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Protein

BTB/POZ domain-containing protein KCTD16

Gene

KCTD16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity).By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD16
Alternative name(s):
Potassium channel tetramerization domain-containing protein 16
Gene namesi
Name:KCTD16
Synonyms:KIAA1317
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000183775.10
HGNCiHGNC:29244 KCTD16
MIMi613423 gene
neXtProtiNX_Q68DU8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi57528
OpenTargetsiENSG00000183775
PharmGKBiPA134973546

Chemistry databases

GuidetoPHARMACOLOGYi1920

Polymorphism and mutation databases

BioMutaiKCTD16
DMDMi74708941

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002485931 – 428BTB/POZ domain-containing protein KCTD16Add BLAST428

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei112PhosphotyrosineBy similarity1
Modified residuei130PhosphoserineBy similarity1
Modified residuei137PhosphoserineBy similarity1
Modified residuei143PhosphoserineBy similarity1
Modified residuei146PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ68DU8
PaxDbiQ68DU8
PeptideAtlasiQ68DU8
PRIDEiQ68DU8

PTM databases

iPTMnetiQ68DU8
PhosphoSitePlusiQ68DU8

Expressioni

Gene expression databases

BgeeiENSG00000183775
CleanExiHS_KCTD16
GenevisibleiQ68DU8 HS

Organism-specific databases

HPAiHPA044590
HPA050154

Interactioni

Subunit structurei

Homopentamer; forms an open pentamer (PubMed:28963344). In contrast to other BTB domain-containing proteins, does not interact with CUL3 (PubMed:28963344). Interacts as a tetramer with GABRB1 and GABRB2.By similarity1 Publication

Protein-protein interaction databases

BioGridi1215873 interactors.
CORUMiQ68DU8
STRINGi9606.ENSP00000424151

Structurei

Secondary structure

1428
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi25 – 31Combined sources7
Beta strandi34 – 39Combined sources6
Helixi40 – 43Combined sources4
Helixi50 – 55Combined sources6
Beta strandi73 – 75Combined sources3
Turni79 – 81Combined sources3
Helixi82 – 91Combined sources10
Helixi103 – 112Combined sources10
Helixi116 – 121Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5A15X-ray2.76A/B/C/D/E/F/G/H/I/J/K/L/M/N/O16-133[»]
ProteinModelPortaliQ68DU8
SMRiQ68DU8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 98BTBAdd BLAST74

Phylogenomic databases

eggNOGiKOG2723 Eukaryota
ENOG410Z155 LUCA
GeneTreeiENSGT00760000119013
HOGENOMiHOG000041197
HOVERGENiHBG052218
InParanoidiQ68DU8
KOiK21918
OMAiSECGFQM
OrthoDBiEOG091G0P3F
PhylomeDBiQ68DU8
TreeFamiTF315332

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

Sequencei

Sequence statusi: Complete.

Q68DU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSGNCSRY YPREQGSAVP NSFPEVVELN VGGQVYFTRH STLISIPHSL
60 70 80 90 100
LWKMFSPKRD TANDLAKDSK GRFFIDRDGF LFRYILDYLR DRQVVLPDHF
110 120 130 140 150
PEKGRLKREA EYFQLPDLVK LLTPDEIKQS PDEFCHSDFE DASQGSDTRI
160 170 180 190 200
CPPSSLLPAD RKWGFITVGY RGSCTLGREG QADAKFRRVP RILVCGRISL
210 220 230 240 250
AKEVFGETLN ESRDPDRAPE RYTSRFYLKF KHLERAFDML SECGFHMVAC
260 270 280 290 300
NSSVTASFIN QYTDDKIWSS YTEYVFYREP SRWSPSHCDC CCKNGKGDKE
310 320 330 340 350
GESGTSCNDL STSSCDSQSE ASSPQETVIC GPVTRQTNIQ TLDRPIKKGP
360 370 380 390 400
VQLIQQSEMR RKSDLLRTLT SGSRESNMSS KKKAVKEKLS IEEELEKCIQ
410 420
DFLKIKIPDR FPERKHPWQS ELLRKYHL
Length:428
Mass (Da):49,138
Last modified:October 11, 2004 - v1
Checksum:i3D50005146B1383A
GO

Sequence cautioni

The sequence BAA92555 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037738 mRNA Translation: BAA92555.1 Different initiation.
CR749266 mRNA Translation: CAH18122.1
BC111962 mRNA Translation: AAI11963.1
BC113435 mRNA Translation: AAI13436.1
CCDSiCCDS34260.1
RefSeqiNP_065819.1, NM_020768.3
XP_005268549.1, XM_005268492.2
XP_005268550.1, XM_005268493.2
XP_006714852.1, XM_006714789.2
XP_011535973.1, XM_011537671.2
UniGeneiHs.661870
Hs.7093

Genome annotation databases

EnsembliENST00000507359; ENSP00000426548; ENSG00000183775
ENST00000512467; ENSP00000424151; ENSG00000183775
GeneIDi57528
KEGGihsa:57528
UCSCiuc003lnm.2 human

Similar proteinsi

Entry informationi

Entry nameiKCD16_HUMAN
AccessioniPrimary (citable) accession number: Q68DU8
Secondary accession number(s): Q9P2M9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: October 11, 2004
Last modified: February 28, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome