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Protein

LMBR1 domain-containing protein 2

Gene

LMBRD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
LMBR1 domain-containing protein 2
Gene namesi
Name:LMBRD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:25287. LMBRD2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 5ExtracellularSequence analysis5
Transmembranei6 – 21HelicalSequence analysisAdd BLAST16
Topological domaini22 – 32CytoplasmicSequence analysisAdd BLAST11
Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Topological domaini54 – 105ExtracellularSequence analysisAdd BLAST52
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Topological domaini127 – 150CytoplasmicSequence analysisAdd BLAST24
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Topological domaini172 – 186ExtracellularSequence analysisAdd BLAST15
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Topological domaini208 – 387CytoplasmicSequence analysisAdd BLAST180
Transmembranei388 – 408HelicalSequence analysisAdd BLAST21
Topological domaini409 – 432ExtracellularSequence analysisAdd BLAST24
Transmembranei433 – 453HelicalSequence analysisAdd BLAST21
Topological domaini454 – 473CytoplasmicSequence analysisAdd BLAST20
Transmembranei474 – 494HelicalSequence analysisAdd BLAST21
Topological domaini495 – 521ExtracellularSequence analysisAdd BLAST27
Transmembranei522 – 542HelicalSequence analysisAdd BLAST21
Topological domaini543 – 695CytoplasmicSequence analysisAdd BLAST153

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi92255.
OpenTargetsiENSG00000164187.
PharmGKBiPA142671541.

Polymorphism and mutation databases

BioMutaiLMBRD2.
DMDMi74708880.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002991611 – 695LMBR1 domain-containing protein 2Add BLAST695

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi78N-linked (GlcNAc...)Sequence analysis1
Modified residuei633PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ68DH5.
MaxQBiQ68DH5.
PaxDbiQ68DH5.
PeptideAtlasiQ68DH5.
PRIDEiQ68DH5.

PTM databases

iPTMnetiQ68DH5.
PhosphoSitePlusiQ68DH5.

Expressioni

Gene expression databases

BgeeiENSG00000164187.
CleanExiHS_LMBRD2.
GenevisibleiQ68DH5. HS.

Organism-specific databases

HPAiHPA012165.

Interactioni

Protein-protein interaction databases

BioGridi124923. 14 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ68DH5.
SMRiQ68DH5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili227 – 262Sequence analysisAdd BLAST36
Coiled coili571 – 603Sequence analysisAdd BLAST33

Sequence similaritiesi

Belongs to the LIMR family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2296. Eukaryota.
ENOG410XR8P. LUCA.
GeneTreeiENSGT00390000018651.
HOGENOMiHOG000007029.
HOVERGENiHBG101370.
InParanoidiQ68DH5.
OMAiHIDPKES.
OrthoDBiEOG091G048E.
PhylomeDBiQ68DH5.
TreeFamiTF314938.

Family and domain databases

InterProiIPR006876. LMBR1-like_membr_prot.
[Graphical view]
PfamiPF04791. LMBR1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68DH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGAALGLEI VFVFFLALFL LHRYGDFKKQ HRLVIIGTLL AWYLCFLIVF
60 70 80 90 100
ILPLDVSTTI YNRCKHAAAN SSPPENSNIT GLYATANPVP SQHPCFKPWS
110 120 130 140 150
YIPDGIMPIF WRVVYWTSQF LTWILLPFMQ SYARSGGFSI TGKIKTALIE
160 170 180 190 200
NAIYYGTYLL IFGAFLIYVA VNPHLHLEWN QLQTIGIAAA NTWGLFLLVL
210 220 230 240 250
LLGYGLVEIP RSYWNGAKRG YLLMKTYFKA AKLMTEKADA EENLEDAMEE
260 270 280 290 300
VRKVNESIKY NHPLRKCVDT ILKKCPTEYQ EKMGRNMDDY EDFDEKHSIY
310 320 330 340 350
PSEKSLVKLH KQVIYSVQRH RRTQVQWQIL LEQAFYLEDV AKNETSATHQ
360 370 380 390 400
FVHTFQSPEP ENRFIQYFYN PTFEWYWECL LRPWFYKILA VVLSIFSVIV
410 420 430 440 450
VWSECTFFST TPVLSLFAVF IQLAEKTYNY IYIEIACFLS IFFLSICVYS
460 470 480 490 500
TVFRIRVFNY YYLASHHQTD AYSLLFSGML FCRLTPPLCL NFLGLTHMDS
510 520 530 540 550
SISHKNTQPT AYTSIMGSMK VLSFIADGFY IYYPMLVVIL CIATYFSLGT
560 570 580 590 600
RCLNLLGFQQ FMGDDDMTSD LVNEGKELIR KEKRKRQRQE EGENRRREWK
610 620 630 640 650
ERYGHNREDS TRNRNIHTDP KESNFSDVNT NRSAFKYTRA NNRTERDRIE
660 670 680 690
LLQDAEPLDF NAETFTDDPL ESESGRYQPG GRYLSMSRSD IFNDV
Length:695
Mass (Da):81,172
Last modified:October 11, 2004 - v1
Checksum:i653291F14D535BC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091295 mRNA. Translation: BAG52328.1.
CR749399 mRNA. Translation: CAH18245.1.
AL137370 mRNA. Translation: CAB70714.1.
BC110506 mRNA. Translation: AAI10507.1.
CCDSiCCDS34145.1.
PIRiT46434.
RefSeqiNP_001007528.1. NM_001007527.1.
XP_011512464.1. XM_011514162.2.
UniGeneiHs.294103.
Hs.599179.

Genome annotation databases

EnsembliENST00000296603; ENSP00000296603; ENSG00000164187.
GeneIDi92255.
KEGGihsa:92255.
UCSCiuc003jka.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091295 mRNA. Translation: BAG52328.1.
CR749399 mRNA. Translation: CAH18245.1.
AL137370 mRNA. Translation: CAB70714.1.
BC110506 mRNA. Translation: AAI10507.1.
CCDSiCCDS34145.1.
PIRiT46434.
RefSeqiNP_001007528.1. NM_001007527.1.
XP_011512464.1. XM_011514162.2.
UniGeneiHs.294103.
Hs.599179.

3D structure databases

ProteinModelPortaliQ68DH5.
SMRiQ68DH5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124923. 14 interactors.

PTM databases

iPTMnetiQ68DH5.
PhosphoSitePlusiQ68DH5.

Polymorphism and mutation databases

BioMutaiLMBRD2.
DMDMi74708880.

Proteomic databases

EPDiQ68DH5.
MaxQBiQ68DH5.
PaxDbiQ68DH5.
PeptideAtlasiQ68DH5.
PRIDEiQ68DH5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296603; ENSP00000296603; ENSG00000164187.
GeneIDi92255.
KEGGihsa:92255.
UCSCiuc003jka.2. human.

Organism-specific databases

CTDi92255.
DisGeNETi92255.
GeneCardsiLMBRD2.
H-InvDBHIX0004810.
HGNCiHGNC:25287. LMBRD2.
HPAiHPA012165.
neXtProtiNX_Q68DH5.
OpenTargetsiENSG00000164187.
PharmGKBiPA142671541.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2296. Eukaryota.
ENOG410XR8P. LUCA.
GeneTreeiENSGT00390000018651.
HOGENOMiHOG000007029.
HOVERGENiHBG101370.
InParanoidiQ68DH5.
OMAiHIDPKES.
OrthoDBiEOG091G048E.
PhylomeDBiQ68DH5.
TreeFamiTF314938.

Miscellaneous databases

GenomeRNAii92255.
PROiQ68DH5.

Gene expression databases

BgeeiENSG00000164187.
CleanExiHS_LMBRD2.
GenevisibleiQ68DH5. HS.

Family and domain databases

InterProiIPR006876. LMBR1-like_membr_prot.
[Graphical view]
PfamiPF04791. LMBR1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLMBD2_HUMAN
AccessioniPrimary (citable) accession number: Q68DH5
Secondary accession number(s): B3KRB6, Q9NTC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.