Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q68DV7

- RNF43_HUMAN

UniProt

Q68DV7 - RNF43_HUMAN

Protein

E3 ubiquitin-protein ligase RNF43

Gene

RNF43

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.3 Publications

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri272 – 31342RING-type; atypicalPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. frizzled binding Source: UniProtKB
    2. ligase activity Source: UniProtKB-KW
    3. protein binding Source: IntAct
    4. ubiquitin-protein transferase activity Source: UniProtKB
    5. zinc ion binding Source: InterPro

    GO - Biological processi

    1. negative regulation of Wnt signaling pathway Source: UniProtKB
    2. protein ubiquitination Source: UniProtKB
    3. protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: UniProtKB
    4. stem cell proliferation Source: UniProtKB
    5. Wnt receptor catabolic process Source: UniProtKB
    6. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway, Wnt signaling pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_200716. regulation of FZD by ubiquitination.
    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    E3 ubiquitin-protein ligase RNF43 (EC:6.3.2.-)
    Alternative name(s):
    RING finger protein 43
    Gene namesi
    Name:RNF43
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:18505. RNF43.

    Subcellular locationi

    Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus envelope
    Note: According to a report, may be secreted.1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of plasma membrane Source: UniProtKB
    3. nuclear envelope Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Endoplasmic reticulum, Membrane, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi290 – 2901C → S: Dominant-negative mutant, loss of E3 ligase activity and activation of the Wnt signaling pathway; when associated with S-292. 2 Publications
    Mutagenesisi292 – 2921H → S: Dominant-negative mutant, loss of E3 ligase activity and activation of the Wnt signaling pathway; when associated with S-290. 2 Publications
    Mutagenesisi295 – 2951H → S: Dominant-negative mutant, loss of E3 ligase activity and activation of the Wnt signaling pathway; when associated with S-298. 1 Publication
    Mutagenesisi298 – 2981C → S: Dominant-negative mutant, loss of E3 ligase activity and activation of the Wnt signaling pathway; when associated with S-295. 1 Publication

    Organism-specific databases

    PharmGKBiPA34441.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 783760E3 ubiquitin-protein ligase RNF43PRO_0000278239Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi62 – 621N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi91 ↔ 119
    Glycosylationi92 – 921N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Autoubiquitinated.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ68DV7.
    PRIDEiQ68DV7.

    Expressioni

    Tissue specificityi

    Expressed in fetal kidney, fetal lung, in colon cancer tissues, hepatocellular carcinomas and lung adenocarcinomas. Overexpressed in colorectal cancer cell lines.2 Publications

    Gene expression databases

    ArrayExpressiQ68DV7.
    BgeeiQ68DV7.
    CleanExiHS_RNF43.
    GenevestigatoriQ68DV7.

    Organism-specific databases

    HPAiHPA008079.

    Interactioni

    Subunit structurei

    Interacts with AKAP8L, NONO and SFPQ. Interacts with FZD5. Identified in a complex composed of RNF43, LGR5 and RSPO1.4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AKAP8LQ9ULX62EBI-1647060,EBI-357530
    UBBP0CG472EBI-1647060,EBI-413034
    UBE2D2P628372EBI-1647060,EBI-347677
    UBE2D3P610772EBI-1647060,EBI-348268

    Protein-protein interaction databases

    BioGridi120241. 15 interactions.
    IntActiQ68DV7. 12 interactions.
    STRINGi9606.ENSP00000385328.

    Structurei

    Secondary structure

    1
    783
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi45 – 5410
    Beta strandi57 – 593
    Beta strandi63 – 697
    Beta strandi71 – 733
    Beta strandi78 – 847
    Turni87 – 893
    Beta strandi104 – 1085
    Turni112 – 1143
    Helixi122 – 13110
    Beta strandi135 – 1406
    Helixi142 – 1465
    Helixi147 – 1504
    Beta strandi157 – 1593
    Beta strandi161 – 1644
    Helixi166 – 17611
    Beta strandi177 – 1793
    Beta strandi184 – 1896

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4KNGX-ray2.50E/F44-198[»]
    ProteinModelPortaliQ68DV7.
    SMRiQ68DV7. Positions 44-191, 272-316.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 197174ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini219 – 783565CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei198 – 21821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi443 – 50361Ser-richAdd
    BLAST
    Compositional biasi547 – 55711His-richAdd
    BLAST
    Compositional biasi569 – 760192Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ZNRF3 family.Curated
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri272 – 31342RING-type; atypicalPROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG329235.
    HOVERGENiHBG093916.
    InParanoidiQ68DV7.
    KOiK15694.
    OMAiHPLIFGP.
    OrthoDBiEOG7P5T06.
    PhylomeDBiQ68DV7.
    TreeFamiTF317074.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF13639. zf-RING_2. 1 hit.
    [Graphical view]
    SMARTiSM00184. RING. 1 hit.
    [Graphical view]
    PROSITEiPS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q68DV7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSGGHQLQLA ALWPWLLMAT LQAGFGRTGL VLAAAVESER SAEQKAIIRV    50
    IPLKMDPTGK LNLTLEGVFA GVAEITPAEG KLMQSHPLYL CNASDDDNLE 100
    PGFISIVKLE SPRRAPRPCL SLASKARMAG ERGASAVLFD ITEDRAAAEQ 150
    LQQPLGLTWP VVLIWGNDAE KLMEFVYKNQ KAHVRIELKE PPAWPDYDVW 200
    ILMTVVGTIF VIILASVLRI RCRPRHSRPD PLQQRTAWAI SQLATRRYQA 250
    SCRQARGEWP DSGSSCSSAP VCAICLEEFS EGQELRVISC LHEFHRNCVD 300
    PWLHQHRTCP LCMFNITEGD SFSQSLGPSR SYQEPGRRLH LIRQHPGHAH 350
    YHLPAAYLLG PSRSAVARPP RPGPFLPSQE PGMGPRHHRF PRAAHPRAPG 400
    EQQRLAGAQH PYAQGWGLSH LQSTSQHPAA CPVPLRRARP PDSSGSGESY 450
    CTERSGYLAD GPASDSSSGP CHGSSSDSVV NCTDISLQGV HGSSSTFCSS 500
    LSSDFDPLVY CSPKGDPQRV DMQPSVTSRP RSLDSVVPTG ETQVSSHVHY 550
    HRHRHHHYKK RFQWHGRKPG PETGVPQSRP PIPRTQPQPE PPSPDQQVTR 600
    SNSAAPSGRL SNPQCPRALP EPAPGPVDAS SICPSTSSLF NLQKSSLSAR 650
    HPQRKRRGGP SEPTPGSRPQ DATVHPACQI FPHYTPSVAY PWSPEAHPLI 700
    CGPPGLDKRL LPETPGPCYS NSQPVWLCLT PRQPLEPHPP GEGPSEWSSD 750
    TAEGRPCPYP HCQVLSAQPG SEEELEELCE QAV 783
    Length:783
    Mass (Da):85,722
    Last modified:October 11, 2004 - v1
    Checksum:i4E87EA0CC359C858
    GO
    Isoform 2 (identifier: Q68DV7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         85-125: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:742
    Mass (Da):81,229
    Checksum:i7A177F5F2AC13F1B
    GO
    Isoform 3 (identifier: Q68DV7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-127: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:656
    Mass (Da):72,106
    Checksum:i6278F14330DC2A94
    GO
    Isoform 4 (identifier: Q68DV7-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         771-783: SEEELEELCEQAV → EFSEGSGCGR...WKAGCDGSCL

    Note: No experimental confirmation available.

    Show »
    Length:869
    Mass (Da):95,038
    Checksum:iAFB4B8ECFA217C83
    GO

    Sequence cautioni

    The sequence BAH12871.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti225 – 2251R → H in BAH12429. (PubMed:14702039)Curated
    Sequence conflicti313 – 3131M → V in BAD51435. (PubMed:15492824)Curated
    Sequence conflicti313 – 3131M → V in BAA91085. (PubMed:14702039)Curated
    Sequence conflicti401 – 4011E → K in BAH12429. (PubMed:14702039)Curated
    Sequence conflicti600 – 6001R → G in BAD51435. (PubMed:15492824)Curated
    Sequence conflicti600 – 6001R → G in BAA91085. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti47 – 471I → V.1 Publication
    Corresponds to variant rs3744093 [ dbSNP | Ensembl ].
    VAR_030713
    Natural varianti117 – 1171R → H.
    Corresponds to variant rs2257205 [ dbSNP | Ensembl ].
    VAR_030714
    Natural varianti221 – 2211R → Q.
    Corresponds to variant rs2285990 [ dbSNP | Ensembl ].
    VAR_030715
    Natural varianti231 – 2311P → L.1 Publication
    Corresponds to variant rs2680701 [ dbSNP | Ensembl ].
    VAR_030716
    Natural varianti343 – 3431R → H.
    Corresponds to variant rs34523089 [ dbSNP | Ensembl ].
    VAR_052103
    Natural varianti418 – 4181L → M.2 Publications
    Corresponds to variant rs2526374 [ dbSNP | Ensembl ].
    VAR_030717
    Natural varianti686 – 6861P → R.1 Publication
    Corresponds to variant rs9652855 [ dbSNP | Ensembl ].
    VAR_030718

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 127127Missing in isoform 3. 1 PublicationVSP_037338Add
    BLAST
    Alternative sequencei85 – 12541Missing in isoform 2. 1 PublicationVSP_037339Add
    BLAST
    Alternative sequencei771 – 78313SEEEL…CEQAV → EFSEGSGCGRERRLQLNISG QVKSANKGLMEAEKDTAEMT TKILNHRDSVSCWLECRNTP PLPGATPLVGRSQGGPREVL VWLRHQKGTWKAGCDGSCL in isoform 4. 1 PublicationVSP_037340Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB081837 mRNA. Translation: BAD51435.1.
    AK000322 mRNA. Translation: BAA91085.1.
    AK291027 mRNA. Translation: BAF83716.1.
    AK296769 mRNA. Translation: BAH12429.1.
    AK298789 mRNA. Translation: BAH12871.1. Different initiation.
    AK299024 mRNA. Translation: BAH12931.1.
    CR627423 mRNA. Translation: CAH10510.1.
    CR749257 mRNA. Translation: CAH18113.1.
    BC109028 mRNA. Translation: AAI09029.1.
    CCDSiCCDS11607.1. [Q68DV7-1]
    RefSeqiNP_060233.3. NM_017763.4. [Q68DV7-1]
    UniGeneiHs.584916.

    Genome annotation databases

    EnsembliENST00000407977; ENSP00000385328; ENSG00000108375. [Q68DV7-1]
    ENST00000577625; ENSP00000463716; ENSG00000108375. [Q68DV7-3]
    ENST00000577716; ENSP00000462764; ENSG00000108375. [Q68DV7-1]
    ENST00000583753; ENSP00000462502; ENSG00000108375. [Q68DV7-2]
    ENST00000584437; ENSP00000463069; ENSG00000108375. [Q68DV7-1]
    GeneIDi54894.
    KEGGihsa:54894.
    UCSCiuc002iwf.3. human. [Q68DV7-1]
    uc010wnv.2. human. [Q68DV7-2]

    Polymorphism databases

    DMDMi74757361.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB081837 mRNA. Translation: BAD51435.1 .
    AK000322 mRNA. Translation: BAA91085.1 .
    AK291027 mRNA. Translation: BAF83716.1 .
    AK296769 mRNA. Translation: BAH12429.1 .
    AK298789 mRNA. Translation: BAH12871.1 . Different initiation.
    AK299024 mRNA. Translation: BAH12931.1 .
    CR627423 mRNA. Translation: CAH10510.1 .
    CR749257 mRNA. Translation: CAH18113.1 .
    BC109028 mRNA. Translation: AAI09029.1 .
    CCDSi CCDS11607.1. [Q68DV7-1 ]
    RefSeqi NP_060233.3. NM_017763.4. [Q68DV7-1 ]
    UniGenei Hs.584916.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4KNG X-ray 2.50 E/F 44-198 [» ]
    ProteinModelPortali Q68DV7.
    SMRi Q68DV7. Positions 44-191, 272-316.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120241. 15 interactions.
    IntActi Q68DV7. 12 interactions.
    STRINGi 9606.ENSP00000385328.

    Polymorphism databases

    DMDMi 74757361.

    Proteomic databases

    PaxDbi Q68DV7.
    PRIDEi Q68DV7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000407977 ; ENSP00000385328 ; ENSG00000108375 . [Q68DV7-1 ]
    ENST00000577625 ; ENSP00000463716 ; ENSG00000108375 . [Q68DV7-3 ]
    ENST00000577716 ; ENSP00000462764 ; ENSG00000108375 . [Q68DV7-1 ]
    ENST00000583753 ; ENSP00000462502 ; ENSG00000108375 . [Q68DV7-2 ]
    ENST00000584437 ; ENSP00000463069 ; ENSG00000108375 . [Q68DV7-1 ]
    GeneIDi 54894.
    KEGGi hsa:54894.
    UCSCi uc002iwf.3. human. [Q68DV7-1 ]
    uc010wnv.2. human. [Q68DV7-2 ]

    Organism-specific databases

    CTDi 54894.
    GeneCardsi GC17M056429.
    HGNCi HGNC:18505. RNF43.
    HPAi HPA008079.
    MIMi 612482. gene.
    neXtProti NX_Q68DV7.
    PharmGKBi PA34441.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG329235.
    HOVERGENi HBG093916.
    InParanoidi Q68DV7.
    KOi K15694.
    OMAi HPLIFGP.
    OrthoDBi EOG7P5T06.
    PhylomeDBi Q68DV7.
    TreeFami TF317074.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .
    Reactomei REACT_200716. regulation of FZD by ubiquitination.

    Miscellaneous databases

    ChiTaRSi RNF43. human.
    GenomeRNAii 54894.
    NextBioi 57898.
    PROi Q68DV7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q68DV7.
    Bgeei Q68DV7.
    CleanExi HS_RNF43.
    Genevestigatori Q68DV7.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF13639. zf-RING_2. 1 hit.
    [Graphical view ]
    SMARTi SM00184. RING. 1 hit.
    [Graphical view ]
    PROSITEi PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel oncoprotein RNF43 functions in an autocrine manner in colorectal cancer."
      Yagyu R., Furukawa Y., Lin Y.-M., Shimokawa T., Yamamura T., Nakamura Y.
      Int. J. Oncol. 25:1343-1348(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANT MET-418.
      Tissue: Colon carcinoma.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 214-783 (ISOFORM 4), VARIANTS VAL-47; LEU-231 AND MET-418.
      Tissue: Hepatoma, Teratocarcinoma and Tongue.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-686.
      Tissue: Colon carcinoma.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "Ring finger protein 43 as a new target for cancer immunotherapy."
      Uchida N., Tsunoda T., Wada S., Furukawa Y., Nakamura Y., Tahara H.
      Clin. Cancer Res. 10:8577-8586(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION AS A CYTOTOXIC T LYMPHOCYTE TUMOR ANTIGEN.
    6. "A cancer-associated RING finger protein, RNF43, is a ubiquitin ligase that interacts with a nuclear protein, HAP95."
      Sugiura T., Yamaguchi A., Miyamoto K.
      Exp. Cell Res. 314:1519-1528(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH AKAP8L, AUTOUBIQUITINATION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, MUTAGENESIS OF CYS-290 AND HIS-292.
    7. "Proteomic identification of a PSF/p54nrb heterodimer as RNF43 oncoprotein-interacting proteins."
      Miyamoto K., Sakurai H., Sugiura T.
      Proteomics 8:2907-2910(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NONO AND SFPQ, SUBCELLULAR LOCATION.
    8. Cited for: FUNCTION, SUBCELLULAR LOCATION.
    9. "Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors."
      Koo B.K., Spit M., Jordens I., Low T.Y., Stange D.E., van de Wetering M., van Es J.H., Mohammed S., Heck A.J., Maurice M.M., Clevers H.
      Nature 488:665-669(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH FZD5, MUTAGENESIS OF CYS-290; HIS-292; HIS-295 AND CYS-298.
    10. "The structural basis of R-spondin recognition by LGR5 and RNF43."
      Chen P.H., Chen X., Lin Z., Fang D., He X.
      Genes Dev. 27:1345-1350(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 44-198 IN COMPLEX WITH RSPO1 AND LGR5, SUBUNIT.

    Entry informationi

    Entry nameiRNF43_HUMAN
    AccessioniPrimary (citable) accession number: Q68DV7
    Secondary accession number(s): A8K4R2
    , B7Z443, B7Z5D5, B7Z5J5, Q65ZA4, Q6AI04, Q9NXD0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 20, 2007
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Acts as a cytotoxic T-lymphocyte tumor antigen, suggesting that it may be used as a target for cancer immunotherapy.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3