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Q68DV7

- RNF43_HUMAN

UniProt

Q68DV7 - RNF43_HUMAN

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Protein
E3 ubiquitin-protein ligase RNF43
Gene
RNF43
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.3 Publications

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri272 – 31342RING-type; atypical
Add
BLAST

GO - Molecular functioni

  1. frizzled binding Source: UniProtKB
  2. ligase activity Source: UniProtKB-KW
  3. protein binding Source: IntAct
  4. ubiquitin-protein transferase activity Source: UniProtKB
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. Wnt receptor catabolic process Source: UniProtKB
  2. Wnt signaling pathway Source: UniProtKB-KW
  3. negative regulation of Wnt signaling pathway Source: UniProtKB
  4. protein ubiquitination Source: UniProtKB
  5. protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: UniProtKB
  6. stem cell proliferation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway, Wnt signaling pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_200716. regulation of FZD by ubiquitination.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RNF43 (EC:6.3.2.-)
Alternative name(s):
RING finger protein 43
Gene namesi
Name:RNF43
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:18505. RNF43.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus envelope
Note: According to a report, may be secreted (1 Publication).5 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 197174Extracellular Reviewed prediction
Add
BLAST
Transmembranei198 – 21821Helical; Reviewed prediction
Add
BLAST
Topological domaini219 – 783565Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of plasma membrane Source: UniProtKB
  3. nuclear envelope Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi290 – 2901C → S: Dominant-negative mutant, loss of E3 ligase activity and activation of the Wnt signaling pathway; when associated with S-292. 2 Publications
Mutagenesisi292 – 2921H → S: Dominant-negative mutant, loss of E3 ligase activity and activation of the Wnt signaling pathway; when associated with S-290. 2 Publications
Mutagenesisi295 – 2951H → S: Dominant-negative mutant, loss of E3 ligase activity and activation of the Wnt signaling pathway; when associated with S-298. 1 Publication
Mutagenesisi298 – 2981C → S: Dominant-negative mutant, loss of E3 ligase activity and activation of the Wnt signaling pathway; when associated with S-295. 1 Publication

Organism-specific databases

PharmGKBiPA34441.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 783760E3 ubiquitin-protein ligase RNF43
PRO_0000278239Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi62 – 621N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi91 ↔ 119
Glycosylationi92 – 921N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Autoubiquitinated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ68DV7.
PRIDEiQ68DV7.

Expressioni

Tissue specificityi

Expressed in fetal kidney, fetal lung, in colon cancer tissues, hepatocellular carcinomas and lung adenocarcinomas. Overexpressed in colorectal cancer cell lines.2 Publications

Gene expression databases

ArrayExpressiQ68DV7.
BgeeiQ68DV7.
CleanExiHS_RNF43.
GenevestigatoriQ68DV7.

Organism-specific databases

HPAiHPA008079.

Interactioni

Subunit structurei

Interacts with AKAP8L, NONO and SFPQ. Interacts with FZD5. Identified in a complex composed of RNF43, LGR5 and RSPO1.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AKAP8LQ9ULX62EBI-1647060,EBI-357530
UBBP0CG472EBI-1647060,EBI-413034
UBE2D2P628372EBI-1647060,EBI-347677
UBE2D3P610772EBI-1647060,EBI-348268

Protein-protein interaction databases

BioGridi120241. 15 interactions.
IntActiQ68DV7. 12 interactions.
STRINGi9606.ENSP00000385328.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi45 – 5410
Beta strandi57 – 593
Beta strandi63 – 697
Beta strandi71 – 733
Beta strandi78 – 847
Turni87 – 893
Beta strandi104 – 1085
Turni112 – 1143
Helixi122 – 13110
Beta strandi135 – 1406
Helixi142 – 1465
Helixi147 – 1504
Beta strandi157 – 1593
Beta strandi161 – 1644
Helixi166 – 17611
Beta strandi177 – 1793
Beta strandi184 – 1896

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4KNGX-ray2.50E/F44-198[»]
ProteinModelPortaliQ68DV7.
SMRiQ68DV7. Positions 44-191, 272-316.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi443 – 50361Ser-rich
Add
BLAST
Compositional biasi547 – 55711His-rich
Add
BLAST
Compositional biasi569 – 760192Pro-rich
Add
BLAST

