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Q68DU8 (KCD16_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
BTB/POZ domain-containing protein KCTD16
Alternative name(s):
Potassium channel tetramerization domain-containing protein 16
Gene names
Name:KCTD16
Synonyms:KIAA1317
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length428 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization By similarity.

Subunit structure

Interacts as a tetramer with GABRB1 and GABRB2 By similarity.

Subcellular location

Cell junctionsynapsepresynaptic cell membrane. Cell junctionsynapsepostsynaptic cell membrane By similarity.

Sequence similarities

Contains 1 BTB (POZ) domain.

Sequence caution

The sequence BAA92555.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 428428BTB/POZ domain-containing protein KCTD16
PRO_0000248593

Regions

Domain25 – 9874BTB

Amino acid modifications

Modified residue1121Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q68DU8 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 3D50005146B1383A

FASTA42849,138
        10         20         30         40         50         60 
MALSGNCSRY YPREQGSAVP NSFPEVVELN VGGQVYFTRH STLISIPHSL LWKMFSPKRD 

        70         80         90        100        110        120 
TANDLAKDSK GRFFIDRDGF LFRYILDYLR DRQVVLPDHF PEKGRLKREA EYFQLPDLVK 

       130        140        150        160        170        180 
LLTPDEIKQS PDEFCHSDFE DASQGSDTRI CPPSSLLPAD RKWGFITVGY RGSCTLGREG 

       190        200        210        220        230        240 
QADAKFRRVP RILVCGRISL AKEVFGETLN ESRDPDRAPE RYTSRFYLKF KHLERAFDML 

       250        260        270        280        290        300 
SECGFHMVAC NSSVTASFIN QYTDDKIWSS YTEYVFYREP SRWSPSHCDC CCKNGKGDKE 

       310        320        330        340        350        360 
GESGTSCNDL STSSCDSQSE ASSPQETVIC GPVTRQTNIQ TLDRPIKKGP VQLIQQSEMR 

       370        380        390        400        410        420 
RKSDLLRTLT SGSRESNMSS KKKAVKEKLS IEEELEKCIQ DFLKIKIPDR FPERKHPWQS 


ELLRKYHL 

« Hide

References

[1]"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Retina.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB037738 mRNA. Translation: BAA92555.1. Different initiation.
CR749266 mRNA. Translation: CAH18122.1.
BC111962 mRNA. Translation: AAI11963.1.
BC113435 mRNA. Translation: AAI13436.1.
CCDSCCDS34260.1.
RefSeqNP_065819.1. NM_020768.3.
XP_005268549.1. XM_005268492.1.
XP_005268550.1. XM_005268493.1.
XP_006714852.1. XM_006714789.1.
UniGeneHs.661870.

3D structure databases

ProteinModelPortalQ68DU8.
SMRQ68DU8. Positions 27-129.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121587. 1 interaction.
STRING9606.ENSP00000329906.

PTM databases

PhosphoSiteQ68DU8.

Polymorphism databases

DMDM74708941.

Proteomic databases

PaxDbQ68DU8.
PRIDEQ68DU8.

Protocols and materials databases

DNASU57528.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000507359; ENSP00000426548; ENSG00000183775.
ENST00000512467; ENSP00000424151; ENSG00000183775.
GeneID57528.
KEGGhsa:57528.
UCSCuc003lnm.1. human.

Organism-specific databases

CTD57528.
GeneCardsGC05P143565.
HGNCHGNC:29244. KCTD16.
HPAHPA044590.
HPA050154.
MIM613423. gene.
neXtProtNX_Q68DU8.
PharmGKBPA134973546.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG295576.
HOGENOMHOG000041197.
HOVERGENHBG052218.
InParanoidQ68DU8.
OMASPDDYCH.
OrthoDBEOG7K3TM1.
PhylomeDBQ68DU8.
TreeFamTF315332.

Gene expression databases

BgeeQ68DU8.
CleanExHS_KCTD16.
GenevestigatorQ68DU8.

Family and domain databases

Gene3D3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR003131. T1-type_BTB.
[Graphical view]
PfamPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF54695. SSF54695. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi57528.
NextBio63924.
PROQ68DU8.
SOURCESearch...

Entry information

Entry nameKCD16_HUMAN
AccessionPrimary (citable) accession number: Q68DU8
Secondary accession number(s): Q9P2M9
Entry history
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: October 11, 2004
Last modified: July 9, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM