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Protein

Zinc finger protein 776

Gene

ZNF776

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri208 – 23023C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri236 – 25823C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri264 – 28623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri292 – 31423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri320 – 34223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri348 – 37023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri376 – 39823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri404 – 42623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri432 – 45423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri460 – 48223C2H2-type 10; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri488 – 51023C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 776
Gene namesi
Name:ZNF776
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:26765. ZNF776.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410382.

Polymorphism and mutation databases

BioMutaiZNF776.
DMDMi296453057.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 518518Zinc finger protein 776PRO_0000305140Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki196 – 196Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ68DI1.
MaxQBiQ68DI1.
PaxDbiQ68DI1.
PeptideAtlasiQ68DI1.
PRIDEiQ68DI1.

PTM databases

iPTMnetiQ68DI1.
PhosphoSiteiQ68DI1.

Expressioni

Gene expression databases

BgeeiENSG00000152443.
CleanExiHS_ZNF776.
ExpressionAtlasiQ68DI1. baseline and differential.
GenevisibleiQ68DI1. HS.

Organism-specific databases

HPAiHPA046653.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000321812.

Structurei

3D structure databases

ProteinModelPortaliQ68DI1.
SMRiQ68DI1. Positions 121-511.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 8976KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri208 – 23023C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri236 – 25823C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri264 – 28623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri292 – 31423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri320 – 34223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri348 – 37023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri376 – 39823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri404 – 42623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri432 – 45423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri460 – 48223C2H2-type 10; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri488 – 51023C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ68DI1.
OMAiSHEPFIF.
OrthoDBiEOG091G02KC.
PhylomeDBiQ68DI1.
TreeFamiTF342033.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 10 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68DI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAALRPPA QGTVTFEDVA VNFSQEEWSL LSEAQRCLYH DVMLENLTLI
60 70 80 90 100
SSLGCWYGAK DETPSKQTLS IQQESPLRTH WTGVCTKKVH LWGMCGPLLG
110 120 130 140 150
DILHQGTQHN QKLNGFGAYE KKLDDDANHH QDQKQHIGEK SYRSNAKGTS
160 170 180 190 200
FVKNCKFHMS HEPFIFHEVG KDFLSSLRLL QQEDIHTSGK SNFETKHGIP
210 220 230 240 250
LQGGKTHYIC GESTIPFSNK HSLVLHQRLL PREGPYVCSD SGKFTSKSNS
260 270 280 290 300
FNNHQGVRTG KRPYQCGQCD ESFWYKAHLT EHQRVHTGER PYECGECDKS
310 320 330 340 350
FSHKHSLVDH QRVHTGERPY ECDECGKSFS HKRSLVHHQR VHTGERPYQC
360 370 380 390 400
GECGKSFNHK CNLIQHQRVH TGERPFECTA CGKLFRSNSH LKEHQRVHTG
410 420 430 440 450
ERPYECKECR KSFRYKSHLT EHQRVHTGER PYECRECGKC FHQKGSLIQH
460 470 480 490 500
QQIHSGERPH ECGECGKCFH QKGSLIRHQQ IHSGERPHEC GECGKCFRQK
510
GNLIKHQRVH TGERHHEC
Length:518
Mass (Da):59,613
Last modified:May 18, 2010 - v2
Checksum:i53CD86B2636EE04B
GO

Sequence cautioni

The sequence BAC04588 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence BAC87119 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti183 – 1831E → V in CAH18239 (PubMed:17974005).Curated
Sequence conflicti462 – 4621C → R in CAH18239 (PubMed:17974005).Curated
Sequence conflicti470 – 4701H → R in BAC04588 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR749390 mRNA. Translation: CAH18239.1.
AC003006 Genomic DNA. No translation available.
AK127764 mRNA. Translation: BAC87119.1. Different initiation.
AK095607 mRNA. Translation: BAC04588.1. Sequence problems.
CCDSiCCDS12962.2.
RefSeqiNP_775903.3. NM_173632.3.
UniGeneiHs.720254.
Hs.737521.

Genome annotation databases

EnsembliENST00000317178; ENSP00000321812; ENSG00000152443.
GeneIDi284309.
KEGGihsa:284309.
UCSCiuc002qqa.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR749390 mRNA. Translation: CAH18239.1.
AC003006 Genomic DNA. No translation available.
AK127764 mRNA. Translation: BAC87119.1. Different initiation.
AK095607 mRNA. Translation: BAC04588.1. Sequence problems.
CCDSiCCDS12962.2.
RefSeqiNP_775903.3. NM_173632.3.
UniGeneiHs.720254.
Hs.737521.

3D structure databases

ProteinModelPortaliQ68DI1.
SMRiQ68DI1. Positions 121-511.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000321812.

PTM databases

iPTMnetiQ68DI1.
PhosphoSiteiQ68DI1.

Polymorphism and mutation databases

BioMutaiZNF776.
DMDMi296453057.

Proteomic databases

EPDiQ68DI1.
MaxQBiQ68DI1.
PaxDbiQ68DI1.
PeptideAtlasiQ68DI1.
PRIDEiQ68DI1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317178; ENSP00000321812; ENSG00000152443.
GeneIDi284309.
KEGGihsa:284309.
UCSCiuc002qqa.3. human.

Organism-specific databases

CTDi284309.
GeneCardsiZNF776.
HGNCiHGNC:26765. ZNF776.
HPAiHPA046653.
neXtProtiNX_Q68DI1.
PharmGKBiPA162410382.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ68DI1.
OMAiSHEPFIF.
OrthoDBiEOG091G02KC.
PhylomeDBiQ68DI1.
TreeFamiTF342033.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF776. human.
GenomeRNAii284309.
PROiQ68DI1.

Gene expression databases

BgeeiENSG00000152443.
CleanExiHS_ZNF776.
ExpressionAtlasiQ68DI1. baseline and differential.
GenevisibleiQ68DI1. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 10 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN776_HUMAN
AccessioniPrimary (citable) accession number: Q68DI1
Secondary accession number(s): Q6ZS36, Q8N968
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: May 18, 2010
Last modified: September 7, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.