Sequence similaritiesi

Belongs to the ZNRF3 family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiNOG329235.
HOVERGENiHBG093916.
InParanoidiQ68DV7.
KOiK15694.
OMAiHPLIFGP.
OrthoDBiEOG7P5T06.
PhylomeDBiQ68DV7.
TreeFamiTF317074.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q68DV7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSGGHQLQLA ALWPWLLMAT LQAGFGRTGL VLAAAVESER SAEQKAIIRV    50
IPLKMDPTGK LNLTLEGVFA GVAEITPAEG KLMQSHPLYL CNASDDDNLE 100
PGFISIVKLE SPRRAPRPCL SLASKARMAG ERGASAVLFD ITEDRAAAEQ 150
LQQPLGLTWP VVLIWGNDAE KLMEFVYKNQ KAHVRIELKE PPAWPDYDVW 200
ILMTVVGTIF VIILASVLRI RCRPRHSRPD PLQQRTAWAI SQLATRRYQA 250
SCRQARGEWP DSGSSCSSAP VCAICLEEFS EGQELRVISC LHEFHRNCVD 300
PWLHQHRTCP LCMFNITEGD SFSQSLGPSR SYQEPGRRLH LIRQHPGHAH 350
YHLPAAYLLG PSRSAVARPP RPGPFLPSQE PGMGPRHHRF PRAAHPRAPG 400
EQQRLAGAQH PYAQGWGLSH LQSTSQHPAA CPVPLRRARP PDSSGSGESY 450
CTERSGYLAD GPASDSSSGP CHGSSSDSVV NCTDISLQGV HGSSSTFCSS 500
LSSDFDPLVY CSPKGDPQRV DMQPSVTSRP RSLDSVVPTG ETQVSSHVHY 550
HRHRHHHYKK RFQWHGRKPG PETGVPQSRP PIPRTQPQPE PPSPDQQVTR 600
SNSAAPSGRL SNPQCPRALP EPAPGPVDAS SICPSTSSLF NLQKSSLSAR 650
HPQRKRRGGP SEPTPGSRPQ DATVHPACQI FPHYTPSVAY PWSPEAHPLI 700
CGPPGLDKRL LPETPGPCYS NSQPVWLCLT PRQPLEPHPP GEGPSEWSSD 750
TAEGRPCPYP HCQVLSAQPG SEEELEELCE QAV 783
Length:783
Mass (Da):85,722
Last modified:October 11, 2004 - v1
Checksum:i4E87EA0CC359C858
GO
Isoform 2 (identifier: Q68DV7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-125: Missing.

Note: No experimental confirmation available.

Show »
Length:742
Mass (Da):81,229
Checksum:i7A177F5F2AC13F1B
GO
Isoform 3 (identifier: Q68DV7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-127: Missing.

Note: No experimental confirmation available.

Show »
Length:656
Mass (Da):72,106
Checksum:i6278F14330DC2A94
GO
Isoform 4 (identifier: Q68DV7-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     771-783: SEEELEELCEQAV → EFSEGSGCGR...WKAGCDGSCL

Note: No experimental confirmation available.

Show »
Length:869
Mass (Da):95,038
Checksum:iAFB4B8ECFA217C83
GO

Sequence cautioni

The sequence BAH12871.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti47 – 471I → V.1 Publication
Corresponds to variant rs3744093 [ dbSNP | Ensembl ].
VAR_030713
Natural varianti117 – 1171R → H.
Corresponds to variant rs2257205 [ dbSNP | Ensembl ].
VAR_030714
Natural varianti221 – 2211R → Q.
Corresponds to variant rs2285990 [ dbSNP | Ensembl ].
VAR_030715
Natural varianti231 – 2311P → L.1 Publication
Corresponds to variant rs2680701 [ dbSNP | Ensembl ].
VAR_030716
Natural varianti343 – 3431R → H.
Corresponds to variant rs34523089 [ dbSNP | Ensembl ].
VAR_052103
Natural varianti418 – 4181L → M.2 Publications
Corresponds to variant rs2526374 [ dbSNP | Ensembl ].
VAR_030717
Natural varianti686 – 6861P → R.1 Publication
Corresponds to variant rs9652855 [ dbSNP | Ensembl ].
VAR_030718

