Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Very large A-kinase anchor protein

Gene

CRYBG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Isoform vlAKAP: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA).1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Lectin

Protein family/group databases

CAZyiCBM13. Carbohydrate-Binding Module Family 13.

Names & Taxonomyi

Protein namesi
Recommended name:
Very large A-kinase anchor protein
Short name:
vlAKAP
Alternative name(s):
Beta/gamma crystallin domain-containing protein 3
Gene namesi
Name:CRYBG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:34427. CRYBG3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164718140.

Polymorphism and mutation databases

BioMutaiCRYBG3.
DMDMi172045724.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 29702970Very large A-kinase anchor proteinPRO_0000325758Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei931 – 9311PhosphoserineCombined sources
Modified residuei2086 – 20861PhosphoserineBy similarity
Modified residuei2093 – 20931PhosphoserineBy similarity
Modified residuei2094 – 20941PhosphoserineBy similarity
Modified residuei2100 – 21001PhosphoserineBy similarity
Modified residuei2104 – 21041PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ68DQ2.
MaxQBiQ68DQ2.
PaxDbiQ68DQ2.
PeptideAtlasiQ68DQ2.
PRIDEiQ68DQ2.

PTM databases

iPTMnetiQ68DQ2.
PhosphoSiteiQ68DQ2.

Expressioni

Gene expression databases

BgeeiENSG00000233280.
CleanExiHS_CRYBG3.
ExpressionAtlasiQ68DQ2. baseline and differential.
GenevisibleiQ68DQ2. HS.

Organism-specific databases

HPAiHPA044122.
HPA054441.

Interactioni

Subunit structurei

Isoform vlAKAP binds to dimeric RII-alpha regulatory subunit of PKA (PRKAR2A/PRKAR2B).1 Publication

Protein-protein interaction databases

BioGridi126284. 7 interactions.
IntActiQ68DQ2. 5 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ68DQ2.
SMRiQ68DQ2. Positions 2477-2568.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2334 – 238350Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd
BLAST
Domaini2429 – 246739Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd
BLAST
Domaini2479 – 252345Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd
BLAST
Domaini2524 – 256643Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd
BLAST
Domaini2572 – 261342Beta/gamma crystallin 'Greek key' 5PROSITE-ProRule annotationAdd
BLAST
Domaini2614 – 265643Beta/gamma crystallin 'Greek key' 6PROSITE-ProRule annotationAdd
BLAST
Domaini2667 – 270337Beta/gamma crystallin 'Greek key' 7PROSITE-ProRule annotationAdd
BLAST
Domaini2704 – 274643Beta/gamma crystallin 'Greek key' 8PROSITE-ProRule annotationAdd
BLAST
Domaini2793 – 283442Beta/gamma crystallin 'Greek key' 9PROSITE-ProRule annotationAdd
BLAST
Domaini2836 – 2968133Ricin B-type lectinPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1299 – 132224RII-binding helix1 PublicationAdd
BLAST

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated
Contains 9 beta/gamma crystallin 'Greek key' domains.PROSITE-ProRule annotation
Contains 1 ricin B-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JBH5. Eukaryota.
ENOG411191B. LUCA.
GeneTreeiENSGT00670000097933.
HOVERGENiHBG107760.
InParanoidiQ68DQ2.
OMAiSTQISEN.
OrthoDBiEOG091G007H.
TreeFamiTF331078.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF00030. Crystall. 6 hits.
PF00652. Ricin_B_lectin. 1 hit.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00458. RICIN. 1 hit.
SM00247. XTALbg. 6 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 3 hits.
SSF50370. SSF50370. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 9 hits.
PS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform vlAKAP (identifier: Q68DQ2-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSGRRRGSA PWHSFSRFFA PRSPSRDKEE EEEERPGTSP PPAPGRSAAS
60 70 80 90 100
VENEPMSTSQ KKENVLSSEA VKIRQSEDKR NHAEKPVTLP VQEDPKKAYD
110 120 130 140 150
LSSSTSDTKI GESDRQPKES FFQFLGNLFN ISGKSSLGEA KQSSFKDDQD
160 170 180 190 200
KTEKDLQNPS DHHEDGIKRE REIFSGSLRT QTHPTEEQDS NSSELSDAFS
210 220 230 240 250
LDTTQDSDQE TTNLLKQIDG KPEKPSVTYA TYRGPRHIGK YLKQQTGLAT
260 270 280 290 300
VNTLDRENES SDSSTNRHID PGSEIEAGVL PLLLSASTDS SMKGNLLEGP
310 320 330 340 350
LEDSDCSKTS FNKENSLTNN PELQNIASSN NLLNKNAWGS IERNRSSPSS
360 370 380 390 400
VTNSSYDGES DSQHHLSCEP VSQTNRNLVC SALLTGSNHR KVPCSPDFQR
410 420 430 440 450
VTTTENTIKE NSTVMSNRTL VQREELVEPQ GPAISDFSCS KSDGSDTTEQ
460 470 480 490 500
ESTNLPSPNK SIRHEHLQLP ESECSDKQTI DSSSKQAATH TNIIALQRHA
510 520 530 540 550
VTDTEFVNEG KRLSAQDSQK NVAVREIRRE TESASAGESI ASSHVKAPED
560 570 580 590 600
KIESLPKDTD QYFETKAKKL DFRSHDKIPH IRMNKKDLAS LNYISESAVV
610 620 630 640 650
ASLGNENAPE LKFELNRSHI SETPLDSESP QQAEVSPDAK TSLSLDCKKL
660 670 680 690 700
NFSISPPTFV SGVGMLSKLD IPDLMNEGSP VPIETGNVNI VGISYQPRKC
710 720 730 740 750
KEENVKNHVE AAGRKSPPPS FCLEYTSAIF EFKEVLSNSE KCQVLPGSEA
760 770 780 790 800
SGPHLTGLEL LSFDSGNLSK DCSSILSQDP NRVELVSSNT KANMSIIEKS
810 820 830 840 850
DSLSLEAKTA NIVSKAEIDG QNNVLVESHS GRGKTISLSK VSLSKVEPRN
860 870 880 890 900
ISQDKMSSFP LKITHVPEKP ILSELTFLEV EQGKRFQSIN HNEIGEKCSD
910 920 930 940 950
AGLKENCQAE LSPAASKYED KPEPEVDALG SPPALLKSNI SWILPPIHDE
960 970 980 990 1000
KISRQMAQNC EAHTCVFHQS LDICGTKKIS GHSEMAELSL TNISPKFQET
1010 1020 1030 1040 1050
GSMKVNSPFL DSDSSLEKNS SASEDSSFLK VPSVLKLEKK SSSYRKKENI
1060 1070 1080 1090 1100
HFLNGGIDSV SSSSSYPEEV SMIVNSHKPQ NNLDSIQVTK DLTHEGTSVT
1110 1120 1130 1140 1150
NLLYPTTSYL EFETSVSIGT EVTPFQEHFG IYTGKISIDF PTAAQFDNLV
1160 1170 1180 1190 1200
EAETGAVAGP AASVNSSGQQ CSEASAEHIE ARRRAHDQLL DLKSSLLKKA
1210 1220 1230 1240 1250
DTLIGEIFNS VREELKFKHT VSTCQEHIAI EGIMNLGTLK EDISEKNPSE
1260 1270 1280 1290 1300
VTLTEIQQTE GLEEQGMENM SEVKEKPCVS PTVGEKNLLV DPNSMNVSCL
1310 1320 1330 1340 1350
LEDKARELVN EIIYVAQEKL RNDTFEDTED TWDSELQANT SKILNSDSVK
1360 1370 1380 1390 1400
PHDVVREFLV SEQPVNQSTQ ISENKVLNEF FSLSNLASGT ESIKGGEIVL
1410 1420 1430 1440 1450
YQKSLFSGNG SGLSDSINLQ ESDTVLLAED MSHKRLDDRV KTHLFRSEDC
1460 1470 1480 1490 1500
NETMEIENVD NNKTETEDRR TLVLNFKWPP LVNDDIHAPG TSKSSLSDSL
1510 1520 1530 1540 1550
VCISEKNLPG HSKNTPLAMS DVGKVHKKDN EINIGKIELI PSMLETGKTN
1560 1570 1580 1590 1600
KKDAELNILK YEAVPPMIEM GRIHKMDAEL NVTKTEPKAN VFKMGEVYQM
1610 1620 1630 1640 1650
DAESCIEKTE GSAVILGMEK AYKMKDTEGD IGKIEVIPMM PEVKNIHQKD
1660 1670 1680 1690 1700
AEGDIVKTEM TPVTVDMENI YQTHAEGDIG KTGTIALSEV ENIHQKGGEG
1710 1720 1730 1740 1750
ISEKAEVIPV TLAMENTYQK DAEGDIGKAE VMPVRLEMEN TYPKDTERDG
1760 1770 1780 1790 1800
GKTEVMPLAL EVVNTYQKNA KGFTGNTEGS VLKMEATYRK TAEEVIKNTE
1810 1820 1830 1840 1850
IVPCVLKVKE AHETAPAPLE MEKACKRDVK ETIGATVSTP SVIEMEKISP
1860 1870 1880 1890 1900
EDRGENIGKH KVLPAVVDIE KIHGTGLELT TKQGEAMLPA FESKTPQEYA
1910 1920 1930 1940 1950
EGSVEETKEE PTEIKEGLIA HENRLPTYFR GYESPTLSKD YEGYPAPAMP
1960 1970 1980 1990 2000
DFQPGDTTVR LDKRMSLTAI YDKRRETDYS DKGYNLAFVS QDEQENSSFT
2010 2020 2030 2040 2050
ILYEEPLQEE DKYASAEARQ TQSVLFHDTS ADSMPVLACE RSESRTDLVH
2060 2070 2080 2090 2100
HFEKGTKLGE TFDSDSSEMF LSVEAKRYKI YPLALSPIYE DDSSQEDILS
2110 2120 2130 2140 2150
SEVSPGHHGP RKSRDSENQS SSVLSLLQSV SERLKMNFDE DDREAADEEE
2160 2170 2180 2190 2200
EEEEAAVLHK GDLRAGSGER VTFQLPDPSI TFYPDDQESV GISKNSYVMP
2210 2220 2230 2240 2250
NEPTTSNLQV GLWPEKTSFL QKSDLTSKLH SSLKSAYHQY LQTSQSHSSE
2260 2270 2280 2290 2300
KGARFGGIFQ EPVSKYFRVQ DSPGRLSPFI ENVDKQTLRC NPRPGKMVIY
2310 2320 2330 2340 2350
DLHESTYKQE VYCNIPDATS WSFPNGVLIK VVRGCWILYE KPHFRGQKCV
2360 2370 2380 2390 2400
LEEGEKVLNR DWILQNRRHP QRNFILGSLK RVLKDCSIPE IELFPQSDPA
2410 2420 2430 2440 2450
CCPVYIQRAV PNLEELNISK SVSFTVKSGV WLAYPDINFK GQATVLEEDH
2460 2470 2480 2490 2500
GLFEISTAEM KSLHPLQMGG LKVEMPMNLK VIIYEKPHFH GQAKEFSEHI
2510 2520 2530 2540 2550
DSVPNFLKNN GDFHRIGSIR VIGGVWVAYE KEHFKGQQFL LEEGDFEDSN
2560 2570 2580 2590 2600
ACGALSSPIL SFRYLQANFI ESSVTLFESD LESGKFIDIT NQEISDLEEI
2610 2620 2630 2640 2650
GFGSKTRSIH VKSGVWVAYQ QKFFCGEQYI LEKGKYKCFF DWGGSNNIIM
2660 2670 2680 2690 2700
SIRPIQLEPL GINEPPHLLK AFSKPGFQGE CIDFTEETSD LTSLMPCSFK
2710 2720 2730 2740 2750
VLRGCWLLYY QEDMFVNHCV LEEGLYADLT SCGCPASKVK SLKPIDYVFE
2760 2770 2780 2790 2800
EPSISLFALE HCEGRELHLE EAVNSVLNKD LHFYTQSVWV KSGLWIAYEG
2810 2820 2830 2840 2850
SNFLGRQILL RPNEIPNWTA FSRWKTIGSL RPMKQPAVYI RIKNRAQGEY
2860 2870 2880 2890 2900
LTVTGSLADT RATSVCISPY SGKNTQIWYY CRGLFKSKAS DTCLDVIGGR
2910 2920 2930 2940 2950
DTPGAKVALW TEHGQFRQKW RLNKNGTISS YLSDQLVLDV KGGNYCDKTH
2960 2970
VIVNQPLEGE ETQKWDIEIL
Length:2,970
Mass (Da):330,633
Last modified:November 26, 2014 - v3
Checksum:iA0851F4BC1252D1E
GO
Isoform 1 (identifier: Q68DQ2-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1948: Missing.

Note: No experimental confirmation available.
Show »
Length:1,022
Mass (Da):116,197
Checksum:iE8483E03F63B775E
GO
Isoform 2 (identifier: Q68DQ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2742: Missing.
     2743-2747: KPIDY → MNKKK

Note: No experimental confirmation available.
Show »
Length:228
Mass (Da):26,033
Checksum:i27006DF42173E491
GO

Sequence cautioni

The sequence AAH36247 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAP97687 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC03608 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAH18168 differs from that shown. Reason: Frameshift at position 14. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2693 – 26931S → P in CAH18168 (PubMed:17974005).Curated
Sequence conflicti2765 – 27651R → G in AAH36247 (PubMed:15489334).Curated
Sequence conflicti2768 – 27714Missing in AAP97687 (Ref. 4) Curated
Sequence conflicti2847 – 28471Q → R in AAH50394 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2381 – 23811R → H.
Corresponds to variant rs11918990 [ dbSNP | Ensembl ].
VAR_039906
Natural varianti2709 – 27091Y → C.
Corresponds to variant rs17302349 [ dbSNP | Ensembl ].
VAR_039907
Natural varianti2874 – 28741N → H.3 Publications
Corresponds to variant rs4857302 [ dbSNP | Ensembl ].
VAR_039908

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 27422742Missing in isoform 2. 1 PublicationVSP_057115Add
BLAST
Alternative sequencei1 – 19481948Missing in isoform 1. VSP_057114Add
BLAST
Alternative sequencei2743 – 27475KPIDY → MNKKK in isoform 2. 1 PublicationVSP_057116

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091199 mRNA. Translation: BAC03608.1. Different initiation.
AK098569 mRNA. Translation: BAC05338.1.
AK296966 mRNA. Translation: BAG59510.1.
AC110491 Genomic DNA. No translation available.
AL831927 mRNA. Translation: CAD38587.1.
CR749313 mRNA. Translation: CAH18168.1. Frameshift.
AF451988 mRNA. Translation: AAP97687.1. Different initiation.
BC036247 mRNA. Translation: AAH36247.1. Different initiation.
BC050394 mRNA. Translation: AAH50394.1.
RefSeqiNP_705833.3. NM_153605.3. [Q68DQ2-3]
UniGeneiHs.733378.

Genome annotation databases

EnsembliENST00000389622; ENSP00000374273; ENSG00000080200. [Q68DQ2-3]
GeneIDi131544.
KEGGihsa:131544.
UCSCiuc021xbn.3. human. [Q68DQ2-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091199 mRNA. Translation: BAC03608.1. Different initiation.
AK098569 mRNA. Translation: BAC05338.1.
AK296966 mRNA. Translation: BAG59510.1.
AC110491 Genomic DNA. No translation available.
AL831927 mRNA. Translation: CAD38587.1.
CR749313 mRNA. Translation: CAH18168.1. Frameshift.
AF451988 mRNA. Translation: AAP97687.1. Different initiation.
BC036247 mRNA. Translation: AAH36247.1. Different initiation.
BC050394 mRNA. Translation: AAH50394.1.
RefSeqiNP_705833.3. NM_153605.3. [Q68DQ2-3]
UniGeneiHs.733378.

3D structure databases

ProteinModelPortaliQ68DQ2.
SMRiQ68DQ2. Positions 2477-2568.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126284. 7 interactions.
IntActiQ68DQ2. 5 interactions.

Protein family/group databases

CAZyiCBM13. Carbohydrate-Binding Module Family 13.

PTM databases

iPTMnetiQ68DQ2.
PhosphoSiteiQ68DQ2.

Polymorphism and mutation databases

BioMutaiCRYBG3.
DMDMi172045724.

Proteomic databases

EPDiQ68DQ2.
MaxQBiQ68DQ2.
PaxDbiQ68DQ2.
PeptideAtlasiQ68DQ2.
PRIDEiQ68DQ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389622; ENSP00000374273; ENSG00000080200. [Q68DQ2-3]
GeneIDi131544.
KEGGihsa:131544.
UCSCiuc021xbn.3. human. [Q68DQ2-3]

Organism-specific databases

CTDi131544.
GeneCardsiCRYBG3.
H-InvDBHIX0003488.
HGNCiHGNC:34427. CRYBG3.
HPAiHPA044122.
HPA054441.
neXtProtiNX_Q68DQ2.
PharmGKBiPA164718140.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JBH5. Eukaryota.
ENOG411191B. LUCA.
GeneTreeiENSGT00670000097933.
HOVERGENiHBG107760.
InParanoidiQ68DQ2.
OMAiSTQISEN.
OrthoDBiEOG091G007H.
TreeFamiTF331078.

Miscellaneous databases

GenomeRNAii131544.
PROiQ68DQ2.

Gene expression databases

BgeeiENSG00000233280.
CleanExiHS_CRYBG3.
ExpressionAtlasiQ68DQ2. baseline and differential.
GenevisibleiQ68DQ2. HS.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF00030. Crystall. 6 hits.
PF00652. Ricin_B_lectin. 1 hit.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00458. RICIN. 1 hit.
SM00247. XTALbg. 6 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 3 hits.
SSF50370. SSF50370. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 9 hits.
PS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRBG3_HUMAN
AccessioniPrimary (citable) accession number: Q68DQ2
Secondary accession number(s): B4DLE8
, F6VHI2, Q4G0V8, Q7Z4R9, Q86VD0, Q8N262, Q8N7F1, Q8NDQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: November 26, 2014
Last modified: September 7, 2016
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.