensembl ].
VAR_047341
Natural varianti500 – 5001E → K.
Corresponds to variant rs10408597 [ dbSNP | Ensembl ].
VAR_047342

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7676Missing in isoform 2. 1 PublicationVSP_022263Add
BLAST
Alternative sequencei77 – 9216MCSHF…EQSMK → SFLQVHSESQSPLHDI in isoform 3. 1 PublicationVSP_043270Add
BLAST
Alternative sequencei93 – 528436Missing in isoform 3. 1 PublicationVSP_043271Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096221 mRNA. Translation: BAC04729.1. Sequence problems.
AK131567 mRNA. No translation available.
CR749233 mRNA. Translation: CAH18089.1. Sequence problems.
AC010636 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84879.1.
BC007116 mRNA. Translation: AAH07116.1.
BC107803 mRNA. Translation: AAI07804.1.
CCDSiCCDS32976.1. [Q68DY1-3]
CCDS42535.1. [Q68DY1-1]
RefSeqiNP_001070143.1. NM_001076675.2. [Q68DY1-1]
NP_660340.1. NM_145297.3. [Q68DY1-3]
UniGeneiHs.657001.

Genome annotation databases

EnsembliENST00000291750; ENSP00000291750; ENSG00000188171. [Q68DY1-3]
ENST00000601440; ENSP00000469958; ENSG00000188171. [Q68DY1-1]
GeneIDi199777.
KEGGihsa:199777.
UCSCiuc002npb.2. human. [Q68DY1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096221 mRNA. Translation: BAC04729.1. Sequence problems.
AK131567 mRNA. No translation available.
CR749233 mRNA. Translation: CAH18089.1. Sequence problems.
AC010636 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84879.1.
BC007116 mRNA. Translation: AAH07116.1.
BC107803 mRNA. Translation: AAI07804.1.
CCDSiCCDS32976.1. [Q68DY1-3]
CCDS42535.1. [Q68DY1-1]
RefSeqiNP_001070143.1. NM_001076675.2. [Q68DY1-1]
NP_660340.1. NM_145297.3. [Q68DY1-3]
UniGeneiHs.657001.

3D structure databases

ProteinModelPortaliQ68DY1.
SMRiQ68DY1. Positions 138-510.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128273. 2 interactions.
IntActiQ68DY1. 3 interactions.
STRINGi9606.ENSP00000469958.

PTM databases

iPTMnetiQ68DY1.
PhosphoSiteiQ68DY1.

Polymorphism and mutation databases

BioMutaiZNF626.
DMDMi215273916.

Proteomic databases

PaxDbiQ68DY1.
PRIDEiQ68DY1.

Protocols and materials databases

DNASUi199777.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291750; ENSP00000291750; ENSG00000188171. [Q68DY1-3]
ENST00000601440; ENSP00000469958; ENSG00000188171. [Q68DY1-1]
GeneIDi199777.
KEGGihsa:199777.
UCSCiuc002npb.2. human. [Q68DY1-1]

Organism-specific databases

CTDi199777.
GeneCardsiZNF626.
HGNCiHGNC:30461. ZNF626.
HPAiHPA045631.
neXtProtiNX_Q68DY1.
PharmGKBiPA134875370.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000231475.
HOVERGENiHBG018163.
InParanoidiQ68DY1.
PhylomeDBiQ68DY1.
TreeFamiTF342117.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF626. human.
GenomeRNAii199777.
PROiQ68DY1.

Gene expression databases

BgeeiQ68DY1.
CleanExiHS_ZNF626.
ExpressionAtlasiQ68DY1. baseline and differential.
GenevisibleiQ68DY1. HS.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Teratocarcinoma.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Lung and Prostate.

Entry informationi

Entry nameiZN626_HUMAN
AccessioniPrimary (citable) accession number: Q68DY1
Secondary accession number(s): Q8N8T4, Q96QM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: November 25, 2008
Last modified: June 8, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.