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 127127Missing in isoform 3.
VSP_037338Add
BLAST
Alternative sequencei85 – 12541Missing in isoform 2.
VSP_037339Add
BLAST
Alternative sequencei771 – 78313SEEEL…CEQAV → EFSEGSGCGRERRLQLNISG QVKSANKGLMEAEKDTAEMT TKILNHRDSVSCWLECRNTP PLPGATPLVGRSQGGPREVL VWLRHQKGTWKAGCDGSCL in isoform 4.
VSP_037340Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti225 – 2251R → H in BAH12429. 1 Publication
Sequence conflicti313 – 3131M → V in BAD51435. 1 Publication
Sequence conflicti313 – 3131M → V in BAA91085. 1 Publication
Sequence conflicti401 – 4011E → K in BAH12429. 1 Publication
Sequence conflicti600 – 6001R → G in BAD51435. 1 Publication
Sequence conflicti600 – 6001R → G in BAA91085. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB081837 mRNA. Translation: BAD51435.1.
AK000322 mRNA. Translation: BAA91085.1.
AK291027 mRNA. Translation: BAF83716.1.
AK296769 mRNA. Translation: BAH12429.1.
AK298789 mRNA. Translation: BAH12871.1. Different initiation.
AK299024 mRNA. Translation: BAH12931.1.
CR627423 mRNA. Translation: CAH10510.1.
CR749257 mRNA. Translation: CAH18113.1.
BC109028 mRNA. Translation: AAI09029.1.
CCDSiCCDS11607.1. [Q68DV7-1]
RefSeqiNP_060233.3. NM_017763.4. [Q68DV7-1]
UniGeneiHs.584916.

Genome annotation databases

EnsembliENST00000407977; ENSP00000385328; ENSG00000108375. [Q68DV7-1]
ENST00000500597; ENSP00000441969; ENSG00000108375. [Q68DV7-2]
ENST00000577625; ENSP00000463716; ENSG00000108375. [Q68DV7-3]
ENST00000577716; ENSP00000462764; ENSG00000108375. [Q68DV7-1]
ENST00000583753; ENSP00000462502; ENSG00000108375. [Q68DV7-2]
ENST00000584437; ENSP00000463069; ENSG00000108375. [Q68DV7-1]
GeneIDi54894.
KEGGihsa:54894.
UCSCiuc002iwf.3. human. [Q68DV7-1]
uc010wnv.2. human. [Q68DV7-2]

Polymorphism databases

DMDMi74757361.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB081837 mRNA. Translation: BAD51435.1 .
AK000322 mRNA. Translation: BAA91085.1 .
AK291027 mRNA. Translation: BAF83716.1 .
AK296769 mRNA. Translation: BAH12429.1 .
AK298789 mRNA. Translation: BAH12871.1 . Different initiation.
AK299024 mRNA. Translation: BAH12931.1 .
CR627423 mRNA. Translation: CAH10510.1 .
CR749257 mRNA. Translation: CAH18113.1 .
BC109028 mRNA. Translation: AAI09029.1 .
CCDSi CCDS11607.1. [Q68DV7-1 ]
RefSeqi NP_060233.3. NM_017763.4. [Q68DV7-1 ]
UniGenei Hs.584916.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4KNG X-ray 2.50 E/F 44-198 [» ]
ProteinModelPortali Q68DV7.
SMRi Q68DV7. Positions 44-191, 272-316.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120241. 15 interactions.
IntActi Q68DV7. 12 interactions.
STRINGi 9606.ENSP00000385328.

Polymorphism databases

DMDMi 74757361.

Proteomic databases

PaxDbi Q68DV7.
PRIDEi Q68DV7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000407977 ; ENSP00000385328 ; ENSG00000108375 . [Q68DV7-1 ]
ENST00000500597 ; ENSP00000441969 ; ENSG00000108375 . [Q68DV7-2 ]
ENST00000577625 ; ENSP00000463716 ; ENSG00000108375 . [Q68DV7-3 ]
ENST00000577716 ; ENSP00000462764 ; ENSG00000108375 . [Q68DV7-1 ]
ENST00000583753 ; ENSP00000462502 ; ENSG00000108375 . [Q68DV7-2 ]
ENST00000584437 ; ENSP00000463069 ; ENSG00000108375 . [Q68DV7-1 ]
GeneIDi 54894.
KEGGi hsa:54894.
UCSCi uc002iwf.3. human. [Q68DV7-1 ]
uc010wnv.2. human. [Q68DV7-2 ]

Organism-specific databases

CTDi 54894.
GeneCardsi GC17M056429.
HGNCi HGNC:18505. RNF43.
HPAi HPA008079.
MIMi 612482. gene.
neXtProti NX_Q68DV7.
PharmGKBi PA34441.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG329235.
HOVERGENi HBG093916.
InParanoidi Q68DV7.
KOi K15694.
OMAi HPLIFGP.
OrthoDBi EOG7P5T06.
PhylomeDBi Q68DV7.
TreeFami TF317074.

Enzyme and pathway databases

UniPathwayi UPA00143 .
Reactomei REACT_200716. regulation of FZD by ubiquitination.

Miscellaneous databases

ChiTaRSi RNF43. human.
GenomeRNAii 54894.
NextBioi 57898.
PROi Q68DV7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q68DV7.
Bgeei Q68DV7.
CleanExi HS_RNF43.
Genevestigatori Q68DV7.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF13639. zf-RING_2. 1 hit.
[Graphical view ]
SMARTi SM00184. RING. 1 hit.
[Graphical view ]
PROSITEi PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel oncoprotein RNF43 functions in an autocrine manner in colorectal cancer."
    Yagyu R., Furukawa Y., Lin Y.-M., Shimokawa T., Yamamura T., Nakamura Y.
    Int. J. Oncol. 25:1343-1348(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANT MET-418.
    Tissue: Colon carcinoma.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 214-783 (ISOFORM 4), VARIANTS VAL-47; LEU-231 AND MET-418.
    Tissue: Hepatoma, Teratocarcinoma and Tongue.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-686.
    Tissue: Colon carcinoma.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Ring finger protein 43 as a new target for cancer immunotherapy."
    Uchida N., Tsunoda T., Wada S., Furukawa Y., Nakamura Y., Tahara H.
    Clin. Cancer Res. 10:8577-8586(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION AS A CYTOTOXIC T LYMPHOCYTE TUMOR ANTIGEN.
  6. "A cancer-associated RING finger protein, RNF43, is a ubiquitin ligase that interacts with a nuclear protein, HAP95."
    Sugiura T., Yamaguchi A., Miyamoto K.
    Exp. Cell Res. 314:1519-1528(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH AKAP8L, AUTOUBIQUITINATION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, MUTAGENESIS OF CYS-290 AND HIS-292.
  7. "Proteomic identification of a PSF/p54nrb heterodimer as RNF43 oncoprotein-interacting proteins."
    Miyamoto K., Sakurai H., Sugiura T.
    Proteomics 8:2907-2910(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NONO AND SFPQ, SUBCELLULAR LOCATION.
  8. Cited for: FUNCTION, SUBCELLULAR LOCATION.
  9. "Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors."
    Koo B.K., Spit M., Jordens I., Low T.Y., Stange D.E., van de Wetering M., van Es J.H., Mohammed S., Heck A.J., Maurice M.M., Clevers H.
    Nature 488:665-669(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH FZD5, MUTAGENESIS OF CYS-290; HIS-292; HIS-295 AND CYS-298.
  10. "The structural basis of R-spondin recognition by LGR5 and RNF43."
    Chen P.H., Chen X., Lin Z., Fang D., He X.
    Genes Dev. 27:1345-1350(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 44-198 IN COMPLEX WITH RSPO1 AND LGR5, SUBUNIT.

Entry informationi

Entry nameiRNF43_HUMAN
AccessioniPrimary (citable) accession number: Q68DV7
Secondary accession number(s): A8K4R2
, B7Z443, B7Z5D5, B7Z5J5, Q65ZA4, Q6AI04, Q9NXD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: October 11, 2004
Last modified: September 3, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Acts as a cytotoxic T-lymphocyte tumor antigen, suggesting that it may be used as a target for cancer immunotherapy (1 Publication).

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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