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Q68DH5 (LMBD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
LMBR1 domain-containing protein 2
Gene names
Name:LMBRD2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length695 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the LIMR family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainCoiled coil
Transmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 695695LMBR1 domain-containing protein 2
PRO_0000299161

Regions

Topological domain1 – 55Extracellular Potential
Transmembrane6 – 2116Helical; Potential
Topological domain22 – 3211Cytoplasmic Potential
Transmembrane33 – 5321Helical; Potential
Topological domain54 – 10552Extracellular Potential
Transmembrane106 – 12621Helical; Potential
Topological domain127 – 15024Cytoplasmic Potential
Transmembrane151 – 17121Helical; Potential
Topological domain172 – 18615Extracellular Potential
Transmembrane187 – 20721Helical; Potential
Topological domain208 – 387180Cytoplasmic Potential
Transmembrane388 – 40821Helical; Potential
Topological domain409 – 43224Extracellular Potential
Transmembrane433 – 45321Helical; Potential
Topological domain454 – 47320Cytoplasmic Potential
Transmembrane474 – 49421Helical; Potential
Topological domain495 – 52127Extracellular Potential
Transmembrane522 – 54221Helical; Potential
Topological domain543 – 695153Cytoplasmic Potential
Coiled coil227 – 26236 Potential
Coiled coil571 – 60333 Potential

Amino acid modifications

Glycosylation781N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q68DH5 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 653291F14D535BC0

FASTA69581,172
        10         20         30         40         50         60 
MSGAALGLEI VFVFFLALFL LHRYGDFKKQ HRLVIIGTLL AWYLCFLIVF ILPLDVSTTI 

        70         80         90        100        110        120 
YNRCKHAAAN SSPPENSNIT GLYATANPVP SQHPCFKPWS YIPDGIMPIF WRVVYWTSQF 

       130        140        150        160        170        180 
LTWILLPFMQ SYARSGGFSI TGKIKTALIE NAIYYGTYLL IFGAFLIYVA VNPHLHLEWN 

       190        200        210        220        230        240 
QLQTIGIAAA NTWGLFLLVL LLGYGLVEIP RSYWNGAKRG YLLMKTYFKA AKLMTEKADA 

       250        260        270        280        290        300 
EENLEDAMEE VRKVNESIKY NHPLRKCVDT ILKKCPTEYQ EKMGRNMDDY EDFDEKHSIY 

       310        320        330        340        350        360 
PSEKSLVKLH KQVIYSVQRH RRTQVQWQIL LEQAFYLEDV AKNETSATHQ FVHTFQSPEP 

       370        380        390        400        410        420 
ENRFIQYFYN PTFEWYWECL LRPWFYKILA VVLSIFSVIV VWSECTFFST TPVLSLFAVF 

       430        440        450        460        470        480 
IQLAEKTYNY IYIEIACFLS IFFLSICVYS TVFRIRVFNY YYLASHHQTD AYSLLFSGML 

       490        500        510        520        530        540 
FCRLTPPLCL NFLGLTHMDS SISHKNTQPT AYTSIMGSMK VLSFIADGFY IYYPMLVVIL 

       550        560        570        580        590        600 
CIATYFSLGT RCLNLLGFQQ FMGDDDMTSD LVNEGKELIR KEKRKRQRQE EGENRRREWK 

       610        620        630        640        650        660 
ERYGHNREDS TRNRNIHTDP KESNFSDVNT NRSAFKYTRA NNRTERDRIE LLQDAEPLDF 

       670        680        690 
NAETFTDDPL ESESGRYQPG GRYLSMSRSD IFNDV 

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Endometrium and Testis.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK091295 mRNA. Translation: BAG52328.1.
CR749399 mRNA. Translation: CAH18245.1.
AL137370 mRNA. Translation: CAB70714.1.
BC110506 mRNA. Translation: AAI10507.1.
CCDSCCDS34145.1.
PIRT46434.
RefSeqNP_001007528.1. NM_001007527.1.
UniGeneHs.294103.

3D structure databases

ProteinModelPortalQ68DH5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124923. 1 interaction.
STRING9606.ENSP00000296603.

PTM databases

PhosphoSiteQ68DH5.

Polymorphism databases

DMDM74708880.

Proteomic databases

MaxQBQ68DH5.
PaxDbQ68DH5.
PeptideAtlasQ68DH5.
PRIDEQ68DH5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000296603; ENSP00000296603; ENSG00000164187.
GeneID92255.
KEGGhsa:92255.
UCSCuc003jkb.1. human.

Organism-specific databases

CTD92255.
GeneCardsGC05M036098.
H-InvDBHIX0004810.
HGNCHGNC:25287. LMBRD2.
HPAHPA012165.
neXtProtNX_Q68DH5.
PharmGKBPA142671541.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG323433.
HOGENOMHOG000007029.
HOVERGENHBG101370.
InParanoidQ68DH5.
OMAATRQFVH.
OrthoDBEOG75J0NC.
PhylomeDBQ68DH5.
TreeFamTF314938.

Gene expression databases

ArrayExpressQ68DH5.
BgeeQ68DH5.
CleanExHS_LMBRD2.
GenevestigatorQ68DH5.

Family and domain databases

InterProIPR006876. LMBR1-like_membr_prot.
[Graphical view]
PfamPF04791. LMBR1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi92255.
NextBio77651.
PROQ68DH5.

Entry information

Entry nameLMBD2_HUMAN
AccessionPrimary (citable) accession number: Q68DH5
Secondary accession number(s): B3KRB6, Q9NTC7
Entry history
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: October 11, 2004
Last modified: July 9, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM