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Q68DK2

- ZFY26_HUMAN

UniProt

Q68DK2 - ZFY26_HUMAN

Protein

Zinc finger FYVE domain-containing protein 26

Gene

ZFYVE26

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri1812 – 187261FYVE-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphatidylinositol-3-phosphate binding Source: UniProtKB
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. cell death Source: UniProtKB-KW
    2. cytokinesis Source: UniProtKB
    3. double-strand break repair via homologous recombination Source: UniProtKB

    Keywords - Biological processi

    Cell cycle, Cell division, DNA damage, DNA repair

    Keywords - Ligandi

    Lipid-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger FYVE domain-containing protein 26
    Alternative name(s):
    FYVE domain-containing centrosomal protein
    Short name:
    FYVE-CENT
    Spastizin
    Gene namesi
    Name:ZFYVE26
    Synonyms:KIAA0321
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:20761. ZFYVE26.

    Subcellular locationi

    Cytoplasmcytoskeletonmicrotubule organizing centercentrosome 1 Publication. Midbody 1 Publication
    Note: Localizes to the centrosome during all stages of the cell cycle. Recruited to the midbody during cytokinesis by KIF13A.

    GO - Cellular componenti

    1. centrosome Source: UniProtKB
    2. lysosomal membrane Source: UniProtKB
    3. midbody Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Involvement in diseasei

    Spastic paraplegia 15, autosomal recessive (SPG15) [MIM:270700]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG15 is a complex form associated with additional neurological symptoms such as cognitive deterioration or mental retardation, axonal neuropathy, mild cerebellar signs, and, less frequently, a central hearing deficit, decreased visual acuity, or retinal degeneration.3 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi1836 – 18361R → A: Abolishes phosphatidylinositol 3-phosphate-binding and localization to the midbody. 1 Publication

    Keywords - Diseasei

    Hereditary spastic paraplegia, Neurodegeneration

    Organism-specific databases

    MIMi270700. phenotype.
    Orphaneti100996. Autosomal recessive spastic paraplegia type 15.
    PharmGKBiPA134904455.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 25392539Zinc finger FYVE domain-containing protein 26PRO_0000314612Add
    BLAST

    Proteomic databases

    MaxQBiQ68DK2.
    PaxDbiQ68DK2.
    PRIDEiQ68DK2.

    PTM databases

    PhosphoSiteiQ68DK2.

    Expressioni

    Tissue specificityi

    Strongest expression in the adrenal gland, bone marrow, adult brain, fetal brain, lung, placenta, prostate, skeletal muscle, testis, thymus, and retina. Intermediate levels are detected in other structures, including the spinal cord.1 Publication

    Gene expression databases

    ArrayExpressiQ68DK2.
    BgeeiQ68DK2.
    CleanExiHS_ZFYVE26.
    GenevestigatoriQ68DK2.

    Organism-specific databases

    HPAiHPA055500.

    Interactioni

    Subunit structurei

    Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with TTC19 and KIF13A.2 Publications

    Protein-protein interaction databases

    BioGridi117050. 1 interaction.
    IntActiQ68DK2. 2 interactions.
    STRINGi9606.ENSP00000251119.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68DK2.
    SMRiQ68DK2. Positions 1809-1868.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili868 – 89528Sequence AnalysisAdd
    BLAST

    Domaini

    The FYVE-type zinc finger mediates binding to phosphatidylinositol 3-phosphate and recruitment to the midbody during cytokinesis.1 Publication

    Sequence similaritiesi

    Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri1812 – 187261FYVE-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG247110.
    HOVERGENiHBG108766.
    InParanoidiQ68DK2.
    OrthoDBiEOG776SP2.
    PhylomeDBiQ68DK2.
    TreeFamiTF324517.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR028730. ZFYVE26.
    IPR000306. Znf_FYVE.
    IPR017455. Znf_FYVE-rel.
    IPR011011. Znf_FYVE_PHD.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PANTHERiPTHR22835:SF115. PTHR22835:SF115. 1 hit.
    PfamiPF01363. FYVE. 1 hit.
    [Graphical view]
    SMARTiSM00064. FYVE. 1 hit.
    [Graphical view]
    SUPFAMiSSF57903. SSF57903. 1 hit.
    PROSITEiPS50178. ZF_FYVE. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q68DK2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNHPFGKEEA ASQKQLFGFF CECLRRGEWE LAQACVPQLQ EGQGDIPKRV     50
    EDILQALVVC PNLLRCGQDI NPQRVAWVWL LVLEKWLARE KKLLPVVFRR 100
    KLEFLLLSED LQGDIPENIL EELYETLTQG AVGHVPDGNP RRESWTPRLS 150
    SEAVSVLWDL LRQSPQPAQA LLELLLEEDD GTGLCHWPLQ NALVDLIRKA 200
    LRALQGPDSV PPGVVDAIYG ALRTLRCPAE PLGVELHLLC EELLEACRTE 250
    GSPLREERLL SCLLHKASRG LLSLYGHTYA EKVTEKPPRA TASGKVSPDH 300
    LDPERAMLAL FSNPNPAEAW KVAYFYCLSN NKHFLEQILV TALTLLKEED 350
    FPNLGCLLDR EFRPLSCLLV LLGWTHCQSL ESAKRLLQTL HRTQGPGCDE 400
    LLRDACDGLW AHLEVLEWCI QQSSNPIPKR DLLYHLHGGD SHSVLYTLHH 450
    LTNLPALREE DVLKLLQKVP AKDPQQEPDA VDAPVPEHLS QCQNLTLYQG 500
    FCAMKYAIYA LCVNSHQHSQ CQDCKDSLSE DLASATEPAN DSLSSPGAAN 550
    LFSTYLARCQ QYLCSIPDSL CLELLENIFS LLLITSADLH PEPHLPEDYA 600
    EDDDIEGKSP SGLRSPSESP QHIAHPERKS ERGSLGVPKT LAYTMPSHVK 650
    AEPKDSYPGP HRHSFLDLKH FTSGISGFLA DEFAIGAFLR LLQEQLDEIS 700
    SRSPPEKPKQ ESQSCSGSRD GLQSRLHRLS KVVSEAQWRH KVVTSNHRSE 750
    EQPSRRYQPA TRHPSLRRGR RTRRSQADGR DRGSNPSLES TSSELSTSTS 800
    EGSLSAMSGR NELHSRLHPH PQSSLIPMMF SPPESLLASC ILRGNFAEAH 850
    QVLFTFNLKS SPSSGELMFM ERYQEVIQEL AQVEHKIENQ NSDAGSSTIR 900
    RTGSGRSTLQ AIGSAAAAGM VFYSISDVTD KLLNTSGDPI PMLQEDFWIS 950
    TALVEPTAPL REVLEDLSPP AMAAFDLACS QCQLWKTCKQ LLETAERRLN 1000
    SSLERRGRRI DHVLLNADGI RGFPVVLQQI SKSLNYLLMS ASQTKSESVE 1050
    EKGGGPPRCS ITELLQMCWP SLSEDCVASH TTLSQQLDQV LQSLREALEL 1100
    PEPRTPPLSS LVEQAAQKAP EAEAHPVQIQ TQLLQKNLGK QTPSGSRQMD 1150
    YLGTFFSYCS TLAAVLLQSL SSEPDHVEVK VGNPFVLLQQ SSSQLVSHLL 1200
    FERQVPPERL AALLAQENLS LSVPQVIVSC CCEPLALCSS RQSQQTSSLL 1250
    TRLGTLAQLH ASHCLDDLPL STPSSPRTTE NPTLERKPYS SPRDSSLPAL 1300
    TSSALAFLKS RSKLLATVAC LGASPRLKVS KPSLSWKELR GRREVPLAAE 1350
    QVARECERLL EQFPLFEAFL LAAWEPLRGS LQQGQSLAVN LCGWASLSTV 1400
    LLGLHSPIAL DVLSEAFEES LVARDWSRAL QLTEVYGRDV DDLSSIKDAV 1450
    LSCAVACDKE GWQYLFPVKD ASLRSRLALQ FVDRWPLESC LEILAYCISD 1500
    TAVQEGLKCE LQRKLAELQV YQKILGLQSP PVWCDWQTLR SCCVEDPSTV 1550
    MNMILEAQEY ELCEEWGCLY PIPREHLISL HQKHLLHLLE RRDHDKALQL 1600
    LRRIPDPTMC LEVTEQSLDQ HTSLATSHFL ANYLTTHFYG QLTAVRHREI 1650
    QALYVGSKIL LTLPEQHRAS YSHLSSNPLF MLEQLLMNMK VDWATVAVQT 1700
    LQQLLVGQEI GFTMDEVDSL LSRYAEKALD FPYPQREKRS DSVIHLQEIV 1750
    HQAADPETLP RSPSAEFSPA APPGISSIHS PSLRERSFPP TQPSQEFVPP 1800
    ATPPARHQWV PDETESICMV CCREHFTMFN RRHHCRRCGR LVCSSCSTKK 1850
    MVVEGCRENP ARVCDQCYSY CNKDVPEEPS EKPEALDSSK SESPPYSFVV 1900
    RVPKADEVEW ILDLKEEENE LVRSEFYYEQ APSASLCIAI LNLHRDSIAC 1950
    GHQLIEHCCR LSKGLTNPEV DAGLLTDIMK QLLFSAKMMF VKAGQSQDLA 2000
    LCDSYISKVD VLNILVAAAY RHVPSLDQIL QPAAVTRLRN QLLEAEYYQL 2050
    GVEVSTKTGL DTTGAWHAWG MACLKAGNLT AAREKFSRCL KPPFDLNQLN 2100
    HGSRLVQDVV EYLESTVRPF VSLQDDDYFA TLRELEATLR TQSLSLAVIP 2150
    EGKIMNNTYY QECLFYLHNY STNLAIISFY VRHSCLREAL LHLLNKESPP 2200
    EVFIEGIFQP SYKSGKLHTL ENLLESIDPT LESWGKYLIA ACQHLQKKNY 2250
    YHILYELQQF MKDQVRAAMT CIRFFSHKAK SYTELGEKLS WLLKAKDHLK 2300
    IYLQETSRSS GRKKTTFFRK KMTAADVSRH MNTLQLQMEV TRFLHRCESA 2350
    GTSQITTLPL PTLFGNNHMK MDVACKVMLG GKNVEDGFGI AFRVLQDFQL 2400
    DAAMTYCRAA RQLVEKEKYS EIQQLLKCVS ESGMAAKSDG DTILLNCLEA 2450
    FKRIPPQELE GLIQAIHNDD NKVRAYLICC KLRSAYLIAV KQEHSRATAL 2500
    VQQVQQAAKS SGDAVVQDIC AQWLLTSHPR GAHGPGSRK 2539
    Length:2,539
    Mass (Da):284,576
    Last modified:May 18, 2010 - v3
    Checksum:i991862A89C8581F1
    GO
    Isoform 2 (identifier: Q68DK2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         203-223: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:2,518
    Mass (Da):282,499
    Checksum:i922EDB05E118C1DA
    GO
    Isoform 4 (identifier: Q68DK2-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         778-791: DGRDRGSNPSLEST → GNLKSSFPCTRQVV
         792-2539: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:791
    Mass (Da):88,820
    Checksum:i380D3A84F74C1023
    GO
    Isoform 3 (identifier: Q68DK2-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1809: Missing.
         1810-1828: VPDETESICMVCCREHFTM → MAISPSLLPLSSPPDGIPQ
         2473-2539: VRAYLICCKL...RGAHGPGSRK → IVPILAALRDRVHTEERGRSPSTLC

    Note: No experimental confirmation available.

    Show »
    Length:688
    Mass (Da):77,970
    Checksum:i2229E6E433962E5B
    GO

    Sequence cautioni

    The sequence BAG11658.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence CAD97882.1 differs from that shown. Reason: Erroneous termination at position 1463. Translated as Gln.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti243 – 2431L → P in CAD97882. (PubMed:17974005)Curated
    Sequence conflicti556 – 5561L → P in BAG11658. (PubMed:9205841)Curated
    Sequence conflicti586 – 5861S → P in CAH18131. (PubMed:17974005)Curated
    Sequence conflicti629 – 6291K → E in CAH18131. (PubMed:17974005)Curated
    Sequence conflicti946 – 9461D → G in CAH18218. (PubMed:17974005)Curated
    Sequence conflicti1040 – 10401S → T in BAG11658. (PubMed:9205841)Curated
    Sequence conflicti1115 – 11151A → T in CAH18131. (PubMed:17974005)Curated
    Sequence conflicti1320 – 13201C → S in CAH18218. (PubMed:17974005)Curated
    Sequence conflicti1358 – 13581R → H in CAH18131. (PubMed:17974005)Curated
    Sequence conflicti1556 – 15561E → V in CAH18131. (PubMed:17974005)Curated
    Sequence conflicti1597 – 15971A → T in CAH10379. (PubMed:17974005)Curated
    Sequence conflicti1615 – 16151E → K in CAH10379. (PubMed:17974005)Curated
    Sequence conflicti1670 – 16701S → N in CAH18218. (PubMed:17974005)Curated
    Sequence conflicti1727 – 17271K → R in CAH10379. (PubMed:17974005)Curated
    Sequence conflicti1774 – 17741G → D in CAD97882. (PubMed:17974005)Curated
    Sequence conflicti2246 – 22461Q → L in CAH18131. (PubMed:17974005)Curated
    Sequence conflicti2288 – 22881K → R in CAD97882. (PubMed:17974005)Curated
    Sequence conflicti2434 – 24341M → L in AAH33235. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti429 – 4291K → E.
    Corresponds to variant rs34059852 [ dbSNP | Ensembl ].
    VAR_037987
    Natural varianti898 – 8981T → S.
    Corresponds to variant rs17192170 [ dbSNP | Ensembl ].
    VAR_037988
    Natural varianti951 – 9511T → M.
    Corresponds to variant rs35471427 [ dbSNP | Ensembl ].
    VAR_037989
    Natural varianti1071 – 10711S → N.
    Corresponds to variant rs7156206 [ dbSNP | Ensembl ].
    VAR_037990
    Natural varianti1103 – 11031P → L.1 Publication
    Corresponds to variant rs3742885 [ dbSNP | Ensembl ].
    VAR_037991
    Natural varianti1122 – 11221A → V.
    Corresponds to variant rs3742884 [ dbSNP | Ensembl ].
    VAR_037992
    Natural varianti1164 – 11641A → E in a breast cancer sample; somatic mutation. 1 Publication
    VAR_037993
    Natural varianti1457 – 14571C → Y.2 Publications
    Corresponds to variant rs2235967 [ dbSNP | Ensembl ].
    VAR_037994
    Natural varianti1891 – 18911S → N.2 Publications
    Corresponds to variant rs3742883 [ dbSNP | Ensembl ].
    VAR_037995
    Natural varianti1945 – 19451R → Q in a breast cancer sample; somatic mutation. 1 Publication
    VAR_037996
    Natural varianti2411 – 24111R → H.
    Corresponds to variant rs34373049 [ dbSNP | Ensembl ].
    VAR_037997

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 18091809Missing in isoform 3. 1 PublicationVSP_030338Add
    BLAST
    Alternative sequencei203 – 22321Missing in isoform 2. 1 PublicationVSP_030339Add
    BLAST
    Alternative sequencei778 – 79114DGRDR…SLEST → GNLKSSFPCTRQVV in isoform 4. 1 PublicationVSP_041049Add
    BLAST
    Alternative sequencei792 – 25391748Missing in isoform 4. 1 PublicationVSP_041050Add
    BLAST
    Alternative sequencei1810 – 182819VPDET…EHFTM → MAISPSLLPLSSPPDGIPQ in isoform 3. 1 PublicationVSP_030340Add
    BLAST
    Alternative sequencei2473 – 253967VRAYL…PGSRK → IVPILAALRDRVHTEERGRS PSTLC in isoform 3. 1 PublicationVSP_030341Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB002319 mRNA. Translation: BAA20779.1.
    AB425197 mRNA. Translation: BAG11658.1. Different initiation.
    AK304428 mRNA. Translation: BAG65255.1.
    AK128496 mRNA. Translation: BAC87467.1.
    BX537886 mRNA. Translation: CAD97882.1. Sequence problems.
    BX538025 mRNA. Translation: CAD97971.1.
    BX648683 mRNA. Translation: CAH10379.1.
    CR749276 mRNA. Translation: CAH18131.1.
    CR749365 mRNA. Translation: CAH18218.1.
    AL049779 Genomic DNA. No translation available.
    AL121595 Genomic DNA. No translation available.
    CH471061 Genomic DNA. Translation: EAW80954.1.
    BC033235 mRNA. Translation: AAH33235.2.
    CCDSiCCDS9788.1. [Q68DK2-1]
    RefSeqiNP_056161.2. NM_015346.3.
    UniGeneiHs.98041.

    Genome annotation databases

    EnsembliENST00000347230; ENSP00000251119; ENSG00000072121.
    GeneIDi23503.
    KEGGihsa:23503.
    UCSCiuc001xka.2. human. [Q68DK2-1]
    uc010tta.2. human. [Q68DK2-4]

    Polymorphism databases

    DMDMi296453077.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB002319 mRNA. Translation: BAA20779.1 .
    AB425197 mRNA. Translation: BAG11658.1 . Different initiation.
    AK304428 mRNA. Translation: BAG65255.1 .
    AK128496 mRNA. Translation: BAC87467.1 .
    BX537886 mRNA. Translation: CAD97882.1 . Sequence problems.
    BX538025 mRNA. Translation: CAD97971.1 .
    BX648683 mRNA. Translation: CAH10379.1 .
    CR749276 mRNA. Translation: CAH18131.1 .
    CR749365 mRNA. Translation: CAH18218.1 .
    AL049779 Genomic DNA. No translation available.
    AL121595 Genomic DNA. No translation available.
    CH471061 Genomic DNA. Translation: EAW80954.1 .
    BC033235 mRNA. Translation: AAH33235.2 .
    CCDSi CCDS9788.1. [Q68DK2-1 ]
    RefSeqi NP_056161.2. NM_015346.3.
    UniGenei Hs.98041.

    3D structure databases

    ProteinModelPortali Q68DK2.
    SMRi Q68DK2. Positions 1809-1868.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117050. 1 interaction.
    IntActi Q68DK2. 2 interactions.
    STRINGi 9606.ENSP00000251119.

    PTM databases

    PhosphoSitei Q68DK2.

    Polymorphism databases

    DMDMi 296453077.

    Proteomic databases

    MaxQBi Q68DK2.
    PaxDbi Q68DK2.
    PRIDEi Q68DK2.

