Q68DV7 (RNF43_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
E3 ubiquitin-protein ligase RNF43
EC=6.3.2.-

Alternative name(s):
RING finger protein 43

Gene names

Name:

RNF43

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	783 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. Ref.6 Ref.8 Ref.9
Pathway	Protein modification; protein ubiquitination.
Subunit structure	Interacts with AKAP8L, NONO and SFPQ. Interacts with FZD5. Ref.6 Ref.7 Ref.9
Subcellular location	Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus envelope. Note: According to a report, may be secreted (Ref.1). Ref.1 Ref.6 Ref.7 Ref.8 Ref.9
Tissue specificity	Expressed in fetal kidney, fetal lung, in colon cancer tissues, hepatocellular carcinomas and lung adenocarcinomas. Overexpressed in colorectal cancer cell lines. Ref.1 Ref.6
Post-translational modification	Autoubiquitinated.
Miscellaneous	Acts as a cytotoxic T-lymphocyte tumor antigen, suggesting that it may be used as a target for cancer immunotherapy (Ref.5).
Sequence similarities	Belongs to the ZNRF3 family. Contains 1 RING-type zinc finger.
Sequence caution	The sequence BAH12871.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Ubl conjugation pathway Wnt signaling pathway
Cellular component	Cell membrane Endoplasmic reticulum Membrane Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane Transmembrane helix Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Ligase
PTM	Glycoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Wnt receptor catabolic process Inferred from direct assay Ref.9. Source: UniProtKB Wnt receptor signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW protein ubiquitination involved in ubiquitin-dependent protein catabolic process Inferred from direct assay Ref.9. Source: UniProtKB stem cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to plasma membrane Inferred from direct assay Ref.8Ref.9. Source: UniProtKB nuclear envelope Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ubiquitin-protein ligase activity Inferred from direct assay Ref.8Ref.9. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
AKAP8L	Q9ULX6	2	EBI-1647060,EBI-357530
UBB	P0CG47	2	EBI-1647060,EBI-413034
UBE2D2	P62837	2	EBI-1647060,EBI-347677
UBE2D3	P61077	2	EBI-1647060,EBI-348268

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q68DV7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q68DV7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     85-125: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q68DV7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-127: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q68DV7-4)

The sequence of this isoform differs from the canonical sequence as follows:
     771-783: SEEELEELCEQAV → EFSEGSGCGR...WKAGCDGSCL

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 783	760	E3 ubiquitin-protein ligase RNF43		PRO_0000278239
Regions
	Topological domain	24 – 197	174	Extracellular Potential
	Transmembrane	198 – 218	21	Helical; Potential
	Topological domain	219 – 783	565	Cytoplasmic Potential
	Zinc finger	272 – 313	42	RING-type; atypical
	Compositional bias	443 – 503	61	Ser-rich
	Compositional bias	547 – 557	11	His-rich
	Compositional bias	569 – 760	192	Pro-rich
Amino acid modifications
	Glycosylation	62	1	N-linked (GlcNAc...) Potential
	Glycosylation	92	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 127	127	Missing in isoform 3.		VSP_037338
	Alternative sequence	85 – 125	41	Missing in isoform 2.		VSP_037339
	Alternative sequence	771 – 783	13	SEEEL…CEQAV → EFSEGSGCGRERRLQLNISG QVKSANKGLMEAEKDTAEMT TKILNHRDSVSCWLECRNTP PLPGATPLVGRSQGGPREVL VWLRHQKGTWKAGCDGSCL in isoform 4.		VSP_037340
	Natural variant	47	1	I → V. Ref.2 Corresponds to variant rs3744093 [ dbSNP | Ensembl ].		VAR_030713
	Natural variant	117	1	R → H. Corresponds to variant rs2257205 [ dbSNP | Ensembl ].		VAR_030714
	Natural variant	221	1	R → Q. Corresponds to variant rs2285990 [ dbSNP | Ensembl ].		VAR_030715
	Natural variant	231	1	P → L. Ref.2 Corresponds to variant rs2680701 [ dbSNP | Ensembl ].		VAR_030716
	Natural variant	343	1	R → H. Corresponds to variant rs34523089 [ dbSNP | Ensembl ].		VAR_052103
	Natural variant	418	1	L → M. Ref.1 Ref.2 Corresponds to variant rs2526374 [ dbSNP | Ensembl ].		VAR_030717
	Natural variant	686	1	P → R. Ref.3 Corresponds to variant rs9652855 [ dbSNP | Ensembl ].		VAR_030718
Experimental info
	Mutagenesis	290	1	C → S: Dominant-negative mutant, loss of E3 ligase activity and activation of the Wnt signaling pathway; when associated with S-292. Ref.6 Ref.9
	Mutagenesis	292	1	H → S: Dominant-negative mutant, loss of E3 ligase activity and activation of the Wnt signaling pathway; when associated with S-290. Ref.6 Ref.9
	Mutagenesis	295	1	H → S: Dominant-negative mutant, loss of E3 ligase activity and activation of the Wnt signaling pathway; when associated with S-298. Ref.9
	Mutagenesis	298	1	C → S: Dominant-negative mutant, loss of E3 ligase activity and activation of the Wnt signaling pathway; when associated with S-295. Ref.9
	Sequence conflict	225	1	R → H in BAH12429. Ref.2
	Sequence conflict	313	1	M → V in BAD51435. Ref.1
	Sequence conflict	313	1	M → V in BAA91085. Ref.2
	Sequence conflict	401	1	E → K in BAH12429. Ref.2
	Sequence conflict	600	1	R → G in BAD51435. Ref.1
	Sequence conflict	600	1	R → G in BAA91085. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 4E87EA0CC359C858	FASTA	783	85,722
