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Q68DK2

- ZFY26_HUMAN

UniProt

Q68DK2 - ZFY26_HUMAN

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Protein

Zinc finger FYVE domain-containing protein 26

Gene

ZFYVE26

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1812 – 187261FYVE-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphatidylinositol-3-phosphate binding Source: UniProtKB

GO - Biological processi

  1. cell death Source: UniProtKB-KW
  2. cytokinesis Source: UniProtKB
  3. double-strand break repair via homologous recombination Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA repair

Keywords - Ligandi

Lipid-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger FYVE domain-containing protein 26
Alternative name(s):
FYVE domain-containing centrosomal protein
Short name:
FYVE-CENT
Spastizin
Gene namesi
Name:ZFYVE26
Synonyms:KIAA0321
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:20761. ZFYVE26.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosome 1 Publication. Midbody 1 Publication
Note: Localizes to the centrosome during all stages of the cell cycle. Recruited to the midbody during cytokinesis by KIF13A.

GO - Cellular componenti

  1. centrosome Source: UniProtKB
  2. lysosomal membrane Source: UniProtKB
  3. midbody Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

Spastic paraplegia 15, autosomal recessive (SPG15) [MIM:270700]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG15 is a complex form associated with additional neurological symptoms such as cognitive deterioration or mental retardation, axonal neuropathy, mild cerebellar signs, and, less frequently, a central hearing deficit, decreased visual acuity, or retinal degeneration.3 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1836 – 18361R → A: Abolishes phosphatidylinositol 3-phosphate-binding and localization to the midbody. 1 Publication

Keywords - Diseasei

Hereditary spastic paraplegia, Neurodegeneration

Organism-specific databases

MIMi270700. phenotype.
Orphaneti100996. Autosomal recessive spastic paraplegia type 15.
PharmGKBiPA134904455.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 25392539Zinc finger FYVE domain-containing protein 26PRO_0000314612Add
BLAST

Proteomic databases

MaxQBiQ68DK2.
PaxDbiQ68DK2.
PRIDEiQ68DK2.

PTM databases

PhosphoSiteiQ68DK2.

Expressioni

Tissue specificityi

Strongest expression in the adrenal gland, bone marrow, adult brain, fetal brain, lung, placenta, prostate, skeletal muscle, testis, thymus, and retina. Intermediate levels are detected in other structures, including the spinal cord.1 Publication

Gene expression databases

BgeeiQ68DK2.
CleanExiHS_ZFYVE26.
ExpressionAtlasiQ68DK2. baseline and differential.
GenevestigatoriQ68DK2.

Organism-specific databases

HPAiHPA055500.

Interactioni

Subunit structurei

Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with TTC19 and KIF13A.2 Publications

Protein-protein interaction databases

BioGridi117050. 1 interaction.
IntActiQ68DK2. 2 interactions.
STRINGi9606.ENSP00000251119.

Structurei

3D structure databases

ProteinModelPortaliQ68DK2.
SMRiQ68DK2. Positions 1809-1868.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili868 – 89528Sequence AnalysisAdd
BLAST

Domaini

The FYVE-type zinc finger mediates binding to phosphatidylinositol 3-phosphate and recruitment to the midbody during cytokinesis.1 Publication

Sequence similaritiesi

Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1812 – 187261FYVE-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG247110.
HOVERGENiHBG108766.
InParanoidiQ68DK2.
OrthoDBiEOG776SP2.
PhylomeDBiQ68DK2.
TreeFamiTF324517.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR028730. ZFYVE26.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR22835:SF115. PTHR22835:SF115. 1 hit.
PfamiPF01363. FYVE. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q68DK2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNHPFGKEEA ASQKQLFGFF CECLRRGEWE LAQACVPQLQ EGQGDIPKRV
60 70 80 90 100
EDILQALVVC PNLLRCGQDI NPQRVAWVWL LVLEKWLARE KKLLPVVFRR
110 120 130 140 150
KLEFLLLSED LQGDIPENIL EELYETLTQG AVGHVPDGNP RRESWTPRLS
160 170 180 190 200
SEAVSVLWDL LRQSPQPAQA LLELLLEEDD GTGLCHWPLQ NALVDLIRKA
210 220 230 240 250
LRALQGPDSV PPGVVDAIYG ALRTLRCPAE PLGVELHLLC EELLEACRTE
260 270 280 290 300
GSPLREERLL SCLLHKASRG LLSLYGHTYA EKVTEKPPRA TASGKVSPDH
310 320 330 340 350
LDPERAMLAL FSNPNPAEAW KVAYFYCLSN NKHFLEQILV TALTLLKEED
360 370 380 390 400
FPNLGCLLDR EFRPLSCLLV LLGWTHCQSL ESAKRLLQTL HRTQGPGCDE
410 420 430 440 450
LLRDACDGLW AHLEVLEWCI QQSSNPIPKR DLLYHLHGGD SHSVLYTLHH
460 470 480 490 500
LTNLPALREE DVLKLLQKVP AKDPQQEPDA VDAPVPEHLS QCQNLTLYQG
510 520 530 540 550
FCAMKYAIYA LCVNSHQHSQ CQDCKDSLSE DLASATEPAN DSLSSPGAAN
560 570 580 590 600
LFSTYLARCQ QYLCSIPDSL CLELLENIFS LLLITSADLH PEPHLPEDYA
610 620 630 640 650
EDDDIEGKSP SGLRSPSESP QHIAHPERKS ERGSLGVPKT LAYTMPSHVK
660 670 680 690 700
AEPKDSYPGP HRHSFLDLKH FTSGISGFLA DEFAIGAFLR LLQEQLDEIS
710 720 730 740 750
SRSPPEKPKQ ESQSCSGSRD GLQSRLHRLS KVVSEAQWRH KVVTSNHRSE
760 770 780 790 800
EQPSRRYQPA TRHPSLRRGR RTRRSQADGR DRGSNPSLES TSSELSTSTS
810 820 830 840 850
EGSLSAMSGR NELHSRLHPH PQSSLIPMMF SPPESLLASC ILRGNFAEAH
860 870 880 890 900
QVLFTFNLKS SPSSGELMFM ERYQEVIQEL AQVEHKIENQ NSDAGSSTIR
910 920 930 940 950
RTGSGRSTLQ AIGSAAAAGM VFYSISDVTD KLLNTSGDPI PMLQEDFWIS
960 970 980 990 1000
TALVEPTAPL REVLEDLSPP AMAAFDLACS QCQLWKTCKQ LLETAERRLN
1010 1020 1030 1040 1050
SSLERRGRRI DHVLLNADGI RGFPVVLQQI SKSLNYLLMS ASQTKSESVE
1060 1070 1080 1090 1100
EKGGGPPRCS ITELLQMCWP SLSEDCVASH TTLSQQLDQV LQSLREALEL
1110 1120 1130 1140 1150
PEPRTPPLSS LVEQAAQKAP EAEAHPVQIQ TQLLQKNLGK QTPSGSRQMD
1160 1170 1180 1190 1200
YLGTFFSYCS TLAAVLLQSL SSEPDHVEVK VGNPFVLLQQ SSSQLVSHLL
1210 1220 1230 1240 1250
FERQVPPERL AALLAQENLS LSVPQVIVSC CCEPLALCSS RQSQQTSSLL
1260 1270 1280 1290 1300
TRLGTLAQLH ASHCLDDLPL STPSSPRTTE NPTLERKPYS SPRDSSLPAL
1310 1320 1330 1340 1350
TSSALAFLKS RSKLLATVAC LGASPRLKVS KPSLSWKELR GRREVPLAAE
1360 1370 1380 1390 1400
QVARECERLL EQFPLFEAFL LAAWEPLRGS LQQGQSLAVN LCGWASLSTV
1410 1420 1430 1440 1450
LLGLHSPIAL DVLSEAFEES LVARDWSRAL QLTEVYGRDV DDLSSIKDAV
1460 1470 1480 1490 1500
LSCAVACDKE GWQYLFPVKD ASLRSRLALQ FVDRWPLESC LEILAYCISD
1510 1520 1530 1540 1550
TAVQEGLKCE LQRKLAELQV YQKILGLQSP PVWCDWQTLR SCCVEDPSTV
1560 1570 1580 1590 1600
MNMILEAQEY ELCEEWGCLY PIPREHLISL HQKHLLHLLE RRDHDKALQL
1610 1620 1630 1640 1650
LRRIPDPTMC LEVTEQSLDQ HTSLATSHFL ANYLTTHFYG QLTAVRHREI
1660 1670 1680 1690 1700
QALYVGSKIL LTLPEQHRAS YSHLSSNPLF MLEQLLMNMK VDWATVAVQT
1710 1720 1730 1740 1750
LQQLLVGQEI GFTMDEVDSL LSRYAEKALD FPYPQREKRS DSVIHLQEIV
1760 1770 1780 1790 1800
HQAADPETLP RSPSAEFSPA APPGISSIHS PSLRERSFPP TQPSQEFVPP
1810 1820 1830 1840 1850
ATPPARHQWV PDETESICMV CCREHFTMFN RRHHCRRCGR LVCSSCSTKK
1860 1870 1880 1890 1900
MVVEGCRENP ARVCDQCYSY CNKDVPEEPS EKPEALDSSK SESPPYSFVV
1910 1920 1930 1940 1950
RVPKADEVEW ILDLKEEENE LVRSEFYYEQ APSASLCIAI LNLHRDSIAC
1960 1970 1980 1990 2000
GHQLIEHCCR LSKGLTNPEV DAGLLTDIMK QLLFSAKMMF VKAGQSQDLA
2010 2020 2030 2040 2050
LCDSYISKVD VLNILVAAAY RHVPSLDQIL QPAAVTRLRN QLLEAEYYQL
2060 2070 2080 2090 2100
GVEVSTKTGL DTTGAWHAWG MACLKAGNLT AAREKFSRCL KPPFDLNQLN
2110 2120 2130 2140 2150
HGSRLVQDVV EYLESTVRPF VSLQDDDYFA TLRELEATLR TQSLSLAVIP
2160 2170 2180 2190 2200
EGKIMNNTYY QECLFYLHNY STNLAIISFY VRHSCLREAL LHLLNKESPP
2210 2220 2230 2240 2250
EVFIEGIFQP SYKSGKLHTL ENLLESIDPT LESWGKYLIA ACQHLQKKNY
2260 2270 2280 2290 2300
YHILYELQQF MKDQVRAAMT CIRFFSHKAK SYTELGEKLS WLLKAKDHLK
2310 2320 2330 2340 2350
IYLQETSRSS GRKKTTFFRK KMTAADVSRH MNTLQLQMEV TRFLHRCESA
2360 2370 2380 2390 2400
GTSQITTLPL PTLFGNNHMK MDVACKVMLG GKNVEDGFGI AFRVLQDFQL
2410 2420 2430 2440 2450
DAAMTYCRAA RQLVEKEKYS EIQQLLKCVS ESGMAAKSDG DTILLNCLEA
2460 2470 2480 2490 2500
FKRIPPQELE GLIQAIHNDD NKVRAYLICC KLRSAYLIAV KQEHSRATAL
2510 2520 2530
VQQVQQAAKS SGDAVVQDIC AQWLLTSHPR GAHGPGSRK
Length:2,539
Mass (Da):284,576
Last modified:May 18, 2010 - v3
Checksum:i991862A89C8581F1
GO
Isoform 2 (identifier: Q68DK2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     203-223: Missing.

Note: No experimental confirmation available.

Show »
Length:2,518
Mass (Da):282,499
Checksum:i922EDB05E118C1DA
GO
Isoform 4 (identifier: Q68DK2-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     778-791: DGRDRGSNPSLEST → GNLKSSFPCTRQVV
     792-2539: Missing.

Note: No experimental confirmation available.

Show »
Length:791
Mass (Da):88,820
Checksum:i380D3A84F74C1023
GO
Isoform 3 (identifier: Q68DK2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1809: Missing.
     1810-1828: VPDETESICMVCCREHFTM → MAISPSLLPLSSPPDGIPQ
     2473-2539: VRAYLICCKL...RGAHGPGSRK → IVPILAALRDRVHTEERGRSPSTLC

Note: No experimental confirmation available.

Show »
Length:688
Mass (Da):77,970
Checksum:i2229E6E433962E5B
GO

Sequence cautioni

The sequence BAG11658.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence CAD97882.1 differs from that shown. Reason: Erroneous termination at position 1463. Translated as Gln.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti243 – 2431L → P in CAD97882. (PubMed:17974005)Curated
Sequence conflicti556 – 5561L → P in BAG11658. (PubMed:9205841)Curated
Sequence conflicti586 – 5861S → P in CAH18131. (PubMed:17974005)Curated
Sequence conflicti629 – 6291K → E in CAH18131. (PubMed:17974005)Curated
Sequence conflicti946 – 9461D → G in CAH18218. (PubMed:17974005)Curated
Sequence conflicti1040 – 10401S → T in BAG11658. (PubMed:9205841)Curated
Sequence conflicti1115 – 11151A → T in CAH18131. (PubMed:17974005)Curated
Sequence conflicti1320 – 13201C → S in CAH18218. (PubMed:17974005)Curated
Sequence conflicti1358 – 13581R → H in CAH18131. (PubMed:17974005)Curated
Sequence conflicti1556 – 15561E → V in CAH18131. (PubMed:17974005)Curated
Sequence conflicti1597 – 15971A → T in CAH10379. (PubMed:17974005)Curated
Sequence conflicti1615 – 16151E → K in CAH10379. (PubMed:17974005)Curated
Sequence conflicti1670 – 16701S → N in CAH18218. (PubMed:17974005)Curated
Sequence conflicti1727 – 17271K → R in CAH10379. (PubMed:17974005)Curated
Sequence conflicti1774 – 17741G → D in CAD97882. (PubMed:17974005)Curated
Sequence conflicti2246 – 22461Q → L in CAH18131. (PubMed:17974005)Curated
Sequence conflicti2288 – 22881K → R in CAD97882. (PubMed:17974005)Curated
Sequence conflicti2434 – 24341M → L in AAH33235. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti429 – 4291K → E.
Corresponds to variant rs34059852 [ dbSNP | Ensembl ].
VAR_037987
Natural varianti898 – 8981T → S.
Corresponds to variant rs17192170 [ dbSNP | Ensembl ].
VAR_037988
Natural varianti951 – 9511T → M.
Corresponds to variant rs35471427 [ dbSNP | Ensembl ].
VAR_037989
Natural varianti1071 – 10711S → N.
Corresponds to variant rs7156206 [ dbSNP | Ensembl ].
VAR_037990
Natural varianti1103 – 11031P → L.1 Publication
Corresponds to variant rs3742885 [ dbSNP | Ensembl ].
VAR_037991
Natural varianti1122 – 11221A → V.
Corresponds to variant rs3742884 [ dbSNP | Ensembl ].
VAR_037992
Natural varianti1164 – 11641A → E in a breast cancer sample; somatic mutation. 1 Publication
VAR_037993
Natural varianti1457 – 14571C → Y.2 Publications
Corresponds to variant rs2235967 [ dbSNP | Ensembl ].
VAR_037994
Natural varianti1891 – 18911S → N.2 Publications
Corresponds to variant rs3742883 [ dbSNP | Ensembl ].
VAR_037995
Natural varianti1945 – 19451R → Q in a breast cancer sample; somatic mutation. 1 Publication
VAR_037996
Natural varianti2411 – 24111R → H.
Corresponds to variant rs34373049 [ dbSNP | Ensembl ].
VAR_037997

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 18091809Missing in isoform 3. 1 PublicationVSP_030338Add
BLAST
Alternative sequencei203 – 22321Missing in isoform 2. 1 PublicationVSP_030339Add
BLAST
Alternative sequencei778 – 79114DGRDR…SLEST → GNLKSSFPCTRQVV in isoform 4. 1 PublicationVSP_041049Add
BLAST
Alternative sequencei792 – 25391748Missing in isoform 4. 1 PublicationVSP_041050Add
BLAST
Alternative sequencei1810 – 182819VPDET…EHFTM → MAISPSLLPLSSPPDGIPQ in isoform 3. 1 PublicationVSP_030340Add
BLAST
Alternative sequencei2473 – 253967VRAYL…PGSRK → IVPILAALRDRVHTEERGRS PSTLC in isoform 3. 1 PublicationVSP_030341Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB002319 mRNA. Translation: BAA20779.1.
AB425197 mRNA. Translation: BAG11658.1. Different initiation.
AK304428 mRNA. Translation: BAG65255.1.
AK128496 mRNA. Translation: BAC87467.1.
BX537886 mRNA. Translation: CAD97882.1. Sequence problems.
BX538025 mRNA. Translation: CAD97971.1.
BX648683 mRNA. Translation: CAH10379.1.
CR749276 mRNA. Translation: CAH18131.1.
CR749365 mRNA. Translation: CAH18218.1.
AL049779 Genomic DNA. No translation available.
AL121595 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW80954.1.
BC033235 mRNA. Translation: AAH33235.2.
CCDSiCCDS9788.1. [Q68DK2-1]
RefSeqiNP_056161.2. NM_015346.3.
UniGeneiHs.98041.

Genome annotation databases

EnsembliENST00000347230; ENSP00000251119; ENSG00000072121.
GeneIDi23503.
KEGGihsa:23503.
UCSCiuc001xka.2. human. [Q68DK2-1]
uc010tta.2. human. [Q68DK2-4]

Polymorphism databases

DMDMi296453077.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB002319 mRNA. Translation: BAA20779.1 .
AB425197 mRNA. Translation: BAG11658.1 . Different initiation.
AK304428 mRNA. Translation: BAG65255.1 .
AK128496 mRNA. Translation: BAC87467.1 .
BX537886 mRNA. Translation: CAD97882.1 . Sequence problems.
BX538025 mRNA. Translation: CAD97971.1 .
BX648683 mRNA. Translation: CAH10379.1 .
CR749276 mRNA. Translation: CAH18131.1 .
CR749365 mRNA. Translation: CAH18218.1 .
AL049779 Genomic DNA. No translation available.
AL121595 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW80954.1 .
BC033235 mRNA. Translation: AAH33235.2 .
CCDSi CCDS9788.1. [Q68DK2-1 ]
RefSeqi NP_056161.2. NM_015346.3.
UniGenei Hs.98041.

3D structure databases

ProteinModelPortali Q68DK2.
SMRi Q68DK2. Positions 1809-1868.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117050. 1 interaction.
IntActi Q68DK2. 2 interactions.
STRINGi 9606.ENSP00000251119.

PTM databases

PhosphoSitei Q68DK2.

Polymorphism databases

DMDMi 296453077.

Proteomic databases

MaxQBi Q68DK2.
PaxDbi Q68DK2.
PRIDEi Q68DK2.

Protocols and materials databases

DNASUi 23503.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000347230 ; ENSP00000251119 ; ENSG00000072121 .
GeneIDi 23503.
KEGGi hsa:23503.
UCSCi uc001xka.2. human. [Q68DK2-1 ]
uc010tta.2. human. [Q68DK2-4 ]

Organism-specific databases

CTDi 23503.
GeneCardsi GC14M068194.
H-InvDB HIX0011757.
HGNCi HGNC:20761. ZFYVE26.
HPAi HPA055500.
MIMi 270700. phenotype.
612012. gene.
neXtProti NX_Q68DK2.
Orphaneti 100996. Autosomal recessive spastic paraplegia type 15.
PharmGKBi PA134904455.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG247110.
HOVERGENi HBG108766.
InParanoidi Q68DK2.
OrthoDBi EOG776SP2.
PhylomeDBi Q68DK2.
TreeFami TF324517.

Miscellaneous databases

ChiTaRSi ZFYVE26. human.
GenomeRNAii 23503.
NextBioi 45881.
PROi Q68DK2.
SOURCEi Search...

Gene expression databases

Bgeei Q68DK2.
CleanExi HS_ZFYVE26.
ExpressionAtlasi Q68DK2. baseline and differential.
Genevestigatori Q68DK2.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR028730. ZFYVE26.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
PANTHERi PTHR22835:SF115. PTHR22835:SF115. 1 hit.
Pfami PF01363. FYVE. 1 hit.
[Graphical view ]
SMARTi SM00064. FYVE. 1 hit.
[Graphical view ]
SUPFAMi SSF57903. SSF57903. 1 hit.
PROSITEi PS50178. ZF_FYVE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS TYR-1457 AND ASN-1891.
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
    Tissue: Trachea.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS LEU-1103; TYR-1457 AND ASN-1891.
    Tissue: Cervix, Endometrial adenocarcinoma and Fetal kidney.
  4. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2057-2539.
    Tissue: Brain.
  7. "Identification of the SPG15 gene, encoding spastizin, as a frequent cause of complicated autosomal-recessive spastic paraplegia, including Kjellin syndrome."
    Hanein S., Martin E., Boukhris A., Byrne P., Goizet C., Hamri A., Benomar A., Lossos A., Denora P., Fernandez J., Elleuch N., Forlani S., Durr A., Feki I., Hutchinson M., Santorelli F.M., Mhiri C., Brice A., Stevanin G.
    Am. J. Hum. Genet. 82:992-1002(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN SPG15, TISSUE SPECIFICITY.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Spastic paraplegia with thinning of the corpus callosum and white matter abnormalities: further mutations and relative frequency in ZFYVE26/SPG15 in the Italian population."
    Denora P.S., Muglia M., Casali C., Truchetto J., Silvestri G., Messina D., Boukrhis A., Magariello A., Modoni A., Masciullo M., Malandrini A., Morelli M., de Leva M.F., Villanova M., Giugni E., Citrigno L., Rizza T., Federico A.
    , Pierallini A., Quattrone A., Filla A., Brice A., Stevanin G., Santorelli F.M.
    J. Neurol. Sci. 277:22-25(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN SPG15.
  10. Cited for: INVOLVEMENT IN SPG15.
  11. "PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody."
    Sagona A.P., Nezis I.P., Pedersen N.M., Liestol K., Poulton J., Rusten T.E., Skotheim R.I., Raiborg C., Stenmark H.
    Nat. Cell Biol. 12:362-371(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHATIDYLINOSITOL 3-PHOSPHATE-BINDING, DOMAIN FYVE-TYPE ZINC-FINGER, INTERACTION WITH TTC19 AND KIF13A, MUTAGENESIS OF ARG-1836.
  12. Cited for: POSSIBLE FUNCTION, INTERACTION WITH AP5Z1; AP5B1; AP5S1 AND SPG11.
  13. Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLU-1164 AND GLN-1945.

Entry informationi

Entry nameiZFY26_HUMAN
AccessioniPrimary (citable) accession number: Q68DK2
Secondary accession number(s): B1B5Y3
, B4E2U3, O15035, Q68DT9, Q6AW90, Q6ZR50, Q7Z3A4, Q7Z3I1, Q8N4W7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3