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Protein

BTB/POZ domain-containing protein KCTD16

Gene

KCTD16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD16
Alternative name(s):
Potassium channel tetramerization domain-containing protein 16
Gene namesi
Name:KCTD16
Synonyms:KIAA1317
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:29244. KCTD16.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134973546.

Polymorphism and mutation databases

BioMutaiKCTD16.
DMDMi74708941.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428BTB/POZ domain-containing protein KCTD16PRO_0000248593Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei112 – 1121PhosphotyrosineBy similarity
Modified residuei130 – 1301PhosphoserineBy similarity
Modified residuei137 – 1371PhosphoserineBy similarity
Modified residuei143 – 1431PhosphoserineBy similarity
Modified residuei146 – 1461PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ68DU8.
PRIDEiQ68DU8.

PTM databases

iPTMnetiQ68DU8.
PhosphoSiteiQ68DU8.

Expressioni

Gene expression databases

BgeeiQ68DU8.
CleanExiHS_KCTD16.
GenevisibleiQ68DU8. HS.

Organism-specific databases

HPAiHPA044590.
HPA050154.

Interactioni

Subunit structurei

Interacts as a tetramer with GABRB1 and GABRB2.By similarity

Protein-protein interaction databases

BioGridi121587. 1 interaction.
STRINGi9606.ENSP00000424151.

Structurei

Secondary structure

1
428
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi25 – 317Combined sources
Beta strandi34 – 396Combined sources
Helixi40 – 434Combined sources
Helixi50 – 556Combined sources
Beta strandi73 – 753Combined sources
Turni79 – 813Combined sources
Helixi82 – 9110Combined sources
Helixi103 – 11210Combined sources
Helixi116 – 1216Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5A15X-ray2.76A/B/C/D/E/F/G/H/I/J/K/L/M/N/O16-133[»]
ProteinModelPortaliQ68DU8.
SMRiQ68DU8. Positions 27-121.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 9874BTBAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.Curated

Phylogenomic databases

eggNOGiKOG2723. Eukaryota.
ENOG410Z155. LUCA.
GeneTreeiENSGT00760000119013.
HOGENOMiHOG000041197.
HOVERGENiHBG052218.
InParanoidiQ68DU8.
OMAiVPRILIC.
OrthoDBiEOG7K3TM1.
PhylomeDBiQ68DU8.
TreeFamiTF315332.

Family and domain databases

InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q68DU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSGNCSRY YPREQGSAVP NSFPEVVELN VGGQVYFTRH STLISIPHSL
60 70 80 90 100
LWKMFSPKRD TANDLAKDSK GRFFIDRDGF LFRYILDYLR DRQVVLPDHF
110 120 130 140 150
PEKGRLKREA EYFQLPDLVK LLTPDEIKQS PDEFCHSDFE DASQGSDTRI
160 170 180 190 200
CPPSSLLPAD RKWGFITVGY RGSCTLGREG QADAKFRRVP RILVCGRISL
210 220 230 240 250
AKEVFGETLN ESRDPDRAPE RYTSRFYLKF KHLERAFDML SECGFHMVAC
260 270 280 290 300
NSSVTASFIN QYTDDKIWSS YTEYVFYREP SRWSPSHCDC CCKNGKGDKE
310 320 330 340 350
GESGTSCNDL STSSCDSQSE ASSPQETVIC GPVTRQTNIQ TLDRPIKKGP
360 370 380 390 400
VQLIQQSEMR RKSDLLRTLT SGSRESNMSS KKKAVKEKLS IEEELEKCIQ
410 420
DFLKIKIPDR FPERKHPWQS ELLRKYHL
Length:428
Mass (Da):49,138
Last modified:October 11, 2004 - v1
Checksum:i3D50005146B1383A
GO

Sequence cautioni

The sequence BAA92555.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037738 mRNA. Translation: BAA92555.1. Different initiation.
CR749266 mRNA. Translation: CAH18122.1.
BC111962 mRNA. Translation: AAI11963.1.
BC113435 mRNA. Translation: AAI13436.1.
CCDSiCCDS34260.1.
RefSeqiNP_065819.1. NM_020768.3.
XP_005268549.1. XM_005268492.2.
XP_005268550.1. XM_005268493.2.
XP_006714852.1. XM_006714789.2.
XP_011535973.1. XM_011537671.1.
UniGeneiHs.661870.
Hs.7093.

Genome annotation databases

EnsembliENST00000507359; ENSP00000426548; ENSG00000183775.
ENST00000512467; ENSP00000424151; ENSG00000183775.
GeneIDi57528.
KEGGihsa:57528.
UCSCiuc003lnm.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037738 mRNA. Translation: BAA92555.1. Different initiation.
CR749266 mRNA. Translation: CAH18122.1.
BC111962 mRNA. Translation: AAI11963.1.
BC113435 mRNA. Translation: AAI13436.1.
CCDSiCCDS34260.1.
RefSeqiNP_065819.1. NM_020768.3.
XP_005268549.1. XM_005268492.2.
XP_005268550.1. XM_005268493.2.
XP_006714852.1. XM_006714789.2.
XP_011535973.1. XM_011537671.1.
UniGeneiHs.661870.
Hs.7093.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5A15X-ray2.76A/B/C/D/E/F/G/H/I/J/K/L/M/N/O16-133[»]
ProteinModelPortaliQ68DU8.
SMRiQ68DU8. Positions 27-121.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121587. 1 interaction.
STRINGi9606.ENSP00000424151.

PTM databases

iPTMnetiQ68DU8.
PhosphoSiteiQ68DU8.

Polymorphism and mutation databases

BioMutaiKCTD16.
DMDMi74708941.

Proteomic databases

PaxDbiQ68DU8.
PRIDEiQ68DU8.

Protocols and materials databases

DNASUi57528.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000507359; ENSP00000426548; ENSG00000183775.
ENST00000512467; ENSP00000424151; ENSG00000183775.
GeneIDi57528.
KEGGihsa:57528.
UCSCiuc003lnm.2. human.

Organism-specific databases

CTDi57528.
GeneCardsiKCTD16.
HGNCiHGNC:29244. KCTD16.
HPAiHPA044590.
HPA050154.
MIMi613423. gene.
neXtProtiNX_Q68DU8.
PharmGKBiPA134973546.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2723. Eukaryota.
ENOG410Z155. LUCA.
GeneTreeiENSGT00760000119013.
HOGENOMiHOG000041197.
HOVERGENiHBG052218.
InParanoidiQ68DU8.
OMAiVPRILIC.
OrthoDBiEOG7K3TM1.
PhylomeDBiQ68DU8.
TreeFamiTF315332.

Miscellaneous databases

GenomeRNAii57528.
PROiQ68DU8.
SOURCEiSearch...

Gene expression databases

BgeeiQ68DU8.
CleanExiHS_KCTD16.
GenevisibleiQ68DU8. HS.

Family and domain databases

InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Retina.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiKCD16_HUMAN
AccessioniPrimary (citable) accession number: Q68DU8
Secondary accession number(s): Q9P2M9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: October 11, 2004
Last modified: June 8, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.