	10 20 30 40 50 60 MSGGHQLQLA ALWPWLLMAT LQAGFGRTGL VLAAAVESER SAEQKAIIRV IPLKMDPTGK 70 80 90 100 110 120 LNLTLEGVFA GVAEITPAEG KLMQSHPLYL CNASDDDNLE PGFISIVKLE SPRRAPRPCL 130 140 150 160 170 180 SLASKARMAG ERGASAVLFD ITEDRAAAEQ LQQPLGLTWP VVLIWGNDAE KLMEFVYKNQ 190 200 210 220 230 240 KAHVRIELKE PPAWPDYDVW ILMTVVGTIF VIILASVLRI RCRPRHSRPD PLQQRTAWAI 250 260 270 280 290 300 SQLATRRYQA SCRQARGEWP DSGSSCSSAP VCAICLEEFS EGQELRVISC LHEFHRNCVD 310 320 330 340 350 360 PWLHQHRTCP LCMFNITEGD SFSQSLGPSR SYQEPGRRLH LIRQHPGHAH YHLPAAYLLG 370 380 390 400 410 420 PSRSAVARPP RPGPFLPSQE PGMGPRHHRF PRAAHPRAPG EQQRLAGAQH PYAQGWGLSH 430 440 450 460 470 480 LQSTSQHPAA CPVPLRRARP PDSSGSGESY CTERSGYLAD GPASDSSSGP CHGSSSDSVV 490 500 510 520 530 540 NCTDISLQGV HGSSSTFCSS LSSDFDPLVY CSPKGDPQRV DMQPSVTSRP RSLDSVVPTG 550 560 570 580 590 600 ETQVSSHVHY HRHRHHHYKK RFQWHGRKPG PETGVPQSRP PIPRTQPQPE PPSPDQQVTR 610 620 630 640 650 660 SNSAAPSGRL SNPQCPRALP EPAPGPVDAS SICPSTSSLF NLQKSSLSAR HPQRKRRGGP 670 680 690 700 710 720 SEPTPGSRPQ DATVHPACQI FPHYTPSVAY PWSPEAHPLI CGPPGLDKRL LPETPGPCYS 730 740 750 760 770 780 NSQPVWLCLT PRQPLEPHPP GEGPSEWSSD TAEGRPCPYP HCQVLSAQPG SEEELEELCE QAV
	Isoform 2 [UniParc]. Checksum: 7A177F5F2AC13F1B	FASTA	742	81,229
	10 20 30 40 50 60 MSGGHQLQLA ALWPWLLMAT LQAGFGRTGL VLAAAVESER SAEQKAIIRV IPLKMDPTGK 70 80 90 100 110 120 LNLTLEGVFA GVAEITPAEG KLMQARMAGE RGASAVLFDI TEDRAAAEQL QQPLGLTWPV 130 140 150 160 170 180 VLIWGNDAEK LMEFVYKNQK AHVRIELKEP PAWPDYDVWI LMTVVGTIFV IILASVLRIR 190 200 210 220 230 240 CRPRHSRPDP LQQRTAWAIS QLATRRYQAS CRQARGEWPD SGSSCSSAPV CAICLEEFSE 250 260 270 280 290 300 GQELRVISCL HEFHRNCVDP WLHQHRTCPL CMFNITEGDS FSQSLGPSRS YQEPGRRLHL 310 320 330 340 350 360 IRQHPGHAHY HLPAAYLLGP SRSAVARPPR PGPFLPSQEP GMGPRHHRFP RAAHPRAPGE 370 380 390 400 410 420 QQRLAGAQHP YAQGWGLSHL QSTSQHPAAC PVPLRRARPP DSSGSGESYC TERSGYLADG 430 440 450 460 470 480 PASDSSSGPC HGSSSDSVVN CTDISLQGVH GSSSTFCSSL SSDFDPLVYC SPKGDPQRVD 490 500 510 520 530 540 MQPSVTSRPR SLDSVVPTGE TQVSSHVHYH RHRHHHYKKR FQWHGRKPGP ETGVPQSRPP 550 560 570 580 590 600 IPRTQPQPEP PSPDQQVTRS NSAAPSGRLS NPQCPRALPE PAPGPVDASS ICPSTSSLFN 610 620 630 640 650 660 LQKSSLSARH PQRKRRGGPS EPTPGSRPQD ATVHPACQIF PHYTPSVAYP WSPEAHPLIC 670 680 690 700 710 720 GPPGLDKRLL PETPGPCYSN SQPVWLCLTP RQPLEPHPPG EGPSEWSSDT AEGRPCPYPH 730 740 CQVLSAQPGS EEELEELCEQ AV
	Isoform 3 [UniParc]. Checksum: 6278F14330DC2A94	FASTA	656	72,106
	10 20 30 40 50 60 MAGERGASAV LFDITEDRAA AEQLQQPLGL TWPVVLIWGN DAEKLMEFVY KNQKAHVRIE 70 80 90 100 110 120 LKEPPAWPDY DVWILMTVVG TIFVIILASV LRIRCRPRHS RPDPLQQRTA WAISQLATRR 130 140 150 160 170 180 YQASCRQARG EWPDSGSSCS SAPVCAICLE EFSEGQELRV ISCLHEFHRN CVDPWLHQHR 190 200 210 220 230 240 TCPLCMFNIT EGDSFSQSLG PSRSYQEPGR RLHLIRQHPG HAHYHLPAAY LLGPSRSAVA 250 260 270 280 290 300 RPPRPGPFLP SQEPGMGPRH HRFPRAAHPR APGEQQRLAG AQHPYAQGWG LSHLQSTSQH 310 320 330 340 350 360 PAACPVPLRR ARPPDSSGSG ESYCTERSGY LADGPASDSS SGPCHGSSSD SVVNCTDISL 370 380 390 400 410 420 QGVHGSSSTF CSSLSSDFDP LVYCSPKGDP QRVDMQPSVT SRPRSLDSVV PTGETQVSSH 430 440 450 460 470 480 VHYHRHRHHH YKKRFQWHGR KPGPETGVPQ SRPPIPRTQP QPEPPSPDQQ VTRSNSAAPS 490 500 510 520 530 540 GRLSNPQCPR ALPEPAPGPV DASSICPSTS SLFNLQKSSL SARHPQRKRR GGPSEPTPGS 550 560 570 580 590 600 RPQDATVHPA CQIFPHYTPS VAYPWSPEAH PLICGPPGLD KRLLPETPGP CYSNSQPVWL 610 620 630 640 650 CLTPRQPLEP HPPGEGPSEW SSDTAEGRPC PYPHCQVLSA QPGSEEELEE LCEQAV
