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Q68DU8

- KCD16_HUMAN

UniProt

Q68DU8 - KCD16_HUMAN

Protein

BTB/POZ domain-containing protein KCTD16

Gene

KCTD16

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization By similarity.By similarity

    GO - Biological processi

    1. protein homooligomerization Source: InterPro
    2. regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    BTB/POZ domain-containing protein KCTD16
    Alternative name(s):
    Potassium channel tetramerization domain-containing protein 16
    Gene namesi
    Name:KCTD16
    Synonyms:KIAA1317
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:29244. KCTD16.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. postsynaptic membrane Source: UniProtKB-SubCell
    3. presynaptic membrane Source: UniProtKB-SubCell
    4. receptor complex Source: Ensembl

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134973546.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 428428BTB/POZ domain-containing protein KCTD16PRO_0000248593Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei112 – 1121PhosphotyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ68DU8.
    PRIDEiQ68DU8.

    PTM databases

    PhosphoSiteiQ68DU8.

    Expressioni

    Gene expression databases

    BgeeiQ68DU8.
    CleanExiHS_KCTD16.
    GenevestigatoriQ68DU8.

    Organism-specific databases

    HPAiHPA044590.
    HPA050154.

    Interactioni

    Subunit structurei

    Interacts as a tetramer with GABRB1 and GABRB2.By similarity

    Protein-protein interaction databases

    BioGridi121587. 1 interaction.
    STRINGi9606.ENSP00000329906.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68DU8.
    SMRiQ68DU8. Positions 27-129.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 9874BTBAdd
    BLAST

    Sequence similaritiesi

    Contains 1 BTB (POZ) domain.Curated

    Phylogenomic databases

    eggNOGiNOG295576.
    HOGENOMiHOG000041197.
    HOVERGENiHBG052218.
    InParanoidiQ68DU8.
    OMAiSPDDYCH.
    OrthoDBiEOG7K3TM1.
    PhylomeDBiQ68DU8.
    TreeFamiTF315332.

    Family and domain databases

    Gene3Di3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR003131. T1-type_BTB.
    [Graphical view]
    PfamiPF02214. BTB_2. 1 hit.
    [Graphical view]
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q68DU8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALSGNCSRY YPREQGSAVP NSFPEVVELN VGGQVYFTRH STLISIPHSL    50
    LWKMFSPKRD TANDLAKDSK GRFFIDRDGF LFRYILDYLR DRQVVLPDHF 100
    PEKGRLKREA EYFQLPDLVK LLTPDEIKQS PDEFCHSDFE DASQGSDTRI 150
    CPPSSLLPAD RKWGFITVGY RGSCTLGREG QADAKFRRVP RILVCGRISL 200
    AKEVFGETLN ESRDPDRAPE RYTSRFYLKF KHLERAFDML SECGFHMVAC 250
    NSSVTASFIN QYTDDKIWSS YTEYVFYREP SRWSPSHCDC CCKNGKGDKE 300
    GESGTSCNDL STSSCDSQSE ASSPQETVIC GPVTRQTNIQ TLDRPIKKGP 350
    VQLIQQSEMR RKSDLLRTLT SGSRESNMSS KKKAVKEKLS IEEELEKCIQ 400
    DFLKIKIPDR FPERKHPWQS ELLRKYHL 428
    Length:428
    Mass (Da):49,138
    Last modified:October 11, 2004 - v1
    Checksum:i3D50005146B1383A
    GO

    Sequence cautioni

    The sequence BAA92555.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB037738 mRNA. Translation: BAA92555.1. Different initiation.
    CR749266 mRNA. Translation: CAH18122.1.
    BC111962 mRNA. Translation: AAI11963.1.
    BC113435 mRNA. Translation: AAI13436.1.
    CCDSiCCDS34260.1.
    RefSeqiNP_065819.1. NM_020768.3.
    XP_005268549.1. XM_005268492.1.
    XP_005268550.1. XM_005268493.1.
    XP_006714852.1. XM_006714789.1.
    UniGeneiHs.661870.

    Genome annotation databases

    EnsembliENST00000507359; ENSP00000426548; ENSG00000183775.
    ENST00000512467; ENSP00000424151; ENSG00000183775.
    GeneIDi57528.
    KEGGihsa:57528.
    UCSCiuc003lnm.1. human.

    Polymorphism databases

    DMDMi74708941.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB037738 mRNA. Translation: BAA92555.1 . Different initiation.
    CR749266 mRNA. Translation: CAH18122.1 .
    BC111962 mRNA. Translation: AAI11963.1 .
    BC113435 mRNA. Translation: AAI13436.1 .
    CCDSi CCDS34260.1.
    RefSeqi NP_065819.1. NM_020768.3.
    XP_005268549.1. XM_005268492.1.
    XP_005268550.1. XM_005268493.1.
    XP_006714852.1. XM_006714789.1.
    UniGenei Hs.661870.

    3D structure databases

    ProteinModelPortali Q68DU8.
    SMRi Q68DU8. Positions 27-129.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121587. 1 interaction.
    STRINGi 9606.ENSP00000329906.

    PTM databases

    PhosphoSitei Q68DU8.

    Polymorphism databases

    DMDMi 74708941.

    Proteomic databases

    PaxDbi Q68DU8.
    PRIDEi Q68DU8.

    Protocols and materials databases

    DNASUi 57528.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000507359 ; ENSP00000426548 ; ENSG00000183775 .
    ENST00000512467 ; ENSP00000424151 ; ENSG00000183775 .
    GeneIDi 57528.
    KEGGi hsa:57528.
    UCSCi uc003lnm.1. human.

    Organism-specific databases

    CTDi 57528.
    GeneCardsi GC05P143565.
    HGNCi HGNC:29244. KCTD16.
    HPAi HPA044590.
    HPA050154.
    MIMi 613423. gene.
    neXtProti NX_Q68DU8.
    PharmGKBi PA134973546.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG295576.
    HOGENOMi HOG000041197.
    HOVERGENi HBG052218.
    InParanoidi Q68DU8.
    OMAi SPDDYCH.
    OrthoDBi EOG7K3TM1.
    PhylomeDBi Q68DU8.
    TreeFami TF315332.

    Miscellaneous databases

    GenomeRNAii 57528.
    NextBioi 63924.
    PROi Q68DU8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q68DU8.
    CleanExi HS_KCTD16.
    Genevestigatori Q68DU8.

    Family and domain databases

    Gene3Di 3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR003131. T1-type_BTB.
    [Graphical view ]
    Pfami PF02214. BTB_2. 1 hit.
    [Graphical view ]
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Retina.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiKCD16_HUMAN
    AccessioniPrimary (citable) accession number: Q68DU8
    Secondary accession number(s): Q9P2M9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3