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Protein

Uncharacterized protein C2orf16

Gene

C2orf16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C2orf16
Gene namesi
Name:C2orf16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:25275. C2orf16.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134977296.

Polymorphism and mutation databases

BioMutaiC2orf16.
DMDMi296439423.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19841984Uncharacterized protein C2orf16PRO_0000281907Add
BLAST

Proteomic databases

EPDiQ68DN1.
PaxDbiQ68DN1.
PeptideAtlasiQ68DN1.
PRIDEiQ68DN1.

PTM databases

iPTMnetiQ68DN1.
PhosphoSiteiQ68DN1.

Expressioni

Gene expression databases

BgeeiENSG00000221843.
CleanExiHS_C2orf16.
GenevisibleiQ68DN1. HS.

Organism-specific databases

HPAiHPA052136.
HPA056962.

Interactioni

Protein-protein interaction databases

IntActiQ68DN1. 1 interaction.
MINTiMINT-4713119.
STRINGi9606.ENSP00000386190.

Structurei

3D structure databases

ProteinModelPortaliQ68DN1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1593 – 160081
Repeati1601 – 160882
Repeati1609 – 161683
Repeati1641 – 164884
Repeati1649 – 165685
Repeati1657 – 166486
Repeati1681 – 168887
Repeati1689 – 169688
Repeati1697 – 170489
Repeati1705 – 1712810
Repeati1713 – 1720811
Repeati1721 – 1728812
Repeati1729 – 1736813
Repeati1737 – 1744814
Repeati1745 – 1752815
Repeati1753 – 1760816
Repeati1761 – 1768817
Repeati1769 – 1776818
Repeati1777 – 1784819
Repeati1785 – 1792820
Repeati1793 – 1800821
Repeati1801 – 1808822
Repeati1848 – 1855823
Repeati1864 – 1871824
Repeati1880 – 1887825
Repeati1921 – 1928826
Repeati1929 – 1935727

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1593 – 193534327 X 8 AA approximative tandem repeat of P-S-E-R-S-H-H-SAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1546 – 1934389Arg-richAdd
BLAST

Domaini

The P-S-E-R-S-H-H-S repeats give rise to an antiparallel beta-structure.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IKCY. Eukaryota.
ENOG4111Y2D. LUCA.
GeneTreeiENSGT00700000104587.
HOGENOMiHOG000090226.
HOVERGENiHBG107576.
InParanoidiQ68DN1.
OMAiERRHHSP.
OrthoDBiEOG091G00CD.
PhylomeDBiQ68DN1.
TreeFamiTF339785.

Sequencei

Sequence statusi: Complete.