    Protocols and materials databases

    DNASUi 23503.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000347230 ; ENSP00000251119 ; ENSG00000072121 .
    GeneIDi 23503.
    KEGGi hsa:23503.
    UCSCi uc001xka.2. human. [Q68DK2-1 ]
    uc010tta.2. human. [Q68DK2-4 ]

    Organism-specific databases

    CTDi 23503.
    GeneCardsi GC14M068194.
    H-InvDB HIX0011757.
    HGNCi HGNC:20761. ZFYVE26.
    HPAi HPA055500.
    MIMi 270700. phenotype.
    612012. gene.
    neXtProti NX_Q68DK2.
    Orphaneti 100996. Autosomal recessive spastic paraplegia type 15.
    PharmGKBi PA134904455.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG247110.
    HOVERGENi HBG108766.
    InParanoidi Q68DK2.
    OrthoDBi EOG776SP2.
    PhylomeDBi Q68DK2.
    TreeFami TF324517.

    Miscellaneous databases

    ChiTaRSi ZFYVE26. human.
    GenomeRNAii 23503.
    NextBioi 45881.
    PROi Q68DK2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q68DK2.
    Bgeei Q68DK2.
    CleanExi HS_ZFYVE26.
    Genevestigatori Q68DK2.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR028730. ZFYVE26.
    IPR000306. Znf_FYVE.
    IPR017455. Znf_FYVE-rel.
    IPR011011. Znf_FYVE_PHD.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    PANTHERi PTHR22835:SF115. PTHR22835:SF115. 1 hit.
    Pfami PF01363. FYVE. 1 hit.
    [Graphical view ]
    SMARTi SM00064. FYVE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57903. SSF57903. 1 hit.
    PROSITEi PS50178. ZF_FYVE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS TYR-1457 AND ASN-1891.
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
      Tissue: Trachea.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS LEU-1103; TYR-1457 AND ASN-1891.
      Tissue: Cervix, Endometrial adenocarcinoma and Fetal kidney.
    4. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2057-2539.
      Tissue: Brain.
    7. "Identification of the SPG15 gene, encoding spastizin, as a frequent cause of complicated autosomal-recessive spastic paraplegia, including Kjellin syndrome."
      Hanein S., Martin E., Boukhris A., Byrne P., Goizet C., Hamri A., Benomar A., Lossos A., Denora P., Fernandez J., Elleuch N., Forlani S., Durr A., Feki I., Hutchinson M., Santorelli F.M., Mhiri C., Brice A., Stevanin G.
      Am. J. Hum. Genet. 82:992-1002(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN SPG15, TISSUE SPECIFICITY.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Spastic paraplegia with thinning of the corpus callosum and white matter abnormalities: further mutations and relative frequency in ZFYVE26/SPG15 in the Italian population."
      Denora P.S., Muglia M., Casali C., Truchetto J., Silvestri G., Messina D., Boukrhis A., Magariello A., Modoni A., Masciullo M., Malandrini A., Morelli M., de Leva M.F., Villanova M., Giugni E., Citrigno L., Rizza T., Federico A.
      , Pierallini A., Quattrone A., Filla A., Brice A., Stevanin G., Santorelli F.M.
      J. Neurol. Sci. 277:22-25(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN SPG15.
    10. Cited for: INVOLVEMENT IN SPG15.
    11. "PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody."
      Sagona A.P., Nezis I.P., Pedersen N.M., Liestol K., Poulton J., Rusten T.E., Skotheim R.I., Raiborg C., Stenmark H.
      Nat. Cell Biol. 12:362-371(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHATIDYLINOSITOL 3-PHOSPHATE-BINDING, DOMAIN FYVE-TYPE ZINC-FINGER, INTERACTION WITH TTC19 AND KIF13A, MUTAGENESIS OF ARG-1836.
    12. Cited for: POSSIBLE FUNCTION, INTERACTION WITH AP5Z1; AP5B1; AP5S1 AND SPG11.
    13. Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLU-1164 AND GLN-1945.

    Entry informationi

    Entry nameiZFY26_HUMAN
    AccessioniPrimary (citable) accession number: Q68DK2
    Secondary accession number(s): B1B5Y3
    , B4E2U3, O15035, Q68DT9, Q6AW90, Q6ZR50, Q7Z3A4, Q7Z3I1, Q8N4W7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 92 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3