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Protein

Zinc finger protein 776

Gene

ZNF776

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri208 – 230C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri236 – 258C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri264 – 286C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri292 – 314C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri320 – 342C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri348 – 370C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri376 – 398C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri404 – 426C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri432 – 454C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri460 – 482C2H2-type 10; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri488 – 510C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 776
Gene namesi
Name:ZNF776
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000152443.12
HGNCiHGNC:26765 ZNF776
neXtProtiNX_Q68DI1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000152443
PharmGKBiPA162410382

Polymorphism and mutation databases

BioMutaiZNF776
DMDMi296453057

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003051401 – 518Zinc finger protein 776Add BLAST518

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki171Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki196Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki220Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki247Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ68DI1
PaxDbiQ68DI1
PeptideAtlasiQ68DI1
PRIDEiQ68DI1

PTM databases

iPTMnetiQ68DI1
PhosphoSitePlusiQ68DI1

Expressioni

Gene expression databases

BgeeiENSG00000152443
CleanExiHS_ZNF776
ExpressionAtlasiQ68DI1 baseline and differential
GenevisibleiQ68DI1 HS

Organism-specific databases

HPAiHPA046653
HPA068553

Interactioni

Protein-protein interaction databases

IntActiQ68DI1, 1 interactor
STRINGi9606.ENSP00000321812

Structurei

3D structure databases

ProteinModelPortaliQ68DI1
SMRiQ68DI1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 89KRABPROSITE-ProRule annotationAdd BLAST76

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri208 – 230C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri236 – 258C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri264 – 286C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri292 – 314C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri320 – 342C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri348 – 370C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri376 – 398C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri404 – 426C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri432 – 454C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri460 – 482C2H2-type 10; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri488 – 510C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119107
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ68DI1
OMAiSHEPFIF
OrthoDBiEOG091G02KC
PhylomeDBiQ68DI1
TreeFamiTF342033

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

Sequencei

Sequence statusi: Complete.

Q68DI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAALRPPA QGTVTFEDVA VNFSQEEWSL LSEAQRCLYH DVMLENLTLI
60 70 80 90 100
SSLGCWYGAK DETPSKQTLS IQQESPLRTH WTGVCTKKVH LWGMCGPLLG
110 120 130 140 150
DILHQGTQHN QKLNGFGAYE KKLDDDANHH QDQKQHIGEK SYRSNAKGTS
160 170 180 190 200
FVKNCKFHMS HEPFIFHEVG KDFLSSLRLL QQEDIHTSGK SNFETKHGIP
210 220 230 240 250
LQGGKTHYIC GESTIPFSNK HSLVLHQRLL PREGPYVCSD SGKFTSKSNS
260 270 280 290 300
FNNHQGVRTG KRPYQCGQCD ESFWYKAHLT EHQRVHTGER PYECGECDKS
310 320 330 340 350
FSHKHSLVDH QRVHTGERPY ECDECGKSFS HKRSLVHHQR VHTGERPYQC
360 370 380 390 400
GECGKSFNHK CNLIQHQRVH TGERPFECTA CGKLFRSNSH LKEHQRVHTG
410 420 430 440 450
ERPYECKECR KSFRYKSHLT EHQRVHTGER PYECRECGKC FHQKGSLIQH
460 470 480 490 500
QQIHSGERPH ECGECGKCFH QKGSLIRHQQ IHSGERPHEC GECGKCFRQK
510
GNLIKHQRVH TGERHHEC
Length:518
Mass (Da):59,613
Last modified:May 18, 2010 - v2
Checksum:i53CD86B2636EE04B
GO

Sequence cautioni

The sequence BAC04588 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence BAC87119 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti183E → V in CAH18239 (PubMed:17974005).Curated1
Sequence conflicti462C → R in CAH18239 (PubMed:17974005).Curated1
Sequence conflicti470H → R in BAC04588 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR749390 mRNA Translation: CAH18239.1
AC003006 Genomic DNA No translation available.
AK127764 mRNA Translation: BAC87119.1 Different initiation.
AK095607 mRNA Translation: BAC04588.1 Sequence problems.
CCDSiCCDS12962.2
RefSeqiNP_001334936.1, NM_001348007.1
NP_775903.3, NM_173632.3
UniGeneiHs.720254
Hs.737521

Genome annotation databases

EnsembliENST00000317178; ENSP00000321812; ENSG00000152443
GeneIDi284309
KEGGihsa:284309
UCSCiuc002qqa.3 human

Similar proteinsi

Entry informationi

Entry nameiZN776_HUMAN
AccessioniPrimary (citable) accession number: Q68DI1
Secondary accession number(s): Q6ZS36, Q8N968
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: May 18, 2010
Last modified: May 23, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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