Q68DN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELTPGAQQQ GINYQELTSG WQDVKSMMLV PEPTRKFPSG PLLTSVRFSN
60 70 80 90 100
LSPESQQQDV KSLEFTVEPK LQSVKHVKLS SVSLQQTIKS VELAPGSLPQ
110 120 130 140 150
RVKYGEQTPR TNYQIMESSE LIPRPGHQFA KYAEMIPQPK YQIPKSANLI
160 170 180 190 200
SIPIYHATES SEMAQGLAYK GIDTVEKSVG LTPKLTGRAK ESLGMLLQPD
210 220 230 240 250
LQVPKFVDLT PMVRDQGSKF LGLTPEKSYQ ILETMELLSQ SRPRVKDVGE
260 270 280 290 300
LYMKPLQQTV EYEGITPELK HYFTEAMGLT AEARIQANEF FGMTPKPTSQ
310 320 330 340 350
ATGFAERSPR LCPQNLECVE VISEKRLQGE ESVVLIPKSL HHVPDSASGM
360 370 380 390 400
TPGLGHRVPE SVELTSKSGV QVEKTLQLTP KPQHHVGSPG IISGLGHQVP
410 420 430 440 450
ESVNLTCKQW LQMEESLEVP LKQTSQVIGH EESVELTSEA RQHREVSMGL
460 470 480 490 500
TKSKNQSMKS PGTTPGPLGR IVEFMRISPE PLDQVTESAR TQLQVAQSEE
510 520 530 540 550
VILIDVPKVV QSVKVTPGPP FQIVKSVTIP RPTPQMVEYI ELTPKLQYVR
560 570 580 590 600
PSEHHTGPCL QDVKSTKLIT KPKHQILETV ELTGFQIVKT MLIPGPSLQI
610 620 630 640 650
VKSEELAPGP IPQVVEPIGV ALESGIEAIN CVDLLPRPHL QELIVPAELT
660 670 680 690 700
PSPCTQVKSA ELTSPQTSPF EEHTILTHKQ GLQAVKSTVI KTEPPKVMET
710 720 730 740 750
EDLNLGHVCQ NRDCQKLTSE ELQVGTDFSR FLQSSSTTLI SSSVRTASEL
760 770 780 790 800
GGLWDSGIQE VSRALDIKNP GTDILQPEET YIDPTMIQSL TFPLALHNQS
810 820 830 840 850
SDKTANIVEN PCPEILGVDV ISKETTKRKQ MEELENSLQR HLPQSWRSRS
860 870 880 890 900
RTFQAESGVQ KGLIKSFPGR QHNVWESHAW RQRLPRKYLS TMLMLGNILG
910 920 930 940 950
TTMERKLCSQ TSLAERATAD TCQSIQNLFG IPAELMEPSQ SLPEKGPVTI
960 970 980 990 1000
SQPSVVKNYI QRHTFYHGHK KRMALRIWTR GSTSSIIQQY SGTRVRIKKT
1010 1020 1030 1040 1050
NSTFNGISQE VIQHMPVSCA GGQLPVLVKS ESSLSIFYDR EDLVPMEESE
1060 1070 1080 1090 1100
DSQSDSQTRI SESQHSLKPN YLSQAKTDFS EQFQLLEDLQ LKIAAKLLRS
1110 1120 1130 1140 1150
QIPPDVPPPL ASGLVLKYPI CLQCGRCSGL NCHHKLQTTS GPYLLIYPQL
1160 1170 1180 1190 1200
HLVRTPEGHG EVRLHLGFRL RIGKRSQISK YRERDRPVIR RSPISPSQRK
1210 1220 1230 1240 1250
AKIYTQASKS PTSTIDLQSG PSQSPAPVQV YIRRGQRSRP DLVEKTKTRA
1260 1270 1280 1290 1300
PGHYEFTQVH NLPESDSEST QNEKRAKVRT KKTSDSKYPM KRITKRLRKH
1310 1320 1330 1340 1350
RKFYTNSRTT IESPSRELAA HLRRKRIGAT QTSTASLKRQ PKKPSQPKFM
1360 1370 1380 1390 1400
QLLFQSLKRA FQTAHRVIAS VGRKPVDGTR PDNLWASKNY YPKQNARDYC
1410 1420 1430 1440 1450
LPSSIKRDKR SADKLTPAGS TIKQEDILWG GTVQCRSAQQ PRRAYSFQPR
1460 1470 1480 1490 1500
PLRLPKPTDS QSGIAFQTAS VGQPLRTVQK DSSSRSKKNF YRNETSSQES
1510 1520 1530 1540 1550
KNLSTPGTRV QARGRILPGS PVKRTWHRHL KDKLTHKEHN HPSFYRERTP
1560 1570 1580 1590 1600
RGPSERTRHN PSWRNHRSPS ERSQRSSLER RHHSPSQRSH CSPSRKNHSS
1610 1620 1630 1640 1650
PSERSWRSPS QRNHCSPPER SCHSLSERGL HSPSQRSHRG PSQRRHHSPS
1660 1670 1680 1690 1700
ERSHRSPSER SHRSSSERRH RSPSQRSHRG PSERSHCSPS ERRHRSPSQR
1710 1720 1730 1740 1750
SHRGPSERRH HSPSKRSHRS PARRSHRSPS ERSHHSPSER SHHSPSERRH
1760 1770 1780 1790 1800
HSPSERSHCS PSERSHCSPS ERRHRSPSER RHHSPSEKSH HSPSERSHHS
1810 1820 1830 1840 1850
PSERRRHSPL ERSRHSLLER SHRSPSERRS HRSFERSHRR ISERSHSPSE
1860 1870 1880 1890 1900
KSHLSPLERS RCSPSERRGH SSSGKTCHSP SERSHRSPSG MRQGRTSERS
1910 1920 1930 1940 1950
HRSSCERTRH SPSEMRPGRP SGRNHCSPSE RSRRSPLKEG LKYSFPGERP
1960 1970 1980
SHSLSRDFKN QTTLLGTTHK NPKAGQVWRP EATR
Length:1,984
Mass (Da):224,321
Last modified:May 18, 2010 - v3
Checksum:iD1232B8DADB28773
GO

Sequence cautioni

The sequence AAX93198 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti613 – 6131Q → L in CAH18189 (PubMed:17974005).Curated
Sequence conflicti1493 – 14931N → D in CAH18189 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti357 – 3571R → G.
Corresponds to variant rs17006143 [ dbSNP | Ensembl ].
VAR_031313
Natural varianti505 – 5051D → V.
Corresponds to variant rs13410886 [ dbSNP | Ensembl ].
VAR_031314
Natural varianti655 – 6551T → S.
Corresponds to variant rs1919125 [ dbSNP | Ensembl ].
VAR_031315
Natural varianti660 – 6601A → E.
Corresponds to variant rs1919126 [ dbSNP | Ensembl ].
VAR_031316
Natural varianti685 – 6851V → A.
Corresponds to variant rs1919127 [ dbSNP | Ensembl ].
VAR_031317
Natural varianti767 – 7671I → T.
Corresponds to variant rs13416968 [ dbSNP | Ensembl ].
VAR_031318
Natural varianti774 – 7741I → V.
Corresponds to variant rs1919128 [ dbSNP | Ensembl ].
VAR_031319
Natural varianti1500 – 15001S → F.
Corresponds to variant rs12618071 [ dbSNP | Ensembl ].
VAR_031320
Natural varianti1559 – 15591H → Y.
Corresponds to variant rs13392197 [ dbSNP | Ensembl ].
VAR_031321
Natural varianti1613 – 16131N → S.
Corresponds to variant rs13031957 [ dbSNP | Ensembl ].
VAR_031322
Natural varianti1665 – 16651S → P.2 Publications
Corresponds to variant rs28381983 [ dbSNP | Ensembl ].
VAR_031323

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834384 mRNA. Translation: CAD39047.1.
CR749335 mRNA. Translation: CAH18189.1.
AC074091 Genomic DNA. Translation: AAX93198.1. Different initiation.
BC140828 mRNA. Translation: AAI40829.1.
AL136898 mRNA. Translation: CAB66832.2.
CCDSiCCDS42666.1.
RefSeqiNP_115642.3. NM_032266.3.
UniGeneiHs.131021.

Genome annotation databases

EnsembliENST00000408964; ENSP00000386190; ENSG00000221843.
GeneIDi84226.
KEGGihsa:84226.
UCSCiuc002rkz.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834384 mRNA. Translation: CAD39047.1.
CR749335 mRNA. Translation: CAH18189.1.
AC074091 Genomic DNA. Translation: AAX93198.1. Different initiation.
BC140828 mRNA. Translation: AAI40829.1.
AL136898 mRNA. Translation: CAB66832.2.
CCDSiCCDS42666.1.
RefSeqiNP_115642.3. NM_032266.3.
UniGeneiHs.131021.

3D structure databases

ProteinModelPortaliQ68DN1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ68DN1. 1 interaction.
MINTiMINT-4713119.
STRINGi9606.ENSP00000386190.

PTM databases

iPTMnetiQ68DN1.
PhosphoSiteiQ68DN1.

Polymorphism and mutation databases

BioMutaiC2orf16.
DMDMi296439423.

Proteomic databases

EPDiQ68DN1.
PaxDbiQ68DN1.
PeptideAtlasiQ68DN1.
PRIDEiQ68DN1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000408964; ENSP00000386190; ENSG00000221843.
GeneIDi84226.
KEGGihsa:84226.
UCSCiuc002rkz.5. human.

Organism-specific databases

CTDi84226.
GeneCardsiC2orf16.
H-InvDBHIX0001926.
HGNCiHGNC:25275. C2orf16.
HPAiHPA052136.
HPA056962.
neXtProtiNX_Q68DN1.
PharmGKBiPA134977296.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKCY. Eukaryota.
ENOG4111Y2D. LUCA.
GeneTreeiENSGT00700000104587.
HOGENOMiHOG000090226.
HOVERGENiHBG107576.
InParanoidiQ68DN1.
OMAiERRHHSP.
OrthoDBiEOG091G00CD.
PhylomeDBiQ68DN1.
TreeFamiTF339785.

Miscellaneous databases

GenomeRNAii84226.
PROiQ68DN1.

Gene expression databases

BgeeiENSG00000221843.
CleanExiHS_C2orf16.
GenevisibleiQ68DN1. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCB016_HUMAN
AccessioniPrimary (citable) accession number: Q68DN1
Secondary accession number(s): B9EIQ4
, Q53S01, Q8ND64, Q9H088
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: May 18, 2010
Last modified: September 7, 2016
This is version 86 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.