	Isoform 4 [UniParc]. Checksum: AFB4B8ECFA217C83	FASTA	869	95,038
	10 20 30 40 50 60 MSGGHQLQLA ALWPWLLMAT LQAGFGRTGL VLAAAVESER SAEQKAIIRV IPLKMDPTGK 70 80 90 100 110 120 LNLTLEGVFA GVAEITPAEG KLMQSHPLYL CNASDDDNLE PGFISIVKLE SPRRAPRPCL 130 140 150 160 170 180 SLASKARMAG ERGASAVLFD ITEDRAAAEQ LQQPLGLTWP VVLIWGNDAE KLMEFVYKNQ 190 200 210 220 230 240 KAHVRIELKE PPAWPDYDVW ILMTVVGTIF VIILASVLRI RCRPRHSRPD PLQQRTAWAI 250 260 270 280 290 300 SQLATRRYQA SCRQARGEWP DSGSSCSSAP VCAICLEEFS EGQELRVISC LHEFHRNCVD 310 320 330 340 350 360 PWLHQHRTCP LCMFNITEGD SFSQSLGPSR SYQEPGRRLH LIRQHPGHAH YHLPAAYLLG 370 380 390 400 410 420 PSRSAVARPP RPGPFLPSQE PGMGPRHHRF PRAAHPRAPG EQQRLAGAQH PYAQGWGLSH 430 440 450 460 470 480 LQSTSQHPAA CPVPLRRARP PDSSGSGESY CTERSGYLAD GPASDSSSGP CHGSSSDSVV 490 500 510 520 530 540 NCTDISLQGV HGSSSTFCSS LSSDFDPLVY CSPKGDPQRV DMQPSVTSRP RSLDSVVPTG 550 560 570 580 590 600 ETQVSSHVHY HRHRHHHYKK RFQWHGRKPG PETGVPQSRP PIPRTQPQPE PPSPDQQVTR 610 620 630 640 650 660 SNSAAPSGRL SNPQCPRALP EPAPGPVDAS SICPSTSSLF NLQKSSLSAR HPQRKRRGGP 670 680 690 700 710 720 SEPTPGSRPQ DATVHPACQI FPHYTPSVAY PWSPEAHPLI CGPPGLDKRL LPETPGPCYS 730 740 750 760 770 780 NSQPVWLCLT PRQPLEPHPP GEGPSEWSSD TAEGRPCPYP HCQVLSAQPG EFSEGSGCGR 790 800 810 820 830 840 ERRLQLNISG QVKSANKGLM EAEKDTAEMT TKILNHRDSV SCWLECRNTP PLPGATPLVG 850 860 RSQGGPREVL VWLRHQKGTW KAGCDGSCL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel oncoprotein RNF43 functions in an autocrine manner in colorectal cancer." Yagyu R., Furukawa Y., Lin Y.-M., Shimokawa T., Yamamura T., Nakamura Y. Int. J. Oncol. 25:1343-1348(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANT MET-418. Tissue: Colon carcinoma.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 214-783 (ISOFORM 4), VARIANTS VAL-47; LEU-231 AND MET-418. Tissue: Hepatoma, Teratocarcinoma and Tongue.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-686. Tissue: Colon carcinoma.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]	"Ring finger protein 43 as a new target for cancer immunotherapy." Uchida N., Tsunoda T., Wada S., Furukawa Y., Nakamura Y., Tahara H. Clin. Cancer Res. 10:8577-8586(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION AS A CYTOTOXIC T LYMPHOCYTE TUMOR ANTIGEN.
[6]	"A cancer-associated RING finger protein, RNF43, is a ubiquitin ligase that interacts with a nuclear protein, HAP95." Sugiura T., Yamaguchi A., Miyamoto K. Exp. Cell Res. 314:1519-1528(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH AKAP8L, AUTOUBIQUITINATION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, MUTAGENESIS OF CYS-290 AND HIS-292.
[7]	"Proteomic identification of a PSF/p54nrb heterodimer as RNF43 oncoprotein-interacting proteins." Miyamoto K., Sakurai H., Sugiura T. Proteomics 8:2907-2910(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH NONO AND SFPQ, SUBCELLULAR LOCATION.
[8]	"ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner." Hao H.X., Xie Y., Zhang Y., Charlat O., Oster E., Avello M., Lei H., Mickanin C., Liu D., Ruffner H., Mao X., Ma Q., Zamponi R., Bouwmeester T., Finan P.M., Kirschner M.W., Porter J.A., Serluca F.C., Cong F. Nature 485:195-200(2012) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[9]	"Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors." Koo B.K., Spit M., Jordens I., Low T.Y., Stange D.E., van de Wetering M., van Es J.H., Mohammed S., Heck A.J., Maurice M.M., Clevers H. Nature 488:665-669(2012) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH FZD5, MUTAGENESIS OF CYS-290; HIS-292; HIS-295 AND CYS-298.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB081837 mRNA. Translation: BAD51435.1. AK000322 mRNA. Translation: BAA91085.1. AK291027 mRNA. Translation: BAF83716.1. AK296769 mRNA. Translation: BAH12429.1. AK298789 mRNA. Translation: BAH12871.1. Different initiation. AK299024 mRNA. Translation: BAH12931.1. CR627423 mRNA. Translation: CAH10510.1. CR749257 mRNA. Translation: CAH18113.1. BC109028 mRNA. Translation: AAI09029.1.
IPI	IPI00744070. IPI00930185. IPI00930238. IPI00930434.
RefSeq	NP_060233.3. NM_017763.4.
UniGene	Hs.584916.
3D structure databases
ProteinModelPortal	Q68DV7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q68DV7. 12 interactions.
STRING	9606.ENSP00000385328.
Polymorphism databases
DMDM	74757361.
Proteomic databases
PaxDb	Q68DV7.
PRIDE	Q68DV7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000407977; ENSP00000385328; ENSG00000108375. ENST00000500597; ENSP00000441969; ENSG00000108375. ENST00000577625; ENSP00000463716; ENSG00000108375. ENST00000577716; ENSP00000462764; ENSG00000108375. ENST00000583753; ENSP00000462502; ENSG00000108375. ENST00000584437; ENSP00000463069; ENSG00000108375.
GeneID	54894.
KEGG	hsa:54894.
UCSC	uc002iwf.3. human. uc010dcw.3. human. uc010wnv.2. human.
Organism-specific databases
CTD	54894.
GeneCards	GC17M056429.
HGNC	HGNC:18505. RNF43.
HPA	HPA008079.
MIM	612482. gene.
neXtProt	NX_Q68DV7.
PharmGKB	PA34441.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG329235.
HOVERGEN	HBG093916.
InParanoid	Q68DV7.
KO	K15694.
OMA	YLLGPSR.
OrthoDB	EOG4N04FJ.
PhylomeDB	Q68DV7.
Enzyme and pathway databases
UniPathway	UPA00143.
Gene expression databases
Bgee	Q68DV7.
CleanEx	HS_RNF43.
Genevestigator	Q68DV7.
Family and domain databases
Gene3D	3.30.40.10. 1 hit.
InterPro	IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. [Graphical view]
Pfam	PF13639. zf-RING_2. 1 hit. [Graphical view]
SMART	SM00184. RING. 1 hit. [Graphical view]
PROSITE	PS00518. ZF_RING_1. False negative. PS50089. ZF_RING_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	RNF43. human.
GenomeRNAi	54894.
NextBio	57898.
SOURCE	Search...

Entry information

Entry name

RNF43_HUMAN

Accession

Primary (citable) accession number: Q68DV7
Secondary accession number(s): A8K4R2 , B7Z443, B7Z5D5, B7Z5J5, Q65ZA4, Q6AI04, Q9NXD0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	October 11, 2004
Last modified:	May 29, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.