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Q68DC2 (ANKS6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ankyrin repeat and SAM domain-containing protein 6
Alternative name(s):
Ankyrin repeat domain-containing protein 14
SamCystin
Sterile alpha motif domain-containing protein 6
Short name=SAM domain-containing protein 6
Gene names
Name:ANKS6
Synonyms:ANKRD14, PKDR1, SAMD6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length871 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for renal function. Ref.10

Subunit structure

Self-associates. Interacts (via SAM domain) with BICC1 (via KH domains) in an RNA-dependent manner By similarity. Central component of a complex containing at least ANKS6, INVS, NEK8 and NPHP3. ANKS6 may organize complex assembly by linking INVS and NPHP3 to NEK8 and INVS may target the complex to the proximal ciliary axoneme. Ref.10

Subcellular location

Cell projectioncilium By similarity. Cytoplasm By similarity. Note: Localizes to the proximal region of the primary cilium in the presence of INVS By similarity.

Domain

The ankyrin repeats and the SAM domain are essential for self-association By similarity. Ankyrin repeats are necessary and sufficient for NEK8-binding. Ref.10

Post-translational modification

Hydroxylated at Asn-138, most probably by HIF1AN. This hydroxylation results in decreased NEK8-binding.

Involvement in disease

Nephronophthisis 16 (NPHP16) [MIM:615382]: A form of nephronophthisis, a chronic tubulo-interstitial nephritis that progresses to end-stage renal failure. Some patients have cystic kidneys of normal size and no extrarenal manifestations, whereas others have enlarged renal size and severe extrarenal defects, including hypertrophic obstructive cardiomyopathy, aortic stenosis, pulmonary stenosis, patent ductus arteriosus, situs inversus, and periportal liver fibrosis.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.10

Sequence similarities

Contains 11 ANK repeats.

Contains 1 SAM (sterile alpha motif) domain.

Sequence caution

The sequence AAH64367.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAC04317.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence CAH18298.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence CAH69985.2 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAH69986.2 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAH71295.2 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAH71296.2 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Cellular componentCell projection
Cilium
Cytoplasm
   Coding sequence diversityAlternative splicing
Polymorphism
   DiseaseCiliopathy
Disease mutation
Joubert syndrome
Nephronophthisis
   DomainANK repeat
Repeat
   PTMHydroxylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcilium

Inferred from electronic annotation. Source: UniProtKB-SubCell

cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q68DC2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q68DC2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     288-335: DEEKRRPDIF...GATPLMLAAV → GQAACPPWLH...RPLRLRKWCA
     336-871: Missing.
Note: Gene prediction confirmed by EST data.
Isoform 3 (identifier: Q68DC2-4)

The sequence of this isoform differs from the canonical sequence as follows:
     714-714: K → KQ
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 871871Ankyrin repeat and SAM domain-containing protein 6
PRO_0000067065

Regions

Repeat8 – 3730ANK 1
Repeat77 – 10630ANK 2
Repeat110 – 13930ANK 3
Repeat143 – 17230ANK 4
Repeat190 – 21930ANK 5
Repeat224 – 25330ANK 6
Repeat257 – 28933ANK 7
Repeat291 – 32131ANK 8
Repeat325 – 35430ANK 9
Repeat359 – 38830ANK 10
Repeat392 – 42332ANK 11
Domain773 – 83664SAM
Compositional bias617 – 769153Ser-rich

Amino acid modifications

Modified residue13813-hydroxyasparagine By similarity

Natural variations

Alternative sequence288 – 33548DEEKR…MLAAV → GQAACPPWLHRGPQIVFMWL KLRIALLEGHAELRVQPCRP LRLRKWCA in isoform 2.
VSP_016496
Alternative sequence336 – 871536Missing in isoform 2.
VSP_016497
Alternative sequence7141K → KQ in isoform 3.
VSP_016498
Natural variant2221R → W. Ref.9
Corresponds to variant rs41283630 [ dbSNP | Ensembl ].
VAR_070105
Natural variant3121A → P in NPHP16. Ref.10
VAR_070106
Natural variant4401R → Q. Ref.9
VAR_070107
Natural variant4411Q → R in NPHP16.
Corresponds to variant rs377750405 [ dbSNP | Ensembl ].
VAR_070108
Natural variant6401G → S. Ref.9
VAR_070109
Natural variant6441V → I. Ref.3 Ref.4 Ref.5 Ref.9
Corresponds to variant rs6415847 [ dbSNP | Ensembl ].
VAR_034794
Natural variant7351P → A. Ref.9
Corresponds to variant rs79414550 [ dbSNP | Ensembl ].
VAR_070110

Experimental info

Sequence conflict2441L → P in CAH18298. Ref.3
Sequence conflict4021L → P in CAH18302. Ref.4
Sequence conflict6471S → G in BAC04317. Ref.5
Sequence conflict8081T → A in CAH18302. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 6, 2005. Version 2.
Checksum: C4E3AFFE9C9DD6C8

FASTA87192,219
        10         20         30         40         50         60 
MGEGGLPPAF QLLLRACDQG DTETARRLLE PGAAEPAERG AEPEAGAEPA GAEVAGPGAA 

        70         80         90        100        110        120 
AAGAVGAPVP VDCSDEAGNT ALQFAAAGGH EPLVRFLLRR GASVNSRNHY GWSALMQAAR 

       130        140        150        160        170        180 
FGHVSVAHLL LDHGADVNAQ NRLGASVLTV ASRGGHLGVV KLLLEAGAFV DHHHPSGEQL 

       190        200        210        220        230        240 
GLGGSRDEPL DITALMAAIQ HGHEAVVRLL MEWGADPNHA ARTVGWSPLM LAALTGRLGV 

       250        260        270        280        290        300 
AQQLVEKGAN PDHLSVLEKT AFEVALDCKH RDLVDYLDPL TTVRPKTDEE KRRPDIFHAL 

       310        320        330        340        350        360 
KMGNFQLVKE IADEDPSHVN LVNGDGATPL MLAAVTGQLA LVQLLVERHA DVDKQDSVHG 

       370        380        390        400        410        420 
WTALMQATYH GNKEIVKYLL NQGADVTLRA KNGYTAFDLV MLLNDPDTEL VRLLASVCMQ 

       430        440        450        460        470        480 
VNKDKGRPSH QPPLPHSKVR QPWSIPVLPD DKGGLKSWWN RMSNRFRKLK LMQTLPRGLS 

       490        500        510        520        530        540 
SNQPLPFSDE PEPALDSTMR AAPQDKTSRS ALPDAAPVTK DNGPGSTRGE KEDTLLTTML 

       550        560        570        580        590        600 
RNGAPLTRLP SDKLKAVIPP FLPPSSFELW SSDRSRTRHN GKADPMKTAL PQRASRGHPV 

       610        620        630        640        650        660 
GGGGTDTTPV RPVKFPSLPR SPASSANSGN FNHSPHSSGG SSGVGVSRHG GELLNRSGGS 

       670        680        690        700        710        720 
IDNVLSQIAA QRKKAAGLLE QKPSHRSSPV GPAPGSSPSE LPASPAGGSA PVGKKLETSK 

       730        740        750        760        770        780 
RPPSGTSTTS KSTSPTLTPS PSPKGHTAES SVSSSSSHRQ SKSSGGSSSG TITDEDELTG 

       790        800        810        820        830        840 
ILKKLSLEKY QPIFEEQEVD MEAFLTLTDG DLKELGIKTD GSRQQILAAI SELNAGKGRE 

       850        860        870 
RQILQETIHN FHSSFESSAS NTRAPGNSPC A 

« Hide

Isoform 2 [UniParc].

Checksum: 88570D12C8D0A758
Show »

FASTA33535,392
Isoform 3 [UniParc].

Checksum: AA7F61B02CE2427C
Show »

FASTA87292,347

References

« Hide 'large scale' references
[1]"Missense mutation in sterile alpha motif of novel protein SamCystin is associated with polycystic kidney disease in (cy/+) rat."
Brown J.H., Bihoreau M.-T., Hoffmann S., Kranzlin B., Tychinskaya I., Obermuller N., Podlich D., Boehn S.N., Kaisaki P.J., Megel N., Danoy P., Copley R.R., Broxholme J., Witzgall R., Lathrop M., Gretz N., Gauguier D.
J. Am. Soc. Nephrol. 16:3517-3526(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 94-871 (ISOFORM 1), VARIANT ILE-644.
Tissue: Fetal kidney and Uterus.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 322-871 (ISOFORM 1), VARIANT ILE-644.
Tissue: Skin.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 533-871 (ISOFORM 3), VARIANT ILE-644.
Tissue: Cerebellum.
[6]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[9]"Genomic organization and mutation screening of the human ortholog of Pkdr1 associated with polycystic kidney disease in the rat."
Kaisaki P.J., Bergmann C., Brown J.H., Outeda P., Lens X.M., Peters D.J., Gretz N., Gauguier D., Bihoreau M.T.
Eur. J. Med. Genet. 51:325-331(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS TRP-222; GLN-440; SER-640; ILE-644 AND ALA-735.
[10]"ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3."
Hoff S., Halbritter J., Epting D., Frank V., Nguyen T.M., van Reeuwijk J., Boehlke C., Schell C., Yasunaga T., Helmstadter M., Mergen M., Filhol E., Boldt K., Horn N., Ueffing M., Otto E.A., Eisenberger T., Elting M.W. expand/collapse author list , van Wijk J.A., Bockenhauer D., Sebire N.J., Rittig S., Vyberg M., Ring T., Pohl M., Pape L., Neuhaus T.J., Elshakhs N.A., Koon S.J., Harris P.C., Grahammer F., Huber T.B., Kuehn E.W., Kramer-Zucker A., Bolz H.J., Roepman R., Saunier S., Walz G., Hildebrandt F., Bergmann C., Lienkamp S.S.
Nat. Genet. 45:951-956(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS NPHP16 PRO-312 AND GLN441ARG, FUNCTION, INTERACTION WITH INVS; NEK8 AND NPHP3, DOMAIN.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ309791 expand/collapse EMBL AC list , DQ309777, DQ309778, DQ309779, DQ309780, DQ309781, DQ309782, DQ309783, DQ309784, DQ309785, DQ309786, DQ309787, DQ309788, DQ309789, DQ309790 Genomic DNA. Translation: ABC48694.1.
AL353782, AL807776 Genomic DNA. Translation: CAH71295.2. Sequence problems.
AL353782, AL807776 Genomic DNA. Translation: CAH71296.2. Sequence problems.
AL353782, AL807776 Genomic DNA. Translation: CAM14169.1.
AL807776, AL353782 Genomic DNA. Translation: CAH69985.2. Sequence problems.
AL807776, AL353782 Genomic DNA. Translation: CAH69986.2. Sequence problems.
AL807776, AL353782 Genomic DNA. Translation: CAM13062.1.
CR749467 mRNA. Translation: CAH18298.1. Different initiation.
CR749472 mRNA. Translation: CAH18302.1.
BC064367 mRNA. Translation: AAH64367.1. Different initiation.
AK094247 mRNA. Translation: BAC04317.1. Different initiation.
CCDSCCDS43856.1. [Q68DC2-1]
RefSeqNP_775822.3. NM_173551.3. [Q68DC2-1]
XP_006717061.1. XM_006716998.1. [Q68DC2-4]
UniGeneHs.406890.

3D structure databases

ProteinModelPortalQ68DC2.
SMRQ68DC2. Positions 9-419, 774-836.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid128464. 1 interaction.
IntActQ68DC2. 1 interaction.
MINTMINT-8201748.

PTM databases

PhosphoSiteQ68DC2.

Polymorphism databases

DMDM83305683.

Proteomic databases

MaxQBQ68DC2.
PaxDbQ68DC2.
PRIDEQ68DC2.

Protocols and materials databases

DNASU203286.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000353234; ENSP00000297837; ENSG00000165138. [Q68DC2-1]
ENST00000375018; ENSP00000364158; ENSG00000165138. [Q68DC2-4]
GeneID203286.
KEGGhsa:203286.
UCSCuc004ayt.3. human. [Q68DC2-1]

Organism-specific databases

CTD203286.
GeneCardsGC09M101493.
H-InvDBHIX0025696.
HGNCHGNC:26724. ANKS6.
HPAHPA008355.
MIM615370. gene.
615382. phenotype.
neXtProtNX_Q68DC2.
Orphanet93591. Infantile autosomal recessive medullary cystic kidney disease.
93592. Juvenile autosomal recessive medullary cystic kidney disease.
PharmGKBPA134931829.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0666.
HOVERGENHBG059049.
OMADRKHRDL.
OrthoDBEOG7DRJ2G.
PhylomeDBQ68DC2.
TreeFamTF328552.

Gene expression databases

ArrayExpressQ68DC2.
BgeeQ68DC2.
CleanExHS_ANKS6.
GenevestigatorQ68DC2.

Family and domain databases

Gene3D1.10.150.50. 1 hit.
1.25.40.20. 3 hits.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view]
PfamPF12796. Ank_2. 3 hits.
PF00536. SAM_1. 1 hit.
[Graphical view]
PRINTSPR01415. ANKYRIN.
SMARTSM00248. ANK. 9 hits.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMSSF47769. SSF47769. 1 hit.
SSF48403. SSF48403. 3 hits.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 7 hits.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi203286.
NextBio90399.
PROQ68DC2.
SOURCESearch...

Entry information

Entry nameANKS6_HUMAN
AccessionPrimary (citable) accession number: Q68DC2
Secondary accession number(s): A0SE62 expand/collapse secondary AC list , Q5VSL0, Q5VSL2, Q5VSL3, Q5VSL4, Q68DB8, Q6P2R2, Q8N9L6, Q96D62
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: July 9, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM