Q68DU8 (KCD16_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
BTB/POZ domain-containing protein KCTD16

Alternative name(s):
Potassium channel tetramerization domain-containing protein 16

Gene names

Name:	KCTD16
Synonyms:	KIAA1317

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	428 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization By similarity.
Subunit structure	Interacts as a tetramer with GABRB1 and GABRB2 By similarity.
Subcellular location	Cell junction › synapse › presynaptic cell membrane. Cell junction › synapse › postsynaptic cell membrane By similarity.
Sequence similarities	Contains 1 BTB (POZ) domain.
Sequence caution	The sequence BAA92555.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Membrane Postsynaptic cell membrane Synapse
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein homooligomerization Inferred from electronic annotation. Source: InterPro regulation of G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: Compara
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-SubCell presynaptic membrane Inferred from electronic annotation. Source: UniProtKB-SubCell receptor complex Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 428	428	BTB/POZ domain-containing protein KCTD16		PRO_0000248593
Regions
	Domain	25 – 98	74	BTB
Amino acid modifications
	Modified residue	112	1	Phosphotyrosine By similarity
	Modified residue	130	1	Phosphoserine By similarity
	Modified residue	390	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q68DU8 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 3D50005146B1383A	FASTA	428	49,138
	10 20 30 40 50 60 MALSGNCSRY YPREQGSAVP NSFPEVVELN VGGQVYFTRH STLISIPHSL LWKMFSPKRD 70 80 90 100 110 120 TANDLAKDSK GRFFIDRDGF LFRYILDYLR DRQVVLPDHF PEKGRLKREA EYFQLPDLVK 130 140 150 160 170 180 LLTPDEIKQS PDEFCHSDFE DASQGSDTRI CPPSSLLPAD RKWGFITVGY RGSCTLGREG 190 200 210 220 230 240 QADAKFRRVP RILVCGRISL AKEVFGETLN ESRDPDRAPE RYTSRFYLKF KHLERAFDML 250 260 270 280 290 300 SECGFHMVAC NSSVTASFIN QYTDDKIWSS YTEYVFYREP SRWSPSHCDC CCKNGKGDKE 310 320 330 340 350 360 GESGTSCNDL STSSCDSQSE ASSPQETVIC GPVTRQTNIQ TLDRPIKKGP VQLIQQSEMR 370 380 390 400 410 420 RKSDLLRTLT SGSRESNMSS KKKAVKEKLS IEEELEKCIQ DFLKIKIPDR FPERKHPWQS ELLRKYHL

References

[1]	"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Retina.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB037738 mRNA. Translation: BAA92555.1. Different initiation. CR749266 mRNA. Translation: CAH18122.1. BC111962 mRNA. Translation: AAI11963.1. BC113435 mRNA. Translation: AAI13436.1.
IPI	IPI00002354.
RefSeq	NP_065819.1. NM_020768.3.
UniGene	Hs.661870.
3D structure databases
ProteinModelPortal	Q68DU8.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000329906.
PTM databases
PhosphoSite	Q68DU8.
Polymorphism databases
DMDM	74708941.
Proteomic databases
PaxDb	Q68DU8.
PRIDE	Q68DU8.
Protocols and materials databases
DNASU	57528.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000507359; ENSP00000426548; ENSG00000183775. ENST00000512467; ENSP00000424151; ENSG00000183775.
GeneID	57528.
KEGG	hsa:57528.
UCSC	uc003lnm.1. human.
Organism-specific databases
CTD	57528.
GeneCards	GC05P143565.
HGNC	HGNC:29244. KCTD16.
HPA	HPA044590. HPA050154.
MIM	613423. gene.
neXtProt	NX_Q68DU8.
PharmGKB	PA134973546.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG295576.
HOGENOM	HOG000041197.
HOVERGEN	HBG052218.
InParanoid	Q68DU8.
OMA	TEDKIWS.
OrthoDB	EOG4MKNGT.
Gene expression databases
Bgee	Q68DU8.
CleanEx	HS_KCTD16.
Genevestigator	Q68DU8.
Family and domain databases
Gene3D	3.30.710.10. 1 hit.
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR003131. T1-type_BTB. [Graphical view]
Pfam	PF02214. K_tetra. 1 hit. [Graphical view]
SMART	SM00225. BTB. 1 hit. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
PROSITE	PS50097. BTB. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	57528.
NextBio	63924.
SOURCE	Search...

Entry information

Entry name

KCD16_HUMAN

Accession

Primary (citable) accession number: Q68DU8
Secondary accession number(s): Q9P2M9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 5, 2006
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.