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Q68DH5

- LMBD2_HUMAN

UniProt

Q68DH5 - LMBD2_HUMAN

Protein

LMBR1 domain-containing protein 2

Gene

LMBRD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    LMBR1 domain-containing protein 2
    Gene namesi
    Name:LMBRD2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:25287. LMBRD2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671541.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 695695LMBR1 domain-containing protein 2PRO_0000299161Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi78 – 781N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ68DH5.
    PaxDbiQ68DH5.
    PeptideAtlasiQ68DH5.
    PRIDEiQ68DH5.

    PTM databases

    PhosphoSiteiQ68DH5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ68DH5.
    BgeeiQ68DH5.
    CleanExiHS_LMBRD2.
    GenevestigatoriQ68DH5.

    Organism-specific databases

    HPAiHPA012165.

    Interactioni

    Protein-protein interaction databases

    BioGridi124923. 1 interaction.
    STRINGi9606.ENSP00000296603.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68DH5.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 55ExtracellularSequence Analysis
    Topological domaini22 – 3211CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini54 – 10552ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini127 – 15024CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini172 – 18615ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini208 – 387180CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini409 – 43224ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini454 – 47320CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini495 – 52127ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini543 – 695153CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei6 – 2116HelicalSequence AnalysisAdd
    BLAST
    Transmembranei33 – 5321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei106 – 12621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei151 – 17121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei187 – 20721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei388 – 40821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei433 – 45321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei474 – 49421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei522 – 54221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili227 – 26236Sequence AnalysisAdd
    BLAST
    Coiled coili571 – 60333Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the LIMR family.Curated

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG323433.
    HOGENOMiHOG000007029.
    HOVERGENiHBG101370.
    InParanoidiQ68DH5.
    OMAiATRQFVH.
    OrthoDBiEOG75J0NC.
    PhylomeDBiQ68DH5.
    TreeFamiTF314938.

    Family and domain databases

    InterProiIPR006876. LMBR1-like_membr_prot.
    [Graphical view]
    PfamiPF04791. LMBR1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q68DH5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGAALGLEI VFVFFLALFL LHRYGDFKKQ HRLVIIGTLL AWYLCFLIVF    50
    ILPLDVSTTI YNRCKHAAAN SSPPENSNIT GLYATANPVP SQHPCFKPWS 100
    YIPDGIMPIF WRVVYWTSQF LTWILLPFMQ SYARSGGFSI TGKIKTALIE 150
    NAIYYGTYLL IFGAFLIYVA VNPHLHLEWN QLQTIGIAAA NTWGLFLLVL 200
    LLGYGLVEIP RSYWNGAKRG YLLMKTYFKA AKLMTEKADA EENLEDAMEE 250
    VRKVNESIKY NHPLRKCVDT ILKKCPTEYQ EKMGRNMDDY EDFDEKHSIY 300
    PSEKSLVKLH KQVIYSVQRH RRTQVQWQIL LEQAFYLEDV AKNETSATHQ 350
    FVHTFQSPEP ENRFIQYFYN PTFEWYWECL LRPWFYKILA VVLSIFSVIV 400
    VWSECTFFST TPVLSLFAVF IQLAEKTYNY IYIEIACFLS IFFLSICVYS 450
    TVFRIRVFNY YYLASHHQTD AYSLLFSGML FCRLTPPLCL NFLGLTHMDS 500
    SISHKNTQPT AYTSIMGSMK VLSFIADGFY IYYPMLVVIL CIATYFSLGT 550
    RCLNLLGFQQ FMGDDDMTSD LVNEGKELIR KEKRKRQRQE EGENRRREWK 600
    ERYGHNREDS TRNRNIHTDP KESNFSDVNT NRSAFKYTRA NNRTERDRIE 650
    LLQDAEPLDF NAETFTDDPL ESESGRYQPG GRYLSMSRSD IFNDV 695
    Length:695
    Mass (Da):81,172
    Last modified:October 11, 2004 - v1
    Checksum:i653291F14D535BC0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK091295 mRNA. Translation: BAG52328.1.
    CR749399 mRNA. Translation: CAH18245.1.
    AL137370 mRNA. Translation: CAB70714.1.
    BC110506 mRNA. Translation: AAI10507.1.
    CCDSiCCDS34145.1.
    PIRiT46434.
    RefSeqiNP_001007528.1. NM_001007527.1.
    UniGeneiHs.294103.

    Genome annotation databases

    EnsembliENST00000296603; ENSP00000296603; ENSG00000164187.
    GeneIDi92255.
    KEGGihsa:92255.
    UCSCiuc003jkb.1. human.

    Polymorphism databases

    DMDMi74708880.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK091295 mRNA. Translation: BAG52328.1 .
    CR749399 mRNA. Translation: CAH18245.1 .
    AL137370 mRNA. Translation: CAB70714.1 .
    BC110506 mRNA. Translation: AAI10507.1 .
    CCDSi CCDS34145.1.
    PIRi T46434.
    RefSeqi NP_001007528.1. NM_001007527.1.
    UniGenei Hs.294103.

    3D structure databases

    ProteinModelPortali Q68DH5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124923. 1 interaction.
    STRINGi 9606.ENSP00000296603.

    PTM databases

    PhosphoSitei Q68DH5.

    Polymorphism databases

    DMDMi 74708880.

    Proteomic databases

    MaxQBi Q68DH5.
    PaxDbi Q68DH5.
    PeptideAtlasi Q68DH5.
    PRIDEi Q68DH5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000296603 ; ENSP00000296603 ; ENSG00000164187 .
    GeneIDi 92255.
    KEGGi hsa:92255.
    UCSCi uc003jkb.1. human.

    Organism-specific databases

    CTDi 92255.
    GeneCardsi GC05M036098.
    H-InvDB HIX0004810.
    HGNCi HGNC:25287. LMBRD2.
    HPAi HPA012165.
    neXtProti NX_Q68DH5.
    PharmGKBi PA142671541.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG323433.
    HOGENOMi HOG000007029.
    HOVERGENi HBG101370.
    InParanoidi Q68DH5.
    OMAi ATRQFVH.
    OrthoDBi EOG75J0NC.
    PhylomeDBi Q68DH5.
    TreeFami TF314938.

    Miscellaneous databases

    GenomeRNAii 92255.
    NextBioi 77651.
    PROi Q68DH5.

    Gene expression databases

    ArrayExpressi Q68DH5.
    Bgeei Q68DH5.
    CleanExi HS_LMBRD2.
    Genevestigatori Q68DH5.

    Family and domain databases

    InterProi IPR006876. LMBR1-like_membr_prot.
    [Graphical view ]
    Pfami PF04791. LMBR1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Endometrium and Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiLMBD2_HUMAN
    AccessioniPrimary (citable) accession number: Q68DH5
    Secondary accession number(s): B3KRB6, Q9NTC7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3