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Protein
Submitted name:

MDM4 protein variant G

Gene

DKFZp781B1423

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
MDM4 protein variant GImported
Submitted name:
MDM4 protein variant YImported
Submitted name:
Protein Mdm4Imported
Submitted name:
Putative uncharacterized protein DKFZp781B1423Imported
Submitted name:
cDNA FLJ56709, highly similar to Mdm4 proteinImported
Gene namesi
Name:DKFZp781B1423Imported
Synonyms:MDM4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:6974. MDM4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PeptideAtlasiQ68DC0.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000356150.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 9162SWIBInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiENOG410IE9V. Eukaryota.
ENOG410XSWN. LUCA.
GeneTreeiENSGT00530000063539.
HOVERGENiHBG054862.

Family and domain databases

Gene3Di1.10.245.10. 1 hit.
InterProiIPR016495. p53_neg-reg_MDM_2/4.
IPR003121. SWIB_MDM2_domain.
[Graphical view]
PfamiPF02201. SWIB. 1 hit.
[Graphical view]
PIRSFiPIRSF006748. p53_MDM_2/4. 1 hit.
SUPFAMiSSF47592. SSF47592. 1 hit.

Sequencei

Sequence statusi: Complete.

Q68DC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSFSTSAQC STSDSACRIS PGQINQVRPK LPLLKILHAA GAQGEMFTVK
60 70 80 90 100
EVMHYLGQYI MVKQLYDQQE QHMVYCGGDL LGELLGRQSF SVKDPSPLYD
110 120 130 140
MLRKNLVTLA TATTAKCRGK FHFQKKNYRR RYPHTAYLRA
Length:140
Mass (Da):15,907
Last modified:October 11, 2004 - v1
Checksum:i79EEF2BFB123B726
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL512306 Genomic DNA. No translation available.
KF435149 mRNA. Translation: AGZ93683.1.
KF435150 mRNA. Translation: AGZ93684.1.
AK304698 mRNA. Translation: BAG65468.1.
CR749470 mRNA. Translation: CAH18300.1.
RefSeqiNP_001265445.1. NM_001278516.1.
XP_011507870.1. XM_011509568.1.
UniGeneiHs.497492.
Hs.715871.

Genome annotation databases

EnsembliENST00000391947; ENSP00000375811; ENSG00000198625.
ENST00000507825; ENSP00000443816; ENSG00000198625.
GeneIDi4194.
UCSCiuc031vkp.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL512306 Genomic DNA. No translation available.
KF435149 mRNA. Translation: AGZ93683.1.
KF435150 mRNA. Translation: AGZ93684.1.
AK304698 mRNA. Translation: BAG65468.1.
CR749470 mRNA. Translation: CAH18300.1.
RefSeqiNP_001265445.1. NM_001278516.1.
XP_011507870.1. XM_011509568.1.
UniGeneiHs.497492.
Hs.715871.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000356150.

Proteomic databases

PeptideAtlasiQ68DC0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391947; ENSP00000375811; ENSG00000198625.
ENST00000507825; ENSP00000443816; ENSG00000198625.
GeneIDi4194.
UCSCiuc031vkp.2. human.

Organism-specific databases

CTDi4194.
HGNCiHGNC:6974. MDM4.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE9V. Eukaryota.
ENOG410XSWN. LUCA.
GeneTreeiENSGT00530000063539.
HOVERGENiHBG054862.

Miscellaneous databases

ChiTaRSiMDM4. human.
GenomeRNAii4194.

Family and domain databases

Gene3Di1.10.245.10. 1 hit.
InterProiIPR016495. p53_neg-reg_MDM_2/4.
IPR003121. SWIB_MDM2_domain.
[Graphical view]
PfamiPF02201. SWIB. 1 hit.
[Graphical view]
PIRSFiPIRSF006748. p53_MDM_2/4. 1 hit.
SUPFAMiSSF47592. SSF47592. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: TestisImported.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R., Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P., Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D., Porter K.M., Prigmore E.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: UterusImported.
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
  5. "Short alternative splice transcripts of MDM4 gene correlate to malignancy in human glioma."
    Wang X.W., Sheng P., Dong Y., Lu Y.C.
    Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ68DC0_HUMAN
AccessioniPrimary (citable) accession number: Q68DC0
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2004
Last sequence update: October 11, 2004
Last modified: July 6, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.