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Q68DH5

- LMBD2_HUMAN

UniProt

Q68DH5 - LMBD2_HUMAN

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Protein

LMBR1 domain-containing protein 2

Gene

LMBRD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
LMBR1 domain-containing protein 2
Gene namesi
Name:LMBRD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:25287. LMBRD2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 55ExtracellularSequence Analysis
Transmembranei6 – 2116HelicalSequence AnalysisAdd
BLAST
Topological domaini22 – 3211CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei33 – 5321HelicalSequence AnalysisAdd
BLAST
Topological domaini54 – 10552ExtracellularSequence AnalysisAdd
BLAST
Transmembranei106 – 12621HelicalSequence AnalysisAdd
BLAST
Topological domaini127 – 15024CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei151 – 17121HelicalSequence AnalysisAdd
BLAST
Topological domaini172 – 18615ExtracellularSequence AnalysisAdd
BLAST
Transmembranei187 – 20721HelicalSequence AnalysisAdd
BLAST
Topological domaini208 – 387180CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei388 – 40821HelicalSequence AnalysisAdd
BLAST
Topological domaini409 – 43224ExtracellularSequence AnalysisAdd
BLAST
Transmembranei433 – 45321HelicalSequence AnalysisAdd
BLAST
Topological domaini454 – 47320CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei474 – 49421HelicalSequence AnalysisAdd
BLAST
Topological domaini495 – 52127ExtracellularSequence AnalysisAdd
BLAST
Transmembranei522 – 54221HelicalSequence AnalysisAdd
BLAST
Topological domaini543 – 695153CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671541.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 695695LMBR1 domain-containing protein 2PRO_0000299161Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi78 – 781N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ68DH5.
PaxDbiQ68DH5.
PeptideAtlasiQ68DH5.
PRIDEiQ68DH5.

PTM databases

PhosphoSiteiQ68DH5.

Expressioni

Gene expression databases

BgeeiQ68DH5.
CleanExiHS_LMBRD2.
ExpressionAtlasiQ68DH5. baseline and differential.
GenevestigatoriQ68DH5.

Organism-specific databases

HPAiHPA012165.

Interactioni

Protein-protein interaction databases

BioGridi124923. 6 interactions.
STRINGi9606.ENSP00000296603.

Structurei

3D structure databases

ProteinModelPortaliQ68DH5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili227 – 26236Sequence AnalysisAdd
BLAST
Coiled coili571 – 60333Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the LIMR family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG323433.
GeneTreeiENSGT00390000018651.
HOGENOMiHOG000007029.
HOVERGENiHBG101370.
InParanoidiQ68DH5.
OMAiATRQFVH.
OrthoDBiEOG75J0NC.
PhylomeDBiQ68DH5.
TreeFamiTF314938.

Family and domain databases

InterProiIPR006876. LMBR1-like_membr_prot.
[Graphical view]
PfamiPF04791. LMBR1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68DH5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGAALGLEI VFVFFLALFL LHRYGDFKKQ HRLVIIGTLL AWYLCFLIVF
60 70 80 90 100
ILPLDVSTTI YNRCKHAAAN SSPPENSNIT GLYATANPVP SQHPCFKPWS
110 120 130 140 150
YIPDGIMPIF WRVVYWTSQF LTWILLPFMQ SYARSGGFSI TGKIKTALIE
160 170 180 190 200
NAIYYGTYLL IFGAFLIYVA VNPHLHLEWN QLQTIGIAAA NTWGLFLLVL
210 220 230 240 250
LLGYGLVEIP RSYWNGAKRG YLLMKTYFKA AKLMTEKADA EENLEDAMEE
260 270 280 290 300
VRKVNESIKY NHPLRKCVDT ILKKCPTEYQ EKMGRNMDDY EDFDEKHSIY
310 320 330 340 350
PSEKSLVKLH KQVIYSVQRH RRTQVQWQIL LEQAFYLEDV AKNETSATHQ
360 370 380 390 400
FVHTFQSPEP ENRFIQYFYN PTFEWYWECL LRPWFYKILA VVLSIFSVIV
410 420 430 440 450
VWSECTFFST TPVLSLFAVF IQLAEKTYNY IYIEIACFLS IFFLSICVYS
460 470 480 490 500
TVFRIRVFNY YYLASHHQTD AYSLLFSGML FCRLTPPLCL NFLGLTHMDS
510 520 530 540 550
SISHKNTQPT AYTSIMGSMK VLSFIADGFY IYYPMLVVIL CIATYFSLGT
560 570 580 590 600
RCLNLLGFQQ FMGDDDMTSD LVNEGKELIR KEKRKRQRQE EGENRRREWK
610 620 630 640 650
ERYGHNREDS TRNRNIHTDP KESNFSDVNT NRSAFKYTRA NNRTERDRIE
660 670 680 690
LLQDAEPLDF NAETFTDDPL ESESGRYQPG GRYLSMSRSD IFNDV
Length:695
Mass (Da):81,172
Last modified:October 11, 2004 - v1
Checksum:i653291F14D535BC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091295 mRNA. Translation: BAG52328.1.
CR749399 mRNA. Translation: CAH18245.1.
AL137370 mRNA. Translation: CAB70714.1.
BC110506 mRNA. Translation: AAI10507.1.
CCDSiCCDS34145.1.
PIRiT46434.
RefSeqiNP_001007528.1. NM_001007527.1.
UniGeneiHs.294103.

Genome annotation databases

EnsembliENST00000296603; ENSP00000296603; ENSG00000164187.
GeneIDi92255.
KEGGihsa:92255.
UCSCiuc003jkb.1. human.

Polymorphism databases

DMDMi74708880.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091295 mRNA. Translation: BAG52328.1 .
CR749399 mRNA. Translation: CAH18245.1 .
AL137370 mRNA. Translation: CAB70714.1 .
BC110506 mRNA. Translation: AAI10507.1 .
CCDSi CCDS34145.1.
PIRi T46434.
RefSeqi NP_001007528.1. NM_001007527.1.
UniGenei Hs.294103.

3D structure databases

ProteinModelPortali Q68DH5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124923. 6 interactions.
STRINGi 9606.ENSP00000296603.

PTM databases

PhosphoSitei Q68DH5.

Polymorphism databases

DMDMi 74708880.

Proteomic databases

MaxQBi Q68DH5.
PaxDbi Q68DH5.
PeptideAtlasi Q68DH5.
PRIDEi Q68DH5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296603 ; ENSP00000296603 ; ENSG00000164187 .
GeneIDi 92255.
KEGGi hsa:92255.
UCSCi uc003jkb.1. human.

Organism-specific databases

CTDi 92255.
GeneCardsi GC05M036098.
H-InvDB HIX0004810.
HGNCi HGNC:25287. LMBRD2.
HPAi HPA012165.
neXtProti NX_Q68DH5.
PharmGKBi PA142671541.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG323433.
GeneTreei ENSGT00390000018651.
HOGENOMi HOG000007029.
HOVERGENi HBG101370.
InParanoidi Q68DH5.
OMAi ATRQFVH.
OrthoDBi EOG75J0NC.
PhylomeDBi Q68DH5.
TreeFami TF314938.

Miscellaneous databases

GenomeRNAii 92255.
NextBioi 77651.
PROi Q68DH5.

Gene expression databases

Bgeei Q68DH5.
CleanExi HS_LMBRD2.
ExpressionAtlasi Q68DH5. baseline and differential.
Genevestigatori Q68DH5.

Family and domain databases

InterProi IPR006876. LMBR1-like_membr_prot.
[Graphical view ]
Pfami PF04791. LMBR1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Endometrium and Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiLMBD2_HUMAN
AccessioniPrimary (citable) accession number: Q68DH5
Secondary accession number(s): B3KRB6, Q9NTC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: October 11, 